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The map label for this gene is yjcE [H]

Identifier: 83594874

GI number: 83594874

Start: 4081538

End: 4083178

Strand: Direct

Name: yjcE [H]

Synonym: Rru_A3545

Alternate gene names: 83594874

Gene position: 4081538-4083178 (Clockwise)

Preceding gene: 83594873

Following gene: 83594875

Centisome position: 93.77

GC content: 65.39

Gene sequence:

>1641_bases
TTGGAAACCATCACGGTCGTTCTGTTCTTGCTGTTTTGCGTGGTGGTCAGCGATCTGCTGGCCCGCACGCTGCCCATACC
GGTGCCCCGCCCGCTTTATCAGATCGCCCTGGGCGGGGTGATCGGCCTGTTCGCCGATCTGCGGGTCGTCCTTGAGCCCG
ATATCTTCTTTCTGCTGTTCCTGCCGCCCTTGCTGTTTCTTGACGGCTGGCATATCGCCCGCGAAGAGGTTTTCAAGGAC
CGCTTCGTCATTTTGGAACTGGCCTTCGGTCTGGTTTTCCTCACCGTTCTGGGCGCCGGGCTGTTCATCCACTGGATGAT
CCCGGCCATGCCGCTGGCCGTCGCCTTCGCCCTGGCCGCCGTGGTGTCGCCCACCGATCCGATCGCGGTTTCGGCGATCG
CCAAGCACGCGCCGATCCCCAAGCGGATGATGAACATCCTAGAAGGGGAATCCCTGCTCAACGACGCCTCGGGTCTGGTC
TGCCTGCGCTTCGCCGTGGCCGCGGCGCTGACCGGCGGCTTTTCGTTGACGGACGCGGCGCTGGAGTTCCTGTGGGTGGC
CCTGGCCGGCATCGCCGTGGGAATTTCCCTGACCTGGGCGGTGACGCGGTCGAAAAACATGCTGGCGCGCCGCATCGGCG
AAAGCAGCGCCACCCAGACCCTGATCAGCCTGCTGATCCCCTTCGGGTCCTATCTGGTCGCCGAGCATCTCGACTGTTCG
GGCATTCTCGCCGCCGTCGCCGCCGGTGTGACCATGAGCATCGAGGAATCCTCGGGTCAGGCCCAGGCGGCCACGCGCAT
TCGCCGCAATACGGTGTGGGATACCATCCAGTTCGCCGCCAACGGGGTGATTTTCGTCATCCTCGGCGAACAACTGCCGG
CGATTCTCGAAAGCGCGGCCGAAACCGTGCGGGTAACCGGCCATCACGAGCCGTGGTGGCTGGGGATCTATGTGGTCGCG
ATCTGCCTGGGGCTGGCCGCCTTGCGGTTTTTGTGGGTCTGGGCGTCGCTGCAGGTGTCGTTGCTCCGCACCGGCCAGAA
ACGCCCCCCCCGTCATTGGCGGCTGATCACCGCCATGTCGCTTTCAGGGGTGCGCGGCGCCATCACCCTGGCCGGCGTGC
TGACCCTGCCACTGACGATGACCGACGGCACGGCCTTTCCCGCCCGCGATCTGGCGATCTTCCTGGCCATGGGGGTGATC
ATCGTGACCATGGTCGTCGCCACCGTCTTTTTGCCGCTGCTGCTCAACGGCTTGGAGATGTCCCAGGATTCGACGGCCGA
CGATCAGGAGGCGGCCGCCCGCATCGCCGCCGCCGAAGTCGCCATCGCCGAGATCGAGCGCGTTCAGCACAGCATGGCCG
AGGGAGCCAAGGACGCCGATCTGTTCGTGACCGTCGGCGCCAGCCTGATGGATGTCTACCGCGAACGCGTCCGCAGCCGC
TCGCAAGAGGGCGAGGCCGCCGTGCTGGTGCGCCGCGTCGACTGGATCGAACGCGAAATGCGGCTGGCCGCCCTGCGCGC
CGAACGGAGCGAGATCTTTCGCCGGGTGCGCAAATACCAGCTGGGCAGCGAAAGGGCGCGCAAGCTGATCCGCGAACTCG
ACTTGCTGGAAACCCGCTATTCGGCCGAACCCAAGGGTTGA

Upstream 100 bases:

>100_bases
CGACACCACCACCCAGACCACCGAAGCCTCCCCCGGCCTTCCCCACTGATCGGGCCCACCCCGGTCGCTCCGGAGAGCCT
AAGAACGGATAACCGAGACC

Downstream 100 bases:

>100_bases
CGACACGCCCGGCGCGGCGCCATGGTTAGGCCATGGACAGCACGCGCCCCCCTCTCGCCGCCCTGATCGGCCGTTGGTGG
TGGTCCCCGCCTTTCGCGGG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
METITVVLFLLFCVVVSDLLARTLPIPVPRPLYQIALGGVIGLFADLRVVLEPDIFFLLFLPPLLFLDGWHIAREEVFKD
RFVILELAFGLVFLTVLGAGLFIHWMIPAMPLAVAFALAAVVSPTDPIAVSAIAKHAPIPKRMMNILEGESLLNDASGLV
CLRFAVAAALTGGFSLTDAALEFLWVALAGIAVGISLTWAVTRSKNMLARRIGESSATQTLISLLIPFGSYLVAEHLDCS
GILAAVAAGVTMSIEESSGQAQAATRIRRNTVWDTIQFAANGVIFVILGEQLPAILESAAETVRVTGHHEPWWLGIYVVA
ICLGLAALRFLWVWASLQVSLLRTGQKRPPRHWRLITAMSLSGVRGAITLAGVLTLPLTMTDGTAFPARDLAIFLAMGVI
IVTMVVATVFLPLLLNGLEMSQDSTADDQEAAARIAAAEVAIAEIERVQHSMAEGAKDADLFVTVGASLMDVYRERVRSR
SQEGEAAVLVRRVDWIEREMRLAALRAERSEIFRRVRKYQLGSERARKLIRELDLLETRYSAEPKG

Sequences:

>Translated_546_residues
METITVVLFLLFCVVVSDLLARTLPIPVPRPLYQIALGGVIGLFADLRVVLEPDIFFLLFLPPLLFLDGWHIAREEVFKD
RFVILELAFGLVFLTVLGAGLFIHWMIPAMPLAVAFALAAVVSPTDPIAVSAIAKHAPIPKRMMNILEGESLLNDASGLV
CLRFAVAAALTGGFSLTDAALEFLWVALAGIAVGISLTWAVTRSKNMLARRIGESSATQTLISLLIPFGSYLVAEHLDCS
GILAAVAAGVTMSIEESSGQAQAATRIRRNTVWDTIQFAANGVIFVILGEQLPAILESAAETVRVTGHHEPWWLGIYVVA
ICLGLAALRFLWVWASLQVSLLRTGQKRPPRHWRLITAMSLSGVRGAITLAGVLTLPLTMTDGTAFPARDLAIFLAMGVI
IVTMVVATVFLPLLLNGLEMSQDSTADDQEAAARIAAAEVAIAEIERVQHSMAEGAKDADLFVTVGASLMDVYRERVRSR
SQEGEAAVLVRRVDWIEREMRLAALRAERSEIFRRVRKYQLGSERARKLIRELDLLETRYSAEPKG
>Mature_546_residues
METITVVLFLLFCVVVSDLLARTLPIPVPRPLYQIALGGVIGLFADLRVVLEPDIFFLLFLPPLLFLDGWHIAREEVFKD
RFVILELAFGLVFLTVLGAGLFIHWMIPAMPLAVAFALAAVVSPTDPIAVSAIAKHAPIPKRMMNILEGESLLNDASGLV
CLRFAVAAALTGGFSLTDAALEFLWVALAGIAVGISLTWAVTRSKNMLARRIGESSATQTLISLLIPFGSYLVAEHLDCS
GILAAVAAGVTMSIEESSGQAQAATRIRRNTVWDTIQFAANGVIFVILGEQLPAILESAAETVRVTGHHEPWWLGIYVVA
ICLGLAALRFLWVWASLQVSLLRTGQKRPPRHWRLITAMSLSGVRGAITLAGVLTLPLTMTDGTAFPARDLAIFLAMGVI
IVTMVVATVFLPLLLNGLEMSQDSTADDQEAAARIAAAEVAIAEIERVQHSMAEGAKDADLFVTVGASLMDVYRERVRSR
SQEGEAAVLVRRVDWIEREMRLAALRAERSEIFRRVRKYQLGSERARKLIRELDLLETRYSAEPKG

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=462, Percent_Identity=24.4588744588745, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI27734935, Length=339, Percent_Identity=25.3687315634218, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI15529998, Length=437, Percent_Identity=24.9427917620137, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI14211919, Length=342, Percent_Identity=24.2690058479532, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI41872703, Length=474, Percent_Identity=22.9957805907173, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI110227626, Length=342, Percent_Identity=24.8538011695906, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI294997330, Length=342, Percent_Identity=24.8538011695906, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI5454070, Length=343, Percent_Identity=25.0728862973761, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790501, Length=546, Percent_Identity=41.3919413919414, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71993590, Length=396, Percent_Identity=28.7878787878788, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71993582, Length=396, Percent_Identity=28.7878787878788, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI25150332, Length=407, Percent_Identity=25.0614250614251, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71999821, Length=419, Percent_Identity=24.3436754176611, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71999819, Length=421, Percent_Identity=24.7030878859857, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71999817, Length=421, Percent_Identity=24.7030878859857, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=355, Percent_Identity=22.5352112676056, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=355, Percent_Identity=22.5352112676056, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980847, Length=389, Percent_Identity=23.6503856041131, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71987559, Length=329, Percent_Identity=23.4042553191489, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=281, Percent_Identity=24.1992882562278, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281364513, Length=466, Percent_Identity=22.3175965665236, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221473222, Length=466, Percent_Identity=22.3175965665236, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221473215, Length=472, Percent_Identity=22.2457627118644, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221473212, Length=263, Percent_Identity=25.0950570342205, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281360447, Length=447, Percent_Identity=25.2796420581655, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221510738, Length=395, Percent_Identity=24.3037974683544, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221510734, Length=395, Percent_Identity=24.3037974683544, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59524; Mature: 59524

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METITVVLFLLFCVVVSDLLARTLPIPVPRPLYQIALGGVIGLFADLRVVLEPDIFFLLF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LPPLLFLDGWHIAREEVFKDRFVILELAFGLVFLTVLGAGLFIHWMIPAMPLAVAFALAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSPTDPIAVSAIAKHAPIPKRMMNILEGESLLNDASGLVCLRFAVAAALTGGFSLTDAA
HHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHH
LEFLWVALAGIAVGISLTWAVTRSKNMLARRIGESSATQTLISLLIPFGSYLVAEHLDCS
HHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHH
GILAAVAAGVTMSIEESSGQAQAATRIRRNTVWDTIQFAANGVIFVILGEQLPAILESAA
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
ETVRVTGHHEPWWLGIYVVAICLGLAALRFLWVWASLQVSLLRTGQKRPPRHWRLITAMS
HHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEHHHH
LSGVRGAITLAGVLTLPLTMTDGTAFPARDLAIFLAMGVIIVTMVVATVFLPLLLNGLEM
HCCCCHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SQDSTADDQEAAARIAAAEVAIAEIERVQHSMAEGAKDADLFVTVGASLMDVYRERVRSR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCC
SQEGEAAVLVRRVDWIEREMRLAALRAERSEIFRRVRKYQLGSERARKLIRELDLLETRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SAEPKG
CCCCCC
>Mature Secondary Structure
METITVVLFLLFCVVVSDLLARTLPIPVPRPLYQIALGGVIGLFADLRVVLEPDIFFLLF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LPPLLFLDGWHIAREEVFKDRFVILELAFGLVFLTVLGAGLFIHWMIPAMPLAVAFALAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSPTDPIAVSAIAKHAPIPKRMMNILEGESLLNDASGLVCLRFAVAAALTGGFSLTDAA
HHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHH
LEFLWVALAGIAVGISLTWAVTRSKNMLARRIGESSATQTLISLLIPFGSYLVAEHLDCS
HHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHH
GILAAVAAGVTMSIEESSGQAQAATRIRRNTVWDTIQFAANGVIFVILGEQLPAILESAA
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
ETVRVTGHHEPWWLGIYVVAICLGLAALRFLWVWASLQVSLLRTGQKRPPRHWRLITAMS
HHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEHHHH
LSGVRGAITLAGVLTLPLTMTDGTAFPARDLAIFLAMGVIIVTMVVATVFLPLLLNGLEM
HCCCCHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SQDSTADDQEAAARIAAAEVAIAEIERVQHSMAEGAKDADLFVTVGASLMDVYRERVRSR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCC
SQEGEAAVLVRRVDWIEREMRLAALRAERSEIFRRVRKYQLGSERARKLIRELDLLETRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SAEPKG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]