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The map label for this gene is mprA [H]

Identifier: 83589979

GI number: 83589979

Start: 1159173

End: 1159853

Strand: Reverse

Name: mprA [H]

Synonym: Moth_1131

Alternate gene names: 83589979

Gene position: 1159853-1159173 (Counterclockwise)

Preceding gene: 83589980

Following gene: 83589978

Centisome position: 44.12

GC content: 55.65

Gene sequence:

>681_bases
TTGCGAGCCCGTATCCTGGTTGTCGATGACGATGCCAAGATTACTTCTATGCTCAAACGCGCTCTGACCTACGAGGGCTA
TGATGTAGAAATAGCTGCCAATGGCCACCAGGCCCTGGCCCTGGCGGCCAATAATCCAGATTTAATTATCCTGGATATCA
TGTTACCCGGCATTGACGGCCTGGCTGTCTGCCGCCAGATACGGTCCAACAGCGATATCCCCATCTTGATGTTGACCGCC
CGGGACGATACCGCCGACCGGGTCCTCGGTTTGGATACCGGGGCTGATGACTATCTGGTCAAACCCTTTGCGCTGGAAGA
ATTACTGGCCCGGATCCGCGCCCTTTTAAGACGCCGATCCCGGGAAACAGAGGCAGAGGTGCTCCAATTCAGTGATCTGA
CCCTGAATACGTCCACCAGGGAGGGCTTTCGGGGCCAGCGCAGCTTTTCCCTGACGGCCAAGGAATATGAACTACTGCTT
TATTTCCTCCAGAACCCGCACCGGGTCCTCACCAGGGATGAACTCATGACCCGGATCTGGGGTTATGACTTCAGTGGTGA
ATCCAATGTCCTGGAGGTTTATATCGGTTACCTGCGGGCTAAACTAGAAGCCGGGGGCGAGCCTCGCCTTATCCAGACAG
TCCGGGGTGTGGGTTATGTCCTCAAGGAGCAGCAGCCATGA

Upstream 100 bases:

>100_bases
AAACTTGGTGGTAATGGGACGCAACCTTGCCTACCTGCCACCCTTGACAGGGAAATAGCAGCCGCGTTATATTTAGAACA
ACCTGAAGGGGGTGTAACTA

Downstream 100 bases:

>100_bases
CCCTGCGTCTACGCCTCACCCTGCTGGTTACCATTACCCTTGGTTTAACCTTCATTGTCCTGGGTGGACTGGTCTATTTC
CTGATGGGACATTACCTGAC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MRARILVVDDDAKITSMLKRALTYEGYDVEIAANGHQALALAANNPDLIILDIMLPGIDGLAVCRQIRSNSDIPILMLTA
RDDTADRVLGLDTGADDYLVKPFALEELLARIRALLRRRSRETEAEVLQFSDLTLNTSTREGFRGQRSFSLTAKEYELLL
YFLQNPHRVLTRDELMTRIWGYDFSGESNVLEVYIGYLRAKLEAGGEPRLIQTVRGVGYVLKEQQP

Sequences:

>Translated_226_residues
MRARILVVDDDAKITSMLKRALTYEGYDVEIAANGHQALALAANNPDLIILDIMLPGIDGLAVCRQIRSNSDIPILMLTA
RDDTADRVLGLDTGADDYLVKPFALEELLARIRALLRRRSRETEAEVLQFSDLTLNTSTREGFRGQRSFSLTAKEYELLL
YFLQNPHRVLTRDELMTRIWGYDFSGESNVLEVYIGYLRAKLEAGGEPRLIQTVRGVGYVLKEQQP
>Mature_226_residues
MRARILVVDDDAKITSMLKRALTYEGYDVEIAANGHQALALAANNPDLIILDIMLPGIDGLAVCRQIRSNSDIPILMLTA
RDDTADRVLGLDTGADDYLVKPFALEELLARIRALLRRRSRETEAEVLQFSDLTLNTSTREGFRGQRSFSLTAKEYELLL
YFLQNPHRVLTRDELMTRIWGYDFSGESNVLEVYIGYLRAKLEAGGEPRLIQTVRGVGYVLKEQQP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=43.4389140271493, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=43.1718061674009, Blast_Score=174, Evalue=3e-45,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=40.8071748878924, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=38.2488479262673, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=40.8256880733945, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=43.1818181818182, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=37.9464285714286, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=38.1165919282511, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=37.10407239819, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.0350877192982, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=37.6106194690265, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=33.6244541484716, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=34.4978165938865, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=32.6086956521739, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1788550, Length=141, Percent_Identity=34.7517730496454, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=34.3065693430657, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790437, Length=134, Percent_Identity=35.0746268656716, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=38.0530973451327, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25504; Mature: 25504

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARILVVDDDAKITSMLKRALTYEGYDVEIAANGHQALALAANNPDLIILDIMLPGIDG
CCEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCEEEEEEECCCCCH
LAVCRQIRSNSDIPILMLTARDDTADRVLGLDTGADDYLVKPFALEELLARIRALLRRRS
HHHHHHHHCCCCCEEEEEEECCCCCHHEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHC
RETEAEVLQFSDLTLNTSTREGFRGQRSFSLTAKEYELLLYFLQNPHRVLTRDELMTRIW
CCCHHHHHEECCEEEECCCCCCCCCCCEEEEEHHHHHHHHEECCCCCHHHHHHHHHHHHH
GYDFSGESNVLEVYIGYLRAKLEAGGEPRLIQTVRGVGYVLKEQQP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCC
>Mature Secondary Structure
MRARILVVDDDAKITSMLKRALTYEGYDVEIAANGHQALALAANNPDLIILDIMLPGIDG
CCEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCEEEEEEECCCCCH
LAVCRQIRSNSDIPILMLTARDDTADRVLGLDTGADDYLVKPFALEELLARIRALLRRRS
HHHHHHHHCCCCCEEEEEEECCCCCHHEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHC
RETEAEVLQFSDLTLNTSTREGFRGQRSFSLTAKEYELLLYFLQNPHRVLTRDELMTRIW
CCCHHHHHEECCEEEECCCCCCCCCCCEEEEEHHHHHHHHEECCCCCHHHHHHHHHHHHH
GYDFSGESNVLEVYIGYLRAKLEAGGEPRLIQTVRGVGYVLKEQQP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA