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The map label for this gene is clpP

Identifier: 82703457

GI number: 82703457

Start: 2667043

End: 2667684

Strand: Reverse

Name: clpP

Synonym: Nmul_A2340

Alternate gene names: 82703457

Gene position: 2667684-2667043 (Counterclockwise)

Preceding gene: 82703458

Following gene: 82703456

Centisome position: 83.78

GC content: 55.3

Gene sequence:

>642_bases
ATGCAACGATTCGAGTGGAAGCAGCGTAATCACGAACCGCAGGATTTGGGTTTGATCCCGATGGTGATTGAAACCAGCGG
GCGGGGCGAGCGCGCATACGATATTTATTCGCGGTTGCTGCGGGAGCGGGTCATATTTCTTGTGGGACCTGTTACCGAAG
CGTCTGCCAACCTGATTGTCGCGCAACTCCTGTTTCTCGAATCGGAAAATGCGGACAAGGATATTCATTTTTACATAAAT
TCGCCCGGGGGCCTGGTTTCCGCGGGAATGGCGGTCTACGATACCATGCAATTCATCAAGCCCGACGTCAGCACGCTTTG
CATAGGGCAGGCGGCCAGCATGGGATCGCTGCTTCTGGCAGCCGGAGCGAAAGGGAAGCGGTTTTGCCTGCCCAACTCCC
GTGTGATGATTCACCAGCCGCTGGGAGGATTCCAGGGGCAGGCATCCGATATCGAGATTCACGCCCGGGAAATCCTGTAT
CTGAAGAACCGATTGAATGAGCTACTGTCAAAACACACCGGTCAGAGTATGGAAACCATTGAAAGAGATACCGACCGGGA
TAACTTTCTGGGGGCGGAGGACTCGGTGAAATACGGCCTGGTGGACGCTGTACTGACCTCGAGGGGAGAGGGCGCCGGTT
GA

Upstream 100 bases:

>100_bases
CGGCAGCGCTGGAGGATAACGTGGTGACATGGGTGCTGGAGAAGGCTGTCGTTACTGGCAAGCCGATGCCGCTGGATGAA
TTGATGGGAAGATCATAAAC

Downstream 100 bases:

>100_bases
AGTTTGACTTCGGGAGAGCTTGTAATCAGTCACGAGCCATTCAGCTCGGATAATGCGGGATAAAACTATGTCAGAGAAAA
CTGGCGGAGAAAAACTGCTT

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MQRFEWKQRNHEPQDLGLIPMVIETSGRGERAYDIYSRLLRERVIFLVGPVTEASANLIVAQLLFLESENADKDIHFYIN
SPGGLVSAGMAVYDTMQFIKPDVSTLCIGQAASMGSLLLAAGAKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILY
LKNRLNELLSKHTGQSMETIERDTDRDNFLGAEDSVKYGLVDAVLTSRGEGAG

Sequences:

>Translated_213_residues
MQRFEWKQRNHEPQDLGLIPMVIETSGRGERAYDIYSRLLRERVIFLVGPVTEASANLIVAQLLFLESENADKDIHFYIN
SPGGLVSAGMAVYDTMQFIKPDVSTLCIGQAASMGSLLLAAGAKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILY
LKNRLNELLSKHTGQSMETIERDTDRDNFLGAEDSVKYGLVDAVLTSRGEGAG
>Mature_213_residues
MQRFEWKQRNHEPQDLGLIPMVIETSGRGERAYDIYSRLLRERVIFLVGPVTEASANLIVAQLLFLESENADKDIHFYIN
SPGGLVSAGMAVYDTMQFIKPDVSTLCIGQAASMGSLLLAAGAKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILY
LKNRLNELLSKHTGQSMETIERDTDRDNFLGAEDSVKYGLVDAVLTSRGEGAG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=57.5916230366492, Blast_Score=241, Evalue=2e-64,
Organism=Escherichia coli, GI1786641, Length=201, Percent_Identity=70.6467661691542, Blast_Score=313, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=58.6387434554974, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI20129427, Length=197, Percent_Identity=55.8375634517767, Blast_Score=244, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_NITMU (Q2Y6J0)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_413023.1
- ProteinModelPortal:   Q2Y6J0
- SMR:   Q2Y6J0
- STRING:   Q2Y6J0
- MEROPS:   S14.001
- GeneID:   3784743
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2340
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   Q2Y6J0
- BioCyc:   NMUL323848:NMUL_A2340-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23529; Mature: 23529

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 113-113 ACT_SITE 138-138

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFEWKQRNHEPQDLGLIPMVIETSGRGERAYDIYSRLLRERVIFLVGPVTEASANLIV
CCCCCCHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHH
AQLLFLESENADKDIHFYINSPGGLVSAGMAVYDTMQFIKPDVSTLCIGQAASMGSLLLA
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEE
AGAKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILYLKNRLNELLSKHTGQSMETI
CCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHH
ERDTDRDNFLGAEDSVKYGLVDAVLTSRGEGAG
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQRFEWKQRNHEPQDLGLIPMVIETSGRGERAYDIYSRLLRERVIFLVGPVTEASANLIV
CCCCCCHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHH
AQLLFLESENADKDIHFYINSPGGLVSAGMAVYDTMQFIKPDVSTLCIGQAASMGSLLLA
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEE
AGAKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILYLKNRLNELLSKHTGQSMETI
CCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHH
ERDTDRDNFLGAEDSVKYGLVDAVLTSRGEGAG
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA