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The map label for this gene is fba [H]

Identifier: 78357384

GI number: 78357384

Start: 2360122

End: 2361045

Strand: Direct

Name: fba [H]

Synonym: Dde_2341

Alternate gene names: 78357384

Gene position: 2360122-2361045 (Clockwise)

Preceding gene: 78357383

Following gene: 78357385

Centisome position: 63.27

GC content: 56.6

Gene sequence:

>924_bases
ATGCCGCTAACAGGCCCAAAAGAAATGTTCGCCCGCGCCTACAAAGAAGGCTATGCCATAGGCGCCTTCAACGTGAACAA
CATGGAAATCATTCAGGGTATCATGCAGGCGGGCGCCGAAGAAAAGGCTCCGCTCATCCTGCAGGTTTCCGCCGGGGCGC
GCAAGTACGCCGGCCAGACGTACATCGTCAAACTCATCGAGGCCGCACTTTCCGAATCCGACCTGCCCGTGGTGCTGCAT
CTGGACCACGGTTCCGGTTTCGATATCTGCAAAGACTGCATTGACGGCGGCTTTACCTCTGTCATGATCGACGGCTCCCA
CCTGCCCTATGAAGAAAACATAGCCGTTACCAGACGCGTGGTGGAATATGCCCACGACAAAGGCGTATGGGTAGAAGCTG
AACTGGGACAGCTGGCCGGAGTGGAAGAAGACGTATCCGCCGAACATTCCGTTTACACCGACCCTGATCAGGCCGTGGAA
TTTGTGGAGCGCACCGGATGCGATTCGCTTGCCATCGCCATAGGCACCAGCCACGGCGCCTACAAATTCACGGGCAAAGC
CACTCTGGATTTTGACCGGCTGTCCACCATCACCGACAAGCTGCCCGGATTTCCGCTGGTGCTGCACGGAGCCTCATCGG
TACCGCAGGAGTTTGTGGCCATGGCCAACCAGTACGGCGGCGAAATAGGCGGCGCTCAGGGCGTACCCGAAGACCTGCTG
CGCAAATCCGCCTCTTACGGCGTATGCAAAATCAACATTGATACCGATATCCGTCTGGCCATGACAGCGTGCATCCGCAA
ACACTTTGCAGAAAATCCCGCAGACTTTGACCCGCGGGCCTATCTCAAGCCCGCCCGCGAAGCTGTGAAAAACATGGTTC
AACATAAAATCCGCAACGTACTGGGTTGCTCCAACAAGGCATAA

Upstream 100 bases:

>100_bases
TCAATGCCTGGCTGACAAGTACCGGAGCCTTGCCGCTCCTTGTCATAACCGTCATTTGCGACCGGCGCAGCACAGCGCCG
GTTTCGCCGAGGAGGACACC

Downstream 100 bases:

>100_bases
AGGAACGCTAGCATGGCTGTTACGCTTGGCATCAACGGGTTCGGCCGCATCGGCCGCTATCTTGTGCGCCTTCTGGCAAA
TGATCCCGAACTGAATACCG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPLTGPKEMFARAYKEGYAIGAFNVNNMEIIQGIMQAGAEEKAPLILQVSAGARKYAGQTYIVKLIEAALSESDLPVVLH
LDHGSGFDICKDCIDGGFTSVMIDGSHLPYEENIAVTRRVVEYAHDKGVWVEAELGQLAGVEEDVSAEHSVYTDPDQAVE
FVERTGCDSLAIAIGTSHGAYKFTGKATLDFDRLSTITDKLPGFPLVLHGASSVPQEFVAMANQYGGEIGGAQGVPEDLL
RKSASYGVCKINIDTDIRLAMTACIRKHFAENPADFDPRAYLKPAREAVKNMVQHKIRNVLGCSNKA

Sequences:

>Translated_307_residues
MPLTGPKEMFARAYKEGYAIGAFNVNNMEIIQGIMQAGAEEKAPLILQVSAGARKYAGQTYIVKLIEAALSESDLPVVLH
LDHGSGFDICKDCIDGGFTSVMIDGSHLPYEENIAVTRRVVEYAHDKGVWVEAELGQLAGVEEDVSAEHSVYTDPDQAVE
FVERTGCDSLAIAIGTSHGAYKFTGKATLDFDRLSTITDKLPGFPLVLHGASSVPQEFVAMANQYGGEIGGAQGVPEDLL
RKSASYGVCKINIDTDIRLAMTACIRKHFAENPADFDPRAYLKPAREAVKNMVQHKIRNVLGCSNKA
>Mature_306_residues
PLTGPKEMFARAYKEGYAIGAFNVNNMEIIQGIMQAGAEEKAPLILQVSAGARKYAGQTYIVKLIEAALSESDLPVVLHL
DHGSGFDICKDCIDGGFTSVMIDGSHLPYEENIAVTRRVVEYAHDKGVWVEAELGQLAGVEEDVSAEHSVYTDPDQAVEF
VERTGCDSLAIAIGTSHGAYKFTGKATLDFDRLSTITDKLPGFPLVLHGASSVPQEFVAMANQYGGEIGGAQGVPEDLLR
KSASYGVCKINIDTDIRLAMTACIRKHFAENPADFDPRAYLKPAREAVKNMVQHKIRNVLGCSNKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=308, Percent_Identity=39.9350649350649, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082041, Length=309, Percent_Identity=36.8932038834951, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788072, Length=302, Percent_Identity=34.7682119205298, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789293, Length=343, Percent_Identity=24.7813411078717, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 33211; Mature: 33080

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTGPKEMFARAYKEGYAIGAFNVNNMEIIQGIMQAGAEEKAPLILQVSAGARKYAGQT
CCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCHH
YIVKLIEAALSESDLPVVLHLDHGSGFDICKDCIDGGFTSVMIDGSHLPYEENIAVTRRV
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHH
VEYAHDKGVWVEAELGQLAGVEEDVSAEHSVYTDPDQAVEFVERTGCDSLAIAIGTSHGA
HHHHHCCCCEEEECHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
YKFTGKATLDFDRLSTITDKLPGFPLVLHGASSVPQEFVAMANQYGGEIGGAQGVPEDLL
EEECCCEEECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHH
RKSASYGVCKINIDTDIRLAMTACIRKHFAENPADFDPRAYLKPAREAVKNMVQHKIRNV
HCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGCSNKA
HCCCCCC
>Mature Secondary Structure 
PLTGPKEMFARAYKEGYAIGAFNVNNMEIIQGIMQAGAEEKAPLILQVSAGARKYAGQT
CCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCHH
YIVKLIEAALSESDLPVVLHLDHGSGFDICKDCIDGGFTSVMIDGSHLPYEENIAVTRRV
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHH
VEYAHDKGVWVEAELGQLAGVEEDVSAEHSVYTDPDQAVEFVERTGCDSLAIAIGTSHGA
HHHHHCCCCEEEECHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
YKFTGKATLDFDRLSTITDKLPGFPLVLHGASSVPQEFVAMANQYGGEIGGAQGVPEDLL
EEECCCEEECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHH
RKSASYGVCKINIDTDIRLAMTACIRKHFAENPADFDPRAYLKPAREAVKNMVQHKIRNV
HCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGCSNKA
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]