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The map label for this gene is glcD [H]

Identifier: 83592116

GI number: 83592116

Start: 928695

End: 930143

Strand: Direct

Name: glcD [H]

Synonym: Rru_A0777

Alternate gene names: 83592116

Gene position: 928695-930143 (Clockwise)

Preceding gene: 83592115

Following gene: 83592117

Centisome position: 21.34

GC content: 70.12

Gene sequence:

>1449_bases
ATGAGCGGGGTCATCGCCCGCTCCCGGCCTCCGGCAAGCGGGCTGGCGGCGGCCCTGGCGGAGCTGTCGACGCTGCTTGG
CGCGCGGCTGAGCACGGCTTTGGCCTTGCGTGAGCACCATTCCCACGACGAATCCCACCATGCCCCGGCCCTGCCCGACG
CGGTGGTCTTCCCCGAAACCACCGCCGAGGTCGCCGCCATCGCCCGCCTTTGCCACGCCCATCGCCTACCCATGGTGCCC
TTTGGCGCCGGCAGTGGCCTGGAAGGGGCGGTGCAAGCGACCTTCGGTGGGGTTTCGATCGATCTTGGGCGGATGGATCA
GGTTCTGGCCATCCATGCCGGGGATATGGACGCCACCGTCCAGGCCGGGGTTCGCCGCCAGACCCTGAACGCCCTGTTGC
GCGACACCGGCTTGTTCTTTCCCATCGATCCCGGCGCCGACGCCAGTTTCGGCGGCATGGCGGCGACCCGGGCCAGCGGC
ACCAACGCCGTGCGCTTTGGCACCATGCGCGAAAACGTTCTGGGGCTGACGGTGGTGCTGGCCGACGGTCAGGTGGTGCG
CACCGGCGGCCGCGCCCGCAAATCCTCGGCCGGCTATGACCTGACGAGGCTGTTCGTGGGCAGCGAGGGCACTTTGGGGA
TCATCACCGAGGTGACGCTGCGCCTGCATCCGATCCCCGAGACGGCGATGACCGCCATCGCCGCCTTTCCCACCCCCGAG
GCGGCGGTCGCCACCGTCACCGCGCTGCTTCAGGCCGGGGTGGCGATCGGCCGGGTCGAGTTCCTGGATCAGGCGGTGGT
CGAGGTTTTCGTTCGCCACGGCAAGATCGATACGCCGGTCCTGCCCAGCCTGTTGATCGAGGTTCACGGCAGCGCCGCGG
CGGCGGCCGATGTCGCCCGCGGCGTCGCCGAGATCGCCGAGGAGGGCGGCGCCAGCCTGTTCCGCTGGGCGGCGAGCGCC
GAGGACAGCGCCAAACTCTGGGAGGCGCGCCGCCTCGCCCTCGGCTGGGCCCGGCGCGACCGTCCGGGGTCGCGGTCCTG
GCCGACCGATGTCTGCGTGCCGATCAGCGCCCTGCCCGGGATCATCGCCGCCACCCGGGCCGATCTGGCCGATTGCCCGA
TCCCGGCTTTCCTGTTCGGCCATGTCGGCGACGGTAATTTCCATTGCGTCTTCCTGATTGATCCCGAACGCCCCGACGAG
ACCACGACCGTTCAACGCCTGACCCGGCGCATGGTCGAGCGCGCCCTGGCGGTGGATGGAACCGCCACCGGCGAGCATGG
GATCGGCCTGGGCAAGCGCGACACCCTGGAAGCCGAGCATGGCGCCCCGGCGATCGCCCTGATGCGCGGCCTCAAGGCGA
CGCTCGATCCCCACGGCCTGCTCAATCCGGGCAAGATCTTTCCCGATGCCGTCGATTCCCCCCGCGAGACGAGGAGCGTT
TTTCCATGA

Upstream 100 bases:

>100_bases
CGCTGGTCCGCTTCTGCTTTGCCAAACGCCTGGAGACCCTGGAAGGCGGCATCGCCCGGCTGGTCGCCTGGCGCGGTGGT
CAGCGCTGGAGGCGGGCATC

Downstream 100 bases:

>100_bases
GGATGGCGAAGATCGTGCGAGTACCCGCCCTTCGCGTGGCCTTGGCTGGGGCGCTGCTGGTCCTTGGCCTTGGCCCTTGC
CTAGCGCAAACCATCCGCCT

Product: D-lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSGVIARSRPPASGLAAALAELSTLLGARLSTALALREHHSHDESHHAPALPDAVVFPETTAEVAAIARLCHAHRLPMVP
FGAGSGLEGAVQATFGGVSIDLGRMDQVLAIHAGDMDATVQAGVRRQTLNALLRDTGLFFPIDPGADASFGGMAATRASG
TNAVRFGTMRENVLGLTVVLADGQVVRTGGRARKSSAGYDLTRLFVGSEGTLGIITEVTLRLHPIPETAMTAIAAFPTPE
AAVATVTALLQAGVAIGRVEFLDQAVVEVFVRHGKIDTPVLPSLLIEVHGSAAAAADVARGVAEIAEEGGASLFRWAASA
EDSAKLWEARRLALGWARRDRPGSRSWPTDVCVPISALPGIIAATRADLADCPIPAFLFGHVGDGNFHCVFLIDPERPDE
TTTVQRLTRRMVERALAVDGTATGEHGIGLGKRDTLEAEHGAPAIALMRGLKATLDPHGLLNPGKIFPDAVDSPRETRSV
FP

Sequences:

>Translated_482_residues
MSGVIARSRPPASGLAAALAELSTLLGARLSTALALREHHSHDESHHAPALPDAVVFPETTAEVAAIARLCHAHRLPMVP
FGAGSGLEGAVQATFGGVSIDLGRMDQVLAIHAGDMDATVQAGVRRQTLNALLRDTGLFFPIDPGADASFGGMAATRASG
TNAVRFGTMRENVLGLTVVLADGQVVRTGGRARKSSAGYDLTRLFVGSEGTLGIITEVTLRLHPIPETAMTAIAAFPTPE
AAVATVTALLQAGVAIGRVEFLDQAVVEVFVRHGKIDTPVLPSLLIEVHGSAAAAADVARGVAEIAEEGGASLFRWAASA
EDSAKLWEARRLALGWARRDRPGSRSWPTDVCVPISALPGIIAATRADLADCPIPAFLFGHVGDGNFHCVFLIDPERPDE
TTTVQRLTRRMVERALAVDGTATGEHGIGLGKRDTLEAEHGAPAIALMRGLKATLDPHGLLNPGKIFPDAVDSPRETRSV
FP
>Mature_481_residues
SGVIARSRPPASGLAAALAELSTLLGARLSTALALREHHSHDESHHAPALPDAVVFPETTAEVAAIARLCHAHRLPMVPF
GAGSGLEGAVQATFGGVSIDLGRMDQVLAIHAGDMDATVQAGVRRQTLNALLRDTGLFFPIDPGADASFGGMAATRASGT
NAVRFGTMRENVLGLTVVLADGQVVRTGGRARKSSAGYDLTRLFVGSEGTLGIITEVTLRLHPIPETAMTAIAAFPTPEA
AVATVTALLQAGVAIGRVEFLDQAVVEVFVRHGKIDTPVLPSLLIEVHGSAAAAADVARGVAEIAEEGGASLFRWAASAE
DSAKLWEARRLALGWARRDRPGSRSWPTDVCVPISALPGIIAATRADLADCPIPAFLFGHVGDGNFHCVFLIDPERPDET
TTVQRLTRRMVERALAVDGTATGEHGIGLGKRDTLEAEHGAPAIALMRGLKATLDPHGLLNPGKIFPDAVDSPRETRSVF
P

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=444, Percent_Identity=50.6756756756757, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI37595754, Length=467, Percent_Identity=48.1798715203426, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI119964728, Length=424, Percent_Identity=33.2547169811321, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI4501993, Length=224, Percent_Identity=28.125, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1789351, Length=463, Percent_Identity=32.1814254859611, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787977, Length=523, Percent_Identity=28.1070745697897, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI48994907, Length=488, Percent_Identity=26.0245901639344, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI48994914, Length=173, Percent_Identity=29.4797687861272, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=467, Percent_Identity=42.3982869379015, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71992381, Length=467, Percent_Identity=41.7558886509636, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI71992392, Length=381, Percent_Identity=44.8818897637795, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17534361, Length=429, Percent_Identity=28.9044289044289, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17556096, Length=201, Percent_Identity=29.8507462686567, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320027, Length=479, Percent_Identity=37.5782881002088, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6320023, Length=434, Percent_Identity=27.6497695852535, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320764, Length=438, Percent_Identity=28.310502283105, Blast_Score=156, Evalue=7e-39,
Organism=Drosophila melanogaster, GI18921117, Length=423, Percent_Identity=28.3687943262411, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24639277, Length=423, Percent_Identity=28.3687943262411, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24639275, Length=423, Percent_Identity=28.3687943262411, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24653753, Length=204, Percent_Identity=31.8627450980392, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 50399; Mature: 50268

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVIARSRPPASGLAAALAELSTLLGARLSTALALREHHSHDESHHAPALPDAVVFPET
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC
TAEVAAIARLCHAHRLPMVPFGAGSGLEGAVQATFGGVSIDLGRMDQVLAIHAGDMDATV
HHHHHHHHHHHHHHCCCCEECCCCCCCCCCHHEECCCEEEECCCCCEEEEEECCCCCHHH
QAGVRRQTLNALLRDTGLFFPIDPGADASFGGMAATRASGTNAVRFGTMRENVLGLTVVL
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCCCCEEEECCHHCCCEEEEEEE
ADGQVVRTGGRARKSSAGYDLTRLFVGSEGTLGIITEVTLRLHPIPETAMTAIAAFPTPE
ECCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCHHHHHHHHCCCCCH
AAVATVTALLQAGVAIGRVEFLDQAVVEVFVRHGKIDTPVLPSLLIEVHGSAAAAADVAR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHH
GVAEIAEEGGASLFRWAASAEDSAKLWEARRLALGWARRDRPGSRSWPTDVCVPISALPG
HHHHHHHHCCCCEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHCH
IIAATRADLADCPIPAFLFGHVGDGNFHCVFLIDPERPDETTTVQRLTRRMVERALAVDG
HHHHHHCCCCCCCCCHHHEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
TATGEHGIGLGKRDTLEAEHGAPAIALMRGLKATLDPHGLLNPGKIFPDAVDSPRETRSV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCC
FP
CC
>Mature Secondary Structure 
SGVIARSRPPASGLAAALAELSTLLGARLSTALALREHHSHDESHHAPALPDAVVFPET
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC
TAEVAAIARLCHAHRLPMVPFGAGSGLEGAVQATFGGVSIDLGRMDQVLAIHAGDMDATV
HHHHHHHHHHHHHHCCCCEECCCCCCCCCCHHEECCCEEEECCCCCEEEEEECCCCCHHH
QAGVRRQTLNALLRDTGLFFPIDPGADASFGGMAATRASGTNAVRFGTMRENVLGLTVVL
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCCCCEEEECCHHCCCEEEEEEE
ADGQVVRTGGRARKSSAGYDLTRLFVGSEGTLGIITEVTLRLHPIPETAMTAIAAFPTPE
ECCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCHHHHHHHHCCCCCH
AAVATVTALLQAGVAIGRVEFLDQAVVEVFVRHGKIDTPVLPSLLIEVHGSAAAAADVAR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHH
GVAEIAEEGGASLFRWAASAEDSAKLWEARRLALGWARRDRPGSRSWPTDVCVPISALPG
HHHHHHHHCCCCEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHCH
IIAATRADLADCPIPAFLFGHVGDGNFHCVFLIDPERPDETTTVQRLTRRMVERALAVDG
HHHHHHCCCCCCCCCHHHEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
TATGEHGIGLGKRDTLEAEHGAPAIALMRGLKATLDPHGLLNPGKIFPDAVDSPRETRSV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCC
FP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]