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The map label for this gene is iscS [H]

Identifier: 83590488

GI number: 83590488

Start: 1686589

End: 1687767

Strand: Reverse

Name: iscS [H]

Synonym: Moth_1652

Alternate gene names: 83590488

Gene position: 1687767-1686589 (Counterclockwise)

Preceding gene: 83590489

Following gene: 83590487

Centisome position: 64.2

GC content: 58.61

Gene sequence:

>1179_bases
ATGCGCAGGGTTTACCTTGATCATAGCGCCACAACTCCGGTAAGGCCCGAAGTCCTGGAGGCCATGTTACCCTTTTTGAA
GGATGAGGCCTTTGGTAATCCTTCCACCGTTTACAGCTACGGCCGGGAAGCGAAAAAGGCCCTGGAGGAAGCCCGGGAAA
AGGTGGCCAACCTCATCGGCGCCCGGCCGGAGGAGATCTTCTTTACCAGCGGCGGCACGGAAGCCGACAACCTGGCCCTT
ATCGGTACGGCTGCGGCCAATGAAAAGAAGGGCCGTCACATTATTACCTCCAGCATCGAACACCATGCCGTCCTGCACAC
GGCCCAGTACCTCCTGCGCCACGGCTTTAAGGTAACCTTCCTGCCGGTGACCCCGGAGGGCCTGGTGCGGGTGGAGGACG
TCGAAAAGGCCATTACCGATGAAACCATCCTCATCAGCGTCATGCATGTTAACAACGAAGTGGGTACCATCCAACCCATC
AAAGAAATAGGGAAACTGGCCCGGGAACGGGGGATCATCTTCCATACCGACGCCGTCCAGAGCGTTGGCAAGCTCCCCGT
TAATGTCGACGAGCTGGGGGTGGACCTGCTGTCGGCCTCCGGGCACAAGATTTATGGCCCCAAGGGCATCGGCTGCCTTT
ATATCCGCAAGGGGACGAAGATCAACCCCATCCTTTACGGCGGTGCCCAGGAGCGTAAACGTCGGCCTGGGACGGAGAAC
ATGCCCGGTATTGTCGGCTTTGGCCGGGCAGCCGAACTGGCCGGCCAGGAACTGGAGAGCGAAATGGAGCGCCTGCAGGC
CCTGCGGGACAAGCTAATTGACGGTATCTTGACACGTATTGAAGACGTCCAGCTGAACGGTGATCCGCGGCAGCGGGTGG
CCACCAATGCCAACTTCAGCTTCCGCTATTGTGAGGGCGAATCCATACTCCTGAGCCTGGACATGAAGGGTATCTGCGCT
TCCAGTGGTTCGGCCTGTACCTCCGGTTCCCTGGACCCGTCCCACGTCCTCCTGGCCATGGGTATCCCCCACGAAGTAGC
CCATGGTTCGGTACGTATGACCCTGGGCCGCGAAAATACAGAAGAAGATATTGACTACGTCCTGGAAGTCATGCCGGAGA
TAATAGCCCGGTTGCGTTCCATGTCACCCCTCTATGAGGAGGCCGCAGGGAAGAGGTAG

Upstream 100 bases:

>100_bases
CCTGGATAGCTTTACCCTGGCGGATATGGTCGCCAAGGCCAATCAAATGCGCCAGGACAGCAAATACTATATGTATTATA
TCTAGAAAAGGGTGGACGAG

Downstream 100 bases:

>100_bases
GGGTTACCTGGCAGGAAGCCCCCCGCAAGAGGTCGTGTTTTGGTGCGAGGATATTTTCCCTAGAAGGAGTGAGCAGGGTG
TACTCGGAAAAAGTCATGGA

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MRRVYLDHSATTPVRPEVLEAMLPFLKDEAFGNPSTVYSYGREAKKALEEAREKVANLIGARPEEIFFTSGGTEADNLAL
IGTAAANEKKGRHIITSSIEHHAVLHTAQYLLRHGFKVTFLPVTPEGLVRVEDVEKAITDETILISVMHVNNEVGTIQPI
KEIGKLARERGIIFHTDAVQSVGKLPVNVDELGVDLLSASGHKIYGPKGIGCLYIRKGTKINPILYGGAQERKRRPGTEN
MPGIVGFGRAAELAGQELESEMERLQALRDKLIDGILTRIEDVQLNGDPRQRVATNANFSFRYCEGESILLSLDMKGICA
SSGSACTSGSLDPSHVLLAMGIPHEVAHGSVRMTLGRENTEEDIDYVLEVMPEIIARLRSMSPLYEEAAGKR

Sequences:

>Translated_392_residues
MRRVYLDHSATTPVRPEVLEAMLPFLKDEAFGNPSTVYSYGREAKKALEEAREKVANLIGARPEEIFFTSGGTEADNLAL
IGTAAANEKKGRHIITSSIEHHAVLHTAQYLLRHGFKVTFLPVTPEGLVRVEDVEKAITDETILISVMHVNNEVGTIQPI
KEIGKLARERGIIFHTDAVQSVGKLPVNVDELGVDLLSASGHKIYGPKGIGCLYIRKGTKINPILYGGAQERKRRPGTEN
MPGIVGFGRAAELAGQELESEMERLQALRDKLIDGILTRIEDVQLNGDPRQRVATNANFSFRYCEGESILLSLDMKGICA
SSGSACTSGSLDPSHVLLAMGIPHEVAHGSVRMTLGRENTEEDIDYVLEVMPEIIARLRSMSPLYEEAAGKR
>Mature_392_residues
MRRVYLDHSATTPVRPEVLEAMLPFLKDEAFGNPSTVYSYGREAKKALEEAREKVANLIGARPEEIFFTSGGTEADNLAL
IGTAAANEKKGRHIITSSIEHHAVLHTAQYLLRHGFKVTFLPVTPEGLVRVEDVEKAITDETILISVMHVNNEVGTIQPI
KEIGKLARERGIIFHTDAVQSVGKLPVNVDELGVDLLSASGHKIYGPKGIGCLYIRKGTKINPILYGGAQERKRRPGTEN
MPGIVGFGRAAELAGQELESEMERLQALRDKLIDGILTRIEDVQLNGDPRQRVATNANFSFRYCEGESILLSLDMKGICA
SSGSACTSGSLDPSHVLLAMGIPHEVAHGSVRMTLGRENTEEDIDYVLEVMPEIIARLRSMSPLYEEAAGKR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=389, Percent_Identity=47.5578406169666, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=39.1304347826087, Blast_Score=263, Evalue=1e-70,
Organism=Escherichia coli, GI48994898, Length=387, Percent_Identity=51.6795865633075, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1787970, Length=381, Percent_Identity=28.0839895013123, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1789175, Length=398, Percent_Identity=27.8894472361809, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=47.2868217054264, Blast_Score=359, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=33.0246913580247, Blast_Score=167, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6319831, Length=388, Percent_Identity=47.9381443298969, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI20129463, Length=388, Percent_Identity=48.7113402061856, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42933; Mature: 42933

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00595 AA_TRANSFER_CLASS_5 ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVYLDHSATTPVRPEVLEAMLPFLKDEAFGNPSTVYSYGREAKKALEEAREKVANLIG
CCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
ARPEEIFFTSGGTEADNLALIGTAAANEKKGRHIITSSIEHHAVLHTAQYLLRHGFKVTF
CCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCEEEE
LPVTPEGLVRVEDVEKAITDETILISVMHVNNEVGTIQPIKEIGKLARERGIIFHTDAVQ
EEECCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECHHHH
SVGKLPVNVDELGVDLLSASGHKIYGPKGIGCLYIRKGTKINPILYGGAQERKRRPGTEN
HHCCCCCCHHHHCHHHHCCCCCEEECCCCCCEEEEECCCEECCEEECCCHHHHCCCCCCC
MPGIVGFGRAAELAGQELESEMERLQALRDKLIDGILTRIEDVQLNGDPRQRVATNANFS
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHCCCCCCE
FRYCEGESILLSLDMKGICASSGSACTSGSLDPSHVLLAMGIPHEVAHGSVRMTLGRENT
EEEECCCEEEEEECCCCEECCCCCCCCCCCCCHHHEEEEECCCHHHCCCCEEEEECCCCC
EEDIDYVLEVMPEIIARLRSMSPLYEEAAGKR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
>Mature Secondary Structure
MRRVYLDHSATTPVRPEVLEAMLPFLKDEAFGNPSTVYSYGREAKKALEEAREKVANLIG
CCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
ARPEEIFFTSGGTEADNLALIGTAAANEKKGRHIITSSIEHHAVLHTAQYLLRHGFKVTF
CCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCEEEE
LPVTPEGLVRVEDVEKAITDETILISVMHVNNEVGTIQPIKEIGKLARERGIIFHTDAVQ
EEECCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECHHHH
SVGKLPVNVDELGVDLLSASGHKIYGPKGIGCLYIRKGTKINPILYGGAQERKRRPGTEN
HHCCCCCCHHHHCHHHHCCCCCEEECCCCCCEEEEECCCEECCEEECCCHHHHCCCCCCC
MPGIVGFGRAAELAGQELESEMERLQALRDKLIDGILTRIEDVQLNGDPRQRVATNANFS
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHCCCCCCE
FRYCEGESILLSLDMKGICASSGSACTSGSLDPSHVLLAMGIPHEVAHGSVRMTLGRENT
EEEECCCEEEEEECCCCEECCCCCCCCCCCCCHHHEEEEECCCHHHCCCCEEEEECCCCC
EEDIDYVLEVMPEIIARLRSMSPLYEEAAGKR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA