Click here to switch to the map view.

The map label for this gene is nuoL [H]

Identifier: 82702152

GI number: 82702152

Start: 1183566

End: 1185554

Strand: Direct

Name: nuoL [H]

Synonym: Nmul_A1023

Alternate gene names: 82702152

Gene position: 1183566-1185554 (Clockwise)

Preceding gene: 82702151

Following gene: 82702153

Centisome position: 37.17

GC content: 57.16

Gene sequence:

>1989_bases
ATGCTGTCCCTGCTCTGGCTCATCCCCACGCTGCCTCTAGCCGGTTTCCTGCTGCTGGTGCTGGGTGGAAACCATCTGGG
GCACCGCAGTATTGCGATGATTGGGACAGGATCGGTGGCGCTCTCGGCACTCGTTGCCATCCTGATCGGGATCGATTTCA
TCACTGCGCCGCCACCGGGTTTTGTTTTCCGGCAGGAAGCATGGACCTGGATCGCTGTGGCCGGTTTCTCGCCAGGGATT
GTTTTTTATCTTGACGCGTTATCGCTGGTGATGGTCGTGGTCGTGACTGTCATCAGTTTCCTGATACACCTCTATTCCAC
AGAGTTCATGAGCGGCGATGAGGGCTATGCCCGCTTTTTCGCCTATATGAATCTCTTCGTCGGCTCGATGTGCATCCTGG
TTCTTGCCGACAACCTGCTGTTTCTTTACCTGGGCTGGGAAGGAGTGGGACTTTGCAGCTACCTGCTGATCGGATTCTGG
TATCGCGATCCTGCCAACGGGCGCGCGGCACGCAAAGCATTTATCGTGACCCGGGTCGGCGATACCGCCATGGCGATCGG
CTTTTTTCTGCTGTTCACTCATCTGGGAACCCTTGATATCCAGCCGTTGATGCAGCGGGCGACGCAGGAGTGGCCGGTGG
GGTCGGAACTCGCTATTCTCGCTGCAGCGCTTCTGCTTGGCGGTGCGGCAGGCAAATCTGCCCAACTCCCGCTACAGACG
TGGCTGCCGGACGCAATGGCCGGCCCCACGCCGGTGAGCGCGCTGATGCATGCGGCGACCATGGTAACGGCAGGCGTATA
TCTGATTGCCCGCACGCACGCGCTCTTTGTGCTTGCGCCGGCAGTGCAGTTCGCGGTAGCAGCGGTCGGCGCGCTTACCC
TGCTGCTGGCCGGGTTCAGCGCGCTCGCACAAAACGACATCAAGCGGGTACTGGCCTATTCGACCATCAGCCAGCTAGGT
TATATGTTCCTTGCCCTGGGAGTAGGGGCTTGGTCAGCCGCCATCTTTCACCTCGTGACGCACGCTTTCTTCAAGGCTCT
GCTGTTCCTGAGCGCGGGCGTGGTCATCATGAGCCTGCACGAGGAACATGATATTTTCCGGATGGGTGCATTGAGGAAAA
AACTCCCCGTCACTTTCTGGACCTTTCTGATTGGCAGCGCCTCGCTTGCGGCACTGCCGCTCGTTACCGCGGGCTTCTAT
AGCAAGGATCTGATTCTTTGGCAGGCCTGGTCGTCGAGAGGAGGGAATCCATGGTTATGGGCCGCGGGATGGGGAGGTGC
AATATTGACGGGCCTCTACATCTTTCGCGTAGTGTTTCTCGTCTTTTTTGGCGAAGCGAGGACTGTGGCGCCCCCCGAAA
TCCGCCGGCCAGGGCGGCGCATAACTGTACCGCTCATCGTTCTTGCAGCCTTTTCTGTGGTTGGCGGATGGATCGAAACT
CCATCTTTTCTCGGAAATTTAACGCTGTTTTCCGATTTCATTCAGCATGCCCTGCCGCCGACTCAGGTTGTTCATGACAG
TAAAAATGACGAAATCGTTCTGGAACTGCTCGCAATTGCTGCCTCTCTTGGCAGCATTGCGCTGGCGTACCTGCTGTTTT
TGAGATATCCCGCCTTTCTCCATGGACTGATGCTGGTCCCGGCATTAGCAAGCATCCGGAAGCTCTGGCATTTTGGCTGG
GGTTTCGACAGTTTTTATGAGTTCCTGTTCGTCCGGCCCTATCTCTGGCTTGCCCACGCCGATCAGCGTGACGTGATCGA
CGATCTCTACCGCATGTCCTTTTCATGCACACTCAGGTGTCTCCAGAAGATCAATCGGCACGACCTGATCGACAATCTCT
ACAGCGGCCTGGCTGGGCTTTGTCTGTTTTTCCATCGCACCTTGAGTGCAACGCAAAGCGGACAGGTACGCCGCTACGCG
GCAGCGATTGCCGCCGGATCGATCGGCATTATATTCGTGGGGGTATTCGCATGGTCCTCGCTGCATTGA

Upstream 100 bases:

>100_bases
GCAAACTCACCAAAAAAGGTAAAGATCAAGTGTCGTAAAAAAATTTTGTAATCAGGGTGGTAACTGAAAATGAGCGATCA
ACTGCCAGGTTTAGGATAAT

Downstream 100 bases:

>100_bases
TTTTCATCCCAATATCGGGCGGTTTGCTCGCATGGATGGCGGACCGGTGGCAGCCGGGTGCGGCAAAGTGGGTCGCCTTG
GTCACGGCGGGTATCGAGTT

Product: proton-translocating NADH-quinone oxidoreductase, chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MLSLLWLIPTLPLAGFLLLVLGGNHLGHRSIAMIGTGSVALSALVAILIGIDFITAPPPGFVFRQEAWTWIAVAGFSPGI
VFYLDALSLVMVVVVTVISFLIHLYSTEFMSGDEGYARFFAYMNLFVGSMCILVLADNLLFLYLGWEGVGLCSYLLIGFW
YRDPANGRAARKAFIVTRVGDTAMAIGFFLLFTHLGTLDIQPLMQRATQEWPVGSELAILAAALLLGGAAGKSAQLPLQT
WLPDAMAGPTPVSALMHAATMVTAGVYLIARTHALFVLAPAVQFAVAAVGALTLLLAGFSALAQNDIKRVLAYSTISQLG
YMFLALGVGAWSAAIFHLVTHAFFKALLFLSAGVVIMSLHEEHDIFRMGALRKKLPVTFWTFLIGSASLAALPLVTAGFY
SKDLILWQAWSSRGGNPWLWAAGWGGAILTGLYIFRVVFLVFFGEARTVAPPEIRRPGRRITVPLIVLAAFSVVGGWIET
PSFLGNLTLFSDFIQHALPPTQVVHDSKNDEIVLELLAIAASLGSIALAYLLFLRYPAFLHGLMLVPALASIRKLWHFGW
GFDSFYEFLFVRPYLWLAHADQRDVIDDLYRMSFSCTLRCLQKINRHDLIDNLYSGLAGLCLFFHRTLSATQSGQVRRYA
AAIAAGSIGIIFVGVFAWSSLH

Sequences:

>Translated_662_residues
MLSLLWLIPTLPLAGFLLLVLGGNHLGHRSIAMIGTGSVALSALVAILIGIDFITAPPPGFVFRQEAWTWIAVAGFSPGI
VFYLDALSLVMVVVVTVISFLIHLYSTEFMSGDEGYARFFAYMNLFVGSMCILVLADNLLFLYLGWEGVGLCSYLLIGFW
YRDPANGRAARKAFIVTRVGDTAMAIGFFLLFTHLGTLDIQPLMQRATQEWPVGSELAILAAALLLGGAAGKSAQLPLQT
WLPDAMAGPTPVSALMHAATMVTAGVYLIARTHALFVLAPAVQFAVAAVGALTLLLAGFSALAQNDIKRVLAYSTISQLG
YMFLALGVGAWSAAIFHLVTHAFFKALLFLSAGVVIMSLHEEHDIFRMGALRKKLPVTFWTFLIGSASLAALPLVTAGFY
SKDLILWQAWSSRGGNPWLWAAGWGGAILTGLYIFRVVFLVFFGEARTVAPPEIRRPGRRITVPLIVLAAFSVVGGWIET
PSFLGNLTLFSDFIQHALPPTQVVHDSKNDEIVLELLAIAASLGSIALAYLLFLRYPAFLHGLMLVPALASIRKLWHFGW
GFDSFYEFLFVRPYLWLAHADQRDVIDDLYRMSFSCTLRCLQKINRHDLIDNLYSGLAGLCLFFHRTLSATQSGQVRRYA
AAIAAGSIGIIFVGVFAWSSLH
>Mature_662_residues
MLSLLWLIPTLPLAGFLLLVLGGNHLGHRSIAMIGTGSVALSALVAILIGIDFITAPPPGFVFRQEAWTWIAVAGFSPGI
VFYLDALSLVMVVVVTVISFLIHLYSTEFMSGDEGYARFFAYMNLFVGSMCILVLADNLLFLYLGWEGVGLCSYLLIGFW
YRDPANGRAARKAFIVTRVGDTAMAIGFFLLFTHLGTLDIQPLMQRATQEWPVGSELAILAAALLLGGAAGKSAQLPLQT
WLPDAMAGPTPVSALMHAATMVTAGVYLIARTHALFVLAPAVQFAVAAVGALTLLLAGFSALAQNDIKRVLAYSTISQLG
YMFLALGVGAWSAAIFHLVTHAFFKALLFLSAGVVIMSLHEEHDIFRMGALRKKLPVTFWTFLIGSASLAALPLVTAGFY
SKDLILWQAWSSRGGNPWLWAAGWGGAILTGLYIFRVVFLVFFGEARTVAPPEIRRPGRRITVPLIVLAAFSVVGGWIET
PSFLGNLTLFSDFIQHALPPTQVVHDSKNDEIVLELLAIAASLGSIALAYLLFLRYPAFLHGLMLVPALASIRKLWHFGW
GFDSFYEFLFVRPYLWLAHADQRDVIDDLYRMSFSCTLRCLQKINRHDLIDNLYSGLAGLCLFFHRTLSATQSGQVRRYA
AAIAAGSIGIIFVGVFAWSSLH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=415, Percent_Identity=38.7951807228916, Blast_Score=258, Evalue=9e-69,
Organism=Escherichia coli, GI1788614, Length=592, Percent_Identity=50.1689189189189, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1788829, Length=336, Percent_Identity=36.3095238095238, Blast_Score=162, Evalue=7e-41,
Organism=Escherichia coli, GI1788827, Length=369, Percent_Identity=33.8753387533875, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI1788831, Length=338, Percent_Identity=27.810650887574, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI2367154, Length=381, Percent_Identity=26.7716535433071, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1788613, Length=319, Percent_Identity=29.4670846394984, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693160, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 72220; Mature: 72220

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLLWLIPTLPLAGFLLLVLGGNHLGHRSIAMIGTGSVALSALVAILIGIDFITAPPPG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
FVFRQEAWTWIAVAGFSPGIVFYLDALSLVMVVVVTVISFLIHLYSTEFMSGDEGYARFF
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AYMNLFVGSMCILVLADNLLFLYLGWEGVGLCSYLLIGFWYRDPANGRAARKAFIVTRVG
HHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECC
DTAMAIGFFLLFTHLGTLDIQPLMQRATQEWPVGSELAILAAALLLGGAAGKSAQLPLQT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
WLPDAMAGPTPVSALMHAATMVTAGVYLIARTHALFVLAPAVQFAVAAVGALTLLLAGFS
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQNDIKRVLAYSTISQLGYMFLALGVGAWSAAIFHLVTHAFFKALLFLSAGVVIMSLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEH
EEHDIFRMGALRKKLPVTFWTFLIGSASLAALPLVTAGFYSKDLILWQAWSSRGGNPWLW
HHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCEEE
AAGWGGAILTGLYIFRVVFLVFFGEARTVAPPEIRRPGRRITVPLIVLAAFSVVGGWIET
ECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEHHHHHHHHHHHHHCCHHCC
PSFLGNLTLFSDFIQHALPPTQVVHDSKNDEIVLELLAIAASLGSIALAYLLFLRYPAFL
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGLMLVPALASIRKLWHFGWGFDSFYEFLFVRPYLWLAHADQRDVIDDLYRMSFSCTLRC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LQKINRHDLIDNLYSGLAGLCLFFHRTLSATQSGQVRRYAAAIAAGSIGIIFVGVFAWSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHC
LH
CC
>Mature Secondary Structure
MLSLLWLIPTLPLAGFLLLVLGGNHLGHRSIAMIGTGSVALSALVAILIGIDFITAPPPG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
FVFRQEAWTWIAVAGFSPGIVFYLDALSLVMVVVVTVISFLIHLYSTEFMSGDEGYARFF
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AYMNLFVGSMCILVLADNLLFLYLGWEGVGLCSYLLIGFWYRDPANGRAARKAFIVTRVG
HHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECC
DTAMAIGFFLLFTHLGTLDIQPLMQRATQEWPVGSELAILAAALLLGGAAGKSAQLPLQT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
WLPDAMAGPTPVSALMHAATMVTAGVYLIARTHALFVLAPAVQFAVAAVGALTLLLAGFS
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQNDIKRVLAYSTISQLGYMFLALGVGAWSAAIFHLVTHAFFKALLFLSAGVVIMSLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEH
EEHDIFRMGALRKKLPVTFWTFLIGSASLAALPLVTAGFYSKDLILWQAWSSRGGNPWLW
HHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCEEE
AAGWGGAILTGLYIFRVVFLVFFGEARTVAPPEIRRPGRRITVPLIVLAAFSVVGGWIET
ECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEHHHHHHHHHHHHHCCHHCC
PSFLGNLTLFSDFIQHALPPTQVVHDSKNDEIVLELLAIAASLGSIALAYLLFLRYPAFL
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGLMLVPALASIRKLWHFGWGFDSFYEFLFVRPYLWLAHADQRDVIDDLYRMSFSCTLRC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LQKINRHDLIDNLYSGLAGLCLFFHRTLSATQSGQVRRYAAAIAAGSIGIIFVGVFAWSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHC
LH
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]