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The map label for this gene is moaA [H]

Identifier: 83592624

GI number: 83592624

Start: 1520773

End: 1521765

Strand: Direct

Name: moaA [H]

Synonym: Rru_A1288

Alternate gene names: 83592624

Gene position: 1520773-1521765 (Clockwise)

Preceding gene: 83592623

Following gene: 83592625

Centisome position: 34.94

GC content: 68.98

Gene sequence:

>993_bases
ATGCGCGATTCCTTTGGCCGTTTGATCACCTATCTGCGCCTATCGGTTACCGACCGCTGCGATCTGCGCTGCCGCTATTG
CATGGGACCCCATCCGGTCTTCATTCCCAAGCGCGACGTTCTCAGTCTGGAGGACCTGGGCGCCATCGCCGGCGCCTTCG
TCGATCTGGGCGTACGCAAGATCCGCCTGACCGGCGGCGAGCCCCTGGTGCGCCGGGGCCTGCCCACGCTGATCGCCGCC
CTGGCCGTCCATAAGGCCGAGGGCCGCCTTGACGAGATCGCGCTTAGCACCAACGGCAGCCTACTTGATCGCCACGCCCA
GGCCTTGGCCGAGGCGGGCATCGCCCGCGTCAATGTGTCGCTTGATACCCTTGATCCGCAGGTCTATTCCCGGGTGACCG
GGGGCGGCGGTCTTGACCGGGTGATGGGGGGGCTGATGGCCGCCCGTCAGGCGGGGATGGCGGTCAAGCTCAATTGCGTC
GCCGCCAAGGGCCTGAACGACGGCGCCCATGTCGGGCTGGTCGATTGGGCGCACGGCAACGGCTTTGATATCACCTTCAT
CGAACTAATGCCGGTGGGCGACGGCGAAAGCCGCAAGGAGTTCGGCTTCCTGCCCCTTGAGAGCGTGCGCGCGGCCCTGG
CGGCGCGCTGGACCCTGCTGGCCGACGACCATTGCTCGGGCGGTCCGGCGCGCTATCTGCGGGTGGCCGAAACCGGGCGG
CGCGTCGGCTTCATCACGGCGATGAGCGCCGAGTTCTGCGGCTCGTGCAACCGGGTGCGCGTCGATTGCCGGGGGCGTTT
GCACACCTGCCTGGGACGGAGCGGCCACCACGGCCTGAAGGCCGCCCTTGATCAGGGACCCGAGGCCCTGCGCGCCGCCA
TCTTGGGCGCCATCACCGCCAAGCCGCGCGCCCACGCCTTCCAAGAGGCCGCCTCGCCAACCCCGACCCCGGGGGCCTTG
CCCGAGCGCACGATGAACGCCACCGGCGGCTAA

Upstream 100 bases:

>100_bases
CGCCTGACGCCTGAGCGCTCCATGCTTCGGGACCGCCGCTTGCCTCCCGGCGGTCCCGGAGCCCTTCTCTCCGGCCTTCC
CCCCTTTTCCGGAGTCTGCG

Downstream 100 bases:

>100_bases
AGCGGTTGGCTTGGGGCTTGCGCTTTTTTGGTCGCTTGCTCAAAAACGCCCGCGTATCCCGGAAAGGGATCGCGGGCGTT
GTCGTGATCATTTGATGACG

Product: molybdenum cofactor synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRDSFGRLITYLRLSVTDRCDLRCRYCMGPHPVFIPKRDVLSLEDLGAIAGAFVDLGVRKIRLTGGEPLVRRGLPTLIAA
LAVHKAEGRLDEIALSTNGSLLDRHAQALAEAGIARVNVSLDTLDPQVYSRVTGGGGLDRVMGGLMAARQAGMAVKLNCV
AAKGLNDGAHVGLVDWAHGNGFDITFIELMPVGDGESRKEFGFLPLESVRAALAARWTLLADDHCSGGPARYLRVAETGR
RVGFITAMSAEFCGSCNRVRVDCRGRLHTCLGRSGHHGLKAALDQGPEALRAAILGAITAKPRAHAFQEAASPTPTPGAL
PERTMNATGG

Sequences:

>Translated_330_residues
MRDSFGRLITYLRLSVTDRCDLRCRYCMGPHPVFIPKRDVLSLEDLGAIAGAFVDLGVRKIRLTGGEPLVRRGLPTLIAA
LAVHKAEGRLDEIALSTNGSLLDRHAQALAEAGIARVNVSLDTLDPQVYSRVTGGGGLDRVMGGLMAARQAGMAVKLNCV
AAKGLNDGAHVGLVDWAHGNGFDITFIELMPVGDGESRKEFGFLPLESVRAALAARWTLLADDHCSGGPARYLRVAETGR
RVGFITAMSAEFCGSCNRVRVDCRGRLHTCLGRSGHHGLKAALDQGPEALRAAILGAITAKPRAHAFQEAASPTPTPGAL
PERTMNATGG
>Mature_330_residues
MRDSFGRLITYLRLSVTDRCDLRCRYCMGPHPVFIPKRDVLSLEDLGAIAGAFVDLGVRKIRLTGGEPLVRRGLPTLIAA
LAVHKAEGRLDEIALSTNGSLLDRHAQALAEAGIARVNVSLDTLDPQVYSRVTGGGGLDRVMGGLMAARQAGMAVKLNCV
AAKGLNDGAHVGLVDWAHGNGFDITFIELMPVGDGESRKEFGFLPLESVRAALAARWTLLADDHCSGGPARYLRVAETGR
RVGFITAMSAEFCGSCNRVRVDCRGRLHTCLGRSGHHGLKAALDQGPEALRAAILGAITAKPRAHAFQEAASPTPTPGAL
PERTMNATGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=311, Percent_Identity=35.3697749196142, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI22027536, Length=311, Percent_Identity=35.3697749196142, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1786999, Length=314, Percent_Identity=33.4394904458599, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17561210, Length=333, Percent_Identity=30.9309309309309, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566329, Length=335, Percent_Identity=31.044776119403, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI32566331, Length=325, Percent_Identity=30.7692307692308, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28574488, Length=311, Percent_Identity=35.6913183279743, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574490, Length=311, Percent_Identity=35.6913183279743, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35007; Mature: 35007

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSFGRLITYLRLSVTDRCDLRCRYCMGPHPVFIPKRDVLSLEDLGAIAGAFVDLGVRK
CCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCEEE
IRLTGGEPLVRRGLPTLIAALAVHKAEGRLDEIALSTNGSLLDRHAQALAEAGIARVNVS
EEECCCCHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEE
LDTLDPQVYSRVTGGGGLDRVMGGLMAARQAGMAVKLNCVAAKGLNDGAHVGLVDWAHGN
EECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEEECCCC
GFDITFIELMPVGDGESRKEFGFLPLESVRAALAARWTLLADDHCSGGPARYLRVAETGR
CCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCHHHEEEEHHCCC
RVGFITAMSAEFCGSCNRVRVDCRGRLHTCLGRSGHHGLKAALDQGPEALRAAILGAITA
EEEEEEEECHHHCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCC
KPRAHAFQEAASPTPTPGALPERTMNATGG
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDSFGRLITYLRLSVTDRCDLRCRYCMGPHPVFIPKRDVLSLEDLGAIAGAFVDLGVRK
CCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCEEE
IRLTGGEPLVRRGLPTLIAALAVHKAEGRLDEIALSTNGSLLDRHAQALAEAGIARVNVS
EEECCCCHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEE
LDTLDPQVYSRVTGGGGLDRVMGGLMAARQAGMAVKLNCVAAKGLNDGAHVGLVDWAHGN
EECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEEECCCC
GFDITFIELMPVGDGESRKEFGFLPLESVRAALAARWTLLADDHCSGGPARYLRVAETGR
CCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCHHHEEEEHHCCC
RVGFITAMSAEFCGSCNRVRVDCRGRLHTCLGRSGHHGLKAALDQGPEALRAAILGAITA
EEEEEEEECHHHCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCC
KPRAHAFQEAASPTPTPGALPERTMNATGG
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]