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The map label for this gene is hemK [H]

Identifier: 83591212

GI number: 83591212

Start: 2516791

End: 2517642

Strand: Reverse

Name: hemK [H]

Synonym: Moth_2396

Alternate gene names: 83591212

Gene position: 2517642-2516791 (Counterclockwise)

Preceding gene: 83591213

Following gene: 83591211

Centisome position: 95.77

GC content: 66.9

Gene sequence:

>852_bases
ATGACCCTGCGGCAAGCCCTGGGGGAGGCCGTCCGGCGCCTGGCGGCCGGGGGGGTTGAACGCCCGCGGCTGGAGGCGGA
AGTCCTTCTCGGGTGGGCCTGTAGTTTAACCCGGCCCCGCCTCCTGGCCCGCCTGGAGGAGGAACTGGCACCGGCAGCCG
CAGGACGGTTCTGGCAGGCAATTGACCGCCGGGCAGCCGGTTACCCCCTCCAGTACCTCACCGGACACCAGGAATTTATG
TCCCTGGACTTTAAAGTCACTCCGGCGGTTTTAATCCCCCGCCAGGATACCGAAGTGGTGGTGGAGGCTGTCCTTGAGCG
TCTGGACCCCTGCGAGAGCTATACCATCGCCGACTGCGGTACGGGCAGCGGGGCCATTGCCCTGAGCCTGGCCCATTACC
TGCCCCGGGCCCGGGTTTACGCCACGGACATCAGCCCGGCGGCCCTGACGGTGGCCCAGGAAAACGCCAGGAAACTGGGG
CTGGCGGCCAGGGTAACCCTTCTCCAGGGTGATTTTTTGGCGCCCCTGCGGGGTTTAAAGCTCGACGCCCTTGTGGCCAA
CCCCCCCTACATACCCACTGCCGCCCTGCCAGGGCTGCCCGCGGATGTCCGCTCTGAACCGCGCCTGGCCCTGGACGGCG
GGCCCGACGGCCTGGATGCCTACCGGTTCCTCCTGCCGGGGGCGGCAGGACTTTTGCGGCCCGGCGGTCTCCTGGCCCTG
GAAATCGGCTCCGACCAGGGACAGGCCGTAAAGGACCTGGCCCGGGCCGTGGGAGCCTATCGCAACGAACAGGTTTTACC
AGATTATGCCGGCCGCGATCGTTGTTTCCTGGCTTATCGCCGGGAAGAATAA

Upstream 100 bases:

>100_bases
CACCACCTGGACCAGGTCCTGGCAGGAGAACTGGACGAGATTATCGACGCCCTGGTCACCACCGACCAGGCAGAACGCCT
GAAAAACATGGAGGCCTGAG

Downstream 100 bases:

>100_bases
AGTCAGAGCGGGAAACATAGAGGTGAAATGGGTGTCTGTAGGTATGCGGACCAAATACTTAAAAATCAATCCCCTGGTAC
CGGAACTGCACAAGATCCGC

Product: HemK family modification methylase

Products: NA

Alternate protein names: M.XfaHemK2P [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTLRQALGEAVRRLAAGGVERPRLEAEVLLGWACSLTRPRLLARLEEELAPAAAGRFWQAIDRRAAGYPLQYLTGHQEFM
SLDFKVTPAVLIPRQDTEVVVEAVLERLDPCESYTIADCGTGSGAIALSLAHYLPRARVYATDISPAALTVAQENARKLG
LAARVTLLQGDFLAPLRGLKLDALVANPPYIPTAALPGLPADVRSEPRLALDGGPDGLDAYRFLLPGAAGLLRPGGLLAL
EIGSDQGQAVKDLARAVGAYRNEQVLPDYAGRDRCFLAYRREE

Sequences:

>Translated_283_residues
MTLRQALGEAVRRLAAGGVERPRLEAEVLLGWACSLTRPRLLARLEEELAPAAAGRFWQAIDRRAAGYPLQYLTGHQEFM
SLDFKVTPAVLIPRQDTEVVVEAVLERLDPCESYTIADCGTGSGAIALSLAHYLPRARVYATDISPAALTVAQENARKLG
LAARVTLLQGDFLAPLRGLKLDALVANPPYIPTAALPGLPADVRSEPRLALDGGPDGLDAYRFLLPGAAGLLRPGGLLAL
EIGSDQGQAVKDLARAVGAYRNEQVLPDYAGRDRCFLAYRREE
>Mature_282_residues
TLRQALGEAVRRLAAGGVERPRLEAEVLLGWACSLTRPRLLARLEEELAPAAAGRFWQAIDRRAAGYPLQYLTGHQEFMS
LDFKVTPAVLIPRQDTEVVVEAVLERLDPCESYTIADCGTGSGAIALSLAHYLPRARVYATDISPAALTVAQENARKLGL
AARVTLLQGDFLAPLRGLKLDALVANPPYIPTAALPGLPADVRSEPRLALDGGPDGLDAYRFLLPGAAGLLRPGGLLALE
IGSDQGQAVKDLARAVGAYRNEQVLPDYAGRDRCFLAYRREE

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=240, Percent_Identity=35, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787463, Length=279, Percent_Identity=37.2759856630824, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI87082085, Length=186, Percent_Identity=36.0215053763441, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324266, Length=184, Percent_Identity=34.7826086956522, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24582226, Length=255, Percent_Identity=32.9411764705882, Blast_Score=131, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 30475; Mature: 30344

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRQALGEAVRRLAAGGVERPRLEAEVLLGWACSLTRPRLLARLEEELAPAAAGRFWQA
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IDRRAAGYPLQYLTGHQEFMSLDFKVTPAVLIPRQDTEVVVEAVLERLDPCESYTIADCG
HHHHCCCCCHHHHCCCHHHHEECEEECCEEEECCCCHHHHHHHHHHHCCCCCCCEEECCC
TGSGAIALSLAHYLPRARVYATDISPAALTVAQENARKLGLAARVTLLQGDFLAPLRGLK
CCCCHHHHHHHHHCCCCEEEEECCCCHHEEHHHHHHHHHHHHHEEEECCCCHHHHHCCCE
LDALVANPPYIPTAALPGLPADVRSEPRLALDGGPDGLDAYRFLLPGAAGLLRPGGLLAL
EEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCHHHCCCCCEEEE
EIGSDQGQAVKDLARAVGAYRNEQVLPDYAGRDRCFLAYRREE
EECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TLRQALGEAVRRLAAGGVERPRLEAEVLLGWACSLTRPRLLARLEEELAPAAAGRFWQA
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IDRRAAGYPLQYLTGHQEFMSLDFKVTPAVLIPRQDTEVVVEAVLERLDPCESYTIADCG
HHHHCCCCCHHHHCCCHHHHEECEEECCEEEECCCCHHHHHHHHHHHCCCCCCCEEECCC
TGSGAIALSLAHYLPRARVYATDISPAALTVAQENARKLGLAARVTLLQGDFLAPLRGLK
CCCCHHHHHHHHHCCCCEEEEECCCCHHEEHHHHHHHHHHHHHEEEECCCCHHHHHCCCE
LDALVANPPYIPTAALPGLPADVRSEPRLALDGGPDGLDAYRFLLPGAAGLLRPGGLLAL
EEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCHHHCCCCCEEEE
EIGSDQGQAVKDLARAVGAYRNEQVLPDYAGRDRCFLAYRREE
EECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]