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The map label for this gene is yngE [H]

Identifier: 83309775

GI number: 83309775

Start: 726215

End: 727822

Strand: Reverse

Name: yngE [H]

Synonym: amb0676

Alternate gene names: 83309775

Gene position: 727822-726215 (Counterclockwise)

Preceding gene: 83309776

Following gene: 83309774

Centisome position: 14.65

GC content: 64.68

Gene sequence:

>1608_bases
ATGACTGTCATCAAATCCTCGATCAATCCCCGCTCGGACGAGTTCAAGGCCAATGCCGAGGCCACGCAAGGTCTGGTGGA
CGACCTCAAGAAGGTGGTGGCCCAGGTCAAGATGGGCGGCGGCCCCGCCATGCGCGAGCGCCACATCGCCCGCGGCAAGC
TGTTGCCCAGGGAACGCATCCGCCGCCTGCTGGACGTGGGCTCGCCCTTCCTGGAATTCTCGCAATTGGCCGCCTGGGAC
ATGTATTCCAAGGACGTGATGGGGGCCGGCATCATCACTGGCATCGGCTCCATCAACGGCCAGGAATGCATGATCGTCGC
CAATGACGGCACGGTGAAGGGCGGGTCTTACTATCCCCTGACCGTCAAGAAGCACCTGCGCGCCCAGGACATCGCCAAGG
AGAACAATCTGCCCTGTGTCTACCTGGTGGAATCGGGCGGCGCCAACCTGCCCAACCAGGACGAGGTGTTCCCCGACCGC
GACCATTTCGGCCGCATCTTCTATAACCAGGCCCAGATGTCGGCCCTTGGCATCCCGCAGATTTCCGTGGTGCATGGCTC
GTGCACGGCGGGCGGCGCCTATATCCCGGCCATGAGCGACGAAAGCGTCATCGTCAAGAACCAGGGCACCATCTTCCTCG
GCGGCCCGCCTTTGGTGAAGGCCGCCACCGGCGAGGTGGTCTCGGCCGAGGAACTGGGCGGCGCCGACGTCCATTGCCGC
ACCTCGGGCGTCACCGACCATTACGCCCAGGACGACGGCCATGCGCTGGCCATCGCCCGGCGCATCGTCGGCAACCTCAA
CCGCATCAAGCCCACCAGCCTGAAAATGGCCACGCCGGAAGAGCCGCTGTACGACCCCAAGGAAATCTACGGCATCATCC
CCAAGGACCGCCGCAAGCCCTATGACGTGCGCGAGGTCATCGCCCGCATCGTCGACGGCTCGCGCCTGGACGAGTTCAAG
CAGACCTACGGCACCACCCTGGTCTGCGGCTTCGCCCATATCTGGGGCTATCCCGTGGGCATCGTCGCCAATAACGGCAT
CCTGTTCTCGGAAAGCGCCCAGAAGGGCGCCCATTTCGTCGAGCTGTGCAGCCAGCGCGGCATTCCGCTGATCTTCCTGC
AGAACATCACCGGCTTCATGATCGGCAAGAAGTACGAGGCCGGCGGCATCGCCAAGGACGGCGCCAAGATGGTTACCGCC
GTGGCCTGCGCCAAGGTGCCGCGCTTCACGGTGATCATGGGCGGCAGCTTCGGGGCCGGCAATTACGGCATGTGCGGCCG
GGCCTATCAGCCGCGCATGCTCTATATGTGGCCGACGGGGCGCGTCTCGGTGATGGGCGGCGAGCAGGCCGCCAACGTCA
TGGCCCAGATCAAGAAGGACGCCATGGAGGCCAAGGGTCAAAGCTGGCCGGCGGATGAAGAGGAAGCCTTCAAGGCCCCC
ATCCGCGACCAGTACGAGACCCAGGGCCATCCCTATTACGCCGGGGCGCGGCTGTGGGACGACGGTCTGGTCGATCCGGC
CGAGACCCGCATGGTGCTGGCGCTGTCGCTGTCCGCCTCCTTCAACGCCCCCATCGAGCCGACCAAGTTCGGCGTGTTCA
GGATGTAA

Upstream 100 bases:

>100_bases
CCACGGGAAACCGGACATGCCGGAGTAGACGGAGATCCCTCACTGCGTTCGGGATGACAAGACAGCGGATGACGAGGCGC
AGGCCCCAGGGACGAACCAA

Downstream 100 bases:

>100_bases
GCGGCATGAGCGCCCTTCTCGTCACCACCCATGACGGCGTGCGGACCATCACCCTCAATCGGGCCGAGCGGCACAACGCC
TTCGATGACGCCCTGATCGC

Product: Acetyl-CoA carboxylase and carboxyltransferase component

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTVIKSSINPRSDEFKANAEATQGLVDDLKKVVAQVKMGGGPAMRERHIARGKLLPRERIRRLLDVGSPFLEFSQLAAWD
MYSKDVMGAGIITGIGSINGQECMIVANDGTVKGGSYYPLTVKKHLRAQDIAKENNLPCVYLVESGGANLPNQDEVFPDR
DHFGRIFYNQAQMSALGIPQISVVHGSCTAGGAYIPAMSDESVIVKNQGTIFLGGPPLVKAATGEVVSAEELGGADVHCR
TSGVTDHYAQDDGHALAIARRIVGNLNRIKPTSLKMATPEEPLYDPKEIYGIIPKDRRKPYDVREVIARIVDGSRLDEFK
QTYGTTLVCGFAHIWGYPVGIVANNGILFSESAQKGAHFVELCSQRGIPLIFLQNITGFMIGKKYEAGGIAKDGAKMVTA
VACAKVPRFTVIMGGSFGAGNYGMCGRAYQPRMLYMWPTGRVSVMGGEQAANVMAQIKKDAMEAKGQSWPADEEEAFKAP
IRDQYETQGHPYYAGARLWDDGLVDPAETRMVLALSLSASFNAPIEPTKFGVFRM

Sequences:

>Translated_535_residues
MTVIKSSINPRSDEFKANAEATQGLVDDLKKVVAQVKMGGGPAMRERHIARGKLLPRERIRRLLDVGSPFLEFSQLAAWD
MYSKDVMGAGIITGIGSINGQECMIVANDGTVKGGSYYPLTVKKHLRAQDIAKENNLPCVYLVESGGANLPNQDEVFPDR
DHFGRIFYNQAQMSALGIPQISVVHGSCTAGGAYIPAMSDESVIVKNQGTIFLGGPPLVKAATGEVVSAEELGGADVHCR
TSGVTDHYAQDDGHALAIARRIVGNLNRIKPTSLKMATPEEPLYDPKEIYGIIPKDRRKPYDVREVIARIVDGSRLDEFK
QTYGTTLVCGFAHIWGYPVGIVANNGILFSESAQKGAHFVELCSQRGIPLIFLQNITGFMIGKKYEAGGIAKDGAKMVTA
VACAKVPRFTVIMGGSFGAGNYGMCGRAYQPRMLYMWPTGRVSVMGGEQAANVMAQIKKDAMEAKGQSWPADEEEAFKAP
IRDQYETQGHPYYAGARLWDDGLVDPAETRMVLALSLSASFNAPIEPTKFGVFRM
>Mature_534_residues
TVIKSSINPRSDEFKANAEATQGLVDDLKKVVAQVKMGGGPAMRERHIARGKLLPRERIRRLLDVGSPFLEFSQLAAWDM
YSKDVMGAGIITGIGSINGQECMIVANDGTVKGGSYYPLTVKKHLRAQDIAKENNLPCVYLVESGGANLPNQDEVFPDRD
HFGRIFYNQAQMSALGIPQISVVHGSCTAGGAYIPAMSDESVIVKNQGTIFLGGPPLVKAATGEVVSAEELGGADVHCRT
SGVTDHYAQDDGHALAIARRIVGNLNRIKPTSLKMATPEEPLYDPKEIYGIIPKDRRKPYDVREVIARIVDGSRLDEFKQ
TYGTTLVCGFAHIWGYPVGIVANNGILFSESAQKGAHFVELCSQRGIPLIFLQNITGFMIGKKYEAGGIAKDGAKMVTAV
ACAKVPRFTVIMGGSFGAGNYGMCGRAYQPRMLYMWPTGRVSVMGGEQAANVMAQIKKDAMEAKGQSWPADEEEAFKAPI
RDQYETQGHPYYAGARLWDDGLVDPAETRMVLALSLSASFNAPIEPTKFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=64.5593869731801, Blast_Score=702, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=497, Percent_Identity=32.3943661971831, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI295821216, Length=517, Percent_Identity=31.3346228239845, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=57.5757575757576, Blast_Score=141, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=60.7879924953096, Blast_Score=700, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=489, Percent_Identity=33.1288343558282, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI25147362, Length=489, Percent_Identity=33.1288343558282, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=64.4283121597096, Blast_Score=743, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 58065; Mature: 57934

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIKSSINPRSDEFKANAEATQGLVDDLKKVVAQVKMGGGPAMRERHIARGKLLPRERI
CCEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
RRLLDVGSPFLEFSQLAAWDMYSKDVMGAGIITGIGSINGQECMIVANDGTVKGGSYYPL
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCEEEEEECCCEECCCCEEEE
TVKKHLRAQDIAKENNLPCVYLVESGGANLPNQDEVFPDRDHFGRIFYNQAQMSALGIPQ
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEECHHHHHHCCCCE
ISVVHGSCTAGGAYIPAMSDESVIVKNQGTIFLGGPPLVKAATGEVVSAEELGGADVHCR
EEEEECCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEEEHHHCCCCCEEEE
TSGVTDHYAQDDGHALAIARRIVGNLNRIKPTSLKMATPEEPLYDPKEIYGIIPKDRRKP
ECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHEECCCCCCCCC
YDVREVIARIVDGSRLDEFKQTYGTTLVCGFAHIWGYPVGIVANNGILFSESAQKGAHFV
CCHHHHHHHHHCCCHHHHHHHHHCCEEEEHHHHHHCCCEEEEECCCEEEECCHHCCHHHH
ELCSQRGIPLIFLQNITGFMIGKKYEAGGIAKDGAKMVTAVACAKVPRFTVIMGGSFGAG
HHHHHCCCCEEEECCCCEEEEECEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYQPRMLYMWPTGRVSVMGGEQAANVMAQIKKDAMEAKGQSWPADEEEAFKAP
CCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
IRDQYETQGHPYYAGARLWDDGLVDPAETRMVLALSLSASFNAPIEPTKFGVFRM
CCCCHHCCCCCEEECCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVIKSSINPRSDEFKANAEATQGLVDDLKKVVAQVKMGGGPAMRERHIARGKLLPRERI
CEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
RRLLDVGSPFLEFSQLAAWDMYSKDVMGAGIITGIGSINGQECMIVANDGTVKGGSYYPL
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCEEEEEECCCEECCCCEEEE
TVKKHLRAQDIAKENNLPCVYLVESGGANLPNQDEVFPDRDHFGRIFYNQAQMSALGIPQ
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEECHHHHHHCCCCE
ISVVHGSCTAGGAYIPAMSDESVIVKNQGTIFLGGPPLVKAATGEVVSAEELGGADVHCR
EEEEECCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEEEHHHCCCCCEEEE
TSGVTDHYAQDDGHALAIARRIVGNLNRIKPTSLKMATPEEPLYDPKEIYGIIPKDRRKP
ECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHEECCCCCCCCC
YDVREVIARIVDGSRLDEFKQTYGTTLVCGFAHIWGYPVGIVANNGILFSESAQKGAHFV
CCHHHHHHHHHCCCHHHHHHHHHCCEEEEHHHHHHCCCEEEEECCCEEEECCHHCCHHHH
ELCSQRGIPLIFLQNITGFMIGKKYEAGGIAKDGAKMVTAVACAKVPRFTVIMGGSFGAG
HHHHHCCCCEEEECCCCEEEEECEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYQPRMLYMWPTGRVSVMGGEQAANVMAQIKKDAMEAKGQSWPADEEEAFKAP
CCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
IRDQYETQGHPYYAGARLWDDGLVDPAETRMVLALSLSASFNAPIEPTKFGVFRM
CCCCHHCCCCCEEECCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]