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The map label for this gene is menA [H]

Identifier: 83594717

GI number: 83594717

Start: 3905015

End: 3905938

Strand: Direct

Name: menA [H]

Synonym: Rru_A3388

Alternate gene names: 83594717

Gene position: 3905015-3905938 (Clockwise)

Preceding gene: 83594716

Following gene: 83594722

Centisome position: 89.71

GC content: 72.29

Gene sequence:

>924_bases
ATGAAGGACGATCGCCCCCCGCCGACGCCCCAGCGCCCGCCGTCACCTTTGGTGTGGTGGGCGGCCGCGCGCCCACGCAC
CCTGGGGCTGTCGCTTGCGCCGGTTCTGGTCGGCGCCGCCCTCGCCTGGGCCCAAACGGCAAGCCTGCGCCTTGATGCCG
CTTTGATTGCCGGGCTGGCGGCGATGGCCATTCAGATCGGCACCAATCTGTTCAACGACGCCGCCGATTTTCTCAATGGC
ACCGATCGGGCCGGCCGCATCGGACCGCCCCGGGTGACCCAGCGCGGCTGGCTGTCGGCCGCCGCCGTCCGCCGCGCCGC
CTTTGCCGCCTTCCTGCTCGCCGCCTTGGGCGGGATCTATCTGGTCGGACTTGGCGGCCCGCCCATCCTTGGCATTGGTC
TGCTCGCCCTGCTCGCCGGCTACGGCTATTCGGATGGGCCCTGGCCGATTTCGCGCGGGCCCTGGGGCGAGGTCATGGTC
ATCGCCTTCTTCGGCATCGCCGCCGTCGCCGGAACCGCTTTCCTGTGCGGCGGTGGCTGGAGCCTGCCGGCGGTGATCCT
GGGCGCGGTGCTCGGCCTGCCCGCCGCCGGGGTCTTGCTGGTCAACAACACCCGCGATCATGACGACGATCGTCTTGCCG
GTCGGCGCACCCTGGCGATCCGCCTGGGCCCGGGGAAAGCGCGGACCCTTTACGCCGGGATGCTGGGGCTGGCCTTCGCC
CTGCTTGTCACCCTTGGCTTCGTGGCGCCGCCGATGGCCGGGGCCCTGCTCGGGCTGACCTGCCTGCCGCTGGCTTGGCG
GGCGGCGCGGCGCTTCGCCCAAGCCACCACGGCGGCCGACTTCGCCGACTGCCTGGGGCGGACGGCGGGGCTGGAAACCG
CCCTCGCCCTGACCATCGGCCTCGGGCTGGCGATGCTGTCCTGA

Upstream 100 bases:

>100_bases
GCGCCCTGCCGACGGGGGAGCAGCGCCGGGGCATGGCCTTGCTGTCGATCGCCGGTGGCCTGGGGTTGGCGGCCACGGTC
GAAACCGTGACCTTCCCGCG

Downstream 100 bases:

>100_bases
GAGGGAAGTCGATCCTTTTTCCCGCTATTGTCTTTGCTGCTGCACGGAGCCGGCCTCTTCAGCTTCGCCGCCGTCATCGG
CGCGTTTGGCCTCTTTGGCC

Product: 1,4-dihydroxy-2-naphtoate prenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKDDRPPPTPQRPPSPLVWWAAARPRTLGLSLAPVLVGAALAWAQTASLRLDAALIAGLAAMAIQIGTNLFNDAADFLNG
TDRAGRIGPPRVTQRGWLSAAAVRRAAFAAFLLAALGGIYLVGLGGPPILGIGLLALLAGYGYSDGPWPISRGPWGEVMV
IAFFGIAAVAGTAFLCGGGWSLPAVILGAVLGLPAAGVLLVNNTRDHDDDRLAGRRTLAIRLGPGKARTLYAGMLGLAFA
LLVTLGFVAPPMAGALLGLTCLPLAWRAARRFAQATTAADFADCLGRTAGLETALALTIGLGLAMLS

Sequences:

>Translated_307_residues
MKDDRPPPTPQRPPSPLVWWAAARPRTLGLSLAPVLVGAALAWAQTASLRLDAALIAGLAAMAIQIGTNLFNDAADFLNG
TDRAGRIGPPRVTQRGWLSAAAVRRAAFAAFLLAALGGIYLVGLGGPPILGIGLLALLAGYGYSDGPWPISRGPWGEVMV
IAFFGIAAVAGTAFLCGGGWSLPAVILGAVLGLPAAGVLLVNNTRDHDDDRLAGRRTLAIRLGPGKARTLYAGMLGLAFA
LLVTLGFVAPPMAGALLGLTCLPLAWRAARRFAQATTAADFADCLGRTAGLETALALTIGLGLAMLS
>Mature_307_residues
MKDDRPPPTPQRPPSPLVWWAAARPRTLGLSLAPVLVGAALAWAQTASLRLDAALIAGLAAMAIQIGTNLFNDAADFLNG
TDRAGRIGPPRVTQRGWLSAAAVRRAAFAAFLLAALGGIYLVGLGGPPILGIGLLALLAGYGYSDGPWPISRGPWGEVMV
IAFFGIAAVAGTAFLCGGGWSLPAVILGAVLGLPAAGVLLVNNTRDHDDDRLAGRRTLAIRLGPGKARTLYAGMLGLAFA
LLVTLGFVAPPMAGALLGLTCLPLAWRAARRFAQATTAADFADCLGRTAGLETALALTIGLGLAMLS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=324, Percent_Identity=28.7037037037037, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1790365, Length=307, Percent_Identity=32.5732899022801, Blast_Score=119, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17737429, Length=268, Percent_Identity=28.7313432835821, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31428; Mature: 31428

Theoretical pI: Translated: 10.87; Mature: 10.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDDRPPPTPQRPPSPLVWWAAARPRTLGLSLAPVLVGAALAWAQTASLRLDAALIAGLA
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAIQIGTNLFNDAADFLNGTDRAGRIGPPRVTQRGWLSAAAVRRAAFAAFLLAALGGIY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVGLGGPPILGIGLLALLAGYGYSDGPWPISRGPWGEVMVIAFFGIAAVAGTAFLCGGGW
EEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCC
SLPAVILGAVLGLPAAGVLLVNNTRDHDDDRLAGRRTLAIRLGPGKARTLYAGMLGLAFA
CHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHH
LLVTLGFVAPPMAGALLGLTCLPLAWRAARRFAQATTAADFADCLGRTAGLETALALTIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLAMLS
HHHHHCC
>Mature Secondary Structure
MKDDRPPPTPQRPPSPLVWWAAARPRTLGLSLAPVLVGAALAWAQTASLRLDAALIAGLA
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAIQIGTNLFNDAADFLNGTDRAGRIGPPRVTQRGWLSAAAVRRAAFAAFLLAALGGIY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVGLGGPPILGIGLLALLAGYGYSDGPWPISRGPWGEVMVIAFFGIAAVAGTAFLCGGGW
EEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCC
SLPAVILGAVLGLPAAGVLLVNNTRDHDDDRLAGRRTLAIRLGPGKARTLYAGMLGLAFA
CHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHH
LLVTLGFVAPPMAGALLGLTCLPLAWRAARRFAQATTAADFADCLGRTAGLETALALTIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLAMLS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]