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The map label for this gene is parC [H]

Identifier: 83593183

GI number: 83593183

Start: 2146560

End: 2148791

Strand: Reverse

Name: parC [H]

Synonym: Rru_A1848

Alternate gene names: 83593183

Gene position: 2148791-2146560 (Counterclockwise)

Preceding gene: 83593184

Following gene: 83593176

Centisome position: 49.37

GC content: 66.17

Gene sequence:

>2232_bases
ATGAGCAAAGGCCCCGTTCCCGAACCCCTGGAGATCCGCGAAACGCCGCTGAGCGAAGCGCTCTCCGAGCGGTATCTGGC
CTATGCGCTGTCGACCATCGTGTCGCGGTCGCTGCCCGATGTCCGCGATGGGTTGAAGCCGGTTCATCGGCGGCTGCTTT
ATGCCATGCGCATGCTCAAGCTCGATCCCGGCTCGGGGTTCAAGAAATGCGCCCGCGTCGTGGGCGATGTGATCGGCAAG
TATCACCCCCACGGCGACGCCGCCGTCTATGAGGCGATGGTTCGCCTTGCCCAGGAATTCGCCGTGCGGTATCCGCTGGT
CGAAGGCCAGGGCAATTTCGGCAATATCGACGGCGATAACGCCGCCGCCATGCGCTATACGGAAGCCCGGCTGACCGCCG
TCGCCAGCGCCCTGATGGAGGGGCTGGACGACGACGCCGTCGATTTCCGCCCGACCTATGATGGCGAGGATCACGAGCCG
GTGGTGATGCCCGCCGCCTTCCCCAATCTTCTGGCCAATGGCTCCTCGGGCATCGCCGTCGGCATGGCGACCAATATCCC
CCCCCATAACGTCGGCGAGTTGTGCGAGGCGCTGCTGCATCTGATCAAGGTGCCGGCCTGTCCGCCCGAAGCCCTGCTGA
GCTTCGTCAAAGGCCCCGATTTTCCCACCGGCGGCGTGCTGGCCGAGCATCCCCAGGCCATCGCCGAGGCCTATCGCACC
GGCCGCGGCGCCATGCGGCTGCGCGCGCGCTGGGAAAAGGAAAATCTGAGCCACGGCCTCTATCAGATTGTTATCACCGA
GATTCCCTATCAGATTCAGAAGGCCAAGCTGGTCGAGCGCATCGCCGAGCTGATCAACGGCCGCAAGCTGCCGATCCTTG
CCGATGTCCGCGATGAATCCGCCGATGACCTGCGTCTGGTGCTCGAACCGCGCAACCGCACCGTCGATGCCGAGACCCTG
ATGGAGCAGCTGTTCCGGCTGACCGATCTGGAGATCCGCTTCAATCTGAACATGAACGTGCTTGATGGCGACGGCGTGCC
CAAGGTGCTGGGCTTGAAGGAGGCGCTGGTCGCCTTTCTTGATCACCGGCTGGTGGTGCTTGGCCGGCGCTCGCGCCATC
GCCTGGGCAAGATCGAACACCGCCTGGAGGTGCTGGCCGGCACCTTGATCGCCTATCTCAACCTTGACGAGGTGATCCGC
ATCATCCGCGAGGAGGACGAACCCAAGCCGGCGCTGATGGCGGCCTTTGGCCTGAGCGATGTGCAAACCGAGGCCATCCT
CAATATGCGGCTGCGCTCCTTGCGCCGGCTTGAGGAGATGGAGATCCGCCGCGAGCATGACGCGCTGTCGGCCGAGAAGG
CCGGGCTGGAGGCCCTGCTCGCCGACGAGGGGCTGTGCTGGAAGGTGATCGCCAAGCAGATCCGCGAGACCCGCAAGACC
TTTGGCGGCGATACCGCCCTGGGGCGGCGGCGCACCGAACTGGGCAGCGCGCCGACGGCGGTGATCGTGCCGATCGAGGC
GCTGGTCGAGCGCGAGCCGATCACCGTCTTGCTGTCGGAGCGCGGCTGGCTGCGCGCCGTCAAGGGCCATCAGGAGCCGG
GCGAGGAGAACAAGTTCAAAGAGGGCGACGCCCTGCTGCTGGCGCTCCACGCCCAGACCACCGACAAGCTGCTGATCCTC
GACAGTACCGGACGCTTCTTTACCCTGCCCGCCGATAAGCTGGCGCGCGGTCGCGGCTTTGGCGAACCGGTGCGGCTGAT
GCTCGATCTGCCCAATGACGCCGATATCGTCAGCCTGCTGGTCCACGATCCGGCGCGCCGCCTGATCCTGGCGGCCAGCG
GCGGCCGGGGTTTCGTCGTCGAGGAAAAGGACGTCCTGGCCCAGACCCGGGCCGGCAAGCAGGTGATGACCGTCGACGCC
GGCGAGCGCGCCCTGCTGTGCCGCGAGGTGCGCGGCGACCATGTGGCGGTGATCGGCCAGAACCGTAAGCTGCTGGTCTT
CCCCTTGACCCAGGTGCCGGTGCTGGCGCGCGGCAAGGGCGTCATCTTGCAGCGCTATAAGGATGGCGGCATCGCCGATA
TCAAGACCTTCGCCATCGCCGATGGCCTGACCTGGAAATCGGGCGAGCGGACGCGCACCGAAAGCGACCTGACCGCCTGG
TTGGGCGACCGGGCCGGCCTGGGACGACTGCCGCCCCAGGGCTTCCCGCGCACCAACAGCTTCGGGCCATAA

Upstream 100 bases:

>100_bases
ATTGCCCGCCAGCCGGCAGAGGTTTGTCGAACGGTTGCGCCGGTGGTCAGCGGCGGACCGGTGATGTCTATGGTGCGTTG
AGAAAGAGGATCCGATCCCG

Downstream 100 bases:

>100_bases
GGTGTTTAGGCGACTTGAATGTTCTGGTCCTGGCGGTGGAGGGTCACTTCGACCTCCATCGACAAGAAGGCGTTGCCCGG
ACCGGCGAAGCTGCCGGTGA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MSKGPVPEPLEIRETPLSEALSERYLAYALSTIVSRSLPDVRDGLKPVHRRLLYAMRMLKLDPGSGFKKCARVVGDVIGK
YHPHGDAAVYEAMVRLAQEFAVRYPLVEGQGNFGNIDGDNAAAMRYTEARLTAVASALMEGLDDDAVDFRPTYDGEDHEP
VVMPAAFPNLLANGSSGIAVGMATNIPPHNVGELCEALLHLIKVPACPPEALLSFVKGPDFPTGGVLAEHPQAIAEAYRT
GRGAMRLRARWEKENLSHGLYQIVITEIPYQIQKAKLVERIAELINGRKLPILADVRDESADDLRLVLEPRNRTVDAETL
MEQLFRLTDLEIRFNLNMNVLDGDGVPKVLGLKEALVAFLDHRLVVLGRRSRHRLGKIEHRLEVLAGTLIAYLNLDEVIR
IIREEDEPKPALMAAFGLSDVQTEAILNMRLRSLRRLEEMEIRREHDALSAEKAGLEALLADEGLCWKVIAKQIRETRKT
FGGDTALGRRRTELGSAPTAVIVPIEALVEREPITVLLSERGWLRAVKGHQEPGEENKFKEGDALLLALHAQTTDKLLIL
DSTGRFFTLPADKLARGRGFGEPVRLMLDLPNDADIVSLLVHDPARRLILAASGGRGFVVEEKDVLAQTRAGKQVMTVDA
GERALLCREVRGDHVAVIGQNRKLLVFPLTQVPVLARGKGVILQRYKDGGIADIKTFAIADGLTWKSGERTRTESDLTAW
LGDRAGLGRLPPQGFPRTNSFGP

Sequences:

>Translated_743_residues
MSKGPVPEPLEIRETPLSEALSERYLAYALSTIVSRSLPDVRDGLKPVHRRLLYAMRMLKLDPGSGFKKCARVVGDVIGK
YHPHGDAAVYEAMVRLAQEFAVRYPLVEGQGNFGNIDGDNAAAMRYTEARLTAVASALMEGLDDDAVDFRPTYDGEDHEP
VVMPAAFPNLLANGSSGIAVGMATNIPPHNVGELCEALLHLIKVPACPPEALLSFVKGPDFPTGGVLAEHPQAIAEAYRT
GRGAMRLRARWEKENLSHGLYQIVITEIPYQIQKAKLVERIAELINGRKLPILADVRDESADDLRLVLEPRNRTVDAETL
MEQLFRLTDLEIRFNLNMNVLDGDGVPKVLGLKEALVAFLDHRLVVLGRRSRHRLGKIEHRLEVLAGTLIAYLNLDEVIR
IIREEDEPKPALMAAFGLSDVQTEAILNMRLRSLRRLEEMEIRREHDALSAEKAGLEALLADEGLCWKVIAKQIRETRKT
FGGDTALGRRRTELGSAPTAVIVPIEALVEREPITVLLSERGWLRAVKGHQEPGEENKFKEGDALLLALHAQTTDKLLIL
DSTGRFFTLPADKLARGRGFGEPVRLMLDLPNDADIVSLLVHDPARRLILAASGGRGFVVEEKDVLAQTRAGKQVMTVDA
GERALLCREVRGDHVAVIGQNRKLLVFPLTQVPVLARGKGVILQRYKDGGIADIKTFAIADGLTWKSGERTRTESDLTAW
LGDRAGLGRLPPQGFPRTNSFGP
>Mature_742_residues
SKGPVPEPLEIRETPLSEALSERYLAYALSTIVSRSLPDVRDGLKPVHRRLLYAMRMLKLDPGSGFKKCARVVGDVIGKY
HPHGDAAVYEAMVRLAQEFAVRYPLVEGQGNFGNIDGDNAAAMRYTEARLTAVASALMEGLDDDAVDFRPTYDGEDHEPV
VMPAAFPNLLANGSSGIAVGMATNIPPHNVGELCEALLHLIKVPACPPEALLSFVKGPDFPTGGVLAEHPQAIAEAYRTG
RGAMRLRARWEKENLSHGLYQIVITEIPYQIQKAKLVERIAELINGRKLPILADVRDESADDLRLVLEPRNRTVDAETLM
EQLFRLTDLEIRFNLNMNVLDGDGVPKVLGLKEALVAFLDHRLVVLGRRSRHRLGKIEHRLEVLAGTLIAYLNLDEVIRI
IREEDEPKPALMAAFGLSDVQTEAILNMRLRSLRRLEEMEIRREHDALSAEKAGLEALLADEGLCWKVIAKQIRETRKTF
GGDTALGRRRTELGSAPTAVIVPIEALVEREPITVLLSERGWLRAVKGHQEPGEENKFKEGDALLLALHAQTTDKLLILD
STGRFFTLPADKLARGRGFGEPVRLMLDLPNDADIVSLLVHDPARRLILAASGGRGFVVEEKDVLAQTRAGKQVMTVDAG
ERALLCREVRGDHVAVIGQNRKLLVFPLTQVPVLARGKGVILQRYKDGGIADIKTFAIADGLTWKSGERTRTESDLTAWL
GDRAGLGRLPPQGFPRTNSFGP

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=669, Percent_Identity=41.4050822122571, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1788562, Length=643, Percent_Identity=40.4354587869362, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17535065, Length=472, Percent_Identity=25.4237288135593, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=464, Percent_Identity=23.4913793103448, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=455, Percent_Identity=25.9340659340659, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=399, Percent_Identity=24.5614035087719, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136538, Length=180, Percent_Identity=30.5555555555556, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 81901; Mature: 81770

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGPVPEPLEIRETPLSEALSERYLAYALSTIVSRSLPDVRDGLKPVHRRLLYAMRMLK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
LDPGSGFKKCARVVGDVIGKYHPHGDAAVYEAMVRLAQEFAVRYPLVEGQGNFGNIDGDN
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCC
AAAMRYTEARLTAVASALMEGLDDDAVDFRPTYDGEDHEPVVMPAAFPNLLANGSSGIAV
CHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCEEE
GMATNIPPHNVGELCEALLHLIKVPACPPEALLSFVKGPDFPTGGVLAEHPQAIAEAYRT
EEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHC
GRGAMRLRARWEKENLSHGLYQIVITEIPYQIQKAKLVERIAELINGRKLPILADVRDES
CCCHHHHHHHHCHHHHCCHHHEEHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
ADDLRLVLEPRNRTVDAETLMEQLFRLTDLEIRFNLNMNVLDGDGVPKVLGLKEALVAFL
CCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHH
DHRLVVLGRRSRHRLGKIEHRLEVLAGTLIAYLNLDEVIRIIREEDEPKPALMAAFGLSD
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHCCCH
VQTEAILNMRLRSLRRLEEMEIRREHDALSAEKAGLEALLADEGLCWKVIAKQIRETRKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHH
FGGDTALGRRRTELGSAPTAVIVPIEALVEREPITVLLSERGWLRAVKGHQEPGEENKFK
CCCCCHHCCHHHHCCCCCCEEEEEHHHHHCCCCEEEEECCCCHHHHHCCCCCCCCCCCCC
EGDALLLALHAQTTDKLLILDSTGRFFTLPADKLARGRGFGEPVRLMLDLPNDADIVSLL
CCCEEEEEEECCCCCCEEEEECCCCEEECCHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
VHDPARRLILAASGGRGFVVEEKDVLAQTRAGKQVMTVDAGERALLCREVRGDHVAVIGQ
HCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEC
NRKLLVFPLTQVPVLARGKGVILQRYKDGGIADIKTFAIADGLTWKSGERTRTESDLTAW
CCEEEEEECCCCCEEECCCCEEEEEECCCCCCHHHHEEEECCCCCCCCCCCCCHHHHHHH
LGDRAGLGRLPPQGFPRTNSFGP
HCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKGPVPEPLEIRETPLSEALSERYLAYALSTIVSRSLPDVRDGLKPVHRRLLYAMRMLK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
LDPGSGFKKCARVVGDVIGKYHPHGDAAVYEAMVRLAQEFAVRYPLVEGQGNFGNIDGDN
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCC
AAAMRYTEARLTAVASALMEGLDDDAVDFRPTYDGEDHEPVVMPAAFPNLLANGSSGIAV
CHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCEEE
GMATNIPPHNVGELCEALLHLIKVPACPPEALLSFVKGPDFPTGGVLAEHPQAIAEAYRT
EEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHC
GRGAMRLRARWEKENLSHGLYQIVITEIPYQIQKAKLVERIAELINGRKLPILADVRDES
CCCHHHHHHHHCHHHHCCHHHEEHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
ADDLRLVLEPRNRTVDAETLMEQLFRLTDLEIRFNLNMNVLDGDGVPKVLGLKEALVAFL
CCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHH
DHRLVVLGRRSRHRLGKIEHRLEVLAGTLIAYLNLDEVIRIIREEDEPKPALMAAFGLSD
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHCCCH
VQTEAILNMRLRSLRRLEEMEIRREHDALSAEKAGLEALLADEGLCWKVIAKQIRETRKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHH
FGGDTALGRRRTELGSAPTAVIVPIEALVEREPITVLLSERGWLRAVKGHQEPGEENKFK
CCCCCHHCCHHHHCCCCCCEEEEEHHHHHCCCCEEEEECCCCHHHHHCCCCCCCCCCCCC
EGDALLLALHAQTTDKLLILDSTGRFFTLPADKLARGRGFGEPVRLMLDLPNDADIVSLL
CCCEEEEEEECCCCCCEEEEECCCCEEECCHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
VHDPARRLILAASGGRGFVVEEKDVLAQTRAGKQVMTVDAGERALLCREVRGDHVAVIGQ
HCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEC
NRKLLVFPLTQVPVLARGKGVILQRYKDGGIADIKTFAIADGLTWKSGERTRTESDLTAW
CCEEEEEECCCCCEEECCCCEEEEEECCCCCCHHHHEEEECCCCCCCCCCCCCHHHHHHH
LGDRAGLGRLPPQGFPRTNSFGP
HCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]