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The map label for this gene is rnz [H]

Identifier: 78779831

GI number: 78779831

Start: 1359895

End: 1360833

Strand: Direct

Name: rnz [H]

Synonym: PMT9312_1447

Alternate gene names: 78779831

Gene position: 1359895-1360833 (Clockwise)

Preceding gene: 78779829

Following gene: 78779832

Centisome position: 79.56

GC content: 33.76

Gene sequence:

>939_bases
GTGAATATCACCTTCTTAGGAACAAGTTCTGGAGTACCTTCTTTAACAAGAAATGTTTCTTCCTTAGCACTTAAGTTATC
ACAGTCATCAGAAGTCTGGCTTTTTGATTGTGGAGAAGGAACACAACATCAAATAATGAAAAGTAATATAAAATCTTCGC
AAATCAAGAAGATATTTATTACTCACATGCATGGAGATCATATATATGGTTTACCTGGACTTTTGGCTACTCTAGGATTA
TCAGGCAATAGTAATGGTATTGAAATTTATGGTCCTTTAGGATTACGAAGTTTTATAAGTTCTGCACTTAGTAGTAGTTT
TTGCAAATTGTCGTTTCCATTGCATTTTGTGGAAGTTGAAAATTTTGCATCAGAAAATAAAATTTTATTTGAAAACAACA
AGCTCAAAGTAAATTGCGCATGCCTTAAACATAAAATACCTGCCTATGGATATCGAGTAAGCGAAAAAGACAAGCCAGGC
ATATTTGATATCAAAAAAGCAGAGTCTATGAAAATAGCTCCTGGACCAATTTATTCAAAACTGCAACAAGGTAAAGAAGT
CTTATTACCAGATGGAAGGACTGTTAATGGGAAAGAATTCTGCGGACCTCCTAGAAAGGGTGAAAGTTTCGTTTATTGCA
CGGATACTGTTTTTAGCGAATCAGCGGTGTCTTTATCAAAAAATGCCGATTTGCTAGTACATGAATCGACATTTTCTCAG
GAGGATGAGAGCATGGCCTATGAAAAATTACATTCCACAACAATTATGGCTGCTAAAACAGCATTATTATCTAATACAAA
AAAATTAATTATTACTCATTTAAGTCCAAGATACACTAGTAAAAATTCAATTACACCAAGTGATTTGCTTAAAGAGGCGC
AAAAAGTTTTTCCAAATACTCACCTAGCCAAAGATTTTCTGGTGGCAGATATTAAATAA

Upstream 100 bases:

>100_bases
TTTAAGTATCACTTTGTTTGAAAAACAAATTCTTAATTTGCCTAAGTTTGACTAAAAGTCTAGATTTAATCCAGATATAA
AAATAAAAATATCATAATAA

Downstream 100 bases:

>100_bases
ACTGCAACAGTTCGTTAGCAGGAGCGTTGTAAATGACCAACCCATGAAATAATAGTCATAGGTTTTTCTATTTGATGTTG
ATCGAAATGGTTTCTATTTT

Product: RNAse Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSNGIEIYGPLGLRSFISSALSSSFCKLSFPLHFVEVENFASENKILFENNKLKVNCACLKHKIPAYGYRVSEKDKPG
IFDIKKAESMKIAPGPIYSKLQQGKEVLLPDGRTVNGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTSKNSITPSDLLKEAQKVFPNTHLAKDFLVADIK

Sequences:

>Translated_312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSNGIEIYGPLGLRSFISSALSSSFCKLSFPLHFVEVENFASENKILFENNKLKVNCACLKHKIPAYGYRVSEKDKPG
IFDIKKAESMKIAPGPIYSKLQQGKEVLLPDGRTVNGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTSKNSITPSDLLKEAQKVFPNTHLAKDFLVADIK
>Mature_312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSNGIEIYGPLGLRSFISSALSSSFCKLSFPLHFVEVENFASENKILFENNKLKVNCACLKHKIPAYGYRVSEKDKPG
IFDIKKAESMKIAPGPIYSKLQQGKEVLLPDGRTVNGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTSKNSITPSDLLKEAQKVFPNTHLAKDFLVADIK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=361, Percent_Identity=37.1191135734072, Blast_Score=218, Evalue=6e-57,
Organism=Escherichia coli, GI87082078, Length=313, Percent_Identity=40.2555910543131, Blast_Score=253, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24652403, Length=217, Percent_Identity=26.7281105990783, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 34300; Mature: 34300

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSNGIEIYGPLGLRSFISSALSSSFCKLSFPLHFVEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEEECCEEEEEEC
NFASENKILFENNKLKVNCACLKHKIPAYGYRVSEKDKPGIFDIKKAESMKIAPGPIYSK
CCCCCCEEEEECCEEEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCEECCCCHHHHH
LQQGKEVLLPDGRTVNGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
HHCCCEEECCCCCEECCHHHCCCCCCCCEEEEEECCHHCCCHHHHCCCCCEEEECCCCCC
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTSKNSITPSDLLKEAQKVFPNT
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
HLAKDFLVADIK
HHHHHHEEEECC
>Mature Secondary Structure
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSNGIEIYGPLGLRSFISSALSSSFCKLSFPLHFVEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEEECCEEEEEEC
NFASENKILFENNKLKVNCACLKHKIPAYGYRVSEKDKPGIFDIKKAESMKIAPGPIYSK
CCCCCCEEEEECCEEEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCEECCCCHHHHH
LQQGKEVLLPDGRTVNGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
HHCCCEEECCCCCEECCHHHCCCCCCCCEEEEEECCHHCCCHHHHCCCCCEEEECCCCCC
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTSKNSITPSDLLKEAQKVFPNT
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
HLAKDFLVADIK
HHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA