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The map label for this gene is hemE

Identifier: 78484468

GI number: 78484468

Start: 155802

End: 156866

Strand: Reverse

Name: hemE

Synonym: Tcr_0123

Alternate gene names: 78484468

Gene position: 156866-155802 (Counterclockwise)

Preceding gene: 78484469

Following gene: 78484464

Centisome position: 6.46

GC content: 47.23

Gene sequence:

>1065_bases
ATGGCGGAGCTACAAAACGACCGTTTCCTACGTGCCCTACTCAAAGAACCCGTTGATCAGACTCCGGTTTGGATGATGCG
CCAAGCAGGCCGCTATTTACCAGAGTACCGCGCTACCCGAAAACAAGCAGGTTCTTTTATGGATTTGTGCCGTAATAAGG
AATTGGCGTGCGAAGTCACCTTGCAGCCACTTGAACGTTATCCGTTAGATGCCGCTATCTTATTTTCTGATATTTTGACG
ATTCCAGATGCAATGGGATTGGAGTTACGTTTCCAGACAGGTGAAGGCCCTATTTTTGATAAACCAATCAAAAGCATGTC
CGATGCAAAAAAACTGTTCGTTCCGGATATGGCCTCAGAGTTAGGGTATGTAATGGATGCTGTAAGCACTATTCGTAAAG
CATTAGACGGCCGCGTTCCTCTGATCGGATTTTCGGGAAGCCCTTGGACCTTGGCGACTTATATGGTCGAAGGCGGCTCC
AGTAAAACGTTCGCGAAAATCAAAGCGATGATGTACGATCAGCCTGCCACGCTCCATCATATTTTGGATGTTCTAGCCGA
TTCGGTCATTGCTTATTTAAATGCACAAATCGAAGCCGGTGCGCAAGCGGTGCAGATTTTTGATACTTGGGGCGGCGTAT
TGACCCCTCGTGACTACAAAGAGTTTTCATTAAACTACATGGCCAAGATCGTCGATGGTCTCAAGCGTGAAAACGATGGC
CGTAAAGTGCCTGTGATTTTGTTCACAAAAGGCGGCGGTCAGTGGTTAGAATCAATGGCAGAAACAGGCTGCGATGCCCT
TGGGTTGGATTGGACAACGGATATTGATGACGCTCGTGCACGTGTGGGTGATAAAGTCGCACTGCAAGGTAACATGGATC
CGAGTGTGTTATATGCGTCTCCAGACAGAATTCGAGAAGAAGTCGCAACCATTTTAGAGAAATATGGCCAAGGAACAGGT
CATGTCTTTAACTTGGGTCATGGCATCCACCCTGAAATTGATCCAGAACATGCTGGAGCCTTTATCAAAGCCGTGACCGA
GTTGAGCCCGAAATACCATAAGTAA

Upstream 100 bases:

>100_bases
ACCGTTAAAATAACCTCTTAAATTTTTTGAGACTTCGTGCTGCCACAACCAGCCTTCTCACTTTAAACCGTATTAGCTAA
AATATTAAAAAGGATTCCTT

Downstream 100 bases:

>100_bases
ATACTTGGTTAATGGCCCACTGATTATAATCACATAAAAAAGCCCGAATCATTCGGGCTTTTTTTATAGCATCATTTCAT
CAAACTTAACGTTAGCTTAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAELQNDRFLRALLKEPVDQTPVWMMRQAGRYLPEYRATRKQAGSFMDLCRNKELACEVTLQPLERYPLDAAILFSDILT
IPDAMGLELRFQTGEGPIFDKPIKSMSDAKKLFVPDMASELGYVMDAVSTIRKALDGRVPLIGFSGSPWTLATYMVEGGS
SKTFAKIKAMMYDQPATLHHILDVLADSVIAYLNAQIEAGAQAVQIFDTWGGVLTPRDYKEFSLNYMAKIVDGLKRENDG
RKVPVILFTKGGGQWLESMAETGCDALGLDWTTDIDDARARVGDKVALQGNMDPSVLYASPDRIREEVATILEKYGQGTG
HVFNLGHGIHPEIDPEHAGAFIKAVTELSPKYHK

Sequences:

>Translated_354_residues
MAELQNDRFLRALLKEPVDQTPVWMMRQAGRYLPEYRATRKQAGSFMDLCRNKELACEVTLQPLERYPLDAAILFSDILT
IPDAMGLELRFQTGEGPIFDKPIKSMSDAKKLFVPDMASELGYVMDAVSTIRKALDGRVPLIGFSGSPWTLATYMVEGGS
SKTFAKIKAMMYDQPATLHHILDVLADSVIAYLNAQIEAGAQAVQIFDTWGGVLTPRDYKEFSLNYMAKIVDGLKRENDG
RKVPVILFTKGGGQWLESMAETGCDALGLDWTTDIDDARARVGDKVALQGNMDPSVLYASPDRIREEVATILEKYGQGTG
HVFNLGHGIHPEIDPEHAGAFIKAVTELSPKYHK
>Mature_353_residues
AELQNDRFLRALLKEPVDQTPVWMMRQAGRYLPEYRATRKQAGSFMDLCRNKELACEVTLQPLERYPLDAAILFSDILTI
PDAMGLELRFQTGEGPIFDKPIKSMSDAKKLFVPDMASELGYVMDAVSTIRKALDGRVPLIGFSGSPWTLATYMVEGGSS
KTFAKIKAMMYDQPATLHHILDVLADSVIAYLNAQIEAGAQAVQIFDTWGGVLTPRDYKEFSLNYMAKIVDGLKRENDGR
KVPVILFTKGGGQWLESMAETGCDALGLDWTTDIDDARARVGDKVALQGNMDPSVLYASPDRIREEVATILEKYGQGTGH
VFNLGHGIHPEIDPEHAGAFIKAVTELSPKYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=49.5726495726496, Blast_Score=343, Evalue=2e-94,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=75.1412429378531, Blast_Score=556, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=39.6067415730337, Blast_Score=272, Evalue=5e-74,
Organism=Drosophila melanogaster, GI221330099, Length=346, Percent_Identity=44.7976878612717, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI19921920, Length=346, Percent_Identity=44.7976878612717, Blast_Score=304, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_THICR (Q31JF4)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390393.1
- ProteinModelPortal:   Q31JF4
- SMR:   Q31JF4
- STRING:   Q31JF4
- GeneID:   3762492
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0123
- NMPDR:   fig|317025.3.peg.139
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q31JF4
- BioCyc:   TCRU317025:TCR_0123-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39250; Mature: 39118

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELQNDRFLRALLKEPVDQTPVWMMRQAGRYLPEYRATRKQAGSFMDLCRNKELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLERYPLDAAILFSDILTIPDAMGLELRFQTGEGPIFDKPIKSMSDAKKLFVPDMASE
ECHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHH
LGYVMDAVSTIRKALDGRVPLIGFSGSPWTLATYMVEGGSSKTFAKIKAMMYDQPATLHH
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCHHHHH
ILDVLADSVIAYLNAQIEAGAQAVQIFDTWGGVLTPRDYKEFSLNYMAKIVDGLKRENDG
HHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
RKVPVILFTKGGGQWLESMAETGCDALGLDWTTDIDDARARVGDKVALQGNMDPSVLYAS
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCCCEEECC
PDRIREEVATILEKYGQGTGHVFNLGHGIHPEIDPEHAGAFIKAVTELSPKYHK
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AELQNDRFLRALLKEPVDQTPVWMMRQAGRYLPEYRATRKQAGSFMDLCRNKELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLERYPLDAAILFSDILTIPDAMGLELRFQTGEGPIFDKPIKSMSDAKKLFVPDMASE
ECHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHH
LGYVMDAVSTIRKALDGRVPLIGFSGSPWTLATYMVEGGSSKTFAKIKAMMYDQPATLHH
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCHHHHH
ILDVLADSVIAYLNAQIEAGAQAVQIFDTWGGVLTPRDYKEFSLNYMAKIVDGLKRENDG
HHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
RKVPVILFTKGGGQWLESMAETGCDALGLDWTTDIDDARARVGDKVALQGNMDPSVLYAS
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCCCEEECC
PDRIREEVATILEKYGQGTGHVFNLGHGIHPEIDPEHAGAFIKAVTELSPKYHK
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA