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The map label for this gene is fadA [H]

Identifier: 83592646

GI number: 83592646

Start: 1546389

End: 1547531

Strand: Reverse

Name: fadA [H]

Synonym: Rru_A1310

Alternate gene names: 83592646

Gene position: 1547531-1546389 (Counterclockwise)

Preceding gene: 83592647

Following gene: 83592645

Centisome position: 35.55

GC content: 69.12

Gene sequence:

>1143_bases
ATGACCCAGGTGGTACTCGCAAGCTACGTCCGGTCCCCCTTCACCCCGGCCCGCAAGGGCGCCCTGGCCCGGGTACGTCC
CGATGATCTGGCCGCCCAGGTGATCAAGGCCCTGGTCGCGCGAACCGGGGTTGATCCGGCCACGATCGAGGATCTGATCC
TCGGTTGCGCCTTTCCCGAGGGTGAGCAGGGTTTGAACGTCGCCCGGCTGATCGGGCTGATGGCCGGCCTGCCCCAATCG
ACCGCCGGGGTGACGGTCAACCGCTTCTGCGGCTCGTCGATGCAATCAATCCACATGGCCGCCGGCGCCATCGCCCTGGG
GGCTGGCGAGGCCTTCGTCTGCGCCGGGGTCGAAAGCATGAGCCGGGTGCCGATGATGGGCTTCAATCCCTTGCCCAATC
CGGCCTTCGCCAAGGCCATGCCCGGCGCCTATATGGGCATGGGCGATACGGCCGAAAACGTGGCCAAGCGCTGGAAGATC
GATCGCAAGGCCCAGGAGGAGTTCGCCCTCCGCTCGCACCAGCGGGCCAAGACGGCCCAGGACGCCGGCCATCTGAGCGA
CGAGATCGTCGCCATCACCGATCCGCGCGGCGGCGCCAGCGTCGAGACCGATGGCTGCGTCCGCCCGGAAACCACCCTGG
ACGGACTGGCCGAGCTGAAGCCGGCCTTTTCGACCGAGGGCGTGGTGACGGCGGGAACCTCCTCGCCGCTGACCGATGGC
GCCTCGGCGGTCTTCGTCTGCTCGCGCGAGTACGCCGATCGCCATGGCCTAACGCCGCTGGCCGCGCTCAAAAGCATCGC
CGTCGCCGGCTGCGACCCGGAGATCATGGGCATCGGCCCGGTGGCGGCCTCGCGCAAGGCCCTGGAGCGGGCGGGGATCG
ACGCCGGCGCCCTTGATGTCATCGAATTGAACGAGGCCTTCGCCTCGCAGGCCCTGGCCTGCCTTGGCGAGCTCGGCCTG
GACGCCGATAAGGTCAATATCGACGGCGGCGCCATCGCCCTTGGCCATCCGCTGGGCGCCACGGGGGCGCGCATCGTCGG
CAAGGCGGCGTCCTTGCTCAAGCGTCAGGGTGGGCGCTACGCGCTAGCCACCCAGTGCATCGGCGGTGGCCAGGGTATCG
CCACCATCCTCGAAGCGGTCTGA

Upstream 100 bases:

>100_bases
CTCGAAGCCCTGAAAGCCAAGGGGGTCAACCCCCACCCACAGGGCTGACTCCGCGTGCTGGCAGCCTATGAACCCGTCCC
AAGGGAGGAGACGACCCAAA

Downstream 100 bases:

>100_bases
CAGGGAGCGTGAGATGAGCGAAATCGCCAAAGTCGCCGTGATCGGCGCCGGGGTCATGGGGGCAGGAATCGCCGCCCATG
TGGCCAATGCCGGGCTACCC

Product: acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTQVVLASYVRSPFTPARKGALARVRPDDLAAQVIKALVARTGVDPATIEDLILGCAFPEGEQGLNVARLIGLMAGLPQS
TAGVTVNRFCGSSMQSIHMAAGAIALGAGEAFVCAGVESMSRVPMMGFNPLPNPAFAKAMPGAYMGMGDTAENVAKRWKI
DRKAQEEFALRSHQRAKTAQDAGHLSDEIVAITDPRGGASVETDGCVRPETTLDGLAELKPAFSTEGVVTAGTSSPLTDG
ASAVFVCSREYADRHGLTPLAALKSIAVAGCDPEIMGIGPVAASRKALERAGIDAGALDVIELNEAFASQALACLGELGL
DADKVNIDGGAIALGHPLGATGARIVGKAASLLKRQGGRYALATQCIGGGQGIATILEAV

Sequences:

>Translated_380_residues
MTQVVLASYVRSPFTPARKGALARVRPDDLAAQVIKALVARTGVDPATIEDLILGCAFPEGEQGLNVARLIGLMAGLPQS
TAGVTVNRFCGSSMQSIHMAAGAIALGAGEAFVCAGVESMSRVPMMGFNPLPNPAFAKAMPGAYMGMGDTAENVAKRWKI
DRKAQEEFALRSHQRAKTAQDAGHLSDEIVAITDPRGGASVETDGCVRPETTLDGLAELKPAFSTEGVVTAGTSSPLTDG
ASAVFVCSREYADRHGLTPLAALKSIAVAGCDPEIMGIGPVAASRKALERAGIDAGALDVIELNEAFASQALACLGELGL
DADKVNIDGGAIALGHPLGATGARIVGKAASLLKRQGGRYALATQCIGGGQGIATILEAV
>Mature_379_residues
TQVVLASYVRSPFTPARKGALARVRPDDLAAQVIKALVARTGVDPATIEDLILGCAFPEGEQGLNVARLIGLMAGLPQST
AGVTVNRFCGSSMQSIHMAAGAIALGAGEAFVCAGVESMSRVPMMGFNPLPNPAFAKAMPGAYMGMGDTAENVAKRWKID
RKAQEEFALRSHQRAKTAQDAGHLSDEIVAITDPRGGASVETDGCVRPETTLDGLAELKPAFSTEGVVTAGTSSPLTDGA
SAVFVCSREYADRHGLTPLAALKSIAVAGCDPEIMGIGPVAASRKALERAGIDAGALDVIELNEAFASQALACLGELGLD
ADKVNIDGGAIALGHPLGATGARIVGKAASLLKRQGGRYALATQCIGGGQGIATILEAV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=39.2307692307692, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=37.9487179487179, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI4501853, Length=384, Percent_Identity=39.5833333333333, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=35.6132075471698, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=33.248730964467, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI194353979, Length=376, Percent_Identity=28.9893617021277, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=47.0149253731343, Blast_Score=311, Evalue=3e-86,
Organism=Escherichia coli, GI48994986, Length=395, Percent_Identity=45.8227848101266, Blast_Score=307, Evalue=7e-85,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=39.7959183673469, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788554, Length=395, Percent_Identity=39.2405063291139, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1788683, Length=430, Percent_Identity=33.953488372093, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=375, Percent_Identity=40, Blast_Score=257, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.7757009345794, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=34.4473007712082, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25147385, Length=372, Percent_Identity=32.5268817204301, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=369, Percent_Identity=27.10027100271, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322031, Length=388, Percent_Identity=36.5979381443299, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=38.1679389312977, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17648125, Length=380, Percent_Identity=38.9473684210526, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=33.2480818414322, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.7647058823529, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 38847; Mature: 38716

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVVLASYVRSPFTPARKGALARVRPDDLAAQVIKALVARTGVDPATIEDLILGCAFPE
CCHHHHHHHHCCCCCHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GEQGLNVARLIGLMAGLPQSTAGVTVNRFCGSSMQSIHMAAGAIALGAGEAFVCAGVESM
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHEEECCCCEEEEECHHHH
SRVPMMGFNPLPNPAFAKAMPGAYMGMGDTAENVAKRWKIDRKAQEEFALRSHQRAKTAQ
HCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DAGHLSDEIVAITDPRGGASVETDGCVRPETTLDGLAELKPAFSTEGVVTAGTSSPLTDG
HHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
ASAVFVCSREYADRHGLTPLAALKSIAVAGCDPEIMGIGPVAASRKALERAGIDAGALDV
CCEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCEEH
IELNEAFASQALACLGELGLDADKVNIDGGAIALGHPLGATGARIVGKAASLLKRQGGRY
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCE
ALATQCIGGGQGIATILEAV
EEEHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TQVVLASYVRSPFTPARKGALARVRPDDLAAQVIKALVARTGVDPATIEDLILGCAFPE
CHHHHHHHHCCCCCHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GEQGLNVARLIGLMAGLPQSTAGVTVNRFCGSSMQSIHMAAGAIALGAGEAFVCAGVESM
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHEEECCCCEEEEECHHHH
SRVPMMGFNPLPNPAFAKAMPGAYMGMGDTAENVAKRWKIDRKAQEEFALRSHQRAKTAQ
HCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DAGHLSDEIVAITDPRGGASVETDGCVRPETTLDGLAELKPAFSTEGVVTAGTSSPLTDG
HHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
ASAVFVCSREYADRHGLTPLAALKSIAVAGCDPEIMGIGPVAASRKALERAGIDAGALDV
CCEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCEEH
IELNEAFASQALACLGELGLDADKVNIDGGAIALGHPLGATGARIVGKAASLLKRQGGRY
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCE
ALATQCIGGGQGIATILEAV
EEEHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]