Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 83591853

GI number: 83591853

Start: 608283

End: 609386

Strand: Direct

Name: pyrD

Synonym: Rru_A0514

Alternate gene names: 83591853

Gene position: 608283-609386 (Clockwise)

Preceding gene: 83591852

Following gene: 83591854

Centisome position: 13.97

GC content: 70.29

Gene sequence:

>1104_bases
ATGGCTGATTGGTATCGCCTCGCTTGGCCGCTGATCTGCGGCCTTGATCCCGAACGCGCCCACCATCTGGCGATTCGCGC
CCTGGCCCTTGGTCTGGCCGGGCACGATCGCGCCGCCGATGATCCGGTGCTCGCCTGCTCGCTGTGGGGGCGGCGCTTCG
CCAATCCCCTGGGCCTCGCCGCCGGTTTCGACAAGAACGGCGAGGTCGCCGACGCCCTGTTCGATCTGGGGTTCGGCTTC
GTCGAGGTCGGCACGGTCACGCCGCGCCCGCAGGCGGGCAATCCGCGCCCGCGCCTGTTCCGGCTGACCCAGGACCGGGC
GGTGATCAACCGCATGGGCTTCAACAACCAGGGCATGGAGGCGATGGCGGCGCGGTTCGTCCGCGCCCGGCCGCGCGGCG
TTCTGGGGATCAACCTGGGTAAGAACAAGACCACCGAGGATGCCGCCGGCGACTATGAGGCGGGGATCGCCAAGCTGGCG
CCCTTGGCCGATTACCTCGTGATCAATGTGTCTTCGCCCAATACCCCGGGGCTGCGCGCCCTGCAGGGGCGCGAGCCGCT
GTCCCTGCTGATCGCCCGCGCCCGCGCCGCCCTCGATGCCGCCTGTCCGGGGCTGCGGCCGCCGCTGCTGCTCAAGGTCG
CCCCCGATCTGACCGACGAGGATATGGCCGATATCGCCGAGGTCGCCCTGGGGGGCGGCCTGGATGGGCTGATCTGCACC
AATACCACCATCGCCCGTCCCAAGAGTCTGGTCAGCGACCATGCCGGGGAAACCGGCGGGCTTTCGGGATTGCCCCTGCG
CTACCGCGCCCGTCAGGTGATCGCCCGGCTTTATGGTCTGACCAAGGGCGCCCTGCCGTTGATCGGCGTGGGCGGCATCG
GCGACGGCGCCGAGGCCTATGCCCGCATCCGCGCCGGCGCCAGCCTGATCCAGATCTATTCCGCCCTGGTCTATGAGGGG
CCGGGGCTGGTCGGCCGCATCAAGCGCGATCTCGCCCAACGCCTGCGCGCCGATGGCTTCGCCAGCGTCGCCGAAGCGGT
GGGCGCCGACCACCGCGATCCTAAGGGGGCAAGCGGGAAGCTTGCTCCCCGCTCGCCCCTCTAG

Upstream 100 bases:

>100_bases
ATCACGGCCTTCGTGTTGGCCGAGGCCCCTTACCGCGGGGTGATCGAGCGGGGCCGGCGGCTCTTTCACGCCCCGGCCCC
CGGCTTGCCGGAGCTTCGCC

Downstream 100 bases:

>100_bases
GCTGTTGATCGTCAAGCAAATCGTCGTCGCGCTCTGCTCCAGAGCGTCGGGGATTTGCTCCATAAGGACCCCGTACCGAT
GACCTCCCCCGTCGCCGCGC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MADWYRLAWPLICGLDPERAHHLAIRALALGLAGHDRAADDPVLACSLWGRRFANPLGLAAGFDKNGEVADALFDLGFGF
VEVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGMEAMAARFVRARPRGVLGINLGKNKTTEDAAGDYEAGIAKLA
PLADYLVINVSSPNTPGLRALQGREPLSLLIARARAALDAACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLDGLICT
NTTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDGAEAYARIRAGASLIQIYSALVYEG
PGLVGRIKRDLAQRLRADGFASVAEAVGADHRDPKGASGKLAPRSPL

Sequences:

>Translated_367_residues
MADWYRLAWPLICGLDPERAHHLAIRALALGLAGHDRAADDPVLACSLWGRRFANPLGLAAGFDKNGEVADALFDLGFGF
VEVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGMEAMAARFVRARPRGVLGINLGKNKTTEDAAGDYEAGIAKLA
PLADYLVINVSSPNTPGLRALQGREPLSLLIARARAALDAACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLDGLICT
NTTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDGAEAYARIRAGASLIQIYSALVYEG
PGLVGRIKRDLAQRLRADGFASVAEAVGADHRDPKGASGKLAPRSPL
>Mature_366_residues
ADWYRLAWPLICGLDPERAHHLAIRALALGLAGHDRAADDPVLACSLWGRRFANPLGLAAGFDKNGEVADALFDLGFGFV
EVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGMEAMAARFVRARPRGVLGINLGKNKTTEDAAGDYEAGIAKLAP
LADYLVINVSSPNTPGLRALQGREPLSLLIARARAALDAACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLDGLICTN
TTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDGAEAYARIRAGASLIQIYSALVYEGP
GLVGRIKRDLAQRLRADGFASVAEAVGADHRDPKGASGKLAPRSPL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=353, Percent_Identity=52.1246458923513, Blast_Score=355, Evalue=4e-98,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=43.3734939759036, Blast_Score=251, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17509475, Length=351, Percent_Identity=50.1424501424501, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI281361352, Length=352, Percent_Identity=47.4431818181818, Blast_Score=319, Evalue=1e-87,
Organism=Drosophila melanogaster, GI17137316, Length=352, Percent_Identity=47.4431818181818, Blast_Score=319, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_RHORT (Q2RX27)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425605.1
- ProteinModelPortal:   Q2RX27
- SMR:   Q2RX27
- STRING:   Q2RX27
- GeneID:   3834212
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0514
- NMPDR:   fig|1085.1.peg.1824
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   Q2RX27
- ProtClustDB:   PRK05286
- BioCyc:   RRUB269796:RRU_A0514-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38649; Mature: 38518

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADWYRLAWPLICGLDPERAHHLAIRALALGLAGHDRAADDPVLACSLWGRRFANPLGLA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHCCHHHHH
AGFDKNGEVADALFDLGFGFVEVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGME
CCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHH
AMAARFVRARPRGVLGINLGKNKTTEDAAGDYEAGIAKLAPLADYLVINVSSPNTPGLRA
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHH
LQGREPLSLLIARARAALDAACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLDGLICT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEC
NTTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDGAEAY
CCCHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
ARIRAGASLIQIYSALVYEGPGLVGRIKRDLAQRLRADGFASVAEAVGADHRDPKGASGK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
LAPRSPL
CCCCCCC
>Mature Secondary Structure 
ADWYRLAWPLICGLDPERAHHLAIRALALGLAGHDRAADDPVLACSLWGRRFANPLGLA
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHCCHHHHH
AGFDKNGEVADALFDLGFGFVEVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGME
CCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHH
AMAARFVRARPRGVLGINLGKNKTTEDAAGDYEAGIAKLAPLADYLVINVSSPNTPGLRA
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHH
LQGREPLSLLIARARAALDAACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLDGLICT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEC
NTTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDGAEAY
CCCHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
ARIRAGASLIQIYSALVYEGPGLVGRIKRDLAQRLRADGFASVAEAVGADHRDPKGASGK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
LAPRSPL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA