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The map label for this gene is pdhA [H]

Identifier: 83593216

GI number: 83593216

Start: 2179319

End: 2180329

Strand: Reverse

Name: pdhA [H]

Synonym: Rru_A1881

Alternate gene names: 83593216

Gene position: 2180329-2179319 (Counterclockwise)

Preceding gene: 83593217

Following gene: 83593215

Centisome position: 50.09

GC content: 63.11

Gene sequence:

>1011_bases
ATGGCAGCGACCCGACGCAAACCCAGGAACGGATCGTCTCCGGCCACGCCCACGCCCGACGACATCAAAGGCTTCTACCG
CGACATGCTGTTGATTCGGCGCTTCGAGGAGAAGGCCGGCCAGCTGTATGGCATGGGGCTGATCGGCGGGTTCTGTCATC
TCTACATCGGTCAGGAAGCGGTGGTCGTCGGCCTGCAGTGTCAGGCCCATCCCGGTGATTCGATCATCACCAGCTATCGC
GATCACGGGCATATGCTGGCCGCCGGCATGGATCCCAAGGGGGTGATGGCCGAGCTGACCGGCCGCCGGGGCGGTTATTC
CAAGGGCAAGGGCGGCTCCATGCACATGTTCAGCAAGGAGAACGGCTTTTACGGCGGTCACGGCATCGTCGGCGCCCAGG
TGCCCTTGGGCACCGGCTTGGCCTTCGCCCACAAGTATCGCGGCGATGGCGGCGTGTGCTTTTGCTATCTGGGCGACGGC
GCGGCCAACCAGGGTCAGGTCTATGAAAGCTTCAACATGGCCGCCCTGTGGAAGTTGCCGGTCATCTATGTGATCGAGAA
CAACAAATACGGCATGGGCACCTCGGTCGAGCGGGCGAGCGCCACCAAGGATCTGGCCACCCGCGGCGCCGCCTATGGCA
TCCCGGGGATTTCCGTCAACGGCATGGACGTTCTCGCCGTCAAGGCCGAGAGCGAGGAGGCCGTTGATCGGGTGCGCGCC
GGCGAGGGGCCGCTGATCCTGGAAATGAAGACCTATCGCTATCGCGGCCATTCGATGTCCGATCCGGCGAAATACCGGAC
CAAGGAGGAGGTCAGCAAGATGCGCGCCGAAAGCGATCCCATCGACCACCTGCGCCAGACTATCGTCAGCGACGCCATCC
TCGATGAGGAGGCGTTGAAGGAGATCGACAAGGAAATCAAATCCGTCGTCTCCCAAGCCGCCGAATTCGCCCAGAACAGC
CCCGAGCCCGACGCGGCCGAGCTGTACACCGACGTTCTCGTCGAAGCCTGA

Upstream 100 bases:

>100_bases
AAGGTCCGATCCCGCCGATGGCGCTTTGCCCGCCGCCGGTACGGCAAGGCCGGTTCCCCCCCGGGAACCGCACACAGGAA
AAGATCGAGAGGGAGAGACC

Downstream 100 bases:

>100_bases
TCGTCCTCCGGGAGCGCCAACCATGCCCGTACAGATTCTGATGCCCGCCCTGTCCCCGACGATGACCGAGGGGACCTTGG
CCAAATGGCTGAAAAAAGAA

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAATRRKPRNGSSPATPTPDDIKGFYRDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLQCQAHPGDSIITSYR
DHGHMLAAGMDPKGVMAELTGRRGGYSKGKGGSMHMFSKENGFYGGHGIVGAQVPLGTGLAFAHKYRGDGGVCFCYLGDG
AANQGQVYESFNMAALWKLPVIYVIENNKYGMGTSVERASATKDLATRGAAYGIPGISVNGMDVLAVKAESEEAVDRVRA
GEGPLILEMKTYRYRGHSMSDPAKYRTKEEVSKMRAESDPIDHLRQTIVSDAILDEEALKEIDKEIKSVVSQAAEFAQNS
PEPDAAELYTDVLVEA

Sequences:

>Translated_336_residues
MAATRRKPRNGSSPATPTPDDIKGFYRDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLQCQAHPGDSIITSYR
DHGHMLAAGMDPKGVMAELTGRRGGYSKGKGGSMHMFSKENGFYGGHGIVGAQVPLGTGLAFAHKYRGDGGVCFCYLGDG
AANQGQVYESFNMAALWKLPVIYVIENNKYGMGTSVERASATKDLATRGAAYGIPGISVNGMDVLAVKAESEEAVDRVRA
GEGPLILEMKTYRYRGHSMSDPAKYRTKEEVSKMRAESDPIDHLRQTIVSDAILDEEALKEIDKEIKSVVSQAAEFAQNS
PEPDAAELYTDVLVEA
>Mature_335_residues
AATRRKPRNGSSPATPTPDDIKGFYRDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLQCQAHPGDSIITSYRD
HGHMLAAGMDPKGVMAELTGRRGGYSKGKGGSMHMFSKENGFYGGHGIVGAQVPLGTGLAFAHKYRGDGGVCFCYLGDGA
ANQGQVYESFNMAALWKLPVIYVIENNKYGMGTSVERASATKDLATRGAAYGIPGISVNGMDVLAVKAESEEAVDRVRAG
EGPLILEMKTYRYRGHSMSDPAKYRTKEEVSKMRAESDPIDHLRQTIVSDAILDEEALKEIDKEIKSVVSQAAEFAQNSP
EPDAAELYTDVLVEA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=305, Percent_Identity=53.4426229508197, Blast_Score=334, Evalue=7e-92,
Organism=Homo sapiens, GI291084742, Length=312, Percent_Identity=53.2051282051282, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI4505685, Length=312, Percent_Identity=53.2051282051282, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI291084744, Length=319, Percent_Identity=52.0376175548589, Blast_Score=308, Evalue=4e-84,
Organism=Homo sapiens, GI291084757, Length=312, Percent_Identity=47.1153846153846, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI11386135, Length=323, Percent_Identity=30.9597523219814, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI258645172, Length=323, Percent_Identity=30.9597523219814, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32564172, Length=328, Percent_Identity=49.390243902439, Blast_Score=313, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17536047, Length=328, Percent_Identity=49.390243902439, Blast_Score=313, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI86563357, Length=288, Percent_Identity=31.5972222222222, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI86563355, Length=288, Percent_Identity=31.5972222222222, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=51.7571884984025, Blast_Score=316, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=51.3931888544892, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=51.3931888544892, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=51.3931888544892, Blast_Score=328, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=52.4590163934426, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24639748, Length=314, Percent_Identity=50.9554140127389, Blast_Score=302, Evalue=2e-82,
Organism=Drosophila melanogaster, GI21355903, Length=317, Percent_Identity=28.0757097791798, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36343; Mature: 36211

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATRRKPRNGSSPATPTPDDIKGFYRDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHEECCCE
VVVGLQCQAHPGDSIITSYRDHGHMLAAGMDPKGVMAELTGRRGGYSKGKGGSMHMFSKE
EEEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEECC
NGFYGGHGIVGAQVPLGTGLAFAHKYRGDGGVCFCYLGDGAANQGQVYESFNMAALWKLP
CCCCCCCCCEECCCCCCCCHHHHHEECCCCCEEEEEECCCCCCCCCCHHCCCCEEEEECC
VIYVIENNKYGMGTSVERASATKDLATRGAAYGIPGISVNGMDVLAVKAESEEAVDRVRA
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCEEEEEEECCCHHHHHHHHC
GEGPLILEMKTYRYRGHSMSDPAKYRTKEEVSKMRAESDPIDHLRQTIVSDAILDEEALK
CCCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHH
EIDKEIKSVVSQAAEFAQNSPEPDAAELYTDVLVEA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AATRRKPRNGSSPATPTPDDIKGFYRDMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHEECCCE
VVVGLQCQAHPGDSIITSYRDHGHMLAAGMDPKGVMAELTGRRGGYSKGKGGSMHMFSKE
EEEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEECC
NGFYGGHGIVGAQVPLGTGLAFAHKYRGDGGVCFCYLGDGAANQGQVYESFNMAALWKLP
CCCCCCCCCEECCCCCCCCHHHHHEECCCCCEEEEEECCCCCCCCCCHHCCCCEEEEECC
VIYVIENNKYGMGTSVERASATKDLATRGAAYGIPGISVNGMDVLAVKAESEEAVDRVRA
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCEEEEEEECCCHHHHHHHHC
GEGPLILEMKTYRYRGHSMSDPAKYRTKEEVSKMRAESDPIDHLRQTIVSDAILDEEALK
CCCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHH
EIDKEIKSVVSQAAEFAQNSPEPDAAELYTDVLVEA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]