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The map label for this gene is hisB

Identifier: 82701950

GI number: 82701950

Start: 931604

End: 932191

Strand: Reverse

Name: hisB

Synonym: Nmul_A0817

Alternate gene names: 82701950

Gene position: 932191-931604 (Counterclockwise)

Preceding gene: 82701951

Following gene: 82701949

Centisome position: 29.28

GC content: 56.97

Gene sequence:

>588_bases
ATGCGTCACGCTCAGGTCAACCGTAATACGCTGGAAACCCGCATCAACATCAAAGTCAATCTCGATGGAAGCGGAAAGGC
GGTTCTGGCTACAGGGGTACCGTTTCTCGATCATATGCTGGACCAGGTTGCGCGTCACGGAATGATCGATCTCGAGGTTT
CAGCCGAGGGAGATTTGCATATCGACGCTCACCACACGGTGGAAGATATCGGCATCACTTTTGGGCAGGCATTCACCCAG
GCGGTTGGAACCAAGAGCGGCTTGCGCCGCTACGGCCATTCCTACGTGCCCCTGGACGAAGCCCTCTCCCGGGTGGTGAT
CGATCTATCCGGCCGCCCCGGAATGGAGTTCAATGTCGAGTTTGTGCGGGCGCGTATCGGGGAATTCGATGTCGATCTCA
TCAGCGAATTTTTCCGGGGTTTTGTCAACCACGCCATGGTTACCCTGCATATCGACAACTTATCGGGCACAAATGCGCAT
CACCAGGCGGAAACCATATTCAAGGCGTTCGGGCGCGCGCTGCGCATGGCGGTGGAAGCCGATCCGCGGGCAGCGGGTGC
AATACCCTCCACCAAAGGCACTCTGTAA

Upstream 100 bases:

>100_bases
GGTCCTGCAAACTTTGCTCGTGAAGGTTGAAGCGAAAGCCTGACGCCCTATCCCCATTTTTATTGCAGTTTTATTCGATT
TATTTCACCTGATTCCTCGC

Downstream 100 bases:

>100_bases
TTTCCCACACTCATAGATGCGGTATGACTGATATTGCAATTGTTGACTACGGCATGGGAAACCTGCGTTCCGTAGCCAAA
GCACTGGAACATGTCGCCCC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRHAQVNRNTLETRINIKVNLDGSGKAVLATGVPFLDHMLDQVARHGMIDLEVSAEGDLHIDAHHTVEDIGITFGQAFTQ
AVGTKSGLRRYGHSYVPLDEALSRVVIDLSGRPGMEFNVEFVRARIGEFDVDLISEFFRGFVNHAMVTLHIDNLSGTNAH
HQAETIFKAFGRALRMAVEADPRAAGAIPSTKGTL

Sequences:

>Translated_195_residues
MRHAQVNRNTLETRINIKVNLDGSGKAVLATGVPFLDHMLDQVARHGMIDLEVSAEGDLHIDAHHTVEDIGITFGQAFTQ
AVGTKSGLRRYGHSYVPLDEALSRVVIDLSGRPGMEFNVEFVRARIGEFDVDLISEFFRGFVNHAMVTLHIDNLSGTNAH
HQAETIFKAFGRALRMAVEADPRAAGAIPSTKGTL
>Mature_195_residues
MRHAQVNRNTLETRINIKVNLDGSGKAVLATGVPFLDHMLDQVARHGMIDLEVSAEGDLHIDAHHTVEDIGITFGQAFTQ
AVGTKSGLRRYGHSYVPLDEALSRVVIDLSGRPGMEFNVEFVRARIGEFDVDLISEFFRGFVNHAMVTLHIDNLSGTNAH
HQAETIFKAFGRALRMAVEADPRAAGAIPSTKGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=45.8762886597938, Blast_Score=182, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.4495412844037, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_NITMU (Q2YAU7)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411516.1
- HSSP:   P34047
- ProteinModelPortal:   Q2YAU7
- SMR:   Q2YAU7
- STRING:   Q2YAU7
- GeneID:   3785861
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0817
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q2YAU7
- BioCyc:   NMUL323848:NMUL_A0817-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21342; Mature: 21342

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHAQVNRNTLETRINIKVNLDGSGKAVLATGVPFLDHMLDQVARHGMIDLEVSAEGDLH
CCCCCCCCCEEEEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCEE
IDAHHTVEDIGITFGQAFTQAVGTKSGLRRYGHSYVPLDEALSRVVIDLSGRPGMEFNVE
EECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCEEHHH
FVRARIGEFDVDLISEFFRGFVNHAMVTLHIDNLSGTNAHHQAETIFKAFGRALRMAVEA
HHHHHHCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
DPRAAGAIPSTKGTL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRHAQVNRNTLETRINIKVNLDGSGKAVLATGVPFLDHMLDQVARHGMIDLEVSAEGDLH
CCCCCCCCCEEEEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCEE
IDAHHTVEDIGITFGQAFTQAVGTKSGLRRYGHSYVPLDEALSRVVIDLSGRPGMEFNVE
EECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCEEHHH
FVRARIGEFDVDLISEFFRGFVNHAMVTLHIDNLSGTNAHHQAETIFKAFGRALRMAVEA
HHHHHHCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
DPRAAGAIPSTKGTL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA