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The map label for this gene is lpd [H]

Identifier: 78356733

GI number: 78356733

Start: 1741946

End: 1743328

Strand: Reverse

Name: lpd [H]

Synonym: Dde_1690

Alternate gene names: 78356733

Gene position: 1743328-1741946 (Counterclockwise)

Preceding gene: 78356734

Following gene: 78356732

Centisome position: 46.74

GC content: 58.42

Gene sequence:

>1383_bases
ATGACGCATGAACAATATGATCTGGTCATTATAGGGGCCGGTCCCGGCGGAAGCCGGGCGGCCCTTGACGCGGCAGCGGC
GGGTATGCGCACGGCACTGGTGGAAAAAGCTGACGCCGGAGGAACATGCCTTAACTGGGGATGCATCCCCACAAAGTTTC
TCCTCGGAGGAACAGCCGCCGTCCCGCTGCTGCAGATTCAGAAAAAATACAAGGCCGCCGGTGGCGATGTACACCTGTCG
CTGGCGGCGCTGCATCAGCGTAAAGACCGTTTTATCAAGGGAACACGCCAGAATCTGGTGAAGCAGCTGACGCAGGCCGG
AGTAAACTTCATTACCGGCGCGGCAAGCTTTGCCGGACCCCGCACTGTGGTCGTGGAAAAAGAAGACGGTTCCTCTCTGC
TTGAATTTGAAAACCTCATTCTTGCAGCCGGCTCTGAACCGGCCTCTTTTCCCGGTCTGATTCCGGACGGAAACTGCGTG
CTGCATTCTTCGCACATACTGCAGCTCGAAACACCGCCGCAAAGTCTTATTATTGTAGGCGGCGGAGCCATTGGCCTTGA
AATGGGCGACCTTTTCGCGCGGTTCGGCACACAGATAACCATTGTCGAAGCACTGCCGCACCTTGTGCCGGCAGAAGACG
GCGATATAGCAGACGCTCTTACCAAAGCGCTGAAGCGCGAAGGATGGACCGTACATACCGGTCGCCGTGTACGTTCGCTG
GTCACTGACGAGGAAGGCGCGTTGCTCACTTTTGAGGACGGCACAGCCATCCGCGCGGATAAAGCTCTGATGGCAGCCGG
AAGAAGCCCCGCCACTGCCGCTCTGCACCCTGAAAAAGCAGGCATAATGACAGACGGCAGAGGCTGGATAAGTACTGATA
ATTTTCTGCAGGCAGCAGAAAATATATACGCCGTCGGCGACGTGAACGGGCGCACCCTGCTGGCCCATGCAGCGGAACAT
CAGGCACGGTACGTTGTTTCACGGCTGCGTGGTCTGACCGCCGCGGAATACCCGGCTCCTGTCATGCCTTCGTGTGTCTA
CGGGCACATGGAGGTTATGCGCACCGGTGCCACCGCCAAGGAACTGACGGCACAGGGCATCTCCGTGTCGGTCTCACGCG
CTCCGCTGGCTTCTAACGCCATAGCGCAGTCCTGCGGGGCCACTCAGGGGTTCGTAAAAGCTGTCTGGGCTGCCGGCAAC
GGCACTCCCGAACTGCGGGGAATCGCTGCCACGGGGCACGGAGTCTCGCATCTGGTTGGTTTGGCCACAGTCATGGTACA
GCAGCGATGGCGCCGTGAAAATATTCACGACATAATCTATGCGCACCCTACACTGGATGAAGCTCTTGAAGCCGCACTGA
GCGCTCCGCTTGAAAATGCGTGA

Upstream 100 bases:

>100_bases
GAAGGTGAGCAGAATCCCGAAGCTCTGCATCAGGCTCCGCTCACCACGCCCGTCCGCCGGCTTGATGAAACACTGGCCGC
GCGCAGCATGGTGCTGACAG

Downstream 100 bases:

>100_bases
ACGGGAGGCAGCACAAAAAGTGCTGCCTCTTTTTTCTTTTAGTGTTGTCACAATAAAGTATTCGCGCTATGTTTTTCACC
ATCAGTATCGGCCGTAACTA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTHEQYDLVIIGAGPGGSRAALDAAAAGMRTALVEKADAGGTCLNWGCIPTKFLLGGTAAVPLLQIQKKYKAAGGDVHLS
LAALHQRKDRFIKGTRQNLVKQLTQAGVNFITGAASFAGPRTVVVEKEDGSSLLEFENLILAAGSEPASFPGLIPDGNCV
LHSSHILQLETPPQSLIIVGGGAIGLEMGDLFARFGTQITIVEALPHLVPAEDGDIADALTKALKREGWTVHTGRRVRSL
VTDEEGALLTFEDGTAIRADKALMAAGRSPATAALHPEKAGIMTDGRGWISTDNFLQAAENIYAVGDVNGRTLLAHAAEH
QARYVVSRLRGLTAAEYPAPVMPSCVYGHMEVMRTGATAKELTAQGISVSVSRAPLASNAIAQSCGATQGFVKAVWAAGN
GTPELRGIAATGHGVSHLVGLATVMVQQRWRRENIHDIIYAHPTLDEALEAALSAPLENA

Sequences:

>Translated_460_residues
MTHEQYDLVIIGAGPGGSRAALDAAAAGMRTALVEKADAGGTCLNWGCIPTKFLLGGTAAVPLLQIQKKYKAAGGDVHLS
LAALHQRKDRFIKGTRQNLVKQLTQAGVNFITGAASFAGPRTVVVEKEDGSSLLEFENLILAAGSEPASFPGLIPDGNCV
LHSSHILQLETPPQSLIIVGGGAIGLEMGDLFARFGTQITIVEALPHLVPAEDGDIADALTKALKREGWTVHTGRRVRSL
VTDEEGALLTFEDGTAIRADKALMAAGRSPATAALHPEKAGIMTDGRGWISTDNFLQAAENIYAVGDVNGRTLLAHAAEH
QARYVVSRLRGLTAAEYPAPVMPSCVYGHMEVMRTGATAKELTAQGISVSVSRAPLASNAIAQSCGATQGFVKAVWAAGN
GTPELRGIAATGHGVSHLVGLATVMVQQRWRRENIHDIIYAHPTLDEALEAALSAPLENA
>Mature_459_residues
THEQYDLVIIGAGPGGSRAALDAAAAGMRTALVEKADAGGTCLNWGCIPTKFLLGGTAAVPLLQIQKKYKAAGGDVHLSL
AALHQRKDRFIKGTRQNLVKQLTQAGVNFITGAASFAGPRTVVVEKEDGSSLLEFENLILAAGSEPASFPGLIPDGNCVL
HSSHILQLETPPQSLIIVGGGAIGLEMGDLFARFGTQITIVEALPHLVPAEDGDIADALTKALKREGWTVHTGRRVRSLV
TDEEGALLTFEDGTAIRADKALMAAGRSPATAALHPEKAGIMTDGRGWISTDNFLQAAENIYAVGDVNGRTLLAHAAEHQ
ARYVVSRLRGLTAAEYPAPVMPSCVYGHMEVMRTGATAKELTAQGISVSVSRAPLASNAIAQSCGATQGFVKAVWAAGNG
TPELRGIAATGHGVSHLVGLATVMVQQRWRRENIHDIIYAHPTLDEALEAALSAPLENA

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=31.1827956989247, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=27.2532188841202, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI22035672, Length=393, Percent_Identity=27.9898218829517, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=30.989010989011, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=29.2576419213974, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI87082354, Length=455, Percent_Identity=26.3736263736264, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789915, Length=438, Percent_Identity=24.4292237442922, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=32.7586206896552, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=25.1054852320675, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=370, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=370, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321091, Length=477, Percent_Identity=32.4947589098532, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=24.1666666666667, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325166, Length=371, Percent_Identity=26.9541778975741, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=32.034632034632, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24640551, Length=389, Percent_Identity=25.1928020565553, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640549, Length=392, Percent_Identity=26.0204081632653, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640553, Length=392, Percent_Identity=26.0204081632653, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48211; Mature: 48079

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHEQYDLVIIGAGPGGSRAALDAAAAGMRTALVEKADAGGTCLNWGCIPTKFLLGGTAA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCHH
VPLLQIQKKYKAAGGDVHLSLAALHQRKDRFIKGTRQNLVKQLTQAGVNFITGAASFAGP
HHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCHHCCCC
RTVVVEKEDGSSLLEFENLILAAGSEPASFPGLIPDGNCVLHSSHILQLETPPQSLIIVG
EEEEEECCCCCCHHHHHCEEEECCCCCCCCCCCCCCCCEEEECCEEEEEECCCCEEEEEC
GGAIGLEMGDLFARFGTQITIVEALPHLVPAEDGDIADALTKALKREGWTVHTGRRVRSL
CCEEEHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHH
VTDEEGALLTFEDGTAIRADKALMAAGRSPATAALHPEKAGIMTDGRGWISTDNFLQAAE
HCCCCCCEEEECCCCEEECCHHHHHCCCCCCCEEECCCCCCEEECCCCCCCCHHHHHHHH
NIYAVGDVNGRTLLAHAAEHQARYVVSRLRGLTAAEYPAPVMPSCVYGHMEVMRTGATAK
CEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHH
ELTAQGISVSVSRAPLASNAIAQSCGATQGFVKAVWAAGNGTPELRGIAATGHGVSHLVG
HHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHEECCCCCCCCEEEEECCCCHHHHHH
LATVMVQQRWRRENIHDIIYAHPTLDEALEAALSAPLENA
HHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
THEQYDLVIIGAGPGGSRAALDAAAAGMRTALVEKADAGGTCLNWGCIPTKFLLGGTAA
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCHH
VPLLQIQKKYKAAGGDVHLSLAALHQRKDRFIKGTRQNLVKQLTQAGVNFITGAASFAGP
HHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCHHCCCC
RTVVVEKEDGSSLLEFENLILAAGSEPASFPGLIPDGNCVLHSSHILQLETPPQSLIIVG
EEEEEECCCCCCHHHHHCEEEECCCCCCCCCCCCCCCCEEEECCEEEEEECCCCEEEEEC
GGAIGLEMGDLFARFGTQITIVEALPHLVPAEDGDIADALTKALKREGWTVHTGRRVRSL
CCEEEHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHH
VTDEEGALLTFEDGTAIRADKALMAAGRSPATAALHPEKAGIMTDGRGWISTDNFLQAAE
HCCCCCCEEEECCCCEEECCHHHHHCCCCCCCEEECCCCCCEEECCCCCCCCHHHHHHHH
NIYAVGDVNGRTLLAHAAEHQARYVVSRLRGLTAAEYPAPVMPSCVYGHMEVMRTGATAK
CEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHH
ELTAQGISVSVSRAPLASNAIAQSCGATQGFVKAVWAAGNGTPELRGIAATGHGVSHLVG
HHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHEECCCCCCCCEEEEECCCCHHHHHH
LATVMVQQRWRRENIHDIIYAHPTLDEALEAALSAPLENA
HHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]