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The map label for this gene is mmgC [H]

Identifier: 83309776

GI number: 83309776

Start: 727976

End: 729145

Strand: Reverse

Name: mmgC [H]

Synonym: amb0677

Alternate gene names: 83309776

Gene position: 729145-727976 (Counterclockwise)

Preceding gene: 83309777

Following gene: 83309775

Centisome position: 14.68

GC content: 65.21

Gene sequence:

>1170_bases
ATGACCGGCTTCAATTCCGCGCTGAACTTCGATCTGGGTGAGACCGCCGACATGATGCGCGACTCGGTCGCCGCCTTCGC
CGCCACCGAAATCGCCCCCCGCGCCGCCGAGATCGACCGCAGCAACGAATTCCCCAACGAGCTTTGGCCGCGCCTGGGCG
CCATGGGCCTGCTGGGCATCACCGTCGACGAGAAGTACGGCGGCGCCGGCATGGGTTACCTGGAGCACGTGGTGGCCATG
GAGGAGATCAGCCGGGCCTCGGCCTCGGTGGGCCTGTCCTACGGCGCGCACTCCAACCTCTGCGTCAACCAGATCAAGCG
CAACGGCACCGAAGCGCAAAAGATGAAGTACCTGCCCAAGCTGATCTCGGGCGAATATATCGGCGCCCTGGCCATGAGCG
AGCCCAATGCCGGCTCCGACGTGGTCTCCATGAAGCTGAAGGCCGAGAAGAAGGGCGACCGCTACGTCCTCAACGGCACC
AAGATGTGGATCACCAACGGCCCCGACGCCGACGTGATCGTGGTCTATGCCAAGACCGACGTCACCGCCGGACCGCGTGG
CATCACCGCCTTCCTGGTGGAGAAGACTTTCAAGGGCTTCTCGGTGGCGCAGAAGCTGGACAAGCTGGGCATGCGCGGCT
CCAACACCGGCGAGCTGGTGTTCCAGGATTGTGAAGTGCCGGAAGAGAACGTGCTGGGCGCCGTGGGCAAGGGCGTCAAC
GTCCTGATGAGCGGCCTGGACTACGAGCGCGTGGTGCTGACCGGCGGACCGCTTGGCATCATGGCCGCCTGCATGGATGT
GGTGGTCCCCTATGTTCACGAGCGCACCCAGTTCGGCCAGCCCATCGGCACCTTCCAGCTGATGCAGGGCAAGCTGGCCG
ACATGTACACCACCTTCAACGCCTGCCGCGCCTACACCTACGCGGTGGCCAAGGCCTGCGACCGGGGCGAGACCTCGCGC
AAGGACGCCGCCGGCGTGATCCTCTACGGCGCCGAGAAGGCCACCTGGATGGCGCTGGAAGCCATCCAGACCCTGGGCGG
CAACGGCTATATCAACGAATACGCCACCGGGCGGCTGCTGCGCGACGCCAAGCTCTACGAGATCGGCGCGGGCACATCCG
AGATCCGCCGCATGCTGATCGGCCGCGAGCTGTTCGAAGAAACCAAGTAG

Upstream 100 bases:

>100_bases
GTGGCTGATGGTGCTGGGAGCCGGTTGAATCCCCTTGCGGCCGAATTAAAAAAACGTATGCTCGTTTAACGCACCAACCG
GGCTGTATGAGGGAACGAGC

Downstream 100 bases:

>100_bases
CTCCCGTGAAACTGTCATCCCGAGCGAGAGCGAGGGATCTCCTCCTGGCACGGCCACGGGAAACCGGACATGCCGGAGTA
GACGGAGATCCCTCACTGCG

Product: Acyl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTGFNSALNFDLGETADMMRDSVAAFAATEIAPRAAEIDRSNEFPNELWPRLGAMGLLGITVDEKYGGAGMGYLEHVVAM
EEISRASASVGLSYGAHSNLCVNQIKRNGTEAQKMKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGT
KMWITNGPDADVIVVYAKTDVTAGPRGITAFLVEKTFKGFSVAQKLDKLGMRGSNTGELVFQDCEVPEENVLGAVGKGVN
VLMSGLDYERVVLTGGPLGIMAACMDVVVPYVHERTQFGQPIGTFQLMQGKLADMYTTFNACRAYTYAVAKACDRGETSR
KDAAGVILYGAEKATWMALEAIQTLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFEETK

Sequences:

>Translated_389_residues
MTGFNSALNFDLGETADMMRDSVAAFAATEIAPRAAEIDRSNEFPNELWPRLGAMGLLGITVDEKYGGAGMGYLEHVVAM
EEISRASASVGLSYGAHSNLCVNQIKRNGTEAQKMKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGT
KMWITNGPDADVIVVYAKTDVTAGPRGITAFLVEKTFKGFSVAQKLDKLGMRGSNTGELVFQDCEVPEENVLGAVGKGVN
VLMSGLDYERVVLTGGPLGIMAACMDVVVPYVHERTQFGQPIGTFQLMQGKLADMYTTFNACRAYTYAVAKACDRGETSR
KDAAGVILYGAEKATWMALEAIQTLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFEETK
>Mature_388_residues
TGFNSALNFDLGETADMMRDSVAAFAATEIAPRAAEIDRSNEFPNELWPRLGAMGLLGITVDEKYGGAGMGYLEHVVAME
EISRASASVGLSYGAHSNLCVNQIKRNGTEAQKMKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGTK
MWITNGPDADVIVVYAKTDVTAGPRGITAFLVEKTFKGFSVAQKLDKLGMRGSNTGELVFQDCEVPEENVLGAVGKGVNV
LMSGLDYERVVLTGGPLGIMAACMDVVVPYVHERTQFGQPIGTFQLMQGKLADMYTTFNACRAYTYAVAKACDRGETSRK
DAAGVILYGAEKATWMALEAIQTLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFEETK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=68.8, Blast_Score=537, Evalue=1e-153,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=67.2972972972973, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI4557233, Length=381, Percent_Identity=39.3700787401575, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=36.2397820163488, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=37.0572207084469, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=34.2857142857143, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=34.2857142857143, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=33.5120643431635, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=37.3529411764706, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=37.3529411764706, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI7656849, Length=366, Percent_Identity=32.5136612021858, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4503943, Length=370, Percent_Identity=32.1621621621622, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=32.7868852459016, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=25, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=25, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=22.3021582733813, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=27.9373368146214, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=27.9373368146214, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87082384, Length=264, Percent_Identity=28.030303030303, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081702, Length=333, Percent_Identity=24.6246246246246, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=65.7894736842105, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=37.7952755905512, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=36.1256544502618, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=389, Percent_Identity=33.4190231362468, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=34.5013477088949, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=33.8541666666667, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=296, Percent_Identity=38.5135135135135, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=362, Percent_Identity=32.0441988950276, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=33.1428571428571, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=31.1345646437995, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.5766423357664, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=30.1075268817204, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=33.4507042253521, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=28.6103542234332, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=28.4552845528455, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=25.9786476868327, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=25.9786476868327, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=63.0208333333333, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=39.8936170212766, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.8297872340425, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI24666513, Length=381, Percent_Identity=34.9081364829396, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=34.375, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI281363737, Length=354, Percent_Identity=33.3333333333333, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=30.1837270341207, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI221473076, Length=327, Percent_Identity=23.8532110091743, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI45550141, Length=327, Percent_Identity=23.8532110091743, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42013; Mature: 41881

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFNSALNFDLGETADMMRDSVAAFAATEIAPRAAEIDRSNEFPNELWPRLGAMGLLGI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHCCCEEEEE
TVDEKYGGAGMGYLEHVVAMEEISRASASVGLSYGAHSNLCVNQIKRNGTEAQKMKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
LISGEYIGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGTKMWITNGPDADVIVVYAKTD
HHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCEEEEEECCCCCCEEEEEEECC
VTAGPRGITAFLVEKTFKGFSVAQKLDKLGMRGSNTGELVFQDCEVPEENVLGAVGKGVN
CCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCHH
VLMSGLDYERVVLTGGPLGIMAACMDVVVPYVHERTQFGQPIGTFQLMQGKLADMYTTFN
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ACRAYTYAVAKACDRGETSRKDAAGVILYGAEKATWMALEAIQTLGGNGYINEYATGRLL
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFEETK
HCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGFNSALNFDLGETADMMRDSVAAFAATEIAPRAAEIDRSNEFPNELWPRLGAMGLLGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHCCCEEEEE
TVDEKYGGAGMGYLEHVVAMEEISRASASVGLSYGAHSNLCVNQIKRNGTEAQKMKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
LISGEYIGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGTKMWITNGPDADVIVVYAKTD
HHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCEEEEEECCCCCCEEEEEEECC
VTAGPRGITAFLVEKTFKGFSVAQKLDKLGMRGSNTGELVFQDCEVPEENVLGAVGKGVN
CCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCHH
VLMSGLDYERVVLTGGPLGIMAACMDVVVPYVHERTQFGQPIGTFQLMQGKLADMYTTFN
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ACRAYTYAVAKACDRGETSRKDAAGVILYGAEKATWMALEAIQTLGGNGYINEYATGRLL
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFEETK
HCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]