Click here to switch to the map view.

The map label for this gene is fmt

Identifier: 82750820

GI number: 82750820

Start: 1165897

End: 1166832

Strand: Direct

Name: fmt

Synonym: SAB1080

Alternate gene names: 82750820

Gene position: 1165897-1166832 (Clockwise)

Preceding gene: 82750819

Following gene: 82750821

Centisome position: 42.51

GC content: 35.04

Gene sequence:

>936_bases
ATGACTAAAATAATATTTATGGGTACACCAGACTTTTCAACAACTGTTTTAGAAATGCTTATTGCAGAACATGATGTCAT
TGCAGTCGTAACGCAACCAGATCGACCTGTTGGACGTAAACGTGTTATGACACCACCACCAGTTAAAAAAGTTGCAATGA
AATATGATTTACCTGTATATCAGCCTGAAAAATTAAGTGGATCAGAAGAATTAGAACAATTGCTTCAATTAGATGTAGAT
TTAATTGTAACTGCTGCTTTTGGACAATTATTACCTGAATCATTGTTGGCATTACCAAAACTTGGCGCAATTAATGTACA
TGCATCATTGTTACCGAAGTATAGAGGTGGTGCACCAATTCATCAGGCAATTATCGATGGTGAACAAGAAACCGGCATAA
CAATTATGTATATGGTTAAAAAATTAGATGCGGGTAATATTATTTCGCAACAAGCAATTAAAATAGAAGAAAATGATAAT
GTCGGTACGATGCATGATAAATTAAGTGTATTAGGGGCAGATTTATTAAAAGAAACTTTACCATCTATTATAGAGGGCAC
AAATGAAAGTGTACCTCAAGATGATACGCAAGCAACATTTGCTTCCAATATTCGACGCGAAGATGAGCGAATTAGCTGGA
ATAAACCAGGAAGACAAGTGTTTAATCAAATTCGAGGATTATCACCATGGCCAGTTGCTTATACAACTATGGATGACACT
AACTTGAAAATATACGATGCTGAACTCGTTGAGACTAATAAGATAAACGAGCCCGGAACAATTATAGAAACGACTAAAAA
AGCCATTATTGTTGCTACAAATGATAATGAAGCTGTTGCAATTAAAGATATGCAATTGGCTGGGAAAAAGAGAATGTTAG
CTGCCAATTATTTAAGTGGTGCGCAAAACATACTAGTAGGGAAGAAACTTATATGA

Upstream 100 bases:

>100_bases
AGAATGATTTTGCATATTATAGATCAAATGAACGGTATCCCTTTTACAGAACGTGCGGACCGTATTTTAACAGATAAAGA
AGTGGAGGCATATTTTATAA

Downstream 100 bases:

>100_bases
TAGAAAACGTGAGAAGTCTTGCTTTTGACACGATTCAAGATATATTAAATGAAGGTGCGTATAGTAACTTGCGTATCAAT
GAAGTGTTGTCAGAAAATGA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVYQPEKLSGSEELEQLLQLDVD
LIVTAAFGQLLPESLLALPKLGAINVHASLLPKYRGGAPIHQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDN
VGTMHDKLSVLGADLLKETLPSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDT
NLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSGAQNILVGKKLI

Sequences:

>Translated_311_residues
MTKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVYQPEKLSGSEELEQLLQLDVD
LIVTAAFGQLLPESLLALPKLGAINVHASLLPKYRGGAPIHQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDN
VGTMHDKLSVLGADLLKETLPSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDT
NLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSGAQNILVGKKLI
>Mature_310_residues
TKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVYQPEKLSGSEELEQLLQLDVDL
IVTAAFGQLLPESLLALPKLGAINVHASLLPKYRGGAPIHQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDNV
GTMHDKLSVLGADLLKETLPSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDTN
LKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSGAQNILVGKKLI

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=317, Percent_Identity=26.813880126183, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI238814322, Length=316, Percent_Identity=25.6329113924051, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI164663775, Length=322, Percent_Identity=28.8819875776398, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1789683, Length=311, Percent_Identity=39.2282958199357, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1788589, Length=275, Percent_Identity=30.9090909090909, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI133930964, Length=327, Percent_Identity=25.6880733944954, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319458, Length=351, Percent_Identity=26.4957264957265, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550868, Length=303, Percent_Identity=28.7128712871287, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=30.2222222222222, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585660, Length=294, Percent_Identity=22.4489795918367, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34238; Mature: 34107

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVY
CCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHEECCCCC
QPEKLSGSEELEQLLQLDVDLIVTAAFGQLLPESLLALPKLGAINVHASLLPKYRGGAPI
CCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCH
HQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDNVGTMHDKLSVLGADLLKETL
HHHHHCCCCCCCEEEEEEEHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
PSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDT
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCC
NLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSG
CEEEEEEEEEECCCCCCCCCEEEECCCEEEEEECCCCEEEEECHHHCCCHHHHHHHHHCC
AQNILVGKKLI
CHHHHCCCCCC
>Mature Secondary Structure 
TKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVY
CEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHEECCCCC
QPEKLSGSEELEQLLQLDVDLIVTAAFGQLLPESLLALPKLGAINVHASLLPKYRGGAPI
CCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCH
HQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDNVGTMHDKLSVLGADLLKETL
HHHHHCCCCCCCEEEEEEEHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
PSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDT
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCC
NLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSG
CEEEEEEEEEECCCCCCCCCEEEECCCEEEEEECCCCEEEEECHHHCCCHHHHHHHHHCC
AQNILVGKKLI
CHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA