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The map label for this gene is hemA

Identifier: 78484735

GI number: 78484735

Start: 439547

End: 440851

Strand: Reverse

Name: hemA

Synonym: Tcr_0390

Alternate gene names: 78484735

Gene position: 440851-439547 (Counterclockwise)

Preceding gene: 78484741

Following gene: 78484734

Centisome position: 18.16

GC content: 44.52

Gene sequence:

>1305_bases
ATGAAACTATTAGTTCTGGGTGTTAACCATGAAACAGCACCTGTTGATATCCGTGAAAAAGTTTCTTTTTCACCAGCACA
AGTGCAAAATGCACTGTCTGAGCTTAAATCGCAAGGACTTGCCAATGAAAGCGTTATTCTTTCAACGTGCAATCGTACTG
AAATCTACACCACATTAAAATCTCAGTCCCCAGAAAAAATTCGTGCCTGGCTGCACGAATACTTTGAACTGGAAGAAGAC
AGCATCAATAGCTTTCTGTATGAATATGCGGATATCGAAGCCATCAAACACATGATGCGTGTTTCCAGTGGTCTAAATTC
ATTGGTTCTAGGGGAACCACAAATTCTAGGGCAGATTAAAGAAGCCTTTCATTTGGCGCACAAATCGGACAGTGTGCATC
AAACACTGCACGCTTTATTTCAGTACATTTTCAAAACTGCTAAACAAGTCCGAACAGACACCGCCATTGGTTCGAGTCCG
GTTTCAGTCGCTTTTTCAGCGGTGGCCCTGTCAAAACAATTTTTTGGCAAATTAGAAAATCAAACCGCTTTATTACTCGG
CGCGGGTGAAACGGTTGAGCTGGTGGCGCGTCACCTAAAAGAAAGCCATATCGGCAACCTGATTATTGCCAACCGTACTT
TATCCAAGGCGCACCAACTCACTGAAAGCCTAGGCGGTTACGCCATCAGTTTGCATGAAATTGATGACCACTTGCATGAA
GCAGACATTGTCATTGCTTCCACCGCCAGCCCGACGCCGATTCTTAAAACCGAGATGGTGGCCAACGCCCTCAAAAAGCG
TCGCAACAAACCCATGTTTATGATTGATATTGCCGTTCCACGTGACATTGAACCGGCCATTGGCAATTTCAGCGACACCT
ATTTATACACCGTTGATGATTTACAGGAAATCATTGAAGAGAATAAACGCTCACGTAAAGATGCGGCCTTAGAAGCTGAA
GAGATTGTGGAACTTCAAGCCGAAAACTTTATGGCGCAATATCAAGCTACACAACAAATCAGCCCCATTATTCAACGCTA
CCGTCAGCAGGCTTATACTTTGAAAGAACACGCCTTACAAGACGCATTGCACCACTTAGAAAATGGCGGCGATCCGCAAG
AACTCCTGACCAAACTTGCGAACCAATTGACCAATAAAATCCTACACACGCCAACCACCAATCTGCACCATGCCGGTTTA
AACGGCCAAAAGGAAGTGATTCAAGCGGCCGAGCAAATTTTATTGACCCAACAGTCAGACGCCAGTGATTCTTCAGAAAA
CGAAAACACACACGCAACGTCTTAA

Upstream 100 bases:

>100_bases
TGAAAAAGTCTTTCAAAACTTGCAATTAGACACATAATTTAGCAAAATTACGCCTCTTTGATTGCATTATTTTTTCCTTT
TTTGGCAAAATCGATTCCTT

Downstream 100 bases:

>100_bases
CTTTTAACCTGACTCCCAAAAAAGAATTCCTATGAAAGAATCCATTCGCAGCAAACTTGAAAACCTGGTCGAACGACTCG
ATGAAGTGAACCATCTTATT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKLLVLGVNHETAPVDIREKVSFSPAQVQNALSELKSQGLANESVILSTCNRTEIYTTLKSQSPEKIRAWLHEYFELEED
SINSFLYEYADIEAIKHMMRVSSGLNSLVLGEPQILGQIKEAFHLAHKSDSVHQTLHALFQYIFKTAKQVRTDTAIGSSP
VSVAFSAVALSKQFFGKLENQTALLLGAGETVELVARHLKESHIGNLIIANRTLSKAHQLTESLGGYAISLHEIDDHLHE
ADIVIASTASPTPILKTEMVANALKKRRNKPMFMIDIAVPRDIEPAIGNFSDTYLYTVDDLQEIIEENKRSRKDAALEAE
EIVELQAENFMAQYQATQQISPIIQRYRQQAYTLKEHALQDALHHLENGGDPQELLTKLANQLTNKILHTPTTNLHHAGL
NGQKEVIQAAEQILLTQQSDASDSSENENTHATS

Sequences:

>Translated_434_residues
MKLLVLGVNHETAPVDIREKVSFSPAQVQNALSELKSQGLANESVILSTCNRTEIYTTLKSQSPEKIRAWLHEYFELEED
SINSFLYEYADIEAIKHMMRVSSGLNSLVLGEPQILGQIKEAFHLAHKSDSVHQTLHALFQYIFKTAKQVRTDTAIGSSP
VSVAFSAVALSKQFFGKLENQTALLLGAGETVELVARHLKESHIGNLIIANRTLSKAHQLTESLGGYAISLHEIDDHLHE
ADIVIASTASPTPILKTEMVANALKKRRNKPMFMIDIAVPRDIEPAIGNFSDTYLYTVDDLQEIIEENKRSRKDAALEAE
EIVELQAENFMAQYQATQQISPIIQRYRQQAYTLKEHALQDALHHLENGGDPQELLTKLANQLTNKILHTPTTNLHHAGL
NGQKEVIQAAEQILLTQQSDASDSSENENTHATS
>Mature_434_residues
MKLLVLGVNHETAPVDIREKVSFSPAQVQNALSELKSQGLANESVILSTCNRTEIYTTLKSQSPEKIRAWLHEYFELEED
SINSFLYEYADIEAIKHMMRVSSGLNSLVLGEPQILGQIKEAFHLAHKSDSVHQTLHALFQYIFKTAKQVRTDTAIGSSP
VSVAFSAVALSKQFFGKLENQTALLLGAGETVELVARHLKESHIGNLIIANRTLSKAHQLTESLGGYAISLHEIDDHLHE
ADIVIASTASPTPILKTEMVANALKKRRNKPMFMIDIAVPRDIEPAIGNFSDTYLYTVDDLQEIIEENKRSRKDAALEAE
EIVELQAENFMAQYQATQQISPIIQRYRQQAYTLKEHALQDALHHLENGGDPQELLTKLANQLTNKILHTPTTNLHHAGL
NGQKEVIQAAEQILLTQQSDASDSSENENTHATS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=407, Percent_Identity=49.6314496314496, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_THICR (Q31IN7)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390660.1
- ProteinModelPortal:   Q31IN7
- SMR:   Q31IN7
- STRING:   Q31IN7
- GeneID:   3760905
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0390
- NMPDR:   fig|317025.3.peg.359
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   LLIDIAN
- PhylomeDB:   Q31IN7
- BioCyc:   TCRU317025:TCR_0390-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48324; Mature: 48324

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 107-107 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVLGVNHETAPVDIREKVSFSPAQVQNALSELKSQGLANESVILSTCNRTEIYTTLK
CEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHH
SQSPEKIRAWLHEYFELEEDSINSFLYEYADIEAIKHMMRVSSGLNSLVLGEPQILGQIK
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHH
EAFHLAHKSDSVHQTLHALFQYIFKTAKQVRTDTAIGSSPVSVAFSAVALSKQFFGKLEN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
QTALLLGAGETVELVARHLKESHIGNLIIANRTLSKAHQLTESLGGYAISLHEIDDHLHE
CEEEEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCEEEEHHHHHHHHHH
ADIVIASTASPTPILKTEMVANALKKRRNKPMFMIDIAVPRDIEPAIGNFSDTYLYTVDD
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEHHH
LQEIIEENKRSRKDAALEAEEIVELQAENFMAQYQATQQISPIIQRYRQQAYTLKEHALQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALHHLENGGDPQELLTKLANQLTNKILHTPTTNLHHAGLNGQKEVIQAAEQILLTQQSD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCC
ASDSSENENTHATS
CCCCCCCCCCCCCC
>Mature Secondary Structure
MKLLVLGVNHETAPVDIREKVSFSPAQVQNALSELKSQGLANESVILSTCNRTEIYTTLK
CEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHH
SQSPEKIRAWLHEYFELEEDSINSFLYEYADIEAIKHMMRVSSGLNSLVLGEPQILGQIK
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHH
EAFHLAHKSDSVHQTLHALFQYIFKTAKQVRTDTAIGSSPVSVAFSAVALSKQFFGKLEN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
QTALLLGAGETVELVARHLKESHIGNLIIANRTLSKAHQLTESLGGYAISLHEIDDHLHE
CEEEEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCEEEEHHHHHHHHHH
ADIVIASTASPTPILKTEMVANALKKRRNKPMFMIDIAVPRDIEPAIGNFSDTYLYTVDD
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEHHH
LQEIIEENKRSRKDAALEAEEIVELQAENFMAQYQATQQISPIIQRYRQQAYTLKEHALQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALHHLENGGDPQELLTKLANQLTNKILHTPTTNLHHAGLNGQKEVIQAAEQILLTQQSD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCC
ASDSSENENTHATS
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA