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The map label for this gene is dtd

Identifier: 78484512

GI number: 78484512

Start: 198069

End: 198518

Strand: Reverse

Name: dtd

Synonym: Tcr_0167

Alternate gene names: 78484512

Gene position: 198518-198069 (Counterclockwise)

Preceding gene: 78484513

Following gene: 78484511

Centisome position: 8.18

GC content: 47.11

Gene sequence:

>450_bases
ATGATTTGTTTACTGCAAAGAGTGACTCACGGAAGCGTGTCGGTTTCCAATGAAACCATCGGACAGATTTCATCTGGCTT
GGTGGTGTTATGCGGATTCCAACCACACGACACAACCGAATCCTTAGAAAAAATGGCTCATAAGCTCCTCCACTACCGCG
TATTCAGTGACGAAGATGACAAAATGAATCTCAACCTGCAGCAAGCCTTCAGCGGCAAGGGTGGAGACTTGCTGCTGGTG
CCGCAATTTACCTTAGCGGCGGATACGAAAAAAGGTCTGCGCCCAAGCTTTCACACCTCGGCTTCGCCAGATTTGGCACA
CAATCTGTTTAATGAGTTTGTAGCGTTAATTACCTTGAAGTTTGGTCCACCTCAAACGGGAAAATTCGGCGCAAACATGC
AGGTCAGCTTAATTAATGACGGGCCTGTAACCTTTTGGCTTGAAACCTAA

Upstream 100 bases:

>100_bases
TGCGACCATGCCGGCCATTCTGCTCTTGAACTGGAGATCGCTCAAGCATTGGTGGGCGCGACCGATCAAATCTATCTTGA
TGCGGACATCTCACCTTAAT

Downstream 100 bases:

>100_bases
TTCCTTCAAAAGGCGTAAGGGTTTTAATTTCGACAAAAAGCGGCTACACTTAGCCAAACAACTTAACGGTGATACGAACT
CCTCATGCCACTTTCTGAGA

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MICLLQRVTHGSVSVSNETIGQISSGLVVLCGFQPHDTTESLEKMAHKLLHYRVFSDEDDKMNLNLQQAFSGKGGDLLLV
PQFTLAADTKKGLRPSFHTSASPDLAHNLFNEFVALITLKFGPPQTGKFGANMQVSLINDGPVTFWLET

Sequences:

>Translated_149_residues
MICLLQRVTHGSVSVSNETIGQISSGLVVLCGFQPHDTTESLEKMAHKLLHYRVFSDEDDKMNLNLQQAFSGKGGDLLLV
PQFTLAADTKKGLRPSFHTSASPDLAHNLFNEFVALITLKFGPPQTGKFGANMQVSLINDGPVTFWLET
>Mature_149_residues
MICLLQRVTHGSVSVSNETIGQISSGLVVLCGFQPHDTTESLEKMAHKLLHYRVFSDEDDKMNLNLQQAFSGKGGDLLLV
PQFTLAADTKKGLRPSFHTSASPDLAHNLFNEFVALITLKFGPPQTGKFGANMQVSLINDGPVTFWLET

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=151, Percent_Identity=39.7350993377483, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790320, Length=148, Percent_Identity=52.027027027027, Blast_Score=164, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI115533292, Length=152, Percent_Identity=36.8421052631579, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319982, Length=152, Percent_Identity=36.8421052631579, Blast_Score=103, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281361569, Length=151, Percent_Identity=35.0993377483444, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_THICR (Q31JB0)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390437.1
- HSSP:   O66742
- ProteinModelPortal:   Q31JB0
- SMR:   Q31JB0
- STRING:   Q31JB0
- GeneID:   3762478
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0167
- NMPDR:   fig|317025.3.peg.119
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q31JB0
- ProtClustDB:   PRK05273
- BioCyc:   TCRU317025:TCR_0167-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16317; Mature: 16317

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: ACT_SITE 84-84

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICLLQRVTHGSVSVSNETIGQISSGLVVLCGFQPHDTTESLEKMAHKLLHYRVFSDEDD
CEEEEEECCCCCEEECCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEECCCCC
KMNLNLQQAFSGKGGDLLLVPQFTLAADTKKGLRPSFHTSASPDLAHNLFNEFVALITLK
CEECCHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEE
FGPPQTGKFGANMQVSLINDGPVTFWLET
CCCCCCCCCCCCEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MICLLQRVTHGSVSVSNETIGQISSGLVVLCGFQPHDTTESLEKMAHKLLHYRVFSDEDD
CEEEEEECCCCCEEECCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEECCCCC
KMNLNLQQAFSGKGGDLLLVPQFTLAADTKKGLRPSFHTSASPDLAHNLFNEFVALITLK
CEECCHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEE
FGPPQTGKFGANMQVSLINDGPVTFWLET
CCCCCCCCCCCCEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA