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The map label for this gene is clpX

Identifier: 82703456

GI number: 82703456

Start: 2665698

End: 2666975

Strand: Reverse

Name: clpX

Synonym: Nmul_A2339

Alternate gene names: 82703456

Gene position: 2666975-2665698 (Counterclockwise)

Preceding gene: 82703457

Following gene: 82703455

Centisome position: 83.76

GC content: 52.97

Gene sequence:

>1278_bases
ATGTCAGAGAAAACTGGCGGAGAAAAACTGCTTTATTGTTCCTTTTGTGGTAAGAGCCAGCATGAGGTAAAGAAGCTGAT
CGCCGGTCCTTCGGTATTCATATGCGACGAATGTATCGAGTTGTGCAACGATATCATTCGTGAGGAAATACAGGGTGTGG
AGGCGGCCAAGCTCGCAAAGTCGGACCTGCCTGTCCCCCATGAAATTCGACAGATCCTGGATCAATACGTGATCGGCCAG
GAGCAGGCGAAGAAAATTCTGTCGGTAGCGGTCTATAATCACTACAAGCGTCTGAGAACGCTTGCAAAATCCGCTGATCC
GGATGAGATCGAGCTGGCGAAGAGCAACATCCTGCTGATTGGCCCCACGGGTTCAGGCAAGACGCTGCTTGCCCAGACGC
TGGCACGTTTGCTGGATGTGCCTTTTGTCATGGCGGATGCGACCACCCTGACCGAGGCGGGTTATGTCGGCGAGGATGTT
GAAAACATCATCCAGAAATTGCTGCAGAAATGTAACTACGACGCGGAAAAGGCGCAGCAAGGCATTGTCTACATAGACGA
AATCGACAAGATTTCGCGCAAGTCAGATAATCCATCCATCACGCGCGATGTCTCGGGTGAGGGCGTACAGCAGGCACTGC
TCAAGCTGATCGAGGGCACGGTTGCGTCCGTGCCGCCGCAGGGGGGGAGAAAGCATCCCAACCAGGAGTTCGTGCAAGTC
GATACCACCAATATTCTTTTCATTTGCGGGGGCGCTTTTGATGGCCTGGAGAAAATCATACGCGCCCGCTCTGAGAAGGG
CGGGATAGGCTTCAGCGCCAGTGTAAGAAGCCAGGATAACCGCAAGGATTTTGGCGCTGTACTGCGCGGGGTCGAGCCCG
AGGATCTGGTGAAGTATGGCCTGATTCCGGAATTCGTCGGCCGATTACCTGTTGTTGCAACCCTTGAGGAACTTGACGAG
GCCGCGTTGATTCAAATCCTGACCGAACCCAGGAATGCGCTCATCAAGCAGTATCAGAAAATGTTTCACATGGAAGGGGG
CATCGATCTCGAATTCCGGGAGCAGGCGCTTAAAGCGATTGCCCGCAAGGCGCTGGTGCGAAAGACCGGTGCGCGAGGTT
TACGTTCCATTCTTGAAGCTGCGCTGCTCGATACGATGTTTGATCTGCCATCACTGGAGAATGTTGCCAAAGTGGTAATT
GACCACACTTCTGTCAATGGGGATATCAAACCCATTCTGATCTATTCGGACAAACCGAAAGTGGCGAAGAGCTGCTAG

Upstream 100 bases:

>100_bases
GTACTGACCTCGAGGGGAGAGGGCGCCGGTTGAAGTTTGACTTCGGGAGAGCTTGTAATCAGTCACGAGCCATTCAGCTC
GGATAATGCGGGATAAAACT

Downstream 100 bases:

>100_bases
TCCGGGTTTCATGTTTCGACATTGCCGTCGTTGCCTTGAATTTCTTTACGGCGCCCCCATAACTATTGTTTGTTTCTTTA
TAGGTGAGCCGATATGTCCT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSEKTGGEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIELCNDIIREEIQGVEAAKLAKSDLPVPHEIRQILDQYVIGQ
EQAKKILSVAVYNHYKRLRTLAKSADPDEIELAKSNILLIGPTGSGKTLLAQTLARLLDVPFVMADATTLTEAGYVGEDV
ENIIQKLLQKCNYDAEKAQQGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFVQV
DTTNILFICGGAFDGLEKIIRARSEKGGIGFSASVRSQDNRKDFGAVLRGVEPEDLVKYGLIPEFVGRLPVVATLEELDE
AALIQILTEPRNALIKQYQKMFHMEGGIDLEFREQALKAIARKALVRKTGARGLRSILEAALLDTMFDLPSLENVAKVVI
DHTSVNGDIKPILIYSDKPKVAKSC

Sequences:

>Translated_425_residues
MSEKTGGEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIELCNDIIREEIQGVEAAKLAKSDLPVPHEIRQILDQYVIGQ
EQAKKILSVAVYNHYKRLRTLAKSADPDEIELAKSNILLIGPTGSGKTLLAQTLARLLDVPFVMADATTLTEAGYVGEDV
ENIIQKLLQKCNYDAEKAQQGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFVQV
DTTNILFICGGAFDGLEKIIRARSEKGGIGFSASVRSQDNRKDFGAVLRGVEPEDLVKYGLIPEFVGRLPVVATLEELDE
AALIQILTEPRNALIKQYQKMFHMEGGIDLEFREQALKAIARKALVRKTGARGLRSILEAALLDTMFDLPSLENVAKVVI
DHTSVNGDIKPILIYSDKPKVAKSC
>Mature_424_residues
SEKTGGEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIELCNDIIREEIQGVEAAKLAKSDLPVPHEIRQILDQYVIGQE
QAKKILSVAVYNHYKRLRTLAKSADPDEIELAKSNILLIGPTGSGKTLLAQTLARLLDVPFVMADATTLTEAGYVGEDVE
NIIQKLLQKCNYDAEKAQQGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFVQVD
TTNILFICGGAFDGLEKIIRARSEKGGIGFSASVRSQDNRKDFGAVLRGVEPEDLVKYGLIPEFVGRLPVVATLEELDEA
ALIQILTEPRNALIKQYQKMFHMEGGIDLEFREQALKAIARKALVRKTGARGLRSILEAALLDTMFDLPSLENVAKVVID
HTSVNGDIKPILIYSDKPKVAKSC

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=330, Percent_Identity=53.9393939393939, Blast_Score=319, Evalue=3e-87,
Organism=Escherichia coli, GI1786642, Length=422, Percent_Identity=74.4075829383886, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1790366, Length=105, Percent_Identity=41.9047619047619, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71982908, Length=293, Percent_Identity=49.4880546075085, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71982905, Length=293, Percent_Identity=49.4880546075085, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71988663, Length=393, Percent_Identity=40.9669211195929, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71988660, Length=252, Percent_Identity=43.2539682539683, Blast_Score=178, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6319704, Length=438, Percent_Identity=39.2694063926941, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24648289, Length=319, Percent_Identity=47.9623824451411, Blast_Score=287, Evalue=9e-78,
Organism=Drosophila melanogaster, GI24648291, Length=319, Percent_Identity=47.9623824451411, Blast_Score=287, Evalue=9e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_NITMU (Q2Y6J1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_413022.1
- ProteinModelPortal:   Q2Y6J1
- STRING:   Q2Y6J1
- GeneID:   3784742
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2339
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q2Y6J1
- ProtClustDB:   PRK05342
- BioCyc:   NMUL323848:NMUL_A2339-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 46682; Mature: 46551

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKTGGEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIELCNDIIREEIQGVEAAKLAK
CCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SDLPVPHEIRQILDQYVIGQEQAKKILSVAVYNHYKRLRTLAKSADPDEIELAKSNILLI
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCEEEE
GPTGSGKTLLAQTLARLLDVPFVMADATTLTEAGYVGEDVENIIQKLLQKCNYDAEKAQQ
ECCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHC
GIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFVQV
CCEEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEEEE
DTTNILFICGGAFDGLEKIIRARSEKGGIGFSASVRSQDNRKDFGAVLRGVEPEDLVKYG
ECCEEEEEECCCHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHCCCCHHHHHHHC
LIPEFVGRLPVVATLEELDEAALIQILTEPRNALIKQYQKMFHMEGGIDLEFREQALKAI
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ARKALVRKTGARGLRSILEAALLDTMFDLPSLENVAKVVIDHTSVNGDIKPILIYSDKPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCC
VAKSC
HHCCC
>Mature Secondary Structure 
SEKTGGEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIELCNDIIREEIQGVEAAKLAK
CCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SDLPVPHEIRQILDQYVIGQEQAKKILSVAVYNHYKRLRTLAKSADPDEIELAKSNILLI
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCEEEE
GPTGSGKTLLAQTLARLLDVPFVMADATTLTEAGYVGEDVENIIQKLLQKCNYDAEKAQQ
ECCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHC
GIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFVQV
CCEEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEEEE
DTTNILFICGGAFDGLEKIIRARSEKGGIGFSASVRSQDNRKDFGAVLRGVEPEDLVKYG
ECCEEEEEECCCHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHCCCCHHHHHHHC
LIPEFVGRLPVVATLEELDEAALIQILTEPRNALIKQYQKMFHMEGGIDLEFREQALKAI
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ARKALVRKTGARGLRSILEAALLDTMFDLPSLENVAKVVIDHTSVNGDIKPILIYSDKPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCC
VAKSC
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA