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The map label for this gene is kinB [H]

Identifier: 78357867

GI number: 78357867

Start: 2811936

End: 2813573

Strand: Reverse

Name: kinB [H]

Synonym: Dde_2826

Alternate gene names: 78357867

Gene position: 2813573-2811936 (Counterclockwise)

Preceding gene: 78357868

Following gene: 78357866

Centisome position: 75.43

GC content: 62.58

Gene sequence:

>1638_bases
GTGGACAACAACGGATATCTGACGCACTGCGGGCGGCCTGATACTGAACGGGAACGTCCCGGCGTGCTGCTGGACACCTC
GCCCGTGGGGGCTTTTCTGGTGTCGTGCGACGGAGCACTGCTGGAGTGCAACCGGACCTTTGCATCACAGGCCGGGCTGG
GTGCCCGGCAGGCTGCAGGACACACGCTGCGCTCTCTGCTGGGCGATGCCGACTGGCCGGTGCACGCAGCCGCGCTTAAA
CGGTGTGCCGAACATGCCGAGCCCGTGCGTTATGAAGTGCTGCTGCCGCAGGGCTGGAGGGCGTTCGCCCTGTATCCTGT
GGCTGCCGCGCTGGGACGCGTGGCCTGTGTGGCCGGATATGCGCTTGATCTGTCAGGTCCGTCTGGGCGCCGTCCGTCCG
GCTTTGCACCGGATTCCGCCTTGCATCCCGAGGAGTGTGCAGGGAGCGGTCAGGATGATGGACAGCCCCCTGAACCGGCT
CATGAACTGGCGGCTGCTCCGGCCGGTGTTTTGTCCGGCGGCGCAGTGCGCCGGGCTGATGCTGCCGGACAGCCGGTACA
TGCGGTGCAGAACTCCGGCGGTGCTGCGGTGGGGTATATTTCGCCCTCGGGGCGGCTGCTGCAGCTCAGCGCTGCCCTGT
GCACCATGCTGGGCGGCTCGCACGACCAGTTACGCGGCAGCGATTTTGCGCTGTCGTTTAATGAGAATGACCGCCCCGCA
GTGCGCGAGCGTCTGCGGGCCGGGGTGGGTTCCGGCGTGGAAGGAGTGGCTTTCGAGGCGCGTCTGAACGCTCTGCAGGA
TGAGGACAAATGGTGCCGGGTGCATTGTCTTGGCGTATGTGCCGCAGAAGACAAACCCCTGTTCGGCATCGTGGTGGCGG
AGGATGTTTCGCACATCCGCAGACTGCGGGCCGAAGCAGTGCGTGCCGGACAGCTTGCTTCGCTGGGCGAACTGGCGGCG
GGTGTTGCTCACGAAATCAATAACCCCGTGAACGGCATCATCAATTACGCCCAGCTGCTGCTTGATGCAGCGGAATCGCG
CAAGGCACAGGCCGAAGCGGGGATAGCCAGAAAAATTATCAAGGAAGGCAGCAGAATAGCAGATATCGCTCATAATCTGC
TGTTTTTTGCCCGGGACAGGCGTCAGGAGATGGCCCTGCTGCGTCCCGAAGCCGTGCTGCTTGAGTCGCTGGACCTTACC
CGTGCCATGATCAGCCGTGACGGCATAACCCTGCAGATTGCCGTAGAGCCTGATCTGCCCATGGTGCGGGGACGCAGCCG
TGAATTGCAGCAGGTTTTTCTGAATGTCATCAGCAATGCGCGTTATGCACTTAACAGACGTTTTGCAACGCCGTGTCCGG
AAAAGCACCTTGCCATATCGCTGCGCAGCCGCCGCGGGGGCGAAGGCATGGTGGTGGCGGAATTTGTCGATCAGGGCGGA
GGAATTCCCGGGCATCTGCGTGCCAGAGTGCTGGAACCTTTTTTTTCCACCAAGCCGGAGCGTGAAGGCACCGGGCTTGG
GCTGTCCATCAGCCAGAGTATTATCAGAGCACATGGCGGCCTGCTGGAACTGTACAGCGACGGGCACACGTATACGCGGG
TGCAGATCAGCCTGCCCACCCCCACAGGAGCGCAATAA

Upstream 100 bases:

>100_bases
CGGATTCTTTTTTCAACAGGCTGTTCACGCGTTCCGTCACCATGCGGCTGCGTGATAACACCCAGCGGTTTGCCCTGTGG
GTGAGTCAGTAGGGGACAGC

Downstream 100 bases:

>100_bases
TGGCCTTTATTCTGGTGGTTGATGATGAAGAATCCATCTGTTTCACGTTCCGCCTGTTTCTGGAACAGGCGGGATATGAC
GTGCAGACGGCCTCGTCCTG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MDNNGYLTHCGRPDTERERPGVLLDTSPVGAFLVSCDGALLECNRTFASQAGLGARQAAGHTLRSLLGDADWPVHAAALK
RCAEHAEPVRYEVLLPQGWRAFALYPVAAALGRVACVAGYALDLSGPSGRRPSGFAPDSALHPEECAGSGQDDGQPPEPA
HELAAAPAGVLSGGAVRRADAAGQPVHAVQNSGGAAVGYISPSGRLLQLSAALCTMLGGSHDQLRGSDFALSFNENDRPA
VRERLRAGVGSGVEGVAFEARLNALQDEDKWCRVHCLGVCAAEDKPLFGIVVAEDVSHIRRLRAEAVRAGQLASLGELAA
GVAHEINNPVNGIINYAQLLLDAAESRKAQAEAGIARKIIKEGSRIADIAHNLLFFARDRRQEMALLRPEAVLLESLDLT
RAMISRDGITLQIAVEPDLPMVRGRSRELQQVFLNVISNARYALNRRFATPCPEKHLAISLRSRRGGEGMVVAEFVDQGG
GIPGHLRARVLEPFFSTKPEREGTGLGLSISQSIIRAHGGLLELYSDGHTYTRVQISLPTPTGAQ

Sequences:

>Translated_545_residues
MDNNGYLTHCGRPDTERERPGVLLDTSPVGAFLVSCDGALLECNRTFASQAGLGARQAAGHTLRSLLGDADWPVHAAALK
RCAEHAEPVRYEVLLPQGWRAFALYPVAAALGRVACVAGYALDLSGPSGRRPSGFAPDSALHPEECAGSGQDDGQPPEPA
HELAAAPAGVLSGGAVRRADAAGQPVHAVQNSGGAAVGYISPSGRLLQLSAALCTMLGGSHDQLRGSDFALSFNENDRPA
VRERLRAGVGSGVEGVAFEARLNALQDEDKWCRVHCLGVCAAEDKPLFGIVVAEDVSHIRRLRAEAVRAGQLASLGELAA
GVAHEINNPVNGIINYAQLLLDAAESRKAQAEAGIARKIIKEGSRIADIAHNLLFFARDRRQEMALLRPEAVLLESLDLT
RAMISRDGITLQIAVEPDLPMVRGRSRELQQVFLNVISNARYALNRRFATPCPEKHLAISLRSRRGGEGMVVAEFVDQGG
GIPGHLRARVLEPFFSTKPEREGTGLGLSISQSIIRAHGGLLELYSDGHTYTRVQISLPTPTGAQ
>Mature_545_residues
MDNNGYLTHCGRPDTERERPGVLLDTSPVGAFLVSCDGALLECNRTFASQAGLGARQAAGHTLRSLLGDADWPVHAAALK
RCAEHAEPVRYEVLLPQGWRAFALYPVAAALGRVACVAGYALDLSGPSGRRPSGFAPDSALHPEECAGSGQDDGQPPEPA
HELAAAPAGVLSGGAVRRADAAGQPVHAVQNSGGAAVGYISPSGRLLQLSAALCTMLGGSHDQLRGSDFALSFNENDRPA
VRERLRAGVGSGVEGVAFEARLNALQDEDKWCRVHCLGVCAAEDKPLFGIVVAEDVSHIRRLRAEAVRAGQLASLGELAA
GVAHEINNPVNGIINYAQLLLDAAESRKAQAEAGIARKIIKEGSRIADIAHNLLFFARDRRQEMALLRPEAVLLESLDLT
RAMISRDGITLQIAVEPDLPMVRGRSRELQQVFLNVISNARYALNRRFATPCPEKHLAISLRSRRGGEGMVVAEFVDQGG
GIPGHLRARVLEPFFSTKPEREGTGLGLSISQSIIRAHGGLLELYSDGHTYTRVQISLPTPTGAQ

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the kinB activity [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=362, Percent_Identity=25.6906077348066, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790436, Length=259, Percent_Identity=31.2741312741313, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=31.304347826087, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790300, Length=279, Percent_Identity=28.673835125448, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57967; Mature: 57967

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNNGYLTHCGRPDTERERPGVLLDTSPVGAFLVSCDGALLECNRTFASQAGLGARQAAG
CCCCCEEEECCCCCCCCCCCCEEEECCCCCEEEEECCCCEEECCHHHHHHCCCCHHHHHH
HTLRSLLGDADWPVHAAALKRCAEHAEPVRYEVLLPQGWRAFALYPVAAALGRVACVAGY
HHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCE
ALDLSGPSGRRPSGFAPDSALHPEECAGSGQDDGQPPEPAHELAAAPAGVLSGGAVRRAD
EEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCCCHHHCCCCEECCC
AAGQPVHAVQNSGGAAVGYISPSGRLLQLSAALCTMLGGSHDQLRGSDFALSFNENDRPA
CCCCCHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHH
VRERLRAGVGSGVEGVAFEARLNALQDEDKWCRVHCLGVCAAEDKPLFGIVVAEDVSHIR
HHHHHHHCCCCCCCCEEHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEHHHHHHHH
RLRAEAVRAGQLASLGELAAGVAHEINNPVNGIINYAQLLLDAAESRKAQAEAGIARKII
HHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEGSRIADIAHNLLFFARDRRQEMALLRPEAVLLESLDLTRAMISRDGITLQIAVEPDLP
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
MVRGRSRELQQVFLNVISNARYALNRRFATPCPEKHLAISLRSRRGGEGMVVAEFVDQGG
CCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHHCCC
GIPGHLRARVLEPFFSTKPEREGTGLGLSISQSIIRAHGGLLELYSDGHTYTRVQISLPT
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEEECCC
PTGAQ
CCCCC
>Mature Secondary Structure
MDNNGYLTHCGRPDTERERPGVLLDTSPVGAFLVSCDGALLECNRTFASQAGLGARQAAG
CCCCCEEEECCCCCCCCCCCCEEEECCCCCEEEEECCCCEEECCHHHHHHCCCCHHHHHH
HTLRSLLGDADWPVHAAALKRCAEHAEPVRYEVLLPQGWRAFALYPVAAALGRVACVAGY
HHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCE
ALDLSGPSGRRPSGFAPDSALHPEECAGSGQDDGQPPEPAHELAAAPAGVLSGGAVRRAD
EEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCCCHHHCCCCEECCC
AAGQPVHAVQNSGGAAVGYISPSGRLLQLSAALCTMLGGSHDQLRGSDFALSFNENDRPA
CCCCCHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHH
VRERLRAGVGSGVEGVAFEARLNALQDEDKWCRVHCLGVCAAEDKPLFGIVVAEDVSHIR
HHHHHHHCCCCCCCCEEHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEHHHHHHHH
RLRAEAVRAGQLASLGELAAGVAHEINNPVNGIINYAQLLLDAAESRKAQAEAGIARKII
HHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEGSRIADIAHNLLFFARDRRQEMALLRPEAVLLESLDLTRAMISRDGITLQIAVEPDLP
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
MVRGRSRELQQVFLNVISNARYALNRRFATPCPEKHLAISLRSRRGGEGMVVAEFVDQGG
CCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHHCCC
GIPGHLRARVLEPFFSTKPEREGTGLGLSISQSIIRAHGGLLELYSDGHTYTRVQISLPT
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEEECCC
PTGAQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]