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The map label for this gene is gyaR [H]

Identifier: 83595119

GI number: 83595119

Start: 4340984

End: 4341970

Strand: Direct

Name: gyaR [H]

Synonym: Rru_A3790

Alternate gene names: 83595119

Gene position: 4340984-4341970 (Clockwise)

Preceding gene: 83595117

Following gene: 83595128

Centisome position: 99.73

GC content: 65.45

Gene sequence:

>987_bases
ATGCCGCAGGCCAAGCCTCTGGTCATCGTTACGCGTAAGTTGCCCGAAGCCATCGAAACCCGCATGGCGGAGCTGTTCGA
TGCCCGGCTGAACGTCGATGACCATCCGTTCACCCGGGAAGAACTCTGCCAGGCCGTGGCGGAGGCCGATGTGCTGGTTC
CCACGGTGACCGACCGCATCGATGGCGGCGTGCTGTCCCATTGCGGGGAGTCGCTGCGGCTGATCGCCAATTTCGGCACC
GGCATCGACCATATCGACGTGGCCACCGCCCATCAGCGCGGCGTCACCGTCACCAATACCCCCGACGTTCTGACCGAAGA
CACCGCCGATATGACGATGGCGATGATCCTGGCCGTGCCGCGTCGGCTGGCCGAGGGCGAGCGCATGGTGCGCGAGGGCC
AGTGGCTGGGCTGGAGCCCGACCCATATGCTGGGCCACCGCATCTGGGGCAAGCGCCTGGGCATCATCGGCATGGGGCGG
ATCGGCCGCGCCGTCGCCCGGCGCGCCCGGGGCTTTGGCATGACCATCCATTACCACAACCGCCGCCGGCTGCACGAAAG
CCTGGAACAGGAACTCGACGCCACCTATTGGGAAAGCCTCGATCAGATGCTGGCGCGGATGGACGTGGTCTCGATCCACT
GTCCCCATACCCCGGCCTCCTATCATCTGTTGTCGGCCCGGCGCTTGGCGCTGCTGCGGCCCGAGGCCTATGTGGTCAAT
ACGGCGCGCGGCGAGGTGATCGACGAGAACGCCCTGGTGCGCATGCTGGCGAAGGGGGACCTGGCCGGTGCGGCCCTTGA
CGTCTTCGAATACGAACCCGCCGTCAATCCCAAGCTGGTCGCCATGAACAACGTCTTGCTGCTCCCCCACATGGGCTCGG
CGACGCTGGAGGGGCGGATCGACATGGGCGAGAAGGTTCTGATCAACATCAAGACCTTCGTCGATGGTCACAAGCCTCCC
GACCGGGTTCTGCCCACCATGCTCTGA

Upstream 100 bases:

>100_bases
CGTCTTGCTACGCAAAGTCGACAATCCTCGGGAGAATCCGGCTCAACGGGTTCCCCTCGTCCGCCCTCGGACCGCTCAGC
CGTAACCGGGAGTTTCCTCT

Downstream 100 bases:

>100_bases
GCCCTTGCGGGACCAGGGCGGCCTTTAAGGCGGAAGGGTGACGGCGGCGGGGCGCGGGCGGGCCTGCGCCCTGACGGGGG
GCCTTGGGCGGCCCCCGGAT

Product: glycolate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPQAKPLVIVTRKLPEAIETRMAELFDARLNVDDHPFTREELCQAVAEADVLVPTVTDRIDGGVLSHCGESLRLIANFGT
GIDHIDVATAHQRGVTVTNTPDVLTEDTADMTMAMILAVPRRLAEGERMVREGQWLGWSPTHMLGHRIWGKRLGIIGMGR
IGRAVARRARGFGMTIHYHNRRRLHESLEQELDATYWESLDQMLARMDVVSIHCPHTPASYHLLSARRLALLRPEAYVVN
TARGEVIDENALVRMLAKGDLAGAALDVFEYEPAVNPKLVAMNNVLLLPHMGSATLEGRIDMGEKVLINIKTFVDGHKPP
DRVLPTML

Sequences:

