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The map label for this gene is dctA [H]

Identifier: 83311990

GI number: 83311990

Start: 3089386

End: 3089877

Strand: Reverse

Name: dctA [H]

Synonym: amb2891

Alternate gene names: 83311990

Gene position: 3089877-3089386 (Counterclockwise)

Preceding gene: 83311993

Following gene: 83311989

Centisome position: 62.21

GC content: 64.84

Gene sequence:

>492_bases
ATGAAGCGTCTGACCAGTCACCTCTATTTTTGGGTTCTGCTCGCCATCTTCGCCGGCGGTACCCTCGGCTTCTTCTATCC
GGACGTGGGCGTCAGCCTGAAGCCCCTGGGCGACGGGTTCATCGCCCTGGTCAAGATGCTGATCAGCCCGGTGATCTTCT
GCACCGTGGTGCTGGGCATCGCCGGCGCCGGCGACATGAAGAAGGTCGGCCGGGTGGGCGGCAAGGCGCTGCTGTATTTC
GAGGTGGTCTCCACCTTCGCCCTGGTCATCGGCCTGATCGTCATGACCGTGCTGCGCCCCGGCGACGGCTTCCACGCCGA
CCCCGCCGCGCTGGACGCCAAGGCGGTGGCAAATACGCCAAGGCCGCCACCGAGCAGAGCACCGTGGACTTCATCCTGCA
CATCATCCCCAAGACCCTGGTGGATGCCTTCACCGGCGGCGGCGATCTGCTGCAGGTGCTGCTGGTGGCCATCCTGTTCG
GCTATGCCATGA

Upstream 100 bases:

>100_bases
TGCGCCTTTGCCGCCGACCATCGGATATCCGCAATCGACAGGCGCTCGCCCGAACGGGTAGGAAGCGGGAAATAATCATA
CCCCATCGAGGAACAAGCCG

Downstream 100 bases:

>100_bases
CCCATATGGGCCGGGCCGGTCAGGGCGTGCACATGTTCATCGAGGAATGCTCGCACATCTTCTTCGCCATGATGAACACC
ATCATGAAGGTCGCCCCCCT

Product: Na+/H+-dicarboxylate symporters

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MKRLTSHLYFWVLLAIFAGGTLGFFYPDVGVSLKPLGDGFIALVKMLISPVIFCTVVLGIAGAGDMKKVGRVGGKALLYF
EVVSTFALVIGLIVMTVLRPGDGFHADPAALDAKAVANTPRPPPSRAPWTSSCTSSPRPWWMPSPAAAICCRCCWWPSCS
AMP

Sequences:

>Translated_163_residues
MKRLTSHLYFWVLLAIFAGGTLGFFYPDVGVSLKPLGDGFIALVKMLISPVIFCTVVLGIAGAGDMKKVGRVGGKALLYF
EVVSTFALVIGLIVMTVLRPGDGFHADPAALDAKAVANTPRPPPSRAPWTSSCTSSPRPWWMPSPAAAICCRCCWWPSCS
AMP
>Mature_163_residues
MKRLTSHLYFWVLLAIFAGGTLGFFYPDVGVSLKPLGDGFIALVKMLISPVIFCTVVLGIAGAGDMKKVGRVGGKALLYF
EVVSTFALVIGLIVMTVLRPGDGFHADPAALDAKAVANTPRPPPSRAPWTSSCTSSPRPWWMPSPAAAICCRCCWWPSCS
AMP

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789947, Length=114, Percent_Identity=64.0350877192982, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1790514, Length=136, Percent_Identity=35.2941176470588, Blast_Score=84, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 17403; Mature: 17403

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLTSHLYFWVLLAIFAGGTLGFFYPDVGVSLKPLGDGFIALVKMLISPVIFCTVVLGI
CCHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AGAGDMKKVGRVGGKALLYFEVVSTFALVIGLIVMTVLRPGDGFHADPAALDAKAVANTP
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
RPPPSRAPWTSSCTSSPRPWWMPSPAAAICCRCCWWPSCSAMP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKRLTSHLYFWVLLAIFAGGTLGFFYPDVGVSLKPLGDGFIALVKMLISPVIFCTVVLGI
CCHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AGAGDMKKVGRVGGKALLYFEVVSTFALVIGLIVMTVLRPGDGFHADPAALDAKAVANTP
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
RPPPSRAPWTSSCTSSPRPWWMPSPAAAICCRCCWWPSCSAMP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA