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The map label for this gene is murC

Identifier: 83592285

GI number: 83592285

Start: 1132145

End: 1133590

Strand: Reverse

Name: murC

Synonym: Rru_A0949

Alternate gene names: 83592285

Gene position: 1133590-1132145 (Counterclockwise)

Preceding gene: 83592286

Following gene: 83592284

Centisome position: 26.04

GC content: 66.8

Gene sequence:

>1446_bases
ATGAGAGCCCTGCCCCTCGATATCGGCCCCTTGCACTTCGTGGGCATCGGCGGCATCGGCATGAGCGGCATCGCCGAGGT
CCTGCATAACCTGGGCTACCGGGTTCAGGGCAGCGACCTGTCCGACAACGCCAACGTCAAGCGCCTGCGTGACCTGGGCA
TTCCCATCGCCATCGGCCATAAGGCCGCCAATCTGGGCGATGCCCAGGTGGTGGTCATCTCCTCGGCGGTCAAAGCCAGC
AATCCCGAGGTCATGGACGCCCGCGCCCGCTTCCTGCCGGTGGTCCGCCGAGCCGAGATGCTGGGCGAGTTGATGCGCCT
GAAATGGTCGATCGCCGTGGCCGGCACCCACGGCAAGACCACCACCACCTCGCTGGTCGCCCAGTTGCTCGACGCCGCCG
GCCTCGATCCGACGGTGATCAACGGCGGCATCCTCAACGCGCGCGGCACCAACGCCTATCTCGGCACCGGCGAATGGATG
GTGGTCGAGGCCGACGAGAGCGACGGCACCTTCACCAAGCTGCCGGCGACGATCTCGCTGGTGACCAACATCGACCCCGA
GCACCTGGATTTCTACGGCACCTTCGACAAGGTGCGCGAGGCCTTCCGCGCCTTCATCCACAATCTGCCCTTCTATGGCT
TCGCCTGCATGTGCATCGACCATCCCGAGGTGCAGGCGATGATCCCCCAGCTTCAGGACCGCAAGATCATCACCTATGGC
CTGTCGCCCCAGGCCGATATTCGCGGCGCCAATGTGACCCTGGGGCCGCGCGGCGCCCGCTTCGACGTGATCTTGACTGA
CCGCGCCGGCGGCGGCAGCCGGACCATCGAAGGCATCCGCCTGCCGATGTATGGCCGCCACAACGTTCTGAACGCGCTGG
GCGCCATCGGCATCGCCGCCGAGATGGGCATCGACGACGCGGTGATCCGCGATGGCCTGTATCACTTCGAAGGGGTCAAG
CGCCGCTTCACCCGCACCGGCGATGCCGGCGGGGTGACGGTGATCGATGATTACGGCCACCACCCCGTCGAGATCGCCGC
CGTTCTCAAGGCGGCGCGCGACGCCACCGAGCGCGAGGTCATCGCCGTCGTCCAGCCCCACCGCTACAGCCGCCTCAACA
GCCTGTTCGAGGATTTCTGCACCTGCTTCAACGATGCCGATCAGGTGGTGGTCGCCGATGTCTATGCCGCCGGCGAGCAA
CCAATCCCCGGGGCGAGCAAGGAGGCCCTGGCCGAGGGCCTGAAGGTCCACGGCCACAAGAGCGTCCATGTGCTGACCAA
CGAACAGGCCCTGCCCGAATTGATCGCCCGCATCGCCAAGCCCGGCGATCTGGTGGTCTGCCTGGGGGCGGGCAGCATTT
CCACCTGGGCCAACGCCCTGCCCAAGCAGCTTGAGGCGGTTCAGGGCAGGCGCCGTCAGACCACCCTGGCCGGGGGGGCG
CCATGA

Upstream 100 bases:

>100_bases
GGGGCGCGGGCGTGCCCGATGCCGCGGTGCGGCTGGCCGATCTGGTGAGCGCGACCGCAGACCATCGGGTGCCCGAGATG
CCCCCCAAGGAGATTTCCGC

Downstream 100 bases:

>100_bases
TCGCCCTGCGCGCGCCAACCCCGCTGATCGACCGACTGCCCGCCGTGCGCGGACGGCTGAGCGCCGATGTCGCCCTCGCC
CCCGTCACCTGGTTTCGCGT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRALPLDIGPLHFVGIGGIGMSGIAEVLHNLGYRVQGSDLSDNANVKRLRDLGIPIAIGHKAANLGDAQVVVISSAVKAS
NPEVMDARARFLPVVRRAEMLGELMRLKWSIAVAGTHGKTTTTSLVAQLLDAAGLDPTVINGGILNARGTNAYLGTGEWM
VVEADESDGTFTKLPATISLVTNIDPEHLDFYGTFDKVREAFRAFIHNLPFYGFACMCIDHPEVQAMIPQLQDRKIITYG
LSPQADIRGANVTLGPRGARFDVILTDRAGGGSRTIEGIRLPMYGRHNVLNALGAIGIAAEMGIDDAVIRDGLYHFEGVK
RRFTRTGDAGGVTVIDDYGHHPVEIAAVLKAARDATEREVIAVVQPHRYSRLNSLFEDFCTCFNDADQVVVADVYAAGEQ
PIPGASKEALAEGLKVHGHKSVHVLTNEQALPELIARIAKPGDLVVCLGAGSISTWANALPKQLEAVQGRRRQTTLAGGA
P

Sequences:

>Translated_481_residues
MRALPLDIGPLHFVGIGGIGMSGIAEVLHNLGYRVQGSDLSDNANVKRLRDLGIPIAIGHKAANLGDAQVVVISSAVKAS
NPEVMDARARFLPVVRRAEMLGELMRLKWSIAVAGTHGKTTTTSLVAQLLDAAGLDPTVINGGILNARGTNAYLGTGEWM
VVEADESDGTFTKLPATISLVTNIDPEHLDFYGTFDKVREAFRAFIHNLPFYGFACMCIDHPEVQAMIPQLQDRKIITYG
LSPQADIRGANVTLGPRGARFDVILTDRAGGGSRTIEGIRLPMYGRHNVLNALGAIGIAAEMGIDDAVIRDGLYHFEGVK
RRFTRTGDAGGVTVIDDYGHHPVEIAAVLKAARDATEREVIAVVQPHRYSRLNSLFEDFCTCFNDADQVVVADVYAAGEQ
PIPGASKEALAEGLKVHGHKSVHVLTNEQALPELIARIAKPGDLVVCLGAGSISTWANALPKQLEAVQGRRRQTTLAGGA
P
>Mature_481_residues
MRALPLDIGPLHFVGIGGIGMSGIAEVLHNLGYRVQGSDLSDNANVKRLRDLGIPIAIGHKAANLGDAQVVVISSAVKAS
NPEVMDARARFLPVVRRAEMLGELMRLKWSIAVAGTHGKTTTTSLVAQLLDAAGLDPTVINGGILNARGTNAYLGTGEWM
VVEADESDGTFTKLPATISLVTNIDPEHLDFYGTFDKVREAFRAFIHNLPFYGFACMCIDHPEVQAMIPQLQDRKIITYG
LSPQADIRGANVTLGPRGARFDVILTDRAGGGSRTIEGIRLPMYGRHNVLNALGAIGIAAEMGIDDAVIRDGLYHFEGVK
RRFTRTGDAGGVTVIDDYGHHPVEIAAVLKAARDATEREVIAVVQPHRYSRLNSLFEDFCTCFNDADQVVVADVYAAGEQ
PIPGASKEALAEGLKVHGHKSVHVLTNEQALPELIARIAKPGDLVVCLGAGSISTWANALPKQLEAVQGRRRQTTLAGGA
P

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=464, Percent_Identity=42.2413793103448, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1790680, Length=482, Percent_Identity=27.8008298755187, Blast_Score=148, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_RHORT (Q2RVU5)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426037.1
- ProteinModelPortal:   Q2RVU5
- SMR:   Q2RVU5
- STRING:   Q2RVU5
- GeneID:   3834406
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0949
- NMPDR:   fig|1085.1.peg.3423
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q2RVU5
- ProtClustDB:   PRK00421
- BioCyc:   RRUB269796:RRU_A0949-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51450; Mature: 51450

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALPLDIGPLHFVGIGGIGMSGIAEVLHNLGYRVQGSDLSDNANVKRLRDLGIPIAIGH
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCEEEECC
KAANLGDAQVVVISSAVKASNPEVMDARARFLPVVRRAEMLGELMRLKWSIAVAGTHGKT
CCCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCC
TTTSLVAQLLDAAGLDPTVINGGILNARGTNAYLGTGEWMVVEADESDGTFTKLPATISL
HHHHHHHHHHHHCCCCCEEECCCEEECCCCCEEECCCCEEEEEECCCCCCEEECCEEEEE
VTNIDPEHLDFYGTFDKVREAFRAFIHNLPFYGFACMCIDHPEVQAMIPQLQDRKIITYG
EECCCHHHCEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCCCCCEEEEEC
LSPQADIRGANVTLGPRGARFDVILTDRAGGGSRTIEGIRLPMYGRHNVLNALGAIGIAA
CCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
EMGIDDAVIRDGLYHFEGVKRRFTRTGDAGGVTVIDDYGHHPVEIAAVLKAARDATEREV
HCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEE
IAVVQPHRYSRLNSLFEDFCTCFNDADQVVVADVYAAGEQPIPGASKEALAEGLKVHGHK
EEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCEECCCC
SVHVLTNEQALPELIARIAKPGDLVVCLGAGSISTWANALPKQLEAVQGRRRQTTLAGGA
EEEEEECCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEECCCCCC
P
C
>Mature Secondary Structure
MRALPLDIGPLHFVGIGGIGMSGIAEVLHNLGYRVQGSDLSDNANVKRLRDLGIPIAIGH
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCEEEECC
KAANLGDAQVVVISSAVKASNPEVMDARARFLPVVRRAEMLGELMRLKWSIAVAGTHGKT
CCCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCC
TTTSLVAQLLDAAGLDPTVINGGILNARGTNAYLGTGEWMVVEADESDGTFTKLPATISL
HHHHHHHHHHHHCCCCCEEECCCEEECCCCCEEECCCCEEEEEECCCCCCEEECCEEEEE
VTNIDPEHLDFYGTFDKVREAFRAFIHNLPFYGFACMCIDHPEVQAMIPQLQDRKIITYG
EECCCHHHCEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCCCCCEEEEEC
LSPQADIRGANVTLGPRGARFDVILTDRAGGGSRTIEGIRLPMYGRHNVLNALGAIGIAA
CCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
EMGIDDAVIRDGLYHFEGVKRRFTRTGDAGGVTVIDDYGHHPVEIAAVLKAARDATEREV
HCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEE
IAVVQPHRYSRLNSLFEDFCTCFNDADQVVVADVYAAGEQPIPGASKEALAEGLKVHGHK
EEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCEECCCC
SVHVLTNEQALPELIARIAKPGDLVVCLGAGSISTWANALPKQLEAVQGRRRQTTLAGGA
EEEEEECCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEECCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA