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The map label for this gene is adh1 [H]

Identifier: 78484556

GI number: 78484556

Start: 250246

End: 251433

Strand: Reverse

Name: adh1 [H]

Synonym: Tcr_0211

Alternate gene names: 78484556

Gene position: 251433-250246 (Counterclockwise)

Preceding gene: 78484557

Following gene: 78484555

Centisome position: 10.36

GC content: 49.58

Gene sequence:

>1188_bases
ATGATTGCAGACTTTCAAATCGCCAACCTCCCTAAAATTCAATTCGGCTGGGGGATTCGAGATCAATTTGCACAAGCCAT
AGCAGAACAAGGCTTTCAATCTATCGTGCTCATTTCAGGTCAATTTTTGGCCAGGCCTGGCGGTTTTTCAGCGGCGTTGA
TCACCCAACTGCAACAAGCCAATATTCGCGTCAATGTCTTTGTTGTGTCCGGCGAACCCTCTCCGAATCTGGTGGATGAA
ATCGTCAAAGCCAGTCCAAACAACGCCGATGCTGTGATCGGCATTGGTGGTGGAAGCGTATTGGATGCCGCCAAAGCGGT
GGCCGGTTTGATTCCCAGCCAAACGTCCGTGATGGATTATCTCGAAGGCGTTGGCAAAGGGCTTAAATTGGCGGGCAATA
CCCTGCCTTTTATCGCGATGCCAACCACCGCCGGCACCGGCAGCGAAACCACCAAAAACGCGGTTTTGTCCCGTTTAGGC
GAATTCAAAAAATCCTTTCGCGATGACAAGCTTCTCGCAAAAGAAGTGTGGTTAGATCCCAGCTTTCTTCCGACCTGCCC
GCATGAAGTGCTTTACAGCACGGGCATGGATGCCTTTACCCAATTATTGGAATCGTACACAACGCTCAAAGCCAACCCGA
TTACCGATGCACTGGCATGGCAAGGCATGACTTTATTTAACGGTGCCTTCAAAGCCATCAACAGTGATAATTTTGAACAG
CAAAAAACCGGCTATGGCAACTTAATGCTGGCGGCCAGTTTATCCGGCATCACTCTCGCCAATGCTGGATTGGGCGCTGT
CCATGGGTTAGCTGGGCCAATCGGAGCCTTTTTTGAAGCGCCCCATGGCGTGCTGTGTGCGGCGTTACTCGCACCGATTA
CCGAAGCAAACATTCAAGCCCTAAAACAGTCAGATGAGCCCCATGCAGAAAGCACCTTAACCAAATACGCTCAAATAGGT
ACCTTATTGTCAGGCGCGTCAAACCATACGACAGACTCTCTCACCGCATTAATCGAACACTTACAACAGCTGACAACCAC
GTACCTTCCTAACCGACTATCGGAATATGGATTGCACGAGGATAACCTGGCGCCGGTTCTAACAAACTGTCGTTCAGGGA
GCATGACAGGAAACCCTTTGATTTTATCCGATGAGGTTCTCATGTCAGCAATTCGACAAACCTTATAA

Upstream 100 bases:

>100_bases
TCCTGAAGAACAAAAAGTCACCGGAAATGCTCATTTAGAAAACTTAAAAGCCATGCTCAACCCGGGTTAACCCTACTCGA
TTAACCAAAAAGGACGACAG

Downstream 100 bases:

>100_bases
TTCAGTTCCTCGTTGAAGGCCCATTCAAGCAAAAATTCCTCGTTTTTATGCCCTTTTTTGCTGTAAAATCAGGACACTAC
CTAACAATACAATTCAAAAA

Product: Iron-containing alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: BDH [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIADFQIANLPKIQFGWGIRDQFAQAIAEQGFQSIVLISGQFLARPGGFSAALITQLQQANIRVNVFVVSGEPSPNLVDE
IVKASPNNADAVIGIGGGSVLDAAKAVAGLIPSQTSVMDYLEGVGKGLKLAGNTLPFIAMPTTAGTGSETTKNAVLSRLG
EFKKSFRDDKLLAKEVWLDPSFLPTCPHEVLYSTGMDAFTQLLESYTTLKANPITDALAWQGMTLFNGAFKAINSDNFEQ
QKTGYGNLMLAASLSGITLANAGLGAVHGLAGPIGAFFEAPHGVLCAALLAPITEANIQALKQSDEPHAESTLTKYAQIG
TLLSGASNHTTDSLTALIEHLQQLTTTYLPNRLSEYGLHEDNLAPVLTNCRSGSMTGNPLILSDEVLMSAIRQTL

Sequences:

>Translated_395_residues
MIADFQIANLPKIQFGWGIRDQFAQAIAEQGFQSIVLISGQFLARPGGFSAALITQLQQANIRVNVFVVSGEPSPNLVDE
IVKASPNNADAVIGIGGGSVLDAAKAVAGLIPSQTSVMDYLEGVGKGLKLAGNTLPFIAMPTTAGTGSETTKNAVLSRLG
EFKKSFRDDKLLAKEVWLDPSFLPTCPHEVLYSTGMDAFTQLLESYTTLKANPITDALAWQGMTLFNGAFKAINSDNFEQ
QKTGYGNLMLAASLSGITLANAGLGAVHGLAGPIGAFFEAPHGVLCAALLAPITEANIQALKQSDEPHAESTLTKYAQIG
TLLSGASNHTTDSLTALIEHLQQLTTTYLPNRLSEYGLHEDNLAPVLTNCRSGSMTGNPLILSDEVLMSAIRQTL
>Mature_395_residues
MIADFQIANLPKIQFGWGIRDQFAQAIAEQGFQSIVLISGQFLARPGGFSAALITQLQQANIRVNVFVVSGEPSPNLVDE
IVKASPNNADAVIGIGGGSVLDAAKAVAGLIPSQTSVMDYLEGVGKGLKLAGNTLPFIAMPTTAGTGSETTKNAVLSRLG
EFKKSFRDDKLLAKEVWLDPSFLPTCPHEVLYSTGMDAFTQLLESYTTLKANPITDALAWQGMTLFNGAFKAINSDNFEQ
QKTGYGNLMLAASLSGITLANAGLGAVHGLAGPIGAFFEAPHGVLCAALLAPITEANIQALKQSDEPHAESTLTKYAQIG
TLLSGASNHTTDSLTALIEHLQQLTTTYLPNRLSEYGLHEDNLAPVLTNCRSGSMTGNPLILSDEVLMSAIRQTL

Specific function: This enzyme has activity using butanol and ethanol as substrates [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=307, Percent_Identity=26.7100977198697, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082107, Length=351, Percent_Identity=27.9202279202279, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI48994951, Length=383, Percent_Identity=28.1984334203655, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789163, Length=378, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787493, Length=381, Percent_Identity=27.0341207349081, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789386, Length=321, Percent_Identity=27.7258566978193, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537053, Length=292, Percent_Identity=29.4520547945205, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321181, Length=386, Percent_Identity=29.5336787564767, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24657991, Length=289, Percent_Identity=28.3737024221453, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: 1.1.1.1

Molecular weight: Translated: 41748; Mature: 41748

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIADFQIANLPKIQFGWGIRDQFAQAIAEQGFQSIVLISGQFLARPGGFSAALITQLQQA
CCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCEECCCCCHHHHHHHHHHC
NIRVNVFVVSGEPSPNLVDEIVKASPNNADAVIGIGGGSVLDAAKAVAGLIPSQTSVMDY
CEEEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHH
LEGVGKGLKLAGNTLPFIAMPTTAGTGSETTKNAVLSRLGEFKKSFRDDKLLAKEVWLDP
HHHHCCCCEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SFLPTCPHEVLYSTGMDAFTQLLESYTTLKANPITDALAWQGMTLFNGAFKAINSDNFEQ
CCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCHH
QKTGYGNLMLAASLSGITLANAGLGAVHGLAGPIGAFFEAPHGVLCAALLAPITEANIQA
HHCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LKQSDEPHAESTLTKYAQIGTLLSGASNHTTDSLTALIEHLQQLTTTYLPNRLSEYGLHE
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNLAPVLTNCRSGSMTGNPLILSDEVLMSAIRQTL
CCCCHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHC
>Mature Secondary Structure
MIADFQIANLPKIQFGWGIRDQFAQAIAEQGFQSIVLISGQFLARPGGFSAALITQLQQA
CCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCEECCCCCHHHHHHHHHHC
NIRVNVFVVSGEPSPNLVDEIVKASPNNADAVIGIGGGSVLDAAKAVAGLIPSQTSVMDY
CEEEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHH
LEGVGKGLKLAGNTLPFIAMPTTAGTGSETTKNAVLSRLGEFKKSFRDDKLLAKEVWLDP
HHHHCCCCEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SFLPTCPHEVLYSTGMDAFTQLLESYTTLKANPITDALAWQGMTLFNGAFKAINSDNFEQ
CCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCHH
QKTGYGNLMLAASLSGITLANAGLGAVHGLAGPIGAFFEAPHGVLCAALLAPITEANIQA
HHCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LKQSDEPHAESTLTKYAQIGTLLSGASNHTTDSLTALIEHLQQLTTTYLPNRLSEYGLHE
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNLAPVLTNCRSGSMTGNPLILSDEVLMSAIRQTL
CCCCHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2673928 [H]