Click here to switch to the map view.

The map label for this gene is kdsA [H]

Identifier: 78356809

GI number: 78356809

Start: 1821817

End: 1822635

Strand: Direct

Name: kdsA [H]

Synonym: Dde_1766

Alternate gene names: 78356809

Gene position: 1821817-1822635 (Clockwise)

Preceding gene: 78356808

Following gene: 78356810

Centisome position: 48.84

GC content: 57.02

Gene sequence:

>819_bases
ATGACGTTTTCTACGACAGAACTCTATAAAACCCTGTGCGACGGCCCGTTTATCATTGCAGGCCCCTGCGTGCTCGAAAG
CTACGAGCTGGCGCTTGAAACTGCCCGCATTGTGCGTGAGGCTGCGGACAGACATGCTGTCACAGCAATTTTTAAAAGCT
CTTTTGACAAGGCCAACCGTACATCGGCCTCCAGCTTCCGCGGCCCCGGAATGACTACGGGGCTGGAGTGGCTGGCCCGC
ATCCGCGAAGAAACGGGCCTGCCTGTCATTACCGATATTCATGAACCTGCTCAGGCCGCACCTGTGGCAGCTGTGGCTGA
CATTTTGCAAATACCGGCATTTCTGTGCAGGCAGACAGCCCTGCTGCAGGCGGCTGCCGCCACCGGCAGCGTGGTCAATG
TAAAGAAAGGCCAGTTTGTGGCGCCTTGGGATATGGGGCCAGTGGTGGAAAAACTGCATGCGGCAGGAAACCGTCACGTG
ATGCTTACCGAAAGAGGGGCAAGTTTCGGCTATAACAATCTTGTGGTCGATTTCCGCTCTTTTTCCATCATGCGCAGCCT
GAATGTTCCTGTAATTTTCGATGCCACCCATTCCGTACAGCTTCCGGGCGGGCAGGGTTCCTGCTCCGGAGGGGACAGAA
GGCATGTTCCTGCACTGGCCCGCGCAGCTGTGGCAGCAGGTGCAAACGGGGTTTTTCTGGAATGTCATCCCGACCCCGAC
AAGGCGCTGTGCGACGGCCCCAACAGCTGGCCCGCGGGGCGCCTGAGCGATCTTGTAGGAGATCTGAAGAGCATCTGGAG
TATTGACTATGCGTGTTAA

Upstream 100 bases:

>100_bases
AGGTTTCCTGTGGTTTTCCGGTTCCGGCATGCTGCCGGACAGCCGCGCCCAAGCCGTGCGCCGCGGCCACCTCACCAAGA
TTTTACCATGGCGGAGATGC

Downstream 100 bases:

>100_bases
AGAGCTGGCCGCCAACATCCGCCTGCTTGTTCTGGATGTGGACGGGGTGCTGACAGACGGCGGTCTGTACTATTTTGGTG
ACGGCAGGGTGGCCAAGCGC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTFSTTELYKTLCDGPFIIAGPCVLESYELALETARIVREAADRHAVTAIFKSSFDKANRTSASSFRGPGMTTGLEWLAR
IREETGLPVITDIHEPAQAAPVAAVADILQIPAFLCRQTALLQAAAATGSVVNVKKGQFVAPWDMGPVVEKLHAAGNRHV
MLTERGASFGYNNLVVDFRSFSIMRSLNVPVIFDATHSVQLPGGQGSCSGGDRRHVPALARAAVAAGANGVFLECHPDPD
KALCDGPNSWPAGRLSDLVGDLKSIWSIDYAC

Sequences:

>Translated_272_residues
MTFSTTELYKTLCDGPFIIAGPCVLESYELALETARIVREAADRHAVTAIFKSSFDKANRTSASSFRGPGMTTGLEWLAR
IREETGLPVITDIHEPAQAAPVAAVADILQIPAFLCRQTALLQAAAATGSVVNVKKGQFVAPWDMGPVVEKLHAAGNRHV
MLTERGASFGYNNLVVDFRSFSIMRSLNVPVIFDATHSVQLPGGQGSCSGGDRRHVPALARAAVAAGANGVFLECHPDPD
KALCDGPNSWPAGRLSDLVGDLKSIWSIDYAC
>Mature_271_residues
TFSTTELYKTLCDGPFIIAGPCVLESYELALETARIVREAADRHAVTAIFKSSFDKANRTSASSFRGPGMTTGLEWLARI
REETGLPVITDIHEPAQAAPVAAVADILQIPAFLCRQTALLQAAAATGSVVNVKKGQFVAPWDMGPVVEKLHAAGNRHVM
LTERGASFGYNNLVVDFRSFSIMRSLNVPVIFDATHSVQLPGGQGSCSGGDRRHVPALARAAVAAGANGVFLECHPDPDK
ALCDGPNSWPAGRLSDLVGDLKSIWSIDYAC

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=255, Percent_Identity=47.843137254902, Blast_Score=253, Evalue=1e-68,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 28994; Mature: 28863

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSTTELYKTLCDGPFIIAGPCVLESYELALETARIVREAADRHAVTAIFKSSFDKANR
CCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TSASSFRGPGMTTGLEWLARIREETGLPVITDIHEPAQAAPVAAVADILQIPAFLCRQTA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLQAAAATGSVVNVKKGQFVAPWDMGPVVEKLHAAGNRHVMLTERGASFGYNNLVVDFRS
HHHHHHCCCCEEEECCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHH
FSIMRSLNVPVIFDATHSVQLPGGQGSCSGGDRRHVPALARAAVAAGANGVFLECHPDPD
HHHHHHCCCCEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCC
KALCDGPNSWPAGRLSDLVGDLKSIWSIDYAC
CHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TFSTTELYKTLCDGPFIIAGPCVLESYELALETARIVREAADRHAVTAIFKSSFDKANR
CCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TSASSFRGPGMTTGLEWLARIREETGLPVITDIHEPAQAAPVAAVADILQIPAFLCRQTA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLQAAAATGSVVNVKKGQFVAPWDMGPVVEKLHAAGNRHVMLTERGASFGYNNLVVDFRS
HHHHHHCCCCEEEECCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHH
FSIMRSLNVPVIFDATHSVQLPGGQGSCSGGDRRHVPALARAAVAAGANGVFLECHPDPD
HHHHHHCCCCEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCC
KALCDGPNSWPAGRLSDLVGDLKSIWSIDYAC
CHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA