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The map label for this gene is arlS [H]

Identifier: 83311993

GI number: 83311993

Start: 3092045

End: 3093427

Strand: Reverse

Name: arlS [H]

Synonym: amb2894

Alternate gene names: 83311993

Gene position: 3093427-3092045 (Counterclockwise)

Preceding gene: 83311994

Following gene: 83311990

Centisome position: 62.28

GC content: 68.04

Gene sequence:

>1383_bases
GTGCGGCCCGCTAGCCTCCTTCGCACCACCACCTTCCGGCTGGCGCTGAGCTATCTCGGCATTTTCACCGTCTCCGCCAT
CGCGCTGCTGGCGCTGGTGTCGTGGAGCACCTCCATGTTCATCGAATGGCAGGTGCAGGAAACGGTGGAGGCCGAGGCCA
CCGGCCTGTCCGAGGTCTATCATTCGCGTGAATTGGGCGGCCTGGCCGAGATCATCGGCAGCCGCATGCGCCAGGACGTG
GAGGGCCGCAATACCTATCTGCTGATGGGCCATTCCGGCCACATCCTGGCCGGCAACATCAAGTCCTGGCCCGCCGAGGT
GTCCAGCCAGGTGGGCTGGGTGCGGTTCCGCCTGCTGCAGCTGGGCAGCGTCGGGCCGGGGGTCGAGGTGCTGGCCCAGG
TCTACGAGCTGGCCGACGGCTACCGCCTGCTGGTGGGCCGCTCCCTGGCCGATGCCAAGCGGGTGAAGTCGGCCATCAAC
CGCGCCCTGGGCTGGGGTCTGGCCCTGACCATCCTGCTGGGCGTGGTCGGCGGCTATTTCACCAGCCGCCACCTGCTGCA
GCGGGTGGAGGAAATGAGCCGCACGGCGCGCCGCATCTTCGGCGGCGACATGAGCCAGCGCATGCAGCTTTCCGGCACCG
ACGACGAGTTCGACTCCCTGGCCGACAGCTTCAACGAGATGATGGACGAGCTGGAGCGCCTGCTGGAAGGCATCCGCACC
GTCTCCGACAATATCGCCCATGACCTGCGCACGCCCCTGAACCGGCTGCGCTCGCGCATCGATCTTGTGCTGCTGGGCGC
CCCCGATTGCGAGGGCTATCGCCGCACCCTGGAAGAGACCCTGGCCGATGCCGACCATCTGCTGGCCACCTTCAACGCCA
TCCTGACCATCTCGCACGCCGAGGCGGCGGCGCGGCTGGACCGTTTCGAGGTCATCGACCCCGCCACCCTGGCCGGCGAC
GTGGCCGAGCTTTACGAGCCCCTGGCCGAGGAGAAGGGCTTGCAACTGCACTGCAGGGCCGATGGCGGCCTGACCCTCAA
GGTCGATCGCCATCTGCTGTTCCAGGCCCTGGCCAATCTGGTGGACAATGCCGTGAAGTACACCCCTGCCGGGGGAGAGG
TCTCGGTCACCGTCGAGGGCGGCCCGTCCAGCGTGGCGGTGTCGGTGGCCGACAGCGGTCCGGGCATTCCCGAGGAATCC
CGCGAAGCGGTGCTGGAGCGTTTCGTCCGCCTGGACGCCACCCGCTCGACGCCGGGCAACGGCCTGGGGCTGTCGCTGGT
TCAGGCGGTGGCCCGCCTGCACTCCGCCCGCCTGTCCCTGGAGGACAACCAGCCCGGTCTGGTGGTGCGGCTGGAATTTC
CTGTTACAGATCGCCAGGCTTGA

Upstream 100 bases:

>100_bases
AATCTGATCGACGTGCATATCAGCCGGTTGCGCCAGAAGGTGGACAAGGATTTCGAACTGCCGCTGATCCATACGGTTCG
CGGCGCCGGATACACCCTTC

Downstream 100 bases:

>100_bases
AGCGCAGCAGCATGCGCCGGGGCCAGGGCTTGCCGTCGTCGGGCGGCATCTGCAGCGGCTGGGCCATGCGTAGCGCCAGC
AGGAAAGTCTCCAGCATGCG

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MRPASLLRTTTFRLALSYLGIFTVSAIALLALVSWSTSMFIEWQVQETVEAEATGLSEVYHSRELGGLAEIIGSRMRQDV
EGRNTYLLMGHSGHILAGNIKSWPAEVSSQVGWVRFRLLQLGSVGPGVEVLAQVYELADGYRLLVGRSLADAKRVKSAIN
RALGWGLALTILLGVVGGYFTSRHLLQRVEEMSRTARRIFGGDMSQRMQLSGTDDEFDSLADSFNEMMDELERLLEGIRT
VSDNIAHDLRTPLNRLRSRIDLVLLGAPDCEGYRRTLEETLADADHLLATFNAILTISHAEAAARLDRFEVIDPATLAGD
VAELYEPLAEEKGLQLHCRADGGLTLKVDRHLLFQALANLVDNAVKYTPAGGEVSVTVEGGPSSVAVSVADSGPGIPEES
REAVLERFVRLDATRSTPGNGLGLSLVQAVARLHSARLSLEDNQPGLVVRLEFPVTDRQA

Sequences:

>Translated_460_residues
MRPASLLRTTTFRLALSYLGIFTVSAIALLALVSWSTSMFIEWQVQETVEAEATGLSEVYHSRELGGLAEIIGSRMRQDV
EGRNTYLLMGHSGHILAGNIKSWPAEVSSQVGWVRFRLLQLGSVGPGVEVLAQVYELADGYRLLVGRSLADAKRVKSAIN
RALGWGLALTILLGVVGGYFTSRHLLQRVEEMSRTARRIFGGDMSQRMQLSGTDDEFDSLADSFNEMMDELERLLEGIRT
VSDNIAHDLRTPLNRLRSRIDLVLLGAPDCEGYRRTLEETLADADHLLATFNAILTISHAEAAARLDRFEVIDPATLAGD
VAELYEPLAEEKGLQLHCRADGGLTLKVDRHLLFQALANLVDNAVKYTPAGGEVSVTVEGGPSSVAVSVADSGPGIPEES
REAVLERFVRLDATRSTPGNGLGLSLVQAVARLHSARLSLEDNQPGLVVRLEFPVTDRQA
>Mature_460_residues
MRPASLLRTTTFRLALSYLGIFTVSAIALLALVSWSTSMFIEWQVQETVEAEATGLSEVYHSRELGGLAEIIGSRMRQDV
EGRNTYLLMGHSGHILAGNIKSWPAEVSSQVGWVRFRLLQLGSVGPGVEVLAQVYELADGYRLLVGRSLADAKRVKSAIN
RALGWGLALTILLGVVGGYFTSRHLLQRVEEMSRTARRIFGGDMSQRMQLSGTDDEFDSLADSFNEMMDELERLLEGIRT
VSDNIAHDLRTPLNRLRSRIDLVLLGAPDCEGYRRTLEETLADADHLLATFNAILTISHAEAAARLDRFEVIDPATLAGD
VAELYEPLAEEKGLQLHCRADGGLTLKVDRHLLFQALANLVDNAVKYTPAGGEVSVTVEGGPSSVAVSVADSGPGIPEES
REAVLERFVRLDATRSTPGNGLGLSLVQAVARLHSARLSLEDNQPGLVVRLEFPVTDRQA

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=407, Percent_Identity=23.3415233415233, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787894, Length=255, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=25.6227758007117, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=280, Percent_Identity=27.8571428571429, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788279, Length=270, Percent_Identity=24.8148148148148, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790346, Length=259, Percent_Identity=28.957528957529, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790861, Length=347, Percent_Identity=26.2247838616715, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789808, Length=299, Percent_Identity=26.4214046822742, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789403, Length=326, Percent_Identity=26.3803680981595, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790551, Length=232, Percent_Identity=25.4310344827586, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=210, Percent_Identity=24.2857142857143, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=27.9816513761468, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=201, Percent_Identity=32.3383084577114, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=25.3218884120172, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=213, Percent_Identity=32.3943661971831, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50155; Mature: 50155

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPASLLRTTTFRLALSYLGIFTVSAIALLALVSWSTSMFIEWQVQETVEAEATGLSEVY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHH
HSRELGGLAEIIGSRMRQDVEGRNTYLLMGHSGHILAGNIKSWPAEVSSQVGWVRFRLLQ
HHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHH
LGSVGPGVEVLAQVYELADGYRLLVGRSLADAKRVKSAINRALGWGLALTILLGVVGGYF
HCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSRHLLQRVEEMSRTARRIFGGDMSQRMQLSGTDDEFDSLADSFNEMMDELERLLEGIRT
HHHHHHHHHHHHHHHHHHHHCCCHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VSDNIAHDLRTPLNRLRSRIDLVLLGAPDCEGYRRTLEETLADADHLLATFNAILTISHA
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHH
EAAARLDRFEVIDPATLAGDVAELYEPLAEEKGLQLHCRADGGLTLKVDRHLLFQALANL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHH
VDNAVKYTPAGGEVSVTVEGGPSSVAVSVADSGPGIPEESREAVLERFVRLDATRSTPGN
HHHHHEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GLGLSLVQAVARLHSARLSLEDNQPGLVVRLEFPVTDRQA
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRPASLLRTTTFRLALSYLGIFTVSAIALLALVSWSTSMFIEWQVQETVEAEATGLSEVY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHH
HSRELGGLAEIIGSRMRQDVEGRNTYLLMGHSGHILAGNIKSWPAEVSSQVGWVRFRLLQ
HHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHH
LGSVGPGVEVLAQVYELADGYRLLVGRSLADAKRVKSAINRALGWGLALTILLGVVGGYF
HCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSRHLLQRVEEMSRTARRIFGGDMSQRMQLSGTDDEFDSLADSFNEMMDELERLLEGIRT
HHHHHHHHHHHHHHHHHHHHCCCHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VSDNIAHDLRTPLNRLRSRIDLVLLGAPDCEGYRRTLEETLADADHLLATFNAILTISHA
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHH
EAAARLDRFEVIDPATLAGDVAELYEPLAEEKGLQLHCRADGGLTLKVDRHLLFQALANL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHH
VDNAVKYTPAGGEVSVTVEGGPSSVAVSVADSGPGIPEESREAVLERFVRLDATRSTPGN
HHHHHEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GLGLSLVQAVARLHSARLSLEDNQPGLVVRLEFPVTDRQA
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA