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The map label for this gene is aphA [H]

Identifier: 83592512

GI number: 83592512

Start: 1391734

End: 1392762

Strand: Direct

Name: aphA [H]

Synonym: Rru_A1176

Alternate gene names: 83592512

Gene position: 1391734-1392762 (Clockwise)

Preceding gene: 83592510

Following gene: 83592513

Centisome position: 31.97

GC content: 69.1

Gene sequence:

>1029_bases
ATGCGCGTGTTCTTTTCCCCCCGCCAGCTTGCCCACGCTCCCGCTTCGGAGTTCTCGCGCGGCGAAATGATCGCCTTTCG
CGAATGCCCCGTCCGCGCCCAATCGATCCTGGCGGCGCTGGCGGCCGCGGGGTTTCCCGCCCCGAGCCAGCCGGTCGATC
CCGGGCTTGCCCCGGTGCTGGCGATCCACGACGGCGAGTATGTCGAGTTCCTGCGAACGGCCTGGACGCGCTGGCGGGCG
GGCGGAGCGACCGTCGCCGCCTATCCCACCGCTTGGCCGGTGCCCGGGATTGGCGAGCGGCGCCCCGACACGGTGGAGGG
CCTGCTTGGCTGGTATATTTTTGATTCGGGTACGCCGATCGTCGCCGAGACCTGGGATGCGGTCAAAGCCGGGGCCGATA
CCGCCCATGCCGGGGCCCTGGCCGTGGCCACCGGCGCCCACTCGGCCTTCGCCCTCTGTCGGCCGCCGGGGCATCACGCC
GCCCGCGCCCTGGCGGGGGGCTATTGCTATCTGAACAACGCCGCCATCGCCGCCCAGACCCTGCGCGACCAGGGGGCGGG
GCGGGTGGCGATCCTTGATGTCGATTACCACCATGGCAATGGCACCCAGGAGATCTTCTACGAGCGCGGCGATGTGCTGT
TCGTCTCGCTCCACGCCGATCCGGCCTTTGGCTATCCCTATTACACCGGCTATGGCGACCAGAGCGGTCGCGGGGCGGGC
GAGGGGACGACGCTCAACCTGCCGCTGGCCGCCGGAACGACCGAAGCGGAATGGCTGGCGGCCCTGGAGCATGGGCTGGC
CCGTTTGGGCGAATTCGCTCCCGACGCCGTGGTGGTGTCGCTGGGCGTGGACACCTGGGCAGGCGATCCCCTGTCGCACT
TCAAGGTGTCCGCCCGCGCCTTCCCCGCCCTTGGCGCCCGCTTGGCCGGGCTTGGTCTTCCCACCCTGTTCGTGATGGAG
GGCGGTTATGCCACGGCAGAGTTGGGTAAGAACGTTGTGGGGGTTTTATCGGGATTTGAGGACGCTTGA

Upstream 100 bases:

>100_bases
GCGCATTTTGCGCTTTTCTCCCCCCGCCCAGGGGGGGAAGCTGCCCTGTCCCGCCCTGTCCCGATCCGCCCGGGGTTCCT
CTCACTTTCGAAGGTCGTCC

Downstream 100 bases:

>100_bases
TTGGCGCCTTTTGCTGCGGCGGCGGACGAGATGCTTTATAAGGCGGCTTGCGAAGATAGATGTAATTGTGGATTTGCAAT
CTTAACCCCTGTTTACATCA

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MRVFFSPRQLAHAPASEFSRGEMIAFRECPVRAQSILAALAAAGFPAPSQPVDPGLAPVLAIHDGEYVEFLRTAWTRWRA
GGATVAAYPTAWPVPGIGERRPDTVEGLLGWYIFDSGTPIVAETWDAVKAGADTAHAGALAVATGAHSAFALCRPPGHHA
ARALAGGYCYLNNAAIAAQTLRDQGAGRVAILDVDYHHGNGTQEIFYERGDVLFVSLHADPAFGYPYYTGYGDQSGRGAG
EGTTLNLPLAAGTTEAEWLAALEHGLARLGEFAPDAVVVSLGVDTWAGDPLSHFKVSARAFPALGARLAGLGLPTLFVME
GGYATAELGKNVVGVLSGFEDA

Sequences:

>Translated_342_residues
MRVFFSPRQLAHAPASEFSRGEMIAFRECPVRAQSILAALAAAGFPAPSQPVDPGLAPVLAIHDGEYVEFLRTAWTRWRA
GGATVAAYPTAWPVPGIGERRPDTVEGLLGWYIFDSGTPIVAETWDAVKAGADTAHAGALAVATGAHSAFALCRPPGHHA
ARALAGGYCYLNNAAIAAQTLRDQGAGRVAILDVDYHHGNGTQEIFYERGDVLFVSLHADPAFGYPYYTGYGDQSGRGAG
EGTTLNLPLAAGTTEAEWLAALEHGLARLGEFAPDAVVVSLGVDTWAGDPLSHFKVSARAFPALGARLAGLGLPTLFVME
GGYATAELGKNVVGVLSGFEDA
>Mature_342_residues
MRVFFSPRQLAHAPASEFSRGEMIAFRECPVRAQSILAALAAAGFPAPSQPVDPGLAPVLAIHDGEYVEFLRTAWTRWRA
GGATVAAYPTAWPVPGIGERRPDTVEGLLGWYIFDSGTPIVAETWDAVKAGADTAHAGALAVATGAHSAFALCRPPGHHA
ARALAGGYCYLNNAAIAAQTLRDQGAGRVAILDVDYHHGNGTQEIFYERGDVLFVSLHADPAFGYPYYTGYGDQSGRGAG
EGTTLNLPLAAGTTEAEWLAALEHGLARLGEFAPDAVVVSLGVDTWAGDPLSHFKVSARAFPALGARLAGLGLPTLFVME
GGYATAELGKNVVGVLSGFEDA

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=195, Percent_Identity=37.4358974358974, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI30795202, Length=195, Percent_Identity=37.4358974358974, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI17158039, Length=215, Percent_Identity=36.2790697674419, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI153085395, Length=212, Percent_Identity=38.2075471698113, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI169234807, Length=185, Percent_Identity=38.9189189189189, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI148539870, Length=185, Percent_Identity=38.9189189189189, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI20070354, Length=200, Percent_Identity=39.5, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13128864, Length=190, Percent_Identity=38.4210526315789, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI62750347, Length=195, Percent_Identity=37.4358974358974, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI62750349, Length=195, Percent_Identity=37.4358974358974, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI8923769, Length=176, Percent_Identity=33.5227272727273, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI13128860, Length=273, Percent_Identity=28.2051282051282, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI262073088, Length=176, Percent_Identity=32.9545454545455, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI226529806, Length=134, Percent_Identity=41.7910447761194, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI13128862, Length=176, Percent_Identity=30.1136363636364, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI293336691, Length=240, Percent_Identity=27.9166666666667, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI262073092, Length=108, Percent_Identity=34.2592592592593, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=204, Percent_Identity=37.2549019607843, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17540332, Length=204, Percent_Identity=37.2549019607843, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI193206283, Length=204, Percent_Identity=37.2549019607843, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI193209491, Length=328, Percent_Identity=29.5731707317073, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537347, Length=255, Percent_Identity=30.9803921568627, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17534739, Length=278, Percent_Identity=28.4172661870504, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=176, Percent_Identity=31.8181818181818, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25154020, Length=214, Percent_Identity=31.3084112149533, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17561978, Length=279, Percent_Identity=26.1648745519713, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25154022, Length=213, Percent_Identity=30.0469483568075, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324307, Length=204, Percent_Identity=37.2549019607843, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323999, Length=174, Percent_Identity=32.183908045977, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321244, Length=176, Percent_Identity=28.4090909090909, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325325, Length=150, Percent_Identity=24.6666666666667, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325141, Length=275, Percent_Identity=24.7272727272727, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281360899, Length=237, Percent_Identity=35.4430379746835, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642142, Length=190, Percent_Identity=39.4736842105263, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642146, Length=190, Percent_Identity=39.4736842105263, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642144, Length=190, Percent_Identity=39.4736842105263, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360801, Length=201, Percent_Identity=37.3134328358209, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281360799, Length=201, Percent_Identity=37.3134328358209, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24641720, Length=201, Percent_Identity=37.3134328358209, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24657891, Length=275, Percent_Identity=27.6363636363636, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644244, Length=176, Percent_Identity=31.8181818181818, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 35771; Mature: 35771

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFFSPRQLAHAPASEFSRGEMIAFRECPVRAQSILAALAAAGFPAPSQPVDPGLAPVL
CCEEECHHHHHCCCHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
AIHDGEYVEFLRTAWTRWRAGGATVAAYPTAWPVPGIGERRPDTVEGLLGWYIFDSGTPI
EEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHEEEEEEECCCCCE
VAETWDAVKAGADTAHAGALAVATGAHSAFALCRPPGHHAARALAGGYCYLNNAAIAAQT
EEECHHHHHCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHCCEEEECCCHHHHHH
LRDQGAGRVAILDVDYHHGNGTQEIFYERGDVLFVSLHADPAFGYPYYTGYGDQSGRGAG
HHHCCCCEEEEEEEEEECCCCCHHHEEECCCEEEEEEECCCCCCCCEECCCCCCCCCCCC
EGTTLNLPLAAGTTEAEWLAALEHGLARLGEFAPDAVVVSLGVDTWAGDPLSHFKVSARA
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHEEHHHH
FPALGARLAGLGLPTLFVMEGGYATAELGKNVVGVLSGFEDA
HHHHHHHHHHCCCCEEEEEECCEEHHHHCCHHHHHHCCCCCC
>Mature Secondary Structure
MRVFFSPRQLAHAPASEFSRGEMIAFRECPVRAQSILAALAAAGFPAPSQPVDPGLAPVL
CCEEECHHHHHCCCHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
AIHDGEYVEFLRTAWTRWRAGGATVAAYPTAWPVPGIGERRPDTVEGLLGWYIFDSGTPI
EEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHEEEEEEECCCCCE
VAETWDAVKAGADTAHAGALAVATGAHSAFALCRPPGHHAARALAGGYCYLNNAAIAAQT
EEECHHHHHCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHCCEEEECCCHHHHHH
LRDQGAGRVAILDVDYHHGNGTQEIFYERGDVLFVSLHADPAFGYPYYTGYGDQSGRGAG
HHHCCCCEEEEEEEEEECCCCCHHHEEECCCEEEEEEECCCCCCCCEECCCCCCCCCCCC
EGTTLNLPLAAGTTEAEWLAALEHGLARLGEFAPDAVVVSLGVDTWAGDPLSHFKVSARA
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHEEHHHH
FPALGARLAGLGLPTLFVMEGGYATAELGKNVVGVLSGFEDA
HHHHHHHHHHCCCCEEEEEECCEEHHHHCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]