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The map label for this gene is zraR [H]

Identifier: 78357866

GI number: 78357866

Start: 2810167

End: 2811936

Strand: Reverse

Name: zraR [H]

Synonym: Dde_2825

Alternate gene names: 78357866

Gene position: 2811936-2810167 (Counterclockwise)

Preceding gene: 78357867

Following gene: 78357865

Centisome position: 75.38

GC content: 59.89

Gene sequence:

>1770_bases
ATGGCCTTTATTCTGGTGGTTGATGATGAAGAATCCATCTGTTTCACGTTCCGCCTGTTTCTGGAACAGGCGGGATATGA
CGTGCAGACGGCCTCGTCCTGCGCGGGGGCGCTGACGGTTATTGACGGGCAGACACCCGACCTGATTTTTGCCGACATCA
TGCTGGGCGGACCCAGCGGCATAGACCTGCTGCGCGAAGTGCGCCACCGCGGGCTGACAATGCCCTTTATTCTCATAACC
GGTGAACCCAGCATGGAAACCGCGGTGGAGGCTCTGGCTCTGGGGGCGGACGAGTATCTGTACAAACCGGTGGATAAAGA
CAAGCTGCTGCTGGCTGCGGAGCGCTGGCTGCGCTACAAGTACGTGGTGGATCAGAAACAGCGGCTGGAACGGGAAAAAG
ACGAACTGCGCAGACATCTGGAAACGGTGTTCAATGCCGTGCCGGATGCCATTGTGACAGTCTCTTCGGGCTTTACGGTG
CTCAGTGTCAATGAAGCCTGCCGGAACATACTGGGCATGGATACGGCAGCCGCAGGCGGACAGCCGTGTGACAAGGCGCT
GGGAAGCGCTGCGGCGGAATGCATGCCGCTGCTGCGGGAGGCCGTGCGCGCGGGGCACATTGTTCAGCGCGGCGGTGTGG
CTGTTCAGCATGACCGTGGCGAGATAATTGTTGATATAAGTGCCGTGCCGCTGGCCTGTGCAGCGACCGCTACTGAGCAC
TCTCCCGGGACCGATGCTTCCGGCGGAGTCATGCTTATAGTGCGTGATGTCACCAGACTGACCGGTCTTGAGCGTGCTCT
GGCGGCGCAGCATATCCGGCGCAGCATGATCGGGCGCAGCAGCGTGATGCGCGGAGTCTTCCGTCTGGTGGAAAGTCTGG
CCGACACGGACACCACCGTGCTTGTCACCGGTGAAAGCGGAACAGGTAAGGAACTGGTGGCCGATGCGCTGCACCATTCC
GGTGCGCGGGCGCAGGGACCGTTTGTCAAAGTCAACTGTTCGGCTTTATCCGAAACGCTGCTTGAAAGTGAACTGTTCGG
CCACGTGCGCGGGGCGTTCACCGGTGCCACAAAGGACAGAACCGGCCGCATACAGATGGCTCACGGAGGAACTCTTTTTC
TGGATGAAATAGGGGATATTTCACCCTCGGTGCAGCTTAAACTGCTTCGGGTGCTGCAGGAAAAAGAAATTGAGAGGGTG
GGTGAAGGGCGCCCCGTGAAAGTGGACGTACGCGTGGTGGCCGCAACCAATAAAAGCCTGCGTGCACTCGTGGCCCGCGG
CAAGTTCCGCGAAGATTTGTATTACCGGCTGAAAGTGGTCGAGGTGCACCTGCCCGCACTGCGCGAACGGCGCGAAGACA
TTCCGCTGCTGGCAGAACATTTTATTGAGGAATTCAACGAGCATTTTCACCGGCGTGTGAGCGGGCTGGACAGCAGCGCG
CAACAGCTGCTGGTGCAGTATGACTGGCCGGGCAATGTCCGTGAACTGCGGCACGCGGTGGAACATGCGTTCATCATGGC
CGGCGGCAATGTCATTCCCGCTGCGGCATTGCCTGCAGAGCTCATGCAAAGCGGCCGTTTTTCGGCACAGAGCGCCGGTA
CGGGCGCCTTGCGTCATGATGCTCCCGATGCCGCCGCGCAGGGGGCGGAGTGGAAACAGCGTCTTTCGGCAGCGCTTAAG
GAAACAGGCGGCAACAAAGCCAAGGCCGCCCGTCTGCTGGGTATTTCGCGCCAGACCATGTACCGCAGACTGCGCGAACT
GGGTATGTGA

Upstream 100 bases:

>100_bases
GTATTATCAGAGCACATGGCGGCCTGCTGGAACTGTACAGCGACGGGCACACGTATACGCGGGTGCAGATCAGCCTGCCC
ACCCCCACAGGAGCGCAATA

Downstream 100 bases:

>100_bases
TTCCGCAGGGCGCCTGCGGCTGCAGCCGGTGGCCGGTTGCACGGCCTGCCGGAGCTGGCAAGTCGGACAGCGGGCCTGTC
AGATCTGGTAAGTCCGGCAG

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MAFILVVDDEESICFTFRLFLEQAGYDVQTASSCAGALTVIDGQTPDLIFADIMLGGPSGIDLLREVRHRGLTMPFILIT
GEPSMETAVEALALGADEYLYKPVDKDKLLLAAERWLRYKYVVDQKQRLEREKDELRRHLETVFNAVPDAIVTVSSGFTV
LSVNEACRNILGMDTAAAGGQPCDKALGSAAAECMPLLREAVRAGHIVQRGGVAVQHDRGEIIVDISAVPLACAATATEH
SPGTDASGGVMLIVRDVTRLTGLERALAAQHIRRSMIGRSSVMRGVFRLVESLADTDTTVLVTGESGTGKELVADALHHS
GARAQGPFVKVNCSALSETLLESELFGHVRGAFTGATKDRTGRIQMAHGGTLFLDEIGDISPSVQLKLLRVLQEKEIERV
GEGRPVKVDVRVVAATNKSLRALVARGKFREDLYYRLKVVEVHLPALRERREDIPLLAEHFIEEFNEHFHRRVSGLDSSA
QQLLVQYDWPGNVRELRHAVEHAFIMAGGNVIPAAALPAELMQSGRFSAQSAGTGALRHDAPDAAAQGAEWKQRLSAALK
ETGGNKAKAARLLGISRQTMYRRLRELGM

Sequences:

>Translated_589_residues
MAFILVVDDEESICFTFRLFLEQAGYDVQTASSCAGALTVIDGQTPDLIFADIMLGGPSGIDLLREVRHRGLTMPFILIT
GEPSMETAVEALALGADEYLYKPVDKDKLLLAAERWLRYKYVVDQKQRLEREKDELRRHLETVFNAVPDAIVTVSSGFTV
LSVNEACRNILGMDTAAAGGQPCDKALGSAAAECMPLLREAVRAGHIVQRGGVAVQHDRGEIIVDISAVPLACAATATEH
SPGTDASGGVMLIVRDVTRLTGLERALAAQHIRRSMIGRSSVMRGVFRLVESLADTDTTVLVTGESGTGKELVADALHHS
GARAQGPFVKVNCSALSETLLESELFGHVRGAFTGATKDRTGRIQMAHGGTLFLDEIGDISPSVQLKLLRVLQEKEIERV
GEGRPVKVDVRVVAATNKSLRALVARGKFREDLYYRLKVVEVHLPALRERREDIPLLAEHFIEEFNEHFHRRVSGLDSSA
QQLLVQYDWPGNVRELRHAVEHAFIMAGGNVIPAAALPAELMQSGRFSAQSAGTGALRHDAPDAAAQGAEWKQRLSAALK
ETGGNKAKAARLLGISRQTMYRRLRELGM
>Mature_588_residues
AFILVVDDEESICFTFRLFLEQAGYDVQTASSCAGALTVIDGQTPDLIFADIMLGGPSGIDLLREVRHRGLTMPFILITG
EPSMETAVEALALGADEYLYKPVDKDKLLLAAERWLRYKYVVDQKQRLEREKDELRRHLETVFNAVPDAIVTVSSGFTVL
SVNEACRNILGMDTAAAGGQPCDKALGSAAAECMPLLREAVRAGHIVQRGGVAVQHDRGEIIVDISAVPLACAATATEHS
PGTDASGGVMLIVRDVTRLTGLERALAAQHIRRSMIGRSSVMRGVFRLVESLADTDTTVLVTGESGTGKELVADALHHSG
ARAQGPFVKVNCSALSETLLESELFGHVRGAFTGATKDRTGRIQMAHGGTLFLDEIGDISPSVQLKLLRVLQEKEIERVG
EGRPVKVDVRVVAATNKSLRALVARGKFREDLYYRLKVVEVHLPALRERREDIPLLAEHFIEEFNEHFHRRVSGLDSSAQ
QLLVQYDWPGNVRELRHAVEHAFIMAGGNVIPAAALPAELMQSGRFSAQSAGTGALRHDAPDAAAQGAEWKQRLSAALKE
TGGNKAKAARLLGISRQTMYRRLRELGM

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=333, Percent_Identity=48.048048048048, Blast_Score=302, Evalue=4e-83,
Organism=Escherichia coli, GI1788550, Length=331, Percent_Identity=42.9003021148036, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1790299, Length=329, Percent_Identity=46.2006079027356, Blast_Score=271, Evalue=1e-73,
Organism=Escherichia coli, GI87082117, Length=323, Percent_Identity=44.5820433436532, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1789087, Length=325, Percent_Identity=43.3846153846154, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1789233, Length=327, Percent_Identity=41.8960244648318, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788905, Length=312, Percent_Identity=41.9871794871795, Blast_Score=244, Evalue=2e-65,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=43.8271604938272, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1786524, Length=353, Percent_Identity=40.2266288951841, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=41.3793103448276, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787583, Length=345, Percent_Identity=34.4927536231884, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI87081858, Length=460, Percent_Identity=26.5217391304348, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789828, Length=315, Percent_Identity=33.968253968254, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=34.5132743362832, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 64104; Mature: 63973

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFILVVDDEESICFTFRLFLEQAGYDVQTASSCAGALTVIDGQTPDLIFADIMLGGPSG
CEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCCCCEEEEEEEECCCCH
IDLLREVRHRGLTMPFILITGEPSMETAVEALALGADEYLYKPVDKDKLLLAAERWLRYK
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHH
YVVDQKQRLEREKDELRRHLETVFNAVPDAIVTVSSGFTVLSVNEACRNILGMDTAAAGG
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHCCCCCCCCC
QPCDKALGSAAAECMPLLREAVRAGHIVQRGGVAVQHDRGEIIVDISAVPLACAATATEH
CCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCEEEEECCCCHHHHHCCCCC
SPGTDASGGVMLIVRDVTRLTGLERALAAQHIRRSMIGRSSVMRGVFRLVESLADTDTTV
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LVTGESGTGKELVADALHHSGARAQGPFVKVNCSALSETLLESELFGHVRGAFTGATKDR
EEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TGRIQMAHGGTLFLDEIGDISPSVQLKLLRVLQEKEIERVGEGRPVKVDVRVVAATNKSL
CCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCHHH
RALVARGKFREDLYYRLKVVEVHLPALRERREDIPLLAEHFIEEFNEHFHRRVSGLDSSA
HHHHHHCCHHHHHHEEEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
QQLLVQYDWPGNVRELRHAVEHAFIMAGGNVIPAAALPAELMQSGRFSAQSAGTGALRHD
HHEEEEECCCCCHHHHHHHHHHHEEEECCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCC
APDAAAQGAEWKQRLSAALKETGGNKAKAARLLGISRQTMYRRLRELGM
CCCHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFILVVDDEESICFTFRLFLEQAGYDVQTASSCAGALTVIDGQTPDLIFADIMLGGPSG
EEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCCCCEEEEEEEECCCCH
IDLLREVRHRGLTMPFILITGEPSMETAVEALALGADEYLYKPVDKDKLLLAAERWLRYK
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHH
YVVDQKQRLEREKDELRRHLETVFNAVPDAIVTVSSGFTVLSVNEACRNILGMDTAAAGG
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHCCCCCCCCC
QPCDKALGSAAAECMPLLREAVRAGHIVQRGGVAVQHDRGEIIVDISAVPLACAATATEH
CCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCEEEEECCCCHHHHHCCCCC
SPGTDASGGVMLIVRDVTRLTGLERALAAQHIRRSMIGRSSVMRGVFRLVESLADTDTTV
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LVTGESGTGKELVADALHHSGARAQGPFVKVNCSALSETLLESELFGHVRGAFTGATKDR
EEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TGRIQMAHGGTLFLDEIGDISPSVQLKLLRVLQEKEIERVGEGRPVKVDVRVVAATNKSL
CCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCHHH
RALVARGKFREDLYYRLKVVEVHLPALRERREDIPLLAEHFIEEFNEHFHRRVSGLDSSA
HHHHHHCCHHHHHHEEEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
QQLLVQYDWPGNVRELRHAVEHAFIMAGGNVIPAAALPAELMQSGRFSAQSAGTGALRHD
HHEEEEECCCCCHHHHHHHHHHHEEEECCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCC
APDAAAQGAEWKQRLSAALKETGGNKAKAARLLGISRQTMYRRLRELGM
CCCHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]