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The map label for this gene is frdB

Identifier: 78356303

GI number: 78356303

Start: 1270225

End: 1271013

Strand: Reverse

Name: frdB

Synonym: Dde_1256

Alternate gene names: 78356303

Gene position: 1271013-1270225 (Counterclockwise)

Preceding gene: 78356304

Following gene: 78356302

Centisome position: 34.07

GC content: 56.91

Gene sequence:

>789_bases
ATGAGTCGCAAACTTCATATAGAGGTGTTCCGGTACAATCCCGCCACCCCCGATACCAAACCTTACATGCAGTCGTTCTT
CATCGACGAATTCGACTCCATGACCCTGTTCATCGCGCTGAACATCATCCGCGACCAGCACGATCCTTCCCTGCAGTTTG
ATTTCTGCTGCCGCGCCGGTATCTGCGGCTCGTGCGGCATGGTCATCAACGGACGTCCCGCGCTGGCCTGCCATACGCAG
ACCCGCGACCTGCCCGATCATATCGTGCTGCATCCTCTGCCGGTATTCAAACTGGTGGGCGACCTGTCAGTTGATACCGG
CGTATGGTTCCGCGATGTGGGCACCCGCATCGAATCATGGATTCACACCCGCAAAGAGTTTGACCCCTCCGCAGAAGAAA
CCCGCATGGAAAATGAGCTGGCCAACCAGATATTCGAGCTGGACCGCTGCATTGAATGCGGCTGCTGCGTGGCTGCCTGC
GGTACTGCCAGAATGCGCGAGGACTTCATAGGGGCCACTTCCATCAACCGCATCGCCCGCTTTTACATGGACCCGCGCGA
CGAACGGTCCGAAGACGACTACTACGACCTTATCGGCAATGATGCCGGTGTGTTCGGCTGCATGGGACTGCTGGCCTGCG
AAGATGTCTGCCCGAAAAAAATCCCGCTGCAGGATCAGCTGGGAATCATGCGCCGCATGCTGGCGCTGAACTCCGTAAAG
GGCATTCTGCCCGCTTCCGTGGTGAAAAAACTGCAAAACCACAAGGGGTGCTGCCATGAAAAGCATTAA

Upstream 100 bases:

>100_bases
CTATGCCGACATTCCCGAAGAAAAGCTGCGCAAACCCGGTGCCGCACCCACCGCCAAGTCTGAAACAACGTCCAAGAAAA
AGGCCTAGGAGGGAGAGTTC

Downstream 100 bases:

>100_bases
GGCCGCCGATCTGCACGCCGCCGTGCGTGACATGATTATGGACGCCAACCGTGTGCTGGGAAAAGACGTGTACAACGCCT
TTCAGACCTGCATGCAGCAA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSRKLHIEVFRYNPATPDTKPYMQSFFIDEFDSMTLFIALNIIRDQHDPSLQFDFCCRAGICGSCGMVINGRPