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The map label for this gene is nqo13 [H]

Identifier: 83592902

GI number: 83592902

Start: 1847492

End: 1849024

Strand: Direct

Name: nqo13 [H]

Synonym: Rru_A1567

Alternate gene names: 83592902

Gene position: 1847492-1849024 (Clockwise)

Preceding gene: 83592901

Following gene: 83592903

Centisome position: 42.44

GC content: 61.64

Gene sequence:

>1533_bases
ATGAACGCCCTTCCGTTGCTTTCGATCATCACCTTCCTGCCGCTTGTCGGCGCGGTCTTCATCTTGACGGTGAAGGGCGA
GGAGGCGGTGGTGGCCCGCAATGCCCGTAACGTGGCGCTGCTGACCACGGGCTTCACTTTCCTGGTCTCGCTGGGGCTCT
GGTTCGGCTTCGATCCGGCACAGAGCGGCTTCCAGTTCGTCGAGAAAGTGTCGTGGCTGCCCGATTACGGCATCAATTAC
CAGATGGGGGTGGATGGCATTTCGGTGCTGTTCGTCCTGCTCTCCACCTTCCTCACCCCGCTGTGCATCCTCGCCTCGTG
GACGTCGATCACCAAGCGGGTCAAGGAATACATGGTCGCCTTCCTCGTTCTTGAAACGATGATGGTTGGCATGTTCTGCG
CCCTTGATTTCGTCGTCTTCTACGTTTTCTTCGAAGGCGTGCTGATCCCGATGTTCCTGATCATCGGCATCTGGGGTGGC
GGTCGGCGGGTCTATGCCTCGTTCAAGTTCTTCCTCTATACCCTGGCCGGCTCGGTGCTGATGATGGTGGCGATGCTCGC
CATGTACATCGAGGCCGGCACCACCGACATTCCGACGCTGATGAGCCACGGCTTCCCGGCGGCGATGCAAACCTGGTTGT
GGCTGGCGATGTTCGCCAGCTTCGCCGTCAAGGTGCCGATGTGGCCGGTCCATACCTGGCTGCCCGACGCCCACGTCGAG
GCGCCGACGGCGGGATCGGTGATCCTGGCCGGCGTCTTGCTGAAAATGGGCGCCTATGGCTTCCTGCGCTTCTCCATTCC
CATGCTGCCCCTGGCCTCGGCCGATTTCGCGCCCTTCATCTTCGCGCTTTCGGTCATCGGCGTGATCTACACCTCGCTGG
TCGCCCTGGTGCAGGAGGACATGAAGAAGCTGATCGCCTATTCGTCGATCGCCCATATGGCTTTCGTCACCGCCGGCATC
TTCGCCGTCAATCAGATGTCGGTGGAAGGCGCGCTCTATCAGATGCTGTCCCACGGCGTGGTTTCGGGGGCTTTGTTCCT
CTGCGTCGGCGTCGTCTATGACCGCCTGCATACCCGCGAGATCAGCCGCTACGGCGGTCTGGCCAAGAACATGCCGCGCT
ACGCCCTGGTCTTCATGGTCTTCATGATGGCGTCAATCGGCCTGCCCGGCACCGGCGGCTTCATCGGCGAATTCCTGATC
ATGATGGGCGTTTTCCAAATCAGCACTTGGGTCGCGCTGTTCATCGCCACCGGGGTGATCCTGGGCGCGGCCTATATGCT
CTATCTCTATCGCCGGGTGATCTTCGGCAAGCTGGAGAAGGAGGACCTCAAGGGCCTTCTCGATCTTAACCGCCGCGAGG
TGGCGATCTTCGCCCCGCTGCTGGTTCTGGTCTTGTGGATGGGGGTCTATCCCTCGACCTTCCTCGACTTCATGCACACC
TCGGTCGCCGACCTCGTTTCCACCTACGAGACAGCGCTCACCGCCGCCGGGACCCCCGGTCCCGACGCGGCGGCGTCGCT
GGCCCAGCGCTAA

Upstream 100 bases:

>100_bases
AGACCGGCTATCTTTACCACTATGCCTTCGCGATGATCACCGGCATTGCCGGGGTCGTCACCTGGGTCATGGTCACCTCC
GCCCACTGAAAGAGGCCGTG

Downstream 100 bases:

>100_bases
AGGCCAAAGGGGTAGTCGCAATGACGTTCCAATCACTGATCCTTGGGCCCGCCCTGCCGGAAATCCTGCTGGCCGTCCTT
GGTCTGGTTCTTTTGATGGT

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNALPLLSIITFLPLVGAVFILTVKGEEAVVARNARNVALLTTGFTFLVSLGLWFGFDPAQSGFQFVEKVSWLPDYGINY
QMGVDGISVLFVLLSTFLTPLCILASWTSITKRVKEYMVAFLVLETMMVGMFCALDFVVFYVFFEGVLIPMFLIIGIWGG
GRRVYASFKFFLYTLAGSVLMMVAMLAMYIEAGTTDIPTLMSHGFPAAMQTWLWLAMFASFAVKVPMWPVHTWLPDAHVE
APTAGSVILAGVLLKMGAYGFLRFSIPMLPLASADFAPFIFALSVIGVIYTSLVALVQEDMKKLIAYSSIAHMAFVTAGI
FAVNQMSVEGALYQMLSHGVVSGALFLCVGVVYDRLHTREISRYGGLAKNMPRYALVFMVFMMASIGLPGTGGFIGEFLI
MMGVFQISTWVALFIATGVILGAAYMLYLYRRVIFGKLEKEDLKGLLDLNRREVAIFAPLLVLVLWMGVYPSTFLDFMHT
SVADLVSTYETALTAAGTPGPDAAASLAQR

Sequences:

>Translated_510_residues
MNALPLLSIITFLPLVGAVFILTVKGEEAVVARNARNVALLTTGFTFLVSLGLWFGFDPAQSGFQFVEKVSWLPDYGINY
QMGVDGISVLFVLLSTFLTPLCILASWTSITKRVKEYMVAFLVLETMMVGMFCALDFVVFYVFFEGVLIPMFLIIGIWGG
GRRVYASFKFFLYTLAGSVLMMVAMLAMYIEAGTTDIPTLMSHGFPAAMQTWLWLAMFASFAVKVPMWPVHTWLPDAHVE
APTAGSVILAGVLLKMGAYGFLRFSIPMLPLASADFAPFIFALSVIGVIYTSLVALVQEDMKKLIAYSSIAHMAFVTAGI
FAVNQMSVEGALYQMLSHGVVSGALFLCVGVVYDRLHTREISRYGGLAKNMPRYALVFMVFMMASIGLPGTGGFIGEFLI
MMGVFQISTWVALFIATGVILGAAYMLYLYRRVIFGKLEKEDLKGLLDLNRREVAIFAPLLVLVLWMGVYPSTFLDFMHT
SVADLVSTYETALTAAGTPGPDAAASLAQR
>Mature_510_residues
MNALPLLSIITFLPLVGAVFILTVKGEEAVVARNARNVALLTTGFTFLVSLGLWFGFDPAQSGFQFVEKVSWLPDYGINY
QMGVDGISVLFVLLSTFLTPLCILASWTSITKRVKEYMVAFLVLETMMVGMFCALDFVVFYVFFEGVLIPMFLIIGIWGG
GRRVYASFKFFLYTLAGSVLMMVAMLAMYIEAGTTDIPTLMSHGFPAAMQTWLWLAMFASFAVKVPMWPVHTWLPDAHVE
APTAGSVILAGVLLKMGAYGFLRFSIPMLPLASADFAPFIFALSVIGVIYTSLVALVQEDMKKLIAYSSIAHMAFVTAGI
FAVNQMSVEGALYQMLSHGVVSGALFLCVGVVYDRLHTREISRYGGLAKNMPRYALVFMVFMMASIGLPGTGGFIGEFLI
MMGVFQISTWVALFIATGVILGAAYMLYLYRRVIFGKLEKEDLKGLLDLNRREVAIFAPLLVLVLWMGVYPSTFLDFMHT
SVADLVSTYETALTAAGTPGPDAAASLAQR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=362, Percent_Identity=34.5303867403315, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI251831117, Length=354, Percent_Identity=23.728813559322, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788613, Length=507, Percent_Identity=36.094674556213, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1788827, Length=282, Percent_Identity=28.7234042553192, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1788831, Length=347, Percent_Identity=25.0720461095101, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788614, Length=423, Percent_Identity=25.0591016548463, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693160, Length=373, Percent_Identity=26.2734584450402, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI2367154, Length=249, Percent_Identity=26.9076305220884, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788829, Length=350, Percent_Identity=25.4285714285714, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55878; Mature: 55878

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]