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The map label for this gene is pyrG

Identifier: 78356808

GI number: 78356808

Start: 1819990

End: 1821636

Strand: Direct

Name: pyrG

Synonym: Dde_1765

Alternate gene names: 78356808

Gene position: 1819990-1821636 (Clockwise)

Preceding gene: 78356805

Following gene: 78356809

Centisome position: 48.79

GC content: 55.07

Gene sequence:

>1647_bases
ATGAAAACCAAGTTTATCTTTATCACCGGCGGGGTGCTTTCGTCGCTGGGCAAAGGGCTGGCTGCCGCATCTGTGGGGGC
ACTGCTGCAGGCCCGGGGACTCAAGGTCACCATTCAGAAACTCGACCCCTACATCAACGTCGACCCCGGCACCATGAACC
CGTTTCAGCACGGTGAAGTGTATGTGACCGACGACGGCGCTGAAACCGACCTTGATCTTGGCCATTACGAGCGCTACCTC
GGCATTCCCATGAACCAGCGCAACAACTACACGTCCGGTTCCATCTACCACCGCGTGATCACAAAGGAACGCCGCGGCGA
CTATCTGGGGGGCACCGTTCAGGTTATTCCGCATATCACCGACGAAATCAAAAGCGTGATCATGAATCTGGCCAGCGACG
ACCTTGATGTGGCGCTGGTGGAAATAGGCGGAACCGTGGGTGACATCGAAGGACAGCCGTTCCTTGAAGCCATCCGGCAG
CTTCGTTCCGATCTGGGCCGTGACCGCTGCATGTACATCCACCTGACGCTGGTACCGTATCTGGCCGCCGCCGGCGAACA
CAAAACCAAGCCTACCCAGCACAGCGTCAAAGAGCTTCGCAGCATAGGCATTCAGCCCGACATTATTCTGTGCCGTTGCG
AAAAAGCCGTCACCGATGACCTCAAGCACAAGATTGCTCTGTTCTGCAACGTGGAAAAAGATGCTGTTTTTTCTGCTGTT
GACGTGAAAAACATCTATGAAGTGCCGCTCAGCTTCTACGAGGAAGGCTTTGATCAGAAGATCGCCATCATGCTGCAGCT
GCCGGCCAAAAATCCTGACCTGAGCAAATGGCAGGAGCTGGTGGACACATGCGCCAACCCGCAGGGCAAGGTGACCATCG
GTATCGTGGGCAAGTATGTCGATCTTAAGGAAGCATACAAAAGCCTGCACGAAGCGCTTATTCACGGCGGTGTGGCCAAC
AAGCTGGCTGTGGAGCTCAAGTACGTCAATTCCGAGCTCATCACCGATGAAAATGTGGCGGAATCTCTGGCCGGTCTCGA
CGGCATTCTGGTTCCCGGCGGCTTCGGCAGCCGAGGCGTGGAAGGAAAAATCCGGGCCATCCGTTATGCCCGTGAGAACA
AGGTGCCTTTCTTCGGCATATGTCTGGGTATGCAATGTGCGGTCATCGAATTTGCCCGCAATGTAGCCGGACTGCCCGCC
GCCAACTCCGAAGAGTTTGACGAACAGACTCCCGACAAGGTGATCTACCTGATGACGGAATGGTTTGATTTCCGCAGCAA
GCAGGTGGAGCGGCGTGATTCAGGCAGCGAAAAAGGCGGCACCATGCGTCTGGGATCGTACCCCTGCGCTGTGGTCAAGG
GTACCAATGCCTTCACTGCCTATCAGGCTGAAAAAGTGGACGAACGCCACCGTCACCGTTTTGAATTCAACAACGCCTAT
CTTGACAAGCTCAAAGAGGCCGGGCTGGTATTCAGTGGTCTGTCACCCGATGGTGAACTTGTCGAAATGGTTGAAATCAA
GGATCATCCCTGGTTCCTCGGCTGTCAGTTCCACCCTGAATTCAAGTCCTACCCCATGACCCCGCATCCGCTTTTCCGCG
AGTTTATAAAAGCCGCCGGAAAACAGGCTGTAAAAAGCAAGCGGTAA

Upstream 100 bases:

>100_bases
TGGCTGACGAGGGGTGTCGTTTTTGATACAATCAGCTGTTACCGTGTGAAACAGGATTTTTTCCCGTTTCCGAATCAAAT
CATGCTGAGGCAGGAGTTAC

Downstream 100 bases:

>100_bases
CGCTTGAACTCCTGCCATAAACGGGGCGCACACCAGTGCGCCCCGTTTTTTTAGACTTTCAATCCGGCTTTGAATCGGAT
AGGTTTCCTGTGGTTTTCCG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MKTKFIFITGGVLSSLGKGLAAASVGALLQARGLKVTIQKLDPYINVDPGTMNPFQHGEVYVTDDGAETDLDLGHYERYL
GIPMNQRNNYTSGSIYHRVITKERRGDYLGGTVQVIPHITDEIKSVIMNLASDDLDVALVEIGGTVGDIEGQPFLEAIRQ
LRSDLGRDRCMYIHLTLVPYLAAAGEHKTKPTQHSVKELRSIGIQPDIILCRCEKAVTDDLKHKIALFCNVEKDAVFSAV
DVKNIYEVPLSFYEEGFDQKIAIMLQLPAKNPDLSKWQELVDTCANPQGKVTIGIVGKYVDLKEAYKSLHEALIHGGVAN
KLAVELKYVNSELITDENVAESLAGLDGILVPGGFGSRGVEGKIRAIRYARENKVPFFGICLGMQCAVIEFARNVAGLPA
ANSEEFDEQTPDKVIYLMTEWFDFRSKQVERRDSGSEKGGTMRLGSYPCAVVKGTNAFTAYQAEKVDERHRHRFEFNNAY
LDKLKEAGLVFSGLSPDGELVEMVEIKDHPWFLGCQFHPEFKSYPMTPHPLFREFIKAAGKQAVKSKR

Sequences:

>Translated_548_residues
MKTKFIFITGGVLSSLGKGLAAASVGALLQARGLKVTIQKLDPYINVDPGTMNPFQHGEVYVTDDGAETDLDLGHYERYL
GIPMNQRNNYTSGSIYHRVITKERRGDYLGGTVQVIPHITDEIKSVIMNLASDDLDVALVEIGGTVGDIEGQPFLEAIRQ
LRSDLGRDRCMYIHLTLVPYLAAAGEHKTKPTQHSVKELRSIGIQPDIILCRCEKAVTDDLKHKIALFCNVEKDAVFSAV
DVKNIYEVPLSFYEEGFDQKIAIMLQLPAKNPDLSKWQELVDTCANPQGKVTIGIVGKYVDLKEAYKSLHEALIHGGVAN
KLAVELKYVNSELITDENVAESLAGLDGILVPGGFGSRGVEGKIRAIRYARENKVPFFGICLGMQCAVIEFARNVAGLPA
ANSEEFDEQTPDKVIYLMTEWFDFRSKQVERRDSGSEKGGTMRLGSYPCAVVKGTNAFTAYQAEKVDERHRHRFEFNNAY
LDKLKEAGLVFSGLSPDGELVEMVEIKDHPWFLGCQFHPEFKSYPMTPHPLFREFIKAAGKQAVKSKR
>Mature_548_residues
MKTKFIFITGGVLSSLGKGLAAASVGALLQARGLKVTIQKLDPYINVDPGTMNPFQHGEVYVTDDGAETDLDLGHYERYL
GIPMNQRNNYTSGSIYHRVITKERRGDYLGGTVQVIPHITDEIKSVIMNLASDDLDVALVEIGGTVGDIEGQPFLEAIRQ
LRSDLGRDRCMYIHLTLVPYLAAAGEHKTKPTQHSVKELRSIGIQPDIILCRCEKAVTDDLKHKIALFCNVEKDAVFSAV
DVKNIYEVPLSFYEEGFDQKIAIMLQLPAKNPDLSKWQELVDTCANPQGKVTIGIVGKYVDLKEAYKSLHEALIHGGVAN
KLAVELKYVNSELITDENVAESLAGLDGILVPGGFGSRGVEGKIRAIRYARENKVPFFGICLGMQCAVIEFARNVAGLPA
ANSEEFDEQTPDKVIYLMTEWFDFRSKQVERRDSGSEKGGTMRLGSYPCAVVKGTNAFTAYQAEKVDERHRHRFEFNNAY
LDKLKEAGLVFSGLSPDGELVEMVEIKDHPWFLGCQFHPEFKSYPMTPHPLFREFIKAAGKQAVKSKR

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=558, Percent_Identity=44.9820788530466, Blast_Score=474, Evalue=1e-133,
Organism=Homo sapiens, GI28559085, Length=559, Percent_Identity=43.4704830053667, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI28559083, Length=559, Percent_Identity=43.4704830053667, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI221316689, Length=559, Percent_Identity=43.4704830053667, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1789142, Length=541, Percent_Identity=56.3770794824399, Blast_Score=607, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI25148299, Length=613, Percent_Identity=38.0097879282219, Blast_Score=420, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322563, Length=577, Percent_Identity=41.0745233968804, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=40, Blast_Score=423, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=43.3691756272401, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=41.948310139165, Blast_Score=393, Evalue=1e-109,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_DESDG (Q310T4)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388257.1
- HSSP:   P17812
- ProteinModelPortal:   Q310T4
- SMR:   Q310T4
- STRING:   Q310T4
- GeneID:   3756765
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1765
- NMPDR:   fig|207559.3.peg.1578
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   DDES207559:DDE_1765-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60868; Mature: 60868

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 518-518 ACT_SITE 520-520

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKFIFITGGVLSSLGKGLAAASVGALLQARGLKVTIQKLDPYINVDPGTMNPFQHGEV
CCEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEE
YVTDDGAETDLDLGHYERYLGIPMNQRNNYTSGSIYHRVITKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECHHH
DEIKSVIMNLASDDLDVALVEIGGTVGDIEGQPFLEAIRQLRSDLGRDRCMYIHLTLVPY
HHHHHHHHHHCCCCCCEEEEEECCCEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
LAAAGEHKTKPTQHSVKELRSIGIQPDIILCRCEKAVTDDLKHKIALFCNVEKDAVFSAV
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCEEEEEEECCHHHHEEHH
DVKNIYEVPLSFYEEGFDQKIAIMLQLPAKNPDLSKWQELVDTCANPQGKVTIGIVGKYV
HHHHHHHCCHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHH
DLKEAYKSLHEALIHGGVANKLAVELKYVNSELITDENVAESLAGLDGILVPGGFGSRGV
HHHHHHHHHHHHHHHCCCCHHEEEEEEECCCHHCCCHHHHHHHHCCCCEEECCCCCCCCC
EGKIRAIRYARENKVPFFGICLGMQCAVIEFARNVAGLPAANSEEFDEQTPDKVIYLMTE
CCHHHHEEEHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEHHH
WFDFRSKQVERRDSGSEKGGTMRLGSYPCAVVKGTNAFTAYQAEKVDERHRHRFEFNNAY
HHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCEEHHHHHHHHHHHHHHHHCCHHH
LDKLKEAGLVFSGLSPDGELVEMVEIKDHPWFLGCQFHPEFKSYPMTPHPLFREFIKAAG
HHHHHHCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
KQAVKSKR
HHHHHCCC
>Mature Secondary Structure
MKTKFIFITGGVLSSLGKGLAAASVGALLQARGLKVTIQKLDPYINVDPGTMNPFQHGEV
CCEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEE
YVTDDGAETDLDLGHYERYLGIPMNQRNNYTSGSIYHRVITKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECHHH
DEIKSVIMNLASDDLDVALVEIGGTVGDIEGQPFLEAIRQLRSDLGRDRCMYIHLTLVPY
HHHHHHHHHHCCCCCCEEEEEECCCEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
LAAAGEHKTKPTQHSVKELRSIGIQPDIILCRCEKAVTDDLKHKIALFCNVEKDAVFSAV
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCEEEEEEECCHHHHEEHH
DVKNIYEVPLSFYEEGFDQKIAIMLQLPAKNPDLSKWQELVDTCANPQGKVTIGIVGKYV
HHHHHHHCCHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHH
DLKEAYKSLHEALIHGGVANKLAVELKYVNSELITDENVAESLAGLDGILVPGGFGSRGV
HHHHHHHHHHHHHHHCCCCHHEEEEEEECCCHHCCCHHHHHHHHCCCCEEECCCCCCCCC
EGKIRAIRYARENKVPFFGICLGMQCAVIEFARNVAGLPAANSEEFDEQTPDKVIYLMTE
CCHHHHEEEHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEHHH
WFDFRSKQVERRDSGSEKGGTMRLGSYPCAVVKGTNAFTAYQAEKVDERHRHRFEFNNAY
HHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCEEHHHHHHHHHHHHHHHHCCHHH
LDKLKEAGLVFSGLSPDGELVEMVEIKDHPWFLGCQFHPEFKSYPMTPHPLFREFIKAAG
HHHHHHCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
KQAVKSKR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA