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The map label for this gene is hisC1

Identifier: 82701951

GI number: 82701951

Start: 932249

End: 933355

Strand: Reverse

Name: hisC1

Synonym: Nmul_A0818

Alternate gene names: 82701951

Gene position: 933355-932249 (Counterclockwise)

Preceding gene: 82701952

Following gene: 82701950

Centisome position: 29.31

GC content: 53.21

Gene sequence:

>1107_bases
TTGGCTGTTATGCCTTTTTCCCCCGATCAGATCATTCGCCCCGAAATTCTCGCGCTTTCCGCTTACCACGTGCCTCCCGC
ATGCGGAATGATAAAGCTGGATGCGATGGAAAACCCTTACCCGCTTCCCCCGGAATTGCGCGATGAAATTGCGAAGCTTG
CAGGTGAGACGCCGGTCAATCGCTACCCCGACCCCGATGCAGCAGCGCTCAAAGCGGCGTTACGCGAGGCATTGAGCATC
CCGGACGGGATGGATATCATGCTCGGCAATGGTTCGGATGAGATCATCCAGATTATTGCTTTAGCATGCGGGAAGCCCGG
CGCGGTATTGATGAGCGTGGAGCCTGCATTCGTCATGTTTCGCATGATTGCCACTTTTGCTTCGATGAATTATGTGGGTG
TCCCATTACATCCCGATTTTTCACTCGACGCGGAGGCAATGCTTGCCGCAATTGCGCGATACCAGCCTGCGGTCATTTTT
ATCGCCTATCCCAATAACCCTACAGGTAACCTGTTTGACGCCGTTGAAATCTCACGTATTATTGACGCTGCCCCGGGCGT
GGTGGTCGTCGATGAGGCTTACCATGCCTTCGCCGATGCGAGTTTCATGGACAAGCTCGCGCATCATCCCAATCTGTTGC
TGATGCGCACACTTTCGAAGCTGGGAATGGCCGGCTTGAGGCTGGGCTTGCTGGCGGGAAAACCCGAATGGCTAAGACAG
CTGGAAAAATTGCGGCTGCCGTATAATGTAGGAATCGTTACTCAACGGATTGCAGAGAAATTACTGCAGCACCGTGATGT
CCTGCTGCAACAGGCGGCAGCCATCAAGCTTGAACGTTCATCGATGAGCAGGCGGCTGGCGGAATTGGAAGGTATCGAGG
TTTTTCCGACGGATGCGAATTTCATCCTGTTTCGCCTGAACCAGGATCATAAGGCAACCCAGGTATTTCAGGAACTCAAA
CAACGTGGCATATTGGTCAAAAATCTGGACGGCGCTCACCCATTGCTCAAAAACTGCTTGCGGGTGACCGTGGGAATGCC
GGATGAAAATGCGCAGTTTCTGGAGGTCCTGCAAACTTTGCTCGTGAAGGTTGAAGCGAAAGCCTGA

Upstream 100 bases:

>100_bases
GCCCTATGATCCCACCGGCCCAGGCTCAAGGAACTATCGACATCCGGCTCGGCGGGGGGATGAATAAACCTGAGGTAATT
AACTCGACCATGAGGTAGAA

Downstream 100 bases:

>100_bases
CGCCCTATCCCCATTTTTATTGCAGTTTTATTCGATTTATTTCACCTGATTCCTCGCATGCGTCACGCTCAGGTCAACCG
TAATACGCTGGAAACCCGCA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MAVMPFSPDQIIRPEILALSAYHVPPACGMIKLDAMENPYPLPPELRDEIAKLAGETPVNRYPDPDAAALKAALREALSI
PDGMDIMLGNGSDEIIQIIALACGKPGAVLMSVEPAFVMFRMIATFASMNYVGVPLHPDFSLDAEAMLAAIARYQPAVIF
IAYPNNPTGNLFDAVEISRIIDAAPGVVVVDEAYHAFADASFMDKLAHHPNLLLMRTLSKLGMAGLRLGLLAGKPEWLRQ
LEKLRLPYNVGIVTQRIAEKLLQHRDVLLQQAAAIKLERSSMSRRLAELEGIEVFPTDANFILFRLNQDHKATQVFQELK
QRGILVKNLDGAHPLLKNCLRVTVGMPDENAQFLEVLQTLLVKVEAKA

Sequences:

>Translated_368_residues
MAVMPFSPDQIIRPEILALSAYHVPPACGMIKLDAMENPYPLPPELRDEIAKLAGETPVNRYPDPDAAALKAALREALSI
PDGMDIMLGNGSDEIIQIIALACGKPGAVLMSVEPAFVMFRMIATFASMNYVGVPLHPDFSLDAEAMLAAIARYQPAVIF
IAYPNNPTGNLFDAVEISRIIDAAPGVVVVDEAYHAFADASFMDKLAHHPNLLLMRTLSKLGMAGLRLGLLAGKPEWLRQ
LEKLRLPYNVGIVTQRIAEKLLQHRDVLLQQAAAIKLERSSMSRRLAELEGIEVFPTDANFILFRLNQDHKATQVFQELK
QRGILVKNLDGAHPLLKNCLRVTVGMPDENAQFLEVLQTLLVKVEAKA
>Mature_367_residues
AVMPFSPDQIIRPEILALSAYHVPPACGMIKLDAMENPYPLPPELRDEIAKLAGETPVNRYPDPDAAALKAALREALSIP
DGMDIMLGNGSDEIIQIIALACGKPGAVLMSVEPAFVMFRMIATFASMNYVGVPLHPDFSLDAEAMLAAIARYQPAVIFI
AYPNNPTGNLFDAVEISRIIDAAPGVVVVDEAYHAFADASFMDKLAHHPNLLLMRTLSKLGMAGLRLGLLAGKPEWLRQL
EKLRLPYNVGIVTQRIAEKLLQHRDVLLQQAAAIKLERSSMSRRLAELEGIEVFPTDANFILFRLNQDHKATQVFQELKQ
RGILVKNLDGAHPLLKNCLRVTVGMPDENAQFLEVLQTLLVKVEAKA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=339, Percent_Identity=28.9085545722714, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322075, Length=391, Percent_Identity=29.923273657289, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_NITMU (Q2YAU6)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411517.1
- ProteinModelPortal:   Q2YAU6
- SMR:   Q2YAU6
- STRING:   Q2YAU6
- GeneID:   3785862
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0818
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- PhylomeDB:   Q2YAU6
- ProtClustDB:   PRK04870
- BioCyc:   NMUL323848:NMUL_A0818-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40456; Mature: 40325

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMPFSPDQIIRPEILALSAYHVPPACGMIKLDAMENPYPLPPELRDEIAKLAGETPVN
CCCCCCCCCCCCCCHHEEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC
RYPDPDAAALKAALREALSIPDGMDIMLGNGSDEIIQIIALACGKPGAVLMSVEPAFVMF
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHH
RMIATFASMNYVGVPLHPDFSLDAEAMLAAIARYQPAVIFIAYPNNPTGNLFDAVEISRI
HHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHH
IDAAPGVVVVDEAYHAFADASFMDKLAHHPNLLLMRTLSKLGMAGLRLGLLAGKPEWLRQ
HHCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHCCCHHHHHH
LEKLRLPYNVGIVTQRIAEKLLQHRDVLLQQAAAIKLERSSMSRRLAELEGIEVFPTDAN
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
FILFRLNQDHKATQVFQELKQRGILVKNLDGAHPLLKNCLRVTVGMPDENAQFLEVLQTL
EEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHEECCCCCCCHHHHHHHHHH
LVKVEAKA
HHHHCCCC
>Mature Secondary Structure 
AVMPFSPDQIIRPEILALSAYHVPPACGMIKLDAMENPYPLPPELRDEIAKLAGETPVN
CCCCCCCCCCCCCHHEEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC
RYPDPDAAALKAALREALSIPDGMDIMLGNGSDEIIQIIALACGKPGAVLMSVEPAFVMF
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHH
RMIATFASMNYVGVPLHPDFSLDAEAMLAAIARYQPAVIFIAYPNNPTGNLFDAVEISRI
HHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHH
IDAAPGVVVVDEAYHAFADASFMDKLAHHPNLLLMRTLSKLGMAGLRLGLLAGKPEWLRQ
HHCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHCCCHHHHHH
LEKLRLPYNVGIVTQRIAEKLLQHRDVLLQQAAAIKLERSSMSRRLAELEGIEVFPTDAN
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
FILFRLNQDHKATQVFQELKQRGILVKNLDGAHPLLKNCLRVTVGMPDENAQFLEVLQTL
EEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHEECCCCCCCHHHHHHHHHH
LVKVEAKA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA