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The map label for this gene is dacC [H]

Identifier: 83593039

GI number: 83593039

Start: 1994316

End: 1995482

Strand: Reverse

Name: dacC [H]

Synonym: Rru_A1704

Alternate gene names: 83593039

Gene position: 1995482-1994316 (Counterclockwise)

Preceding gene: 83593040

Following gene: 83593038

Centisome position: 45.84

GC content: 62.98

Gene sequence:

>1167_bases
GTGATTGCGCTCGCCCGCCATCTTACGCCATTCGTGCTGGCCGCCGGCCTGCTGACCGCCATGCCCGCCCAGGCTTTCGA
AACCAAGGCGCGCCATGCCCTGGTCATCGACCTGGATACCGATACGGTTCTGCTTGATAAAGACGCCGATGTGCCGATGC
CGCCGTCGTCGATGAGCAAGCTGATGACCGCCTATATGCTGTTCGAGCGGCTGAAAAGCGGCTCGCTGTCGCTTGATGAC
ACCTTCAGCGTCAGCGAAAACGCTTGGCGCAAGGGCGGGGCGGCCAGCGGCGGCTCGACGATGTTCCTCAATCCCGGCGC
CCAGGTGAAGGTCCATGACCTGATGCGCGGCATCATCATCCAATCGGGCAATGACGCCTGCGTGGTGGTGGCCGAGAATC
TCGCCGGCGACGAGGCGACTTTCGCCGCGGCGATGAACCGTCGGGCGAAGGAACTGGGGCTGACCAACAGCCATTTCGTC
AATGCCACCGGCCTGCCCGATCCCGAGCATTATATGACGGCCCATGATCTGGTGCTTTTGGCCGAACATATCATCCGGGA
TTTCCCGGAATTCTACGAGATCTACGGCGAGACCAAATTCACCTATAACGGCATCGTTCAGCACAACCGAAATCCTTTGT
TGTATATGAACATGGGCGCCGATGGCCTGAAAACCGGCCATACCAATATCGCCGGCTTCGGCCTGACCGCCTCGGCCGTC
CAGGATGGACGGCGGCTGCTGATGGTGATCAACGGCCTGCAAAGCAACAAGGAACGCTCGGAAGAAGCCGAACGGCTGAT
GTCGTGGGGCTTCCGCAATTTCGAGACGGTGACCCTACTCAAGGCCGGCCAGCCGATCAGCGACGCCGATGTCTGGATGG
GCGAGGAGGAAACCGTGCCGCTGGTTTCGGTGAACGACCTCAAGATCACCCTGCCACGGGCGGCGCGCCGCGACATGGTG
GCCAAGGCGGTGTTCGAGACGCCGATCCCGGCGCCGATCCAGGCCGGCGACCGCATCGCCACCCTGGTGCTGACCGGGCC
GGATATGGCCAAGCTGGAATACCCGCTGGTCGCCGGACGGGCGGTGGAACAGCTGTCGTTCTTCGGGCGCATCCTGGCCT
CGGCGCGCAATGCGGTGTTCGGCACCGCCCAGCCCGCCGCCCACTAG

Upstream 100 bases:

>100_bases
CCCGCCGCCGGGACGCGGGTCGACTCGGCGCTGGGCCGTATGCCACGGACCCATTCCCCAGGCGAGTTGACCGTCACTTT
TTCGATGGAGCGATAAGGTC

Downstream 100 bases:

>100_bases
GCCGATGAAGCGGGAAACGCCGGTGACCGGCGGACGGTTCATCACCTTGGAAGGCGGCGAGGGCGCGGGCAAGACCACCC
AACTCAGCCGTCTCGCCCAA

Product: serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIALARHLTPFVLAAGLLTAMPAQAFETKARHALVIDLDTDTVLLDKDADVPMPPSSMSKLMTAYMLFERLKSGSLSLDD
TFSVSENAWRKGGAASGGSTMFLNPGAQVKVHDLMRGIIIQSGNDACVVVAENLAGDEATFAAAMNRRAKELGLTNSHFV
NATGLPDPEHYMTAHDLVLLAEHIIRDFPEFYEIYGETKFTYNGIVQHNRNPLLYMNMGADGLKTGHTNIAGFGLTASAV
QDGRRLLMVINGLQSNKERSEEAERLMSWGFRNFETVTLLKAGQPISDADVWMGEEETVPLVSVNDLKITLPRAARRDMV
AKAVFETPIPAPIQAGDRIATLVLTGPDMAKLEYPLVAGRAVEQLSFFGRILASARNAVFGTAQPAAH

Sequences:

>Translated_388_residues
MIALARHLTPFVLAAGLLTAMPAQAFETKARHALVIDLDTDTVLLDKDADVPMPPSSMSKLMTAYMLFERLKSGSLSLDD
TFSVSENAWRKGGAASGGSTMFLNPGAQVKVHDLMRGIIIQSGNDACVVVAENLAGDEATFAAAMNRRAKELGLTNSHFV
NATGLPDPEHYMTAHDLVLLAEHIIRDFPEFYEIYGETKFTYNGIVQHNRNPLLYMNMGADGLKTGHTNIAGFGLTASAV
QDGRRLLMVINGLQSNKERSEEAERLMSWGFRNFETVTLLKAGQPISDADVWMGEEETVPLVSVNDLKITLPRAARRDMV
AKAVFETPIPAPIQAGDRIATLVLTGPDMAKLEYPLVAGRAVEQLSFFGRILASARNAVFGTAQPAAH
>Mature_388_residues
MIALARHLTPFVLAAGLLTAMPAQAFETKARHALVIDLDTDTVLLDKDADVPMPPSSMSKLMTAYMLFERLKSGSLSLDD
TFSVSENAWRKGGAASGGSTMFLNPGAQVKVHDLMRGIIIQSGNDACVVVAENLAGDEATFAAAMNRRAKELGLTNSHFV
NATGLPDPEHYMTAHDLVLLAEHIIRDFPEFYEIYGETKFTYNGIVQHNRNPLLYMNMGADGLKTGHTNIAGFGLTASAV
QDGRRLLMVINGLQSNKERSEEAERLMSWGFRNFETVTLLKAGQPISDADVWMGEEETVPLVSVNDLKITLPRAARRDMV
AKAVFETPIPAPIQAGDRIATLVLTGPDMAKLEYPLVAGRAVEQLSFFGRILASARNAVFGTAQPAAH

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=345, Percent_Identity=39.7101449275362, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1786851, Length=349, Percent_Identity=38.10888252149, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082022, Length=376, Percent_Identity=37.5, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87082054, Length=258, Percent_Identity=28.2945736434109, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42100; Mature: 42100

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALARHLTPFVLAAGLLTAMPAQAFETKARHALVIDLDTDTVLLDKDADVPMPPSSMSK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCHHHHHH
LMTAYMLFERLKSGSLSLDDTFSVSENAWRKGGAASGGSTMFLNPGAQVKVHDLMRGIII
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCEEHHHHHHHHEE
QSGNDACVVVAENLAGDEATFAAAMNRRAKELGLTNSHFVNATGLPDPEHYMTAHDLVLL
ECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHH
AEHIIRDFPEFYEIYGETKFTYNGIVQHNRNPLLYMNMGADGLKTGHTNIAGFGLTASAV
HHHHHHHCHHHHHHHCCCEEEECCEEEECCCCEEEEECCCCCCCCCCCCEEECCCCHHHH
QDGRRLLMVINGLQSNKERSEEAERLMSWGFRNFETVTLLKAGQPISDADVWMGEEETVP
HCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCE
LVSVNDLKITLPRAARRDMVAKAVFETPIPAPIQAGDRIATLVLTGPDMAKLEYPLVAGR
EEEECCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHCCCCHHHHH
AVEQLSFFGRILASARNAVFGTAQPAAH
HHHHHHHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MIALARHLTPFVLAAGLLTAMPAQAFETKARHALVIDLDTDTVLLDKDADVPMPPSSMSK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCHHHHHH
LMTAYMLFERLKSGSLSLDDTFSVSENAWRKGGAASGGSTMFLNPGAQVKVHDLMRGIII
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCEEHHHHHHHHEE
QSGNDACVVVAENLAGDEATFAAAMNRRAKELGLTNSHFVNATGLPDPEHYMTAHDLVLL
ECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHH
AEHIIRDFPEFYEIYGETKFTYNGIVQHNRNPLLYMNMGADGLKTGHTNIAGFGLTASAV
HHHHHHHCHHHHHHHCCCEEEECCEEEECCCCEEEEECCCCCCCCCCCCEEECCCCHHHH
QDGRRLLMVINGLQSNKERSEEAERLMSWGFRNFETVTLLKAGQPISDADVWMGEEETVP
HCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCE
LVSVNDLKITLPRAARRDMVAKAVFETPIPAPIQAGDRIATLVLTGPDMAKLEYPLVAGR
EEEECCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHCCCCHHHHH
AVEQLSFFGRILASARNAVFGTAQPAAH
HHHHHHHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]