>Translated_328_residues
MPQAKPLVIVTRKLPEAIETRMAELFDARLNVDDHPFTREELCQAVAEADVLVPTVTDRIDGGVLSHCGESLRLIANFGT
GIDHIDVATAHQRGVTVTNTPDVLTEDTADMTMAMILAVPRRLAEGERMVREGQWLGWSPTHMLGHRIWGKRLGIIGMGR
IGRAVARRARGFGMTIHYHNRRRLHESLEQELDATYWESLDQMLARMDVVSIHCPHTPASYHLLSARRLALLRPEAYVVN
TARGEVIDENALVRMLAKGDLAGAALDVFEYEPAVNPKLVAMNNVLLLPHMGSATLEGRIDMGEKVLINIKTFVDGHKPP
DRVLPTML
>Mature_327_residues
PQAKPLVIVTRKLPEAIETRMAELFDARLNVDDHPFTREELCQAVAEADVLVPTVTDRIDGGVLSHCGESLRLIANFGTG
IDHIDVATAHQRGVTVTNTPDVLTEDTADMTMAMILAVPRRLAEGERMVREGQWLGWSPTHMLGHRIWGKRLGIIGMGRI
GRAVARRARGFGMTIHYHNRRRLHESLEQELDATYWESLDQMLARMDVVSIHCPHTPASYHLLSARRLALLRPEAYVVNT
ARGEVIDENALVRMLAKGDLAGAALDVFEYEPAVNPKLVAMNNVLLLPHMGSATLEGRIDMGEKVLINIKTFVDGHKPPD
RVLPTML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=298, Percent_Identity=33.5570469798658, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=31.9587628865979, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI61743967, Length=256, Percent_Identity=33.984375, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557497, Length=256, Percent_Identity=33.984375, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=33.4630350194552, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=33.4630350194552, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=33.5849056603774, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI87082289, Length=323, Percent_Identity=36.5325077399381, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789279, Length=257, Percent_Identity=31.9066147859922, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=26.5917602996255, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788660, Length=286, Percent_Identity=23.4265734265734, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=279, Percent_Identity=28.3154121863799, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=30.3501945525292, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=261, Percent_Identity=35.632183908046, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320925, Length=293, Percent_Identity=29.0102389078498, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=321, Percent_Identity=27.1028037383178, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=219, Percent_Identity=28.7671232876712, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=288, Percent_Identity=27.0833333333333, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=29.0697674418605, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571528, Length=287, Percent_Identity=36.2369337979094, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24585514, Length=275, Percent_Identity=31.2727272727273, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI28574282, Length=275, Percent_Identity=31.2727272727273, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI45551003, Length=275, Percent_Identity=31.2727272727273, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI28574284, Length=275, Percent_Identity=31.2727272727273, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI45552429, Length=276, Percent_Identity=31.1594202898551, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI28574286, Length=310, Percent_Identity=29.6774193548387, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19921140, Length=272, Percent_Identity=33.4558823529412, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=34.375, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=34.375, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=34.375, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=34.375, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=34.375, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585516, Length=289, Percent_Identity=28.3737024221453, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36486; Mature: 36355

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQAKPLVIVTRKLPEAIETRMAELFDARLNVDDHPFTREELCQAVAEADVLVPTVTDRI
CCCCCCEEEEEHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECHHHHC
DGGVLSHCGESLRLIANFGTGIDHIDVATAHQRGVTVTNTPDVLTEDTADMTMAMILAVP
CCHHHHHCCHHHEEHHHCCCCCCCEEEEEHHHCCEEECCCCCCCCCCHHHHHHHHHHHHH
RRLAEGERMVREGQWLGWSPTHMLGHRIWGKRLGIIGMGRIGRAVARRARGFGMTIHYHN
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHCCCCEEEEECC
RRRLHESLEQELDATYWESLDQMLARMDVVSIHCPHTPASYHLLSARRLALLRPEAYVVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
TARGEVIDENALVRMLAKGDLAGAALDVFEYEPAVNPKLVAMNNVLLLPHMGSATLEGRI
CCCCCEECCHHHHHHHHCCCCCHHEEHHEECCCCCCCEEEEECCEEEEECCCCCEECCCC
DMGEKVLINIKTFVDGHKPPDRVLPTML
CCCCEEEEEEEEHHCCCCCHHHCCCCCC
>Mature Secondary Structure 
PQAKPLVIVTRKLPEAIETRMAELFDARLNVDDHPFTREELCQAVAEADVLVPTVTDRI
CCCCCEEEEEHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECHHHHC
DGGVLSHCGESLRLIANFGTGIDHIDVATAHQRGVTVTNTPDVLTEDTADMTMAMILAVP
CCHHHHHCCHHHEEHHHCCCCCCCEEEEEHHHCCEEECCCCCCCCCCHHHHHHHHHHHHH
RRLAEGERMVREGQWLGWSPTHMLGHRIWGKRLGIIGMGRIGRAVARRARGFGMTIHYHN
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHCCCCEEEEECC
RRRLHESLEQELDATYWESLDQMLARMDVVSIHCPHTPASYHLLSARRLALLRPEAYVVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
TARGEVIDENALVRMLAKGDLAGAALDVFEYEPAVNPKLVAMNNVLLLPHMGSATLEGRI
CCCCCEECCHHHHHHHHCCCCCHHEEHHEECCCCCCCEEEEECCEEEEECCCCCEECCCC
DMGEKVLINIKTFVDGHKPPDRVLPTML
CCCCEEEEEEEEHHCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA