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The map label for this gene is hisE

Identifier: 82701945

GI number: 82701945

Start: 928326

End: 928691

Strand: Reverse

Name: hisE

Synonym: Nmul_A0812

Alternate gene names: 82701945

Gene position: 928691-928326 (Counterclockwise)

Preceding gene: 82701946

Following gene: 82701944

Centisome position: 29.17

GC content: 51.37

Gene sequence:

>366_bases
ATGAGCGATCCCGATATTCTTTTTCGCCTTGCCGAGACCATAGAGGCACGTAAACAGTCTGATCCCCATGCTTCTTATGT
GGCGAAGCTGCTGCATGACGGACGGGACAAGATTCTGAAAAAGATTGCGGAAGAATCAGCGGAGGTTCTGCTGGCATCGA
AAGATGGGGATAGCACGCACGTAGTGCGCGAGACGGCGGATCTTTGGTTTCATTGCCTGGTGTTACTGGCTCATCATAAT
CTGAAGCTGGGGGATGTGCTGGATGAGTTACGCCGGCGGGAAGGGGTTTCAGGAATTGATGAAAAAGCTGCCCGCAAAGC
AGGACTGGCAGATAACGGAATCGGCAGGATGAATCAGGATAAGTAA

Upstream 100 bases:

>100_bases
ATACCGGCAGGCATCATTGCTTTTTCAAAAAACTGGAACAGGACCAGTGGTTGGTGACCGAACCCGTCATCAAGAATCCC
GAAGAGATCTACGGGCAGCG

Downstream 100 bases:

>100_bases
ATGGACAGTTGTATTTTTTGCAAGATTGTGCGAGGAGAAATTCCGAGCGAGAAAGTGTATGAGGATGCCCGCGTTTATGC
ATTCCATGATATCCACCCGG

Product: phosphoribosyl-ATP pyrophosphohydrolase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 121; Mature: 120

Protein sequence:

>121_residues
MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTHVVRETADLWFHCLVLLAHHN
LKLGDVLDELRRREGVSGIDEKAARKAGLADNGIGRMNQDK

Sequences:

>Translated_121_residues
MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTHVVRETADLWFHCLVLLAHHN
LKLGDVLDELRRREGVSGIDEKAARKAGLADNGIGRMNQDK
>Mature_120_residues
SDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTHVVRETADLWFHCLVLLAHHNL
KLGDVLDELRRREGVSGIDEKAARKAGLADNGIGRMNQDK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=38.6363636363636, Blast_Score=67, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_NITMU (Q2YAV2)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411511.1
- ProteinModelPortal:   Q2YAV2
- SMR:   Q2YAV2
- STRING:   Q2YAV2
- GeneID:   3785856
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0812
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- BioCyc:   NMUL323848:NMUL_A0812-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13465; Mature: 13334

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTH
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHH
VVRETADLWFHCLVLLAHHNLKLGDVLDELRRREGVSGIDEKAARKAGLADNGIGRMNQD
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCC
K
C
>Mature Secondary Structure 
SDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTH
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHH
VVRETADLWFHCLVLLAHHNLKLGDVLDELRRREGVSGIDEKAARKAGLADNGIGRMNQD
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA