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The map label for this gene is typA [H]

Identifier: 78484514

GI number: 78484514

Start: 199629

End: 201452

Strand: Reverse

Name: typA [H]

Synonym: Tcr_0169

Alternate gene names: 78484514

Gene position: 201452-199629 (Counterclockwise)

Preceding gene: 78484515

Following gene: 78484513

Centisome position: 8.3

GC content: 45.72

Gene sequence:

>1824_bases
ATGAACACAGATCATATTCGCAACATTGCCATTATTGCGCACGTTGACCACGGTAAAACCACGTTGGTTGACCAACTTCT
AAGACAATCTGGCACCTTTGACGATATCCGTAAAGACATGGGGGATCGTATGATGGACTCCAATGATCTAGAAAAAGAAC
GTGGTATCACGATCCTGTCTAAAAACACAGCCGTCAAATGGAACGATTTCCGTATCAATATCGTTGATACTCCAGGCCAT
GCCGATTTCGGTGGTGAAGTTGAACGTATTCTATCGATGGTTGACTCGGTATTGCTTTTGGTTGATTCCGTTGAAGGACC
AATGCCACAAACACGATTTGTAACGGAAAAAGCCTTGAAGCAAGGCCTAAAACCAATTGTTGTCATCAACAAAATTGACC
GCCCAGGTGCGCGCCCTGACTGGGTTCTAGACCAGACATTTGATTTGTTTGACCGCCTAGGAGCCACCGATGAGCAAATG
GATTTTGATGTTATCTATGCCTCGGGCTTAAACGGCTTTGCCGGACTGGAAGAAGATGTTCGCGAAGGTGACATGACTCC
AGTGTTCAAAATCATCACTGAAAATGTACCTGCGCCAGATGTTGATTTAGGCGGACCTTTCCAATTGCAATGTATCTCGC
TGGATTATGACACTTATAAAGGGGTCATTGGAACAGGCCGTATCAAACGCGGTGCCGTTCAAACAGGGATGCCGATTGTT
ATCGTTGATGCCGAAGGGAAAGAGCGTAAAGGTAAGATGGGTGAACTGTTCGGTTACCACGGTCTTGAGCGTGTCAGCGT
TGAAGAAGCGCATGCGGGTGACATCGTAGCATTCACTGGATTAGACCCTTTAAACATTTCAGATACATTATGTGATCCAA
ACCATGTTGAAGCCTTACCGGCTTTGACGGTTGATGAACCAACGGTCAGCATGACATTCCAGGTCAACGACTCTCCTTTT
GTAGGACAAGATGGTAAGTTATTAACGTCTCGCCAAATCCGTGAGCGCTTGGATAAAGAATTATTAACCAACGTTGCCTT
ACGCGTTGAAGAAACGGAAGATGCCAACAAATTCCGAGTCTCTGGTCGTGGAGAACTGCATCTATCGGTTCTGATTGAAA
CAATGCGTCGTGAAGGTTTCGAAATGGGAATCTCTCGTCCGGAAGTTATCTTCAAAGAAGTTGATGGTGAAACGCATGAA
CCGTATGAAAACCTAACGGTGGACGTGCCAGAAGAAGCGCAAGGCGCCATCATGGAAAAACTCGGTGAGCGTAAAGCCGA
AATGCAAGACATGGTGCCAGACGGACATGGTCGCGTGCGTATCGATTTCATCATTCCATCTCGCGGTCTGATCGGTTTCC
GTACCGAATTTATGACGGCGACCCAAGGAAACGGTTTGATTTTCTCAAGTTTTTCACATTATGGTCCAAAATTCTCTGGC
ACATTGGGTGAACGTAACAACGGTGTTTTGATCTCAATTGGTCAAGGGAAAGCATTGGCATTTGCGCTGTTTAACCTGCA
GGATCGTGGTCGCTTATACATTGGTCACGGGGAAGAAGTGTACGAAGGGATGATTATCGGACTGCACAGTCGTGCCAATG
ACTTAACGGTTAACCCTTTGAAAGGGAAACAGTTAACGAACATGCGTGCCTCTGGAACCGATGAAGCCTTAACTCTAACG
CCACCGATCATTTTCTCGCTGGAACAAGCGCTTGAATTTATCGATGATGATGAATTGGTTGAAGTCACACCACATCACGT
ACGTATTCGTAAAAAATTATTGACTGAAAACGAACGTAAAAAAGCAGGGCGTAGCAAGCTCTAA

Upstream 100 bases:

>100_bases
TAACATTCTGCAATAAATCGTAATCATTTCATCAGATTACACAAACTTCTATTGTCATTCCAGTATAATACGTTTTTTTG
AAAAATTGAGAGTCCCCCGC

Downstream 100 bases:

>100_bases
GCGTAACGCTCCTCTCTGCTTCCATTAAAAGCCCTTAAAAGTAGCCAGGCCTGGTCATTTTTAGGGGCTTTTTTCGTTTA
TAGCCTGGGGAAAAGATTCT

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MNTDHIRNIAIIAHVDHGKTTLVDQLLRQSGTFDDIRKDMGDRMMDSNDLEKERGITILSKNTAVKWNDFRINIVDTPGH
ADFGGEVERILSMVDSVLLLVDSVEGPMPQTRFVTEKALKQGLKPIVVINKIDRPGARPDWVLDQTFDLFDRLGATDEQM
DFDVIYASGLNGFAGLEEDVREGDMTPVFKIITENVPAPDVDLGGPFQLQCISLDYDTYKGVIGTGRIKRGAVQTGMPIV
IVDAEGKERKGKMGELFGYHGLERVSVEEAHAGDIVAFTGLDPLNISDTLCDPNHVEALPALTVDEPTVSMTFQVNDSPF
VGQDGKLLTSRQIRERLDKELLTNVALRVEETEDANKFRVSGRGELHLSVLIETMRREGFEMGISRPEVIFKEVDGETHE
PYENLTVDVPEEAQGAIMEKLGERKAEMQDMVPDGHGRVRIDFIIPSRGLIGFRTEFMTATQGNGLIFSSFSHYGPKFSG
TLGERNNGVLISIGQGKALAFALFNLQDRGRLYIGHGEEVYEGMIIGLHSRANDLTVNPLKGKQLTNMRASGTDEALTLT
PPIIFSLEQALEFIDDDELVEVTPHHVRIRKKLLTENERKKAGRSKL

Sequences:

>Translated_607_residues
MNTDHIRNIAIIAHVDHGKTTLVDQLLRQSGTFDDIRKDMGDRMMDSNDLEKERGITILSKNTAVKWNDFRINIVDTPGH
ADFGGEVERILSMVDSVLLLVDSVEGPMPQTRFVTEKALKQGLKPIVVINKIDRPGARPDWVLDQTFDLFDRLGATDEQM
DFDVIYASGLNGFAGLEEDVREGDMTPVFKIITENVPAPDVDLGGPFQLQCISLDYDTYKGVIGTGRIKRGAVQTGMPIV
IVDAEGKERKGKMGELFGYHGLERVSVEEAHAGDIVAFTGLDPLNISDTLCDPNHVEALPALTVDEPTVSMTFQVNDSPF
VGQDGKLLTSRQIRERLDKELLTNVALRVEETEDANKFRVSGRGELHLSVLIETMRREGFEMGISRPEVIFKEVDGETHE
PYENLTVDVPEEAQGAIMEKLGERKAEMQDMVPDGHGRVRIDFIIPSRGLIGFRTEFMTATQGNGLIFSSFSHYGPKFSG
TLGERNNGVLISIGQGKALAFALFNLQDRGRLYIGHGEEVYEGMIIGLHSRANDLTVNPLKGKQLTNMRASGTDEALTLT
PPIIFSLEQALEFIDDDELVEVTPHHVRIRKKLLTENERKKAGRSKL
>Mature_607_residues
MNTDHIRNIAIIAHVDHGKTTLVDQLLRQSGTFDDIRKDMGDRMMDSNDLEKERGITILSKNTAVKWNDFRINIVDTPGH
ADFGGEVERILSMVDSVLLLVDSVEGPMPQTRFVTEKALKQGLKPIVVINKIDRPGARPDWVLDQTFDLFDRLGATDEQM
DFDVIYASGLNGFAGLEEDVREGDMTPVFKIITENVPAPDVDLGGPFQLQCISLDYDTYKGVIGTGRIKRGAVQTGMPIV
IVDAEGKERKGKMGELFGYHGLERVSVEEAHAGDIVAFTGLDPLNISDTLCDPNHVEALPALTVDEPTVSMTFQVNDSPF
VGQDGKLLTSRQIRERLDKELLTNVALRVEETEDANKFRVSGRGELHLSVLIETMRREGFEMGISRPEVIFKEVDGETHE
PYENLTVDVPEEAQGAIMEKLGERKAEMQDMVPDGHGRVRIDFIIPSRGLIGFRTEFMTATQGNGLIFSSFSHYGPKFSG
TLGERNNGVLISIGQGKALAFALFNLQDRGRLYIGHGEEVYEGMIIGLHSRANDLTVNPLKGKQLTNMRASGTDEALTLT
PPIIFSLEQALEFIDDDELVEVTPHHVRIRKKLLTENERKKAGRSKL

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=514, Percent_Identity=28.0155642023346, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI94966754, Length=137, Percent_Identity=43.0656934306569, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI18390331, Length=146, Percent_Identity=42.4657534246575, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI4503483, Length=165, Percent_Identity=35.1515151515151, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI25306287, Length=140, Percent_Identity=37.1428571428571, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI19923640, Length=140, Percent_Identity=37.1428571428571, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI25306283, Length=133, Percent_Identity=39.0977443609023, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=38.5714285714286, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=38.5714285714286, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI310132016, Length=117, Percent_Identity=40.1709401709402, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310110807, Length=117, Percent_Identity=40.1709401709402, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310123363, Length=117, Percent_Identity=40.1709401709402, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI94966752, Length=133, Percent_Identity=30.8270676691729, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI34147630, Length=235, Percent_Identity=27.6595744680851, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI48994988, Length=602, Percent_Identity=69.6013289036545, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=544, Percent_Identity=26.6544117647059, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1789738, Length=218, Percent_Identity=33.4862385321101, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=32.4137931034483, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790412, Length=285, Percent_Identity=27.3684210526316, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789737, Length=285, Percent_Identity=27.3684210526316, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=233, Percent_Identity=35.1931330472103, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533571, Length=179, Percent_Identity=39.1061452513966, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=132, Percent_Identity=41.6666666666667, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=132, Percent_Identity=41.6666666666667, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=133, Percent_Identity=41.3533834586466, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=176, Percent_Identity=34.0909090909091, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=185, Percent_Identity=33.5135135135135, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=288, Percent_Identity=26.0416666666667, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=280, Percent_Identity=27.5, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=500, Percent_Identity=26.4, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324707, Length=148, Percent_Identity=40.5405405405405, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=148, Percent_Identity=40.5405405405405, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=165, Percent_Identity=41.2121212121212, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323098, Length=152, Percent_Identity=38.1578947368421, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324761, Length=244, Percent_Identity=27.8688524590164, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324166, Length=143, Percent_Identity=39.8601398601399, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI78706572, Length=517, Percent_Identity=25.3384912959381, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24582462, Length=146, Percent_Identity=43.1506849315069, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=40.2877697841727, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221458488, Length=136, Percent_Identity=42.6470588235294, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24585709, Length=171, Percent_Identity=33.9181286549708, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585711, Length=171, Percent_Identity=33.9181286549708, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585713, Length=171, Percent_Identity=33.9181286549708, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357743, Length=206, Percent_Identity=31.5533980582524, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363316, Length=312, Percent_Identity=29.4871794871795, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864358, Length=312, Percent_Identity=29.4871794871795, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921738, Length=237, Percent_Identity=30.379746835443, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67424; Mature: 67424

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDHIRNIAIIAHVDHGKTTLVDQLLRQSGTFDDIRKDMGDRMMDSNDLEKERGITILS
CCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCEEEEE
KNTAVKWNDFRINIVDTPGHADFGGEVERILSMVDSVLLLVDSVEGPMPQTRFVTEKALK
CCCEEEEECEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QGLKPIVVINKIDRPGARPDWVLDQTFDLFDRLGATDEQMDFDVIYASGLNGFAGLEEDV
HCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHH
REGDMTPVFKIITENVPAPDVDLGGPFQLQCISLDYDTYKGVIGTGRIKRGAVQTGMPIV
HCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHCCEEECCCCCCCHHHCCCCEE
IVDAEGKERKGKMGELFGYHGLERVSVEEAHAGDIVAFTGLDPLNISDTLCDPNHVEALP
EEECCCCCCCCCHHHHHCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCC
ALTVDEPTVSMTFQVNDSPFVGQDGKLLTSRQIRERLDKELLTNVALRVEETEDANKFRV
CEEECCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEE
SGRGELHLSVLIETMRREGFEMGISRPEVIFKEVDGETHEPYENLTVDVPEEAQGAIMEK
CCCCCEEHHHHHHHHHHCCHHCCCCCHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHH
LGERKAEMQDMVPDGHGRVRIDFIIPSRGLIGFRTEFMTATQGNGLIFSSFSHYGPKFSG
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEEEEEECCCCEEEECHHHCCCCCCC
TLGERNNGVLISIGQGKALAFALFNLQDRGRLYIGHGEEVYEGMIIGLHSRANDLTVNPL
CCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEECCCHHHHCCEEEEEECCCCCCEECCC
KGKQLTNMRASGTDEALTLTPPIIFSLEQALEFIDDDELVEVTPHHVRIRKKLLTENERK
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCHHH
KAGRSKL
HCCCCCC
>Mature Secondary Structure
MNTDHIRNIAIIAHVDHGKTTLVDQLLRQSGTFDDIRKDMGDRMMDSNDLEKERGITILS
CCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCEEEEE
KNTAVKWNDFRINIVDTPGHADFGGEVERILSMVDSVLLLVDSVEGPMPQTRFVTEKALK
CCCEEEEECEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QGLKPIVVINKIDRPGARPDWVLDQTFDLFDRLGATDEQMDFDVIYASGLNGFAGLEEDV
HCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHH
REGDMTPVFKIITENVPAPDVDLGGPFQLQCISLDYDTYKGVIGTGRIKRGAVQTGMPIV
HCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHCCEEECCCCCCCHHHCCCCEE
IVDAEGKERKGKMGELFGYHGLERVSVEEAHAGDIVAFTGLDPLNISDTLCDPNHVEALP
EEECCCCCCCCCHHHHHCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCC
ALTVDEPTVSMTFQVNDSPFVGQDGKLLTSRQIRERLDKELLTNVALRVEETEDANKFRV
CEEECCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEE
SGRGELHLSVLIETMRREGFEMGISRPEVIFKEVDGETHEPYENLTVDVPEEAQGAIMEK
CCCCCEEHHHHHHHHHHCCHHCCCCCHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHH
LGERKAEMQDMVPDGHGRVRIDFIIPSRGLIGFRTEFMTATQGNGLIFSSFSHYGPKFSG
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEEEEEECCCCEEEECHHHCCCCCCC
TLGERNNGVLISIGQGKALAFALFNLQDRGRLYIGHGEEVYEGMIIGLHSRANDLTVNPL
CCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEECCCHHHHCCEEEEEECCCCCCEECCC
KGKQLTNMRASGTDEALTLTPPIIFSLEQALEFIDDDELVEVTPHHVRIRKKLLTENERK
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCHHH
KAGRSKL
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]