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The map label for this gene is gcvPB [H]

Identifier: 78356734

GI number: 78356734

Start: 1743318

End: 1744763

Strand: Reverse

Name: gcvPB [H]

Synonym: Dde_1691

Alternate gene names: 78356734

Gene position: 1744763-1743318 (Counterclockwise)

Preceding gene: 78356735

Following gene: 78356733

Centisome position: 46.77

GC content: 55.53

Gene sequence:

>1446_bases
ATGAAGACCGTATTTTCACAGTCTGTACCGGGCCGCATGGCCTGCGTTCCCCCCGAAGCAGAAGAGCACGCAGCCGACTT
CATCCCGAAGAACCTGCTGCGTACCCGACGTCCCGCTCTGCCTGAGCTGAGCGAACTTGATGTGGTACGCCACTTCACCC
GCCTCAGCCGTCTTAATTACAGCGTGGACAGCAATTTCTATCCTCTCGGGTCGTGCACCATGAAGTACAACCCGAAATTC
ACCGAACCGCTGGCCGCTTTGCCCGGCTTTACCGAACTGCATCCTCTGATGGCACAGATTAAAAGTGCAGGCCTGTACAC
GCAGGGAGCTCTTGAAGTCATGTACGAAACAGAGCGCCTGCTGTGCGAAATCAACGGGATGCATGCATTCACCCTGCATC
CCATGGCCGGTGCTCATGGTGAACTGACCGGCGTAATGCTTATCGCGGCCTATCACCGTGATAAGGGGAACAAAAAAACA
AAGATCATCTGCCCTGATTCGGCCCACGGCACCAACCCTGCTTCCGCTGCGCTGGGCGGCTACGAAGTGGTCAACGTGGA
ATCAAAAGACGGCATAGTCGATCCGGAAGCTCTGGAGGCCGTGCTGGACAACGACGTGGCCGCCGTGATGATGACCTGCC
CCAACACGCTTGGACTGTTCGAAAAACACCTGCCGAGAATTGTGGAAAAACTGCGCTCGGTTGATGCTCTGCTGTATTAT
GACGGCGCCAACCTGAACGCGATCATGGGTAAAATGCGCGTAGGCGATGTCGGATTTGATGTCGTGCACCTGAACCTGCA
CAAAACATTCGGCACCCCGCACGGTGGCGGCGGCCCCGGCAGCGGTCCCGTTGGCGTCAGCGAGCGGCTGGAACCCTATC
TGCCGGTTTCCCGCGTTGACAGACTTCGCGACGGACGCCTGTTCCTCAACTACGATTACCCCAAATCCATAGGGTACATG
GCTCCCTTTTACGGCAACTTCGGTGTGTACATCAAAGCGCTGGCCTACATCATGCGTCTGGGCAGAGAAGGAATACCCAA
AGCCGCCGAGCTGGCTGTGCTGAACGCCAACTACCTGCGCAAAAAGCTGGAACAGTATATAACCATACCCTATAACCGCA
TATGCATGCATGAATTCGTGGCTTCCGCCTGTGACAAGGCTGAATGCGGTGTGCGTGCGCTGGATATAGCCAAAGGTCTG
CTGGATAAAGGCTATCATGCTCCGACAATTTACTTCCCGCTGATTGTCAAAGAATGCCTGATGTTTGAACCCACAGAGAC
TGAAAGCAAGGAAACGCTTGATACGTTTGTGGATGATCTTGCAGCCATACTGAAAGAAGGTGAGCAGAATCCCGAAGCTC
TGCATCAGGCTCCGCTCACCACGCCCGTCCGCCGGCTTGATGAAACACTGGCCGCGCGCAGCATGGTGCTGACAGATGAC
GCATGA

Upstream 100 bases:

>100_bases
ACTACGCCGGCATGGATGACGTGCTGCTTGTGGCATGCACTGAAAAGCATTCATTTGAACAGATCGGCATAATGGCTGAA
CTGGTGGGAGGCATGCTCTA

Downstream 100 bases:

>100_bases
ACAATATGATCTGGTCATTATAGGGGCCGGTCCCGGCGGAAGCCGGGCGGCCCTTGACGCGGCAGCGGCGGGTATGCGCA
CGGCACTGGTGGAAAAAGCT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKTVFSQSVPGRMACVPPEAEEHAADFIPKNLLRTRRPALPELSELDVVRHFTRLSRLNYSVDSNFYPLGSCTMKYNPKF
TEPLAALPGFTELHPLMAQIKSAGLYTQGALEVMYETERLLCEINGMHAFTLHPMAGAHGELTGVMLIAAYHRDKGNKKT
KIICPDSAHGTNPASAALGGYEVVNVESKDGIVDPEALEAVLDNDVAAVMMTCPNTLGLFEKHLPRIVEKLRSVDALLYY
DGANLNAIMGKMRVGDVGFDVVHLNLHKTFGTPHGGGGPGSGPVGVSERLEPYLPVSRVDRLRDGRLFLNYDYPKSIGYM
APFYGNFGVYIKALAYIMRLGREGIPKAAELAVLNANYLRKKLEQYITIPYNRICMHEFVASACDKAECGVRALDIAKGL
LDKGYHAPTIYFPLIVKECLMFEPTETESKETLDTFVDDLAAILKEGEQNPEALHQAPLTTPVRRLDETLAARSMVLTDD
A

Sequences:

>Translated_481_residues
MKTVFSQSVPGRMACVPPEAEEHAADFIPKNLLRTRRPALPELSELDVVRHFTRLSRLNYSVDSNFYPLGSCTMKYNPKF
TEPLAALPGFTELHPLMAQIKSAGLYTQGALEVMYETERLLCEINGMHAFTLHPMAGAHGELTGVMLIAAYHRDKGNKKT
KIICPDSAHGTNPASAALGGYEVVNVESKDGIVDPEALEAVLDNDVAAVMMTCPNTLGLFEKHLPRIVEKLRSVDALLYY
DGANLNAIMGKMRVGDVGFDVVHLNLHKTFGTPHGGGGPGSGPVGVSERLEPYLPVSRVDRLRDGRLFLNYDYPKSIGYM
APFYGNFGVYIKALAYIMRLGREGIPKAAELAVLNANYLRKKLEQYITIPYNRICMHEFVASACDKAECGVRALDIAKGL
LDKGYHAPTIYFPLIVKECLMFEPTETESKETLDTFVDDLAAILKEGEQNPEALHQAPLTTPVRRLDETLAARSMVLTDD
A
>Mature_481_residues
MKTVFSQSVPGRMACVPPEAEEHAADFIPKNLLRTRRPALPELSELDVVRHFTRLSRLNYSVDSNFYPLGSCTMKYNPKF
TEPLAALPGFTELHPLMAQIKSAGLYTQGALEVMYETERLLCEINGMHAFTLHPMAGAHGELTGVMLIAAYHRDKGNKKT
KIICPDSAHGTNPASAALGGYEVVNVESKDGIVDPEALEAVLDNDVAAVMMTCPNTLGLFEKHLPRIVEKLRSVDALLYY
DGANLNAIMGKMRVGDVGFDVVHLNLHKTFGTPHGGGGPGSGPVGVSERLEPYLPVSRVDRLRDGRLFLNYDYPKSIGYM
APFYGNFGVYIKALAYIMRLGREGIPKAAELAVLNANYLRKKLEQYITIPYNRICMHEFVASACDKAECGVRALDIAKGL
LDKGYHAPTIYFPLIVKECLMFEPTETESKETLDTFVDDLAAILKEGEQNPEALHQAPLTTPVRRLDETLAARSMVLTDD
A

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=413, Percent_Identity=38.9830508474576, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1789269, Length=416, Percent_Identity=37.9807692307692, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17535605, Length=415, Percent_Identity=39.5180722891566, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI32564013, Length=372, Percent_Identity=39.7849462365591, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323843, Length=462, Percent_Identity=37.6623376623377, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24645648, Length=414, Percent_Identity=39.1304347826087, Blast_Score=228, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53006; Mature: 53006

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVFSQSVPGRMACVPPEAEEHAADFIPKNLLRTRRPALPELSELDVVRHFTRLSRLNY
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
SVDSNFYPLGSCTMKYNPKFTEPLAALPGFTELHPLMAQIKSAGLYTQGALEVMYETERL
CCCCCEEECCCEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LCEINGMHAFTLHPMAGAHGELTGVMLIAAYHRDKGNKKTKIICPDSAHGTNPASAALGG
HEEECCEEEEEECCCCCCCCCHHHEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHCCC
YEVVNVESKDGIVDPEALEAVLDNDVAAVMMTCPNTLGLFEKHLPRIVEKLRSVDALLYY
EEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEE
DGANLNAIMGKMRVGDVGFDVVHLNLHKTFGTPHGGGGPGSGPVGVSERLEPYLPVSRVD
CCCCHHHHHHCCEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHH
RLRDGRLFLNYDYPKSIGYMAPFYGNFGVYIKALAYIMRLGREGIPKAAELAVLNANYLR
HCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEECHHHHH
KKLEQYITIPYNRICMHEFVASACDKAECGVRALDIAKGLLDKGYHAPTIYFPLIVKECL
HHHHHHCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
MFEPTETESKETLDTFVDDLAAILKEGEQNPEALHQAPLTTPVRRLDETLAARSMVLTDD
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHEEEEECC
A
C
>Mature Secondary Structure
MKTVFSQSVPGRMACVPPEAEEHAADFIPKNLLRTRRPALPELSELDVVRHFTRLSRLNY
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
SVDSNFYPLGSCTMKYNPKFTEPLAALPGFTELHPLMAQIKSAGLYTQGALEVMYETERL
CCCCCEEECCCEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LCEINGMHAFTLHPMAGAHGELTGVMLIAAYHRDKGNKKTKIICPDSAHGTNPASAALGG
HEEECCEEEEEECCCCCCCCCHHHEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHCCC
YEVVNVESKDGIVDPEALEAVLDNDVAAVMMTCPNTLGLFEKHLPRIVEKLRSVDALLYY
EEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEE
DGANLNAIMGKMRVGDVGFDVVHLNLHKTFGTPHGGGGPGSGPVGVSERLEPYLPVSRVD
CCCCHHHHHHCCEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHH
RLRDGRLFLNYDYPKSIGYMAPFYGNFGVYIKALAYIMRLGREGIPKAAELAVLNANYLR
HCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEECHHHHH
KKLEQYITIPYNRICMHEFVASACDKAECGVRALDIAKGLLDKGYHAPTIYFPLIVKECL
HHHHHHCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
MFEPTETESKETLDTFVDDLAAILKEGEQNPEALHQAPLTTPVRRLDETLAARSMVLTDD
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHEEEEECC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA