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The map label for this gene is hisI

Identifier: 82701946

GI number: 82701946

Start: 928688

End: 929080

Strand: Reverse

Name: hisI

Synonym: Nmul_A0813

Alternate gene names: 82701946

Gene position: 929080-928688 (Counterclockwise)

Preceding gene: 82701947

Following gene: 82701945

Centisome position: 29.18

GC content: 51.65

Gene sequence:

>393_bases
ATGTCTGATACATGGCTCAACAAAGTAAACTGGTCTGCGGACGGATTAGTGCCGGTCGTGACACAGGATGCCATCAGCAA
TAAGGTACTGATGGTAGCCTGGATGAATCCCGAGGCATTGAGACTTACTGCGCAAACGGGGGAGGCCCATTACTGGTCAC
GCTCGCGCAAAAAACTCTGGCATAAAGGTGAAGAATCCGGGCATGTGCAGAAAGTAAAAGAAATCCGGCTGGATTGTGAT
GAGGACGTCCTGCTGCTGGTAGTGGAACAAGTCGGGGGGGTCGCTTGTCATACCGGCAGGCATCATTGCTTTTTCAAAAA
ACTGGAACAGGACCAGTGGTTGGTGACCGAACCCGTCATCAAGAATCCCGAAGAGATCTACGGGCAGCGATGA

Upstream 100 bases:

>100_bases
TATGGCGAATATACCGTTCGCCAGGCCAAGGAATATATGTCACAGCATGGTATTGAAGTACGACTATAGTAACAGGATCG
AATCAAACTCCGGCATATTC

Downstream 100 bases:

>100_bases
GCGATCCCGATATTCTTTTTCGCCTTGCCGAGACCATAGAGGCACGTAAACAGTCTGATCCCCATGCTTCTTATGTGGCG
AAGCTGCTGCATGACGGACG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MSDTWLNKVNWSADGLVPVVTQDAISNKVLMVAWMNPEALRLTAQTGEAHYWSRSRKKLWHKGEESGHVQKVKEIRLDCD
EDVLLLVVEQVGGVACHTGRHHCFFKKLEQDQWLVTEPVIKNPEEIYGQR

Sequences:

>Translated_130_residues
MSDTWLNKVNWSADGLVPVVTQDAISNKVLMVAWMNPEALRLTAQTGEAHYWSRSRKKLWHKGEESGHVQKVKEIRLDCD
EDVLLLVVEQVGGVACHTGRHHCFFKKLEQDQWLVTEPVIKNPEEIYGQR
>Mature_129_residues
SDTWLNKVNWSADGLVPVVTQDAISNKVLMVAWMNPEALRLTAQTGEAHYWSRSRKKLWHKGEESGHVQKVKEIRLDCDE
DVLLLVVEQVGGVACHTGRHHCFFKKLEQDQWLVTEPVIKNPEEIYGQR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=121, Percent_Identity=40.495867768595, Blast_Score=96, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=120, Percent_Identity=34.1666666666667, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_NITMU (Q2YAV1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411512.1
- ProteinModelPortal:   Q2YAV1
- SMR:   Q2YAV1
- STRING:   Q2YAV1
- GeneID:   3785857
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0813
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- PhylomeDB:   Q2YAV1
- ProtClustDB:   PRK00051
- BioCyc:   NMUL323848:NMUL_A0813-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14963; Mature: 14832

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTWLNKVNWSADGLVPVVTQDAISNKVLMVAWMNPEALRLTAQTGEAHYWSRSRKKLW
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
HKGEESGHVQKVKEIRLDCDEDVLLLVVEQVGGVACHTGRHHCFFKKLEQDQWLVTEPVI
HCCCCCCHHHHHHHHHCCCCCCHHHHEEHHHCCEEEECCCCHHHHHHHCCCCEEEECCCC
KNPEEIYGQR
CCHHHHCCCC
>Mature Secondary Structure 
SDTWLNKVNWSADGLVPVVTQDAISNKVLMVAWMNPEALRLTAQTGEAHYWSRSRKKLW
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
HKGEESGHVQKVKEIRLDCDEDVLLLVVEQVGGVACHTGRHHCFFKKLEQDQWLVTEPVI
HCCCCCCHHHHHHHHHCCCCCCHHHHEEHHHCCEEEECCCCHHHHHHHCCCCEEEECCCC
KNPEEIYGQR
CCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA