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The map label for this gene is nuoM [H]

Identifier: 82702153

GI number: 82702153

Start: 1185536

End: 1187038

Strand: Direct

Name: nuoM [H]

Synonym: Nmul_A1024

Alternate gene names: 82702153

Gene position: 1185536-1187038 (Clockwise)

Preceding gene: 82702152

Following gene: 82702154

Centisome position: 37.23

GC content: 56.75

Gene sequence:

>1503_bases
ATGGTCCTCGCTGCATTGATTTTCATCCCAATATCGGGCGGTTTGCTCGCATGGATGGCGGACCGGTGGCAGCCGGGTGC
GGCAAAGTGGGTCGCCTTGGTCACGGCGGGTATCGAGTTCGTATTGACGATGGGACTTTGGCTGCAGTCTGCCAGCGCTA
TGGCTCTTCCCGCTCACGGGGGGTGGCTTGTCGAGACCCGGGCGGAATGGATTCCGCGTTTCGGAGTGAGCTTTCATCTG
GCCGTGGATGGAACAAGCCTCATCCTGGTCGTGCTGACCGCTTTTCTGGGGATAGTATCGGTGGCATGTTCCTGGACGGA
AATCCAGAAGCGTGTCGGATTCTTTTACTTCAACCTGCTATGGACTGTGGCAGGGGCGATCGGTGTATTCCTTGCGCTGG
ACCTGTTTCTGTTTTTCTTCTTTTGGGAGCTGATGCTGGTGCCGATGTATTTCCTGATCGGGATCTGGGGCCATGAGAAT
CGGCAGTATGCATCGATCAAGTTCTTCATTTTCGCGCAGGGGAGCGGCATGTTCATGCTGGTGGCAATTCTTGCGCTGGT
ATTCGTTCATTACCGCGGTACTGGAGTCCTGACATTCGATTATTTCGATCTGCTGAATGCCACCCTCTCTCCCTCCACCG
AGTTGTGGATCATGCTCGGCTTTTTCATTGCGTTCGCAGTCAAGACCCCCATCGTGCCATTTCACACCTGGCTGCCGGAT
GCACATACCGAGGCGCCGACAGCAGGAAGCGTGATTCTTGCAGGAGTGCTGCTGAAAACAGGAGCCTACGGACTATTGCG
TTTTATTGTTCCGCTATTTCCCGAGGCCGCGGCGTATTTTGCTCCGGTGGCGATGGTGCTGGGAGCAACCGGGGTTCTCT
ATGGCGCTTTCCTGGCGTTCGCCCAGACGGATTTCAAGCGCCTCGTGGCCTACACCAGCGTGAGTCACCTGGGGTTTGCA
GTGCTCGGGATATTCGCCTGGAATCCCTGGTCGCTTGGGGGAGCCGTGATGCAGATGATCGCGCACGGCATCAGTACGGG
GGCACTGTTTGTAATCGCTGGCATTTTGCAGGAGCGGACCCACACACGCGATATGCAGCGCTTTGAAGGCCTGTGGAGCG
TCATGCCGCGCCTGGCGGCAATGGGATTGTTTTTTGCCATTGCCGCGCTTGGGCTGCCGGGAATGGGAAACTTCGTCGGG
GAATTCCTGGTACTGATGGGATTATCCAGCAGCAGCAGCGTGCTGGCGTCCGCGGCGACCGTGGTATTTGTCGCCAGTGT
CGTATATGCGCTTGCGCTGGTGCAGAAAACTTTTCATGGCGAGAACAAGCATGGTTGGCAACTACATGATCTGTCAGGCC
GTGAAATGGCAACCCTGTTCTCAATGGCAGCCATTACCCTATGGCTGGGCCTGTATCCCCAGCCGGTCCTGAATGCCGCG
CCAAACCCCGCAAACAGTCCGCCTGCGATTGCTGTTGCCCACCATGAGGTCAATGTGGAATGA

Upstream 100 bases:

>100_bases
TCCATCGCACCTTGAGTGCAACGCAAAGCGGACAGGTACGCCGCTACGCGGCAGCGATTGCCGCCGGATCGATCGGCATT
ATATTCGTGGGGGTATTCGC

Downstream 100 bases:

>100_bases
ATCCGATGCCCTCTGCACTACCCTCCGATTTTCTGCACGTGGACCTCGTGACCCTGTCGCCGCTCATTCTCCTTGCCGCA
GCAGCGGTAGTGGTGATGCT

Product: proton-translocating NADH-quinone oxidoreductase, chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MVLAALIFIPISGGLLAWMADRWQPGAAKWVALVTAGIEFVLTMGLWLQSASAMALPAHGGWLVETRAEWIPRFGVSFHL
AVDGTSLILVVLTAFLGIVSVACSWTEIQKRVGFFYFNLLWTVAGAIGVFLALDLFLFFFFWELMLVPMYFLIGIWGHEN
RQYASIKFFIFAQGSGMFMLVAILALVFVHYRGTGVLTFDYFDLLNATLSPSTELWIMLGFFIAFAVKTPIVPFHTWLPD
AHTEAPTAGSVILAGVLLKTGAYGLLRFIVPLFPEAAAYFAPVAMVLGATGVLYGAFLAFAQTDFKRLVAYTSVSHLGFA
VLGIFAWNPWSLGGAVMQMIAHGISTGALFVIAGILQERTHTRDMQRFEGLWSVMPRLAAMGLFFAIAALGLPGMGNFVG
EFLVLMGLSSSSSVLASAATVVFVASVVYALALVQKTFHGENKHGWQLHDLSGREMATLFSMAAITLWLGLYPQPVLNAA
PNPANSPPAIAVAHHEVNVE

Sequences:

>Translated_500_residues
MVLAALIFIPISGGLLAWMADRWQPGAAKWVALVTAGIEFVLTMGLWLQSASAMALPAHGGWLVETRAEWIPRFGVSFHL
AVDGTSLILVVLTAFLGIVSVACSWTEIQKRVGFFYFNLLWTVAGAIGVFLALDLFLFFFFWELMLVPMYFLIGIWGHEN
RQYASIKFFIFAQGSGMFMLVAILALVFVHYRGTGVLTFDYFDLLNATLSPSTELWIMLGFFIAFAVKTPIVPFHTWLPD
AHTEAPTAGSVILAGVLLKTGAYGLLRFIVPLFPEAAAYFAPVAMVLGATGVLYGAFLAFAQTDFKRLVAYTSVSHLGFA
VLGIFAWNPWSLGGAVMQMIAHGISTGALFVIAGILQERTHTRDMQRFEGLWSVMPRLAAMGLFFAIAALGLPGMGNFVG
EFLVLMGLSSSSSVLASAATVVFVASVVYALALVQKTFHGENKHGWQLHDLSGREMATLFSMAAITLWLGLYPQPVLNAA
PNPANSPPAIAVAHHEVNVE
>Mature_500_residues
MVLAALIFIPISGGLLAWMADRWQPGAAKWVALVTAGIEFVLTMGLWLQSASAMALPAHGGWLVETRAEWIPRFGVSFHL
AVDGTSLILVVLTAFLGIVSVACSWTEIQKRVGFFYFNLLWTVAGAIGVFLALDLFLFFFFWELMLVPMYFLIGIWGHEN
RQYASIKFFIFAQGSGMFMLVAILALVFVHYRGTGVLTFDYFDLLNATLSPSTELWIMLGFFIAFAVKTPIVPFHTWLPD
AHTEAPTAGSVILAGVLLKTGAYGLLRFIVPLFPEAAAYFAPVAMVLGATGVLYGAFLAFAQTDFKRLVAYTSVSHLGFA
VLGIFAWNPWSLGGAVMQMIAHGISTGALFVIAGILQERTHTRDMQRFEGLWSVMPRLAAMGLFFAIAALGLPGMGNFVG
EFLVLMGLSSSSSVLASAATVVFVASVVYALALVQKTFHGENKHGWQLHDLSGREMATLFSMAAITLWLGLYPQPVLNAA
PNPANSPPAIAVAHHEVNVE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=354, Percent_Identity=33.8983050847458, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1788613, Length=489, Percent_Identity=53.3742331288344, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1788827, Length=405, Percent_Identity=26.1728395061728, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1788831, Length=263, Percent_Identity=27.3764258555133, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1788614, Length=389, Percent_Identity=24.9357326478149, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693160, Length=428, Percent_Identity=27.3364485981308, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788829, Length=342, Percent_Identity=25.7309941520468, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI2367154, Length=307, Percent_Identity=24.1042345276873, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54303; Mature: 54303

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLAALIFIPISGGLLAWMADRWQPGAAKWVALVTAGIEFVLTMGLWLQSASAMALPAHG
CCEEEEEEHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
GWLVETRAEWIPRFGVSFHLAVDGTSLILVVLTAFLGIVSVACSWTEIQKRVGFFYFNLL
CEEEECHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
WTVAGAIGVFLALDLFLFFFFWELMLVPMYFLIGIWGHENRQYASIKFFIFAQGSGMFML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHH
VAILALVFVHYRGTGVLTFDYFDLLNATLSPSTELWIMLGFFIAFAVKTPIVPFHTWLPD
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCC
AHTEAPTAGSVILAGVLLKTGAYGLLRFIVPLFPEAAAYFAPVAMVLGATGVLYGAFLAF
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQTDFKRLVAYTSVSHLGFAVLGIFAWNPWSLGGAVMQMIAHGISTGALFVIAGILQERT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HTRDMQRFEGLWSVMPRLAAMGLFFAIAALGLPGMGNFVGEFLVLMGLSSSSSVLASAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
VVFVASVVYALALVQKTFHGENKHGWQLHDLSGREMATLFSMAAITLWLGLYPQPVLNAA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCC
PNPANSPPAIAVAHHEVNVE
CCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MVLAALIFIPISGGLLAWMADRWQPGAAKWVALVTAGIEFVLTMGLWLQSASAMALPAHG
CCEEEEEEHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
GWLVETRAEWIPRFGVSFHLAVDGTSLILVVLTAFLGIVSVACSWTEIQKRVGFFYFNLL
CEEEECHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
WTVAGAIGVFLALDLFLFFFFWELMLVPMYFLIGIWGHENRQYASIKFFIFAQGSGMFML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHH
VAILALVFVHYRGTGVLTFDYFDLLNATLSPSTELWIMLGFFIAFAVKTPIVPFHTWLPD
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCC
AHTEAPTAGSVILAGVLLKTGAYGLLRFIVPLFPEAAAYFAPVAMVLGATGVLYGAFLAF
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQTDFKRLVAYTSVSHLGFAVLGIFAWNPWSLGGAVMQMIAHGISTGALFVIAGILQERT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HTRDMQRFEGLWSVMPRLAAMGLFFAIAALGLPGMGNFVGEFLVLMGLSSSSSVLASAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
VVFVASVVYALALVQKTFHGENKHGWQLHDLSGREMATLFSMAAITLWLGLYPQPVLNAA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCC
PNPANSPPAIAVAHHEVNVE
CCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]