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The map label for this gene is parC [H]

Identifier: 83311684

GI number: 83311684

Start: 2770299

End: 2772533

Strand: Reverse

Name: parC [H]

Synonym: amb2585

Alternate gene names: 83311684

Gene position: 2772533-2770299 (Counterclockwise)

Preceding gene: 83311685

Following gene: 83311683

Centisome position: 55.82

GC content: 65.01

Gene sequence:

>2235_bases
ATGACCAAGCCCGCCGTCACCGGCGATATCCGCGACACGCCGCTTGCCGAGGCCCTGGGCGAGCGCTATCTCGCCTATGC
CATGTCCACCATCGTGTCGCGCTCGCTGCCCGATGTGCGCGACGGGTTGAAGCCGGTGCATCGCCGCCTGCTGTTCGCCA
TGCGCCAGCTCAAGCTGGACCCCAGCGGCGGCTTCAAGAAGTGCGCCCGCGTGGTCGGTGACGTCATCGGTAAGTACCAT
CCCCACGGCGACGTGGCGGTCTACGACACCCTGGTGCGCCTAGCCCAGGACTTCGCCGTGCGCTATCCCCTGGTGGAGGG
CCAGGGCAATTTCGGCAATATCGACGGCGATAACGCGGCGGCCATGCGTTACACCGAGGCCAAGCTGACCGAGATCGCCG
CCGCCCTGATGGAAGGCCTCGACGAGGACAGCGTCGACTTCCGCCCCACCTATGACGGCACCGAGGAAGAGCCGGTGGTC
ATGCCGTCGGCCTTTCCCAATTTGCTGGCCAACGGTTCGGCCGGTATCGCGGTGGGCATGGCCACCAGCATCCCGCCTCA
TAATATCGGCGAGATCTGCGACGCGCTGGACCACCTGATCGCCAAGCCCGATTGCGACGTGGACGAACTGATCGCCCACA
TGCCCGGCCCCGATTTTCCCACCGGCGGCGTGCTGGTGGAGACCCAGGCGGCCATCACCGAGGCCTACCGCACCGGCAAG
GGCGCCTTTCGGGTCCGGGCCAAATGGGCGGTGGAAAAGCTCTCCCACGGGCTTTACCAGATCGTCATCACCGAGATTCC
CTATCAGGTGCAGAAGGCCAAGCTGATCGAGAAGATCGCCGAGCTTTTGTCCGAGAAGAAGCTGCCCCTGCTGGCCGATA
TCAGAGACGAATCGGCCGAGGACATCCGTCTGGTGCTGGAGCCCAGGAATCGCACGGTCGAGGCCGAACTGGTGATGGAG
CAACTGTTCCGCCAGACCGACCTGGAATCGCGCTTCTCGCTCAACATGAACGTCCTGGCTCCCGACGCCCACGGCCACCT
GACGCCCGGCGTCATGAATCTGAAGGAGGTGCTGCGCGCCTTCCTCGACCACCGCATGGTGGTTCTCGAGCGCCGCGCCC
GTTTCCGCCTGGAGAAGATCGCCAAGCGCCTGGAGGTGCTGGAAGGTTTCCTCAAGGTCTATGCCGATCTCGATAAGGTC
ATCCGGATCATCCGCTTCGCCGACGAGCCCAAGGCCGAGCTGATCAAGACCTTCAAGCTGTCCGAGGTGCAGGCCGAGGC
CATCCTCAACATGCGCCTGCGCAGCTTGAACAAGCTGCAGGAACTGGAGATCAAGACCGAGCACGCCGAATTGTCGGCGG
AAAAGGCCGATCTTGAAGCCCTGCTGGCCGATGAACCCCGCCGCTGGGCCGCCATCGCCGCCCAGAACGACGAGACCCGC
AAGGCCTTCGGCGGGGCCACGGCCCTGGGCAAGCGCCGCACCGAGCTGGGCGACGCCCCCTCGGCGGTGGTGGTGCCCAT
CGAGGCCTATGTGGAGCGCGAGGCCATCACCATGGTCCTGTCCGAAAAGGGCTGGATCAGGGCGCTCAAGGGGCATTCCG
ACGCGCCCGAGGCGCTGAAGTTCAAGGAAGGCGACCAGCTTGGGCATCTGCTCAAGGCCTGGACCACCGACAAGATCCTG
GTCTTCGCCACCGATGGTCGCTTCTACACCATCGGCGGCGACAAGCTGCCGTCGGGGCGCGGCCATGGCGAGCCGCTGCG
CCTGATGATCGATCTGGCCGGCGACGTGGACATCGCCGCGGTGATGGTCCACAAGCCGGGCCGCAAGCTTCTGGTCGCCA
CCAATACCGATCGCGGCTTCGTGGTCGAGGAGAACGAGGTCCTGGCCCAGACCCGGGCCGGCAAGATGGTTCTGAACTGC
GCCGATGGCGAGAAGGCCAAATTCTGCTTGCCGTTCGAGGGCGATGCCGTGGCGGTGATCGGCGAGAACCGCAAGCTGCT
GGTGTTCATGGCCGAGGAAATTCCGGTGCTGACCCGGGGCAGGGGGGTGATCTTGCAGAAATACCGCGATGGCGGCATGG
CCGACATCAAGGTCTTCACCCTGGCCCAGGGCCTGACCTGGAACCTGGGCGACCGGGTGCGCACCGAATCCGACCTGACC
CCCTGGCTGGGCAAGCGTGCCTCGGTCGGCCGCCTGCCACCCACCGGATTTCCCAGGAATAACCGTTTCTCATAA

Upstream 100 bases:

>100_bases
CAAGGGGCGGCGGCAGTGGGAAAAGCTCGGCGTCACCACGATCTGTTGACGCCTCCCCCTCTTTGAGTACTATATCTGGC
TCAAATTCCGAGGGGACCCC

Downstream 100 bases:

>100_bases
GGGATATGACGGTTTTCCGAAGTGGCCGGTCGCGTTGCGTCCCCCTTGCATTGGTGTAGGATAATTTCCACCTGATCCGG
ATCAACCGGCAAAAGTTTTC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MTKPAVTGDIRDTPLAEALGERYLAYAMSTIVSRSLPDVRDGLKPVHRRLLFAMRQLKLDPSGGFKKCARVVGDVIGKYH
PHGDVAVYDTLVRLAQDFAVRYPLVEGQGNFGNIDGDNAAAMRYTEAKLTEIAAALMEGLDEDSVDFRPTYDGTEEEPVV
MPSAFPNLLANGSAGIAVGMATSIPPHNIGEICDALDHLIAKPDCDVDELIAHMPGPDFPTGGVLVETQAAITEAYRTGK
GAFRVRAKWAVEKLSHGLYQIVITEIPYQVQKAKLIEKIAELLSEKKLPLLADIRDESAEDIRLVLEPRNRTVEAELVME
QLFRQTDLESRFSLNMNVLAPDAHGHLTPGVMNLKEVLRAFLDHRMVVLERRARFRLEKIAKRLEVLEGFLKVYADLDKV
IRIIRFADEPKAELIKTFKLSEVQAEAILNMRLRSLNKLQELEIKTEHAELSAEKADLEALLADEPRRWAAIAAQNDETR
KAFGGATALGKRRTELGDAPSAVVVPIEAYVEREAITMVLSEKGWIRALKGHSDAPEALKFKEGDQLGHLLKAWTTDKIL
VFATDGRFYTIGGDKLPSGRGHGEPLRLMIDLAGDVDIAAVMVHKPGRKLLVATNTDRGFVVEENEVLAQTRAGKMVLNC
ADGEKAKFCLPFEGDAVAVIGENRKLLVFMAEEIPVLTRGRGVILQKYRDGGMADIKVFTLAQGLTWNLGDRVRTESDLT
PWLGKRASVGRLPPTGFPRNNRFS

Sequences:

>Translated_744_residues
MTKPAVTGDIRDTPLAEALGERYLAYAMSTIVSRSLPDVRDGLKPVHRRLLFAMRQLKLDPSGGFKKCARVVGDVIGKYH
PHGDVAVYDTLVRLAQDFAVRYPLVEGQGNFGNIDGDNAAAMRYTEAKLTEIAAALMEGLDEDSVDFRPTYDGTEEEPVV
MPSAFPNLLANGSAGIAVGMATSIPPHNIGEICDALDHLIAKPDCDVDELIAHMPGPDFPTGGVLVETQAAITEAYRTGK
GAFRVRAKWAVEKLSHGLYQIVITEIPYQVQKAKLIEKIAELLSEKKLPLLADIRDESAEDIRLVLEPRNRTVEAELVME
QLFRQTDLESRFSLNMNVLAPDAHGHLTPGVMNLKEVLRAFLDHRMVVLERRARFRLEKIAKRLEVLEGFLKVYADLDKV
IRIIRFADEPKAELIKTFKLSEVQAEAILNMRLRSLNKLQELEIKTEHAELSAEKADLEALLADEPRRWAAIAAQNDETR
KAFGGATALGKRRTELGDAPSAVVVPIEAYVEREAITMVLSEKGWIRALKGHSDAPEALKFKEGDQLGHLLKAWTTDKIL
VFATDGRFYTIGGDKLPSGRGHGEPLRLMIDLAGDVDIAAVMVHKPGRKLLVATNTDRGFVVEENEVLAQTRAGKMVLNC
ADGEKAKFCLPFEGDAVAVIGENRKLLVFMAEEIPVLTRGRGVILQKYRDGGMADIKVFTLAQGLTWNLGDRVRTESDLT
PWLGKRASVGRLPPTGFPRNNRFS
>Mature_743_residues
TKPAVTGDIRDTPLAEALGERYLAYAMSTIVSRSLPDVRDGLKPVHRRLLFAMRQLKLDPSGGFKKCARVVGDVIGKYHP
HGDVAVYDTLVRLAQDFAVRYPLVEGQGNFGNIDGDNAAAMRYTEAKLTEIAAALMEGLDEDSVDFRPTYDGTEEEPVVM
PSAFPNLLANGSAGIAVGMATSIPPHNIGEICDALDHLIAKPDCDVDELIAHMPGPDFPTGGVLVETQAAITEAYRTGKG
AFRVRAKWAVEKLSHGLYQIVITEIPYQVQKAKLIEKIAELLSEKKLPLLADIRDESAEDIRLVLEPRNRTVEAELVMEQ
LFRQTDLESRFSLNMNVLAPDAHGHLTPGVMNLKEVLRAFLDHRMVVLERRARFRLEKIAKRLEVLEGFLKVYADLDKVI
RIIRFADEPKAELIKTFKLSEVQAEAILNMRLRSLNKLQELEIKTEHAELSAEKADLEALLADEPRRWAAIAAQNDETRK
AFGGATALGKRRTELGDAPSAVVVPIEAYVEREAITMVLSEKGWIRALKGHSDAPEALKFKEGDQLGHLLKAWTTDKILV
FATDGRFYTIGGDKLPSGRGHGEPLRLMIDLAGDVDIAAVMVHKPGRKLLVATNTDRGFVVEENEVLAQTRAGKMVLNCA
DGEKAKFCLPFEGDAVAVIGENRKLLVFMAEEIPVLTRGRGVILQKYRDGGMADIKVFTLAQGLTWNLGDRVRTESDLTP
WLGKRASVGRLPPTGFPRNNRFS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=410, Percent_Identity=25.8536585365854, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI19913408, Length=386, Percent_Identity=25.1295336787565, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789396, Length=726, Percent_Identity=38.4297520661157, Blast_Score=490, Evalue=1e-139,
Organism=Escherichia coli, GI1788562, Length=685, Percent_Identity=41.021897810219, Blast_Score=452, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI212645845, Length=371, Percent_Identity=25.8760107816712, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=461, Percent_Identity=25.5965292841649, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=380, Percent_Identity=27.1052631578947, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=389, Percent_Identity=24.6786632390745, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136538, Length=175, Percent_Identity=33.1428571428571, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82208; Mature: 82077

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPAVTGDIRDTPLAEALGERYLAYAMSTIVSRSLPDVRDGLKPVHRRLLFAMRQLKLD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
PSGGFKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQDFAVRYPLVEGQGNFGNIDGDNAA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCC
AMRYTEAKLTEIAAALMEGLDEDSVDFRPTYDGTEEEPVVMPSAFPNLLANGSAGIAVGM
EEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCCCCCEEEEE
ATSIPPHNIGEICDALDHLIAKPDCDVDELIAHMPGPDFPTGGVLVETQAAITEAYRTGK
ECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHCCC
GAFRVRAKWAVEKLSHGLYQIVITEIPYQVQKAKLIEKIAELLSEKKLPLLADIRDESAE
CEEEEEHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
DIRLVLEPRNRTVEAELVMEQLFRQTDLESRFSLNMNVLAPDAHGHLTPGVMNLKEVLRA
CEEEEECCCCCEEHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCCCHHHHHHHHHH
FLDHRMVVLERRARFRLEKIAKRLEVLEGFLKVYADLDKVIRIIRFADEPKAELIKTFKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SEVQAEAILNMRLRSLNKLQELEIKTEHAELSAEKADLEALLADEPRRWAAIAAQNDETR
HHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHH
KAFGGATALGKRRTELGDAPSAVVVPIEAYVEREAITMVLSEKGWIRALKGHSDAPEALK
HHHCCHHHHCCHHHHCCCCCCEEEEEHHHHHHHHHHEEEECCCCCEEEECCCCCCCHHHC
FKEGDQLGHLLKAWTTDKILVFATDGRFYTIGGDKLPSGRGHGEPLRLMIDLAGDVDIAA
CCCCHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEE
VMVHKPGRKLLVATNTDRGFVVEENEVLAQTRAGKMVLNCADGEKAKFCLPFEGDAVAVI
EEEECCCCEEEEEECCCCCEEEECCHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEE
GENRKLLVFMAEEIPVLTRGRGVILQKYRDGGMADIKVFTLAQGLTWNLGDRVRTESDLT
ECCCEEEEEEECCCCEEECCCCEEEEEECCCCCCEEEEEEEECCCEECCCCCCCCCCCCC
PWLGKRASVGRLPPTGFPRNNRFS
HHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKPAVTGDIRDTPLAEALGERYLAYAMSTIVSRSLPDVRDGLKPVHRRLLFAMRQLKLD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
PSGGFKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQDFAVRYPLVEGQGNFGNIDGDNAA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCC
AMRYTEAKLTEIAAALMEGLDEDSVDFRPTYDGTEEEPVVMPSAFPNLLANGSAGIAVGM
EEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCCCCCEEEEE
ATSIPPHNIGEICDALDHLIAKPDCDVDELIAHMPGPDFPTGGVLVETQAAITEAYRTGK
ECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHCCC
GAFRVRAKWAVEKLSHGLYQIVITEIPYQVQKAKLIEKIAELLSEKKLPLLADIRDESAE
CEEEEEHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
DIRLVLEPRNRTVEAELVMEQLFRQTDLESRFSLNMNVLAPDAHGHLTPGVMNLKEVLRA
CEEEEECCCCCEEHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCCCHHHHHHHHHH
FLDHRMVVLERRARFRLEKIAKRLEVLEGFLKVYADLDKVIRIIRFADEPKAELIKTFKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SEVQAEAILNMRLRSLNKLQELEIKTEHAELSAEKADLEALLADEPRRWAAIAAQNDETR
HHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHH
KAFGGATALGKRRTELGDAPSAVVVPIEAYVEREAITMVLSEKGWIRALKGHSDAPEALK
HHHCCHHHHCCHHHHCCCCCCEEEEEHHHHHHHHHHEEEECCCCCEEEECCCCCCCHHHC
FKEGDQLGHLLKAWTTDKILVFATDGRFYTIGGDKLPSGRGHGEPLRLMIDLAGDVDIAA
CCCCHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEE
VMVHKPGRKLLVATNTDRGFVVEENEVLAQTRAGKMVLNCADGEKAKFCLPFEGDAVAVI
EEEECCCCEEEEEECCCCCEEEECCHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEE
GENRKLLVFMAEEIPVLTRGRGVILQKYRDGGMADIKVFTLAQGLTWNLGDRVRTESDLT
ECCCEEEEEEECCCCEEECCCCEEEEEECCCCCCEEEEEEEECCCEECCCCCCCCCCCCC
PWLGKRASVGRLPPTGFPRNNRFS
HHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]