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The map label for this gene is mutM

Identifier: 83595128

GI number: 83595128

Start: 4349659

End: 4350504

Strand: Direct

Name: mutM

Synonym: Rru_A3799

Alternate gene names: 83595128

Gene position: 4349659-4350504 (Clockwise)

Preceding gene: 83595119

Following gene: 83595129

Centisome position: 99.93

GC content: 66.55

Gene sequence:

>846_bases
ATGCCAGAATTACCCGAAGTGGAAACCGTGCGCTTGGGCTTGACCCCGGCTCTTGTCGGAGAACGGCTAAGCCGGGTGGC
GGCGCGACGGCCGGCGCTGCGTCTGCCGATCCCGGTCGATCTGGTCCAACGGCTGACCGGAAAGGTTGTCGGTAGTCTCG
ATCGCCGGGCTAAGTATCTGTTATTACGCATGATCGATGGGCCGGTGGCGCTGATCCATCTTGGCATGTCGGGCAGCATG
ACCGTTGGGCCGCTGGCCGGTCATGCCGAACCGGGGCCCCATGATCATATTTTGTTCGAAACCGAGGCTGGCCTGCGCGT
CACCTTTCGCGACCCCCGGCGCTTCGGTCTGATCACCCTGGCCGAGCCCGAGACTCTGGATGATCACCCGCTGCTGGCCA
AGCTTGGTCCCGAGCCGCTGTCCGAGGCTTTCGACGCCGAGGTCCTGGTGCGCCGGCTGAACGGCCGTCAGGCGCCGATC
AAGGCGGCGCTGCTTGATCAGGGCGTGGTGGCCGGGCTTGGCAATATCTATGTCAGCGAGGCCTTGTTCCGCGCCGGCAT
TTCGCCGCTGCGCCCGGCGGCCAGCGTCACCGGCGCCTGGGCCGAGGCGCTGGTGGCGGCGATTCGCGCCGTTTTGGGCG
AAGCCATCGCCGCGGGCGGCTCGTCGTTGCGCGACCATCGCCAGACCGATGGGGCTTTGGGCTATTTTCAGCACCGCTTC
GCCGTTTACGATCGCGTCGGCCAACCCTGCCCGGGCTGCGACTGCGATGTGGCGCGGACCGGCGGCATCGAACGGATGGT
CCAGTCCGGGCGATCCACCTTTTTCTGCGGGCGTCGTCAGCGGTGA

Upstream 100 bases:

>100_bases
AGTATAAGCGACGGGGCCACGCCACACGAACGTTGGCGCCCCGGAGAACGGGGTGCGTCCCGCGCCATCTTGGCGGGGAA
CCCCAAGGGAAGCGGACCAT

Downstream 100 bases:

>100_bases
TGGTGTAGTCTCCGGCCCATGAACGCGCCAAGACTCCAGGGAAAGCCCCCGAGCCGCCGCTACCTTTCGACTCGATCGGT
AGCTTTTGCCCCCATGCTGA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MPELPEVETVRLGLTPALVGERLSRVAARRPALRLPIPVDLVQRLTGKVVGSLDRRAKYLLLRMIDGPVALIHLGMSGSM
TVGPLAGHAEPGPHDHILFETEAGLRVTFRDPRRFGLITLAEPETLDDHPLLAKLGPEPLSEAFDAEVLVRRLNGRQAPI
KAALLDQGVVAGLGNIYVSEALFRAGISPLRPAASVTGAWAEALVAAIRAVLGEAIAAGGSSLRDHRQTDGALGYFQHRF
AVYDRVGQPCPGCDCDVARTGGIERMVQSGRSTFFCGRRQR

Sequences:

>Translated_281_residues
MPELPEVETVRLGLTPALVGERLSRVAARRPALRLPIPVDLVQRLTGKVVGSLDRRAKYLLLRMIDGPVALIHLGMSGSM
TVGPLAGHAEPGPHDHILFETEAGLRVTFRDPRRFGLITLAEPETLDDHPLLAKLGPEPLSEAFDAEVLVRRLNGRQAPI
KAALLDQGVVAGLGNIYVSEALFRAGISPLRPAASVTGAWAEALVAAIRAVLGEAIAAGGSSLRDHRQTDGALGYFQHRF
AVYDRVGQPCPGCDCDVARTGGIERMVQSGRSTFFCGRRQR
>Mature_280_residues
PELPEVETVRLGLTPALVGERLSRVAARRPALRLPIPVDLVQRLTGKVVGSLDRRAKYLLLRMIDGPVALIHLGMSGSMT
VGPLAGHAEPGPHDHILFETEAGLRVTFRDPRRFGLITLAEPETLDDHPLLAKLGPEPLSEAFDAEVLVRRLNGRQAPIK
AALLDQGVVAGLGNIYVSEALFRAGISPLRPAASVTGAWAEALVAAIRAVLGEAIAAGGSSLRDHRQTDGALGYFQHRFA
VYDRVGQPCPGCDCDVARTGGIERMVQSGRSTFFCGRRQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=281, Percent_Identity=41.6370106761566, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1786932, Length=285, Percent_Identity=28.4210526315789, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_RHORT (Q2RMQ2)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428880.1
- HSSP:   P42371
- ProteinModelPortal:   Q2RMQ2
- SMR:   Q2RMQ2
- STRING:   Q2RMQ2
- GeneID:   3837256
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3799
- NMPDR:   fig|1085.1.peg.1117
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   REAISEC
- PhylomeDB:   Q2RMQ2
- ProtClustDB:   PRK01103
- BioCyc:   RRUB269796:RRU_A3799-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30195; Mature: 30064

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 271-271 BINDING 94-94 BINDING 113-113 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRLGLTPALVGERLSRVAARRPALRLPIPVDLVQRLTGKVVGSLDRRAKYL
CCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
LLRMIDGPVALIHLGMSGSMTVGPLAGHAEPGPHDHILFETEAGLRVTFRDPRRFGLITL
HHHHHCCCEEEEEECCCCCCEECCCCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEE
AEPETLDDHPLLAKLGPEPLSEAFDAEVLVRRLNGRQAPIKAALLDQGVVAGLGNIYVSE
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALFRAGISPLRPAASVTGAWAEALVAAIRAVLGEAIAAGGSSLRDHRQTDGALGYFQHRF
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHH
AVYDRVGQPCPGCDCDVARTGGIERMVQSGRSTFFCGRRQR
HHHHHCCCCCCCCCCCHHHCCCHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure 
PELPEVETVRLGLTPALVGERLSRVAARRPALRLPIPVDLVQRLTGKVVGSLDRRAKYL
CCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
LLRMIDGPVALIHLGMSGSMTVGPLAGHAEPGPHDHILFETEAGLRVTFRDPRRFGLITL
HHHHHCCCEEEEEECCCCCCEECCCCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEE
AEPETLDDHPLLAKLGPEPLSEAFDAEVLVRRLNGRQAPIKAALLDQGVVAGLGNIYVSE
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALFRAGISPLRPAASVTGAWAEALVAAIRAVLGEAIAAGGSSLRDHRQTDGALGYFQHRF
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHH
AVYDRVGQPCPGCDCDVARTGGIERMVQSGRSTFFCGRRQR
HHHHHCCCCCCCCCCCHHHCCCHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA