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The map label for this gene is adk [H]

Identifier: 78780016

GI number: 78780016

Start: 1528249

End: 1528797

Strand: Reverse

Name: adk [H]

Synonym: PMT9312_1631

Alternate gene names: 78780016

Gene position: 1528797-1528249 (Counterclockwise)

Preceding gene: 78780017

Following gene: 78780015

Centisome position: 89.44

GC content: 31.69

Gene sequence:

>549_bases
ATGAAAAAACATTTACTATTTTTAGGAGCCCCTGGCGCAGGGAAAGGGACTCAGGCGGAATTATTAAGTAAAACCAATTC
TTACTTGCACCTTTCCACAGGTGAATTGTTAAGAAAAGAAATTGAAACGAATACTAACCTTGGTAGACAGGTAAAGGATA
TTATTAACCGGGGAGAACTTGTGAGTGACGAACTTGTATTAAAAATAGTAAGGCAAAATTTAGATCAGGATAATAAAGGT
TGGATTCTAGATGGTTACCCAAGAAATTTATCTCAAGCAAATTCATTGAATGAGGTTTTAATTGAGATCAATCAACCTTT
AGAAGTAGTTTTTTACTTAGATATTCCAGAAGAAGTTCTAATAAAGCGTTTGCTTTTAAGAGGGAGAAAAGATGATACTG
AAGAGACTATTAGAACAAGAGTTGACATTTATAAAAAAACTACAGAACCATTGATTAAATATTTTAAAGATCTTTCATTA
CTAGAATATATTGATGCTGATAGAGATTTAAAAACCATTTCCTCTGATATCAAACAAAAAATGGCTTGA

Upstream 100 bases:

>100_bases
CAACTTCATTACTCATCCTCGTGGGTGTTGCTATTGATACTGCTAAGCAAATTCAGACTTATGTTATTTCCCAAAGGTAT
GAGGGACTAATTAACAATTA

Downstream 100 bases:

>100_bases
TGATGATGTAGAATATAGAATTAACGTTTTATTTGTAAAACCCCTATGAAGGTCAGATCTTCAGTCAAAAAAATTAGCCC
TGACGATCAGATCGTGAGGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKKHLLFLGAPGAGKGTQAELLSKTNSYLHLSTGELLRKEIETNTNLGRQVKDIINRGELVSDELVLKIVRQNLDQDNKG
WILDGYPRNLSQANSLNEVLIEINQPLEVVFYLDIPEEVLIKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIKYFKDLSL
LEYIDADRDLKTISSDIKQKMA

Sequences:

>Translated_182_residues
MKKHLLFLGAPGAGKGTQAELLSKTNSYLHLSTGELLRKEIETNTNLGRQVKDIINRGELVSDELVLKIVRQNLDQDNKG
WILDGYPRNLSQANSLNEVLIEINQPLEVVFYLDIPEEVLIKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIKYFKDLSL
LEYIDADRDLKTISSDIKQKMA
>Mature_182_residues
MKKHLLFLGAPGAGKGTQAELLSKTNSYLHLSTGELLRKEIETNTNLGRQVKDIINRGELVSDELVLKIVRQNLDQDNKG
WILDGYPRNLSQANSLNEVLIEINQPLEVVFYLDIPEEVLIKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIKYFKDLSL
LEYIDADRDLKTISSDIKQKMA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=35.1648351648352, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI4502013, Length=206, Percent_Identity=30.5825242718447, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI7524346, Length=206, Percent_Identity=30.5825242718447, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI28144899, Length=172, Percent_Identity=34.3023255813954, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI28144897, Length=172, Percent_Identity=34.3023255813954, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=30.7291666666667, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI19923437, Length=184, Percent_Identity=29.8913043478261, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310110345, Length=189, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI53832003, Length=189, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI8051579, Length=189, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI53832001, Length=189, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI22749187, Length=126, Percent_Identity=34.9206349206349, Blast_Score=84, Evalue=7e-17,
Organism=Escherichia coli, GI1786680, Length=184, Percent_Identity=34.7826086956522, Blast_Score=123, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=32.7014218009479, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=177, Percent_Identity=34.4632768361582, Blast_Score=113, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=29.8913043478261, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=188, Percent_Identity=29.7872340425532, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25147457, Length=185, Percent_Identity=28.6486486486486, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=27.4193548387097, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=34.4262295081967, Blast_Score=121, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320432, Length=212, Percent_Identity=30.188679245283, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=30.6122448979592, Blast_Score=101, Evalue=6e-23,
Organism=Drosophila melanogaster, GI22026816, Length=206, Percent_Identity=32.5242718446602, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=30.1075268817204, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=30.1075268817204, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737899, Length=188, Percent_Identity=30.3191489361702, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=188, Percent_Identity=30.3191489361702, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=29.8913043478261, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=29.8913043478261, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24582962, Length=184, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20894; Mature: 20894

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHLLFLGAPGAGKGTQAELLSKTNSYLHLSTGELLRKEIETNTNLGRQVKDIINRGEL
CCCCEEEEECCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHCCCC
VSDELVLKIVRQNLDQDNKGWILDGYPRNLSQANSLNEVLIEINQPLEVVFYLDIPEEVL
CHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
IKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIKYFKDLSLLEYIDADRDLKTISSDIKQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MA
CC
>Mature Secondary Structure
MKKHLLFLGAPGAGKGTQAELLSKTNSYLHLSTGELLRKEIETNTNLGRQVKDIINRGEL
CCCCEEEEECCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHCCCC
VSDELVLKIVRQNLDQDNKGWILDGYPRNLSQANSLNEVLIEINQPLEVVFYLDIPEEVL
CHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
IKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIKYFKDLSLLEYIDADRDLKTISSDIKQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA