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The map label for this gene is mprB [H]

Identifier: 83589978

GI number: 83589978

Start: 1157767

End: 1159176

Strand: Reverse

Name: mprB [H]

Synonym: Moth_1130

Alternate gene names: 83589978

Gene position: 1159176-1157767 (Counterclockwise)

Preceding gene: 83589979

Following gene: 83589977

Centisome position: 44.1

GC content: 54.04

Gene sequence:

>1410_bases
ATGACCCTGCGTCTACGCCTCACCCTGCTGGTTACCATTACCCTTGGTTTAACCTTCATTGTCCTGGGTGGACTGGTCTA
TTTCCTGATGGGACATTACCTGACCAATGAAATTGATCGTTCCCTGGTCGCCCGGGCCCAGGAGGTTGTCCGTTCTTTTC
GAGTAGAGGGAAACTTGCGCTTGCAGCGCATTACGCTGCCCAATGTGAATGTTTTCTCGGCTCCGGATACCTTTATCCAG
ATAGTTGATATAAATGGTTTCGTAGTCACCCGTTCTGATAATCTGGGTCAACAATCTTTACCCCTTGGACCGCAAACCCT
CATTCAAGCCGGGGAAGGCATCGCCTTTTTTGAAACCGAGATAGTCGGTAACCATCCCCTGCGACTTTATAATGTACCCC
TTTTATTGCAAAACCAGCCGGTAGGGCTTCTCCAGGTAGCCCGCCTTCTCAGTCCCGTCCAGCAGACCCTGGGCAACCTG
CGCCGGGTACTGCTCTTCCTGGGGCTTTTATTAATCTTCCTGGCTGCCACCCTTGGTTATATCTTAGCCCGTACTGCCCT
GCGGCCCATTGATCGTCTAACCCAGGTGGCTGAACAAATAGGGGAGGGCAAGGATCTGGATCAGCGGGTTCCCTACCAGG
GCCCTATGGATGAAGTCGGCCGGCTGGCTGCTACCTTTAATGCTATGCTGGCCCGGCTTCAGCGAGCCTACACCCGCCTG
GAGGAAGCCTATAGCGCCCAGCGGCGCTTCGTAGCCGACGCTTCCCATGAACTGCGCACCCCCCTGACTACCATCCGCGG
TAATGTCGACCTATTACGGAAAGTACAGGGTCAAGGGGAAGCATGGCAGGATGAAGCCCTGGCCGATATTGCCAGTGAGG
CCGAGCGAATGAGCCGGCTGGTCAATGACCTCTTGACCCTTGCCCGGGCTGACGCCGGTCAGGAGATAAAACGTGAACCA
CTGGAAATACTTCCTCTCTTACAGGAGGTGGCCCGCCAAGCACCTTTATTGGGAACGGCCACCTTCACAGCCATCGGATT
GGAAAACCTGGCCGGAGTCCACATCATGGGAAACCGGGATTACCTCAAACAGCTATTCTTTATCCTTCTGGATAACGCCT
TTAAATATACCCCTTCCGAAGGTAAAATCGATTTAATAGTTAACGTTGAACCCCAGCAGCGGTTGATCATTAAAGTCAGG
GATACCGGCCCGGGTATCCCTCCCCGGGATCTGGAGCATATTTTTGAACGGTTCTATCGCGCCGATGCTACCCGCAGCAG
TGAAGGAACCGGACTGGGCCTGGCCATAGCTCGGTGGATAGTTGAACAGCACCAGGGTCATATCGGGGTTGAAAGTACGG
TGGGGAAGGGCACCACCTTCACCATTACCATCCCCCTGTTGAAAGGTTGA

Upstream 100 bases:

>100_bases
TTTATATCGGTTACCTGCGGGCTAAACTAGAAGCCGGGGGCGAGCCTCGCCTTATCCAGACAGTCCGGGGTGTGGGTTAT
GTCCTCAAGGAGCAGCAGCC

Downstream 100 bases:

>100_bases
TTTCTTATCTTTTTCTCAGGTTAATTTCATCAAGTTTTAACCATTATGGGTTAGTATAATTCCCAGAAGGGAGGTGAGAT
CTTGGCCAGGATCAAGAAGC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTLRLRLTLLVTITLGLTFIVLGGLVYFLMGHYLTNEIDRSLVARAQEVVRSFRVEGNLRLQRITLPNVNVFSAPDTFIQ
IVDINGFVVTRSDNLGQQSLPLGPQTLIQAGEGIAFFETEIVGNHPLRLYNVPLLLQNQPVGLLQVARLLSPVQQTLGNL
RRVLLFLGLLLIFLAATLGYILARTALRPIDRLTQVAEQIGEGKDLDQRVPYQGPMDEVGRLAATFNAMLARLQRAYTRL
EEAYSAQRRFVADASHELRTPLTTIRGNVDLLRKVQGQGEAWQDEALADIASEAERMSRLVNDLLTLARADAGQEIKREP
LEILPLLQEVARQAPLLGTATFTAIGLENLAGVHIMGNRDYLKQLFFILLDNAFKYTPSEGKIDLIVNVEPQQRLIIKVR
DTGPGIPPRDLEHIFERFYRADATRSSEGTGLGLAIARWIVEQHQGHIGVESTVGKGTTFTITIPLLKG

Sequences:

>Translated_469_residues
MTLRLRLTLLVTITLGLTFIVLGGLVYFLMGHYLTNEIDRSLVARAQEVVRSFRVEGNLRLQRITLPNVNVFSAPDTFIQ
IVDINGFVVTRSDNLGQQSLPLGPQTLIQAGEGIAFFETEIVGNHPLRLYNVPLLLQNQPVGLLQVARLLSPVQQTLGNL
RRVLLFLGLLLIFLAATLGYILARTALRPIDRLTQVAEQIGEGKDLDQRVPYQGPMDEVGRLAATFNAMLARLQRAYTRL
EEAYSAQRRFVADASHELRTPLTTIRGNVDLLRKVQGQGEAWQDEALADIASEAERMSRLVNDLLTLARADAGQEIKREP
LEILPLLQEVARQAPLLGTATFTAIGLENLAGVHIMGNRDYLKQLFFILLDNAFKYTPSEGKIDLIVNVEPQQRLIIKVR
DTGPGIPPRDLEHIFERFYRADATRSSEGTGLGLAIARWIVEQHQGHIGVESTVGKGTTFTITIPLLKG
>Mature_468_residues
TLRLRLTLLVTITLGLTFIVLGGLVYFLMGHYLTNEIDRSLVARAQEVVRSFRVEGNLRLQRITLPNVNVFSAPDTFIQI
VDINGFVVTRSDNLGQQSLPLGPQTLIQAGEGIAFFETEIVGNHPLRLYNVPLLLQNQPVGLLQVARLLSPVQQTLGNLR
RVLLFLGLLLIFLAATLGYILARTALRPIDRLTQVAEQIGEGKDLDQRVPYQGPMDEVGRLAATFNAMLARLQRAYTRLE
EAYSAQRRFVADASHELRTPLTTIRGNVDLLRKVQGQGEAWQDEALADIASEAERMSRLVNDLLTLARADAGQEIKREPL
EILPLLQEVARQAPLLGTATFTAIGLENLAGVHIMGNRDYLKQLFFILLDNAFKYTPSEGKIDLIVNVEPQQRLIIKVRD
TGPGIPPRDLEHIFERFYRADATRSSEGTGLGLAIARWIVEQHQGHIGVESTVGKGTTFTITIPLLKG

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=292, Percent_Identity=33.2191780821918, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1788393, Length=290, Percent_Identity=34.1379310344828, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786783, Length=384, Percent_Identity=29.1666666666667, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790346, Length=290, Percent_Identity=31.0344827586207, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788279, Length=330, Percent_Identity=27.8787878787879, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI145693157, Length=249, Percent_Identity=34.136546184739, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081816, Length=337, Percent_Identity=29.3768545994065, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=348, Percent_Identity=28.735632183908, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082128, Length=328, Percent_Identity=25.9146341463415, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=320, Percent_Identity=27.8125, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=31.9391634980989, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=27.5862068965517, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789403, Length=295, Percent_Identity=31.864406779661, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=265, Percent_Identity=28.6792452830189, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=31.2217194570136, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=35.0649350649351, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787894, Length=304, Percent_Identity=27.6315789473684, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=299, Percent_Identity=27.0903010033445, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=26.0416666666667, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787374, Length=285, Percent_Identity=27.719298245614, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322044, Length=72, Percent_Identity=47.2222222222222, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52114; Mature: 51983

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLRLTLLVTITLGLTFIVLGGLVYFLMGHYLTNEIDRSLVARAQEVVRSFRVEGNLR
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LQRITLPNVNVFSAPDTFIQIVDINGFVVTRSDNLGQQSLPLGPQTLIQAGEGIAFFETE
EEEEECCCCEEEECCCCEEEEEECCCEEEECCCCCCCCCCCCCHHHHHHCCCCEEEEEEE
IVGNHPLRLYNVPLLLQNQPVGLLQVARLLSPVQQTLGNLRRVLLFLGLLLIFLAATLGY
ECCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILARTALRPIDRLTQVAEQIGEGKDLDQRVPYQGPMDEVGRLAATFNAMLARLQRAYTRL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EEAYSAQRRFVADASHELRTPLTTIRGNVDLLRKVQGQGEAWQDEALADIASEAERMSRL
HHHHHHHHHHHHCCCHHHHCCHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VNDLLTLARADAGQEIKREPLEILPLLQEVARQAPLLGTATFTAIGLENLAGVHIMGNRD
HHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCHH
YLKQLFFILLDNAFKYTPSEGKIDLIVNVEPQQRLIIKVRDTGPGIPPRDLEHIFERFYR
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHH
ADATRSSEGTGLGLAIARWIVEQHQGHIGVESTVGKGTTFTITIPLLKG
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
TLRLRLTLLVTITLGLTFIVLGGLVYFLMGHYLTNEIDRSLVARAQEVVRSFRVEGNLR
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LQRITLPNVNVFSAPDTFIQIVDINGFVVTRSDNLGQQSLPLGPQTLIQAGEGIAFFETE
EEEEECCCCEEEECCCCEEEEEECCCEEEECCCCCCCCCCCCCHHHHHHCCCCEEEEEEE
IVGNHPLRLYNVPLLLQNQPVGLLQVARLLSPVQQTLGNLRRVLLFLGLLLIFLAATLGY
ECCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILARTALRPIDRLTQVAEQIGEGKDLDQRVPYQGPMDEVGRLAATFNAMLARLQRAYTRL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EEAYSAQRRFVADASHELRTPLTTIRGNVDLLRKVQGQGEAWQDEALADIASEAERMSRL
HHHHHHHHHHHHCCCHHHHCCHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VNDLLTLARADAGQEIKREPLEILPLLQEVARQAPLLGTATFTAIGLENLAGVHIMGNRD
HHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCHH
YLKQLFFILLDNAFKYTPSEGKIDLIVNVEPQQRLIIKVRDTGPGIPPRDLEHIFERFYR
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHH
ADATRSSEGTGLGLAIARWIVEQHQGHIGVESTVGKGTTFTITIPLLKG
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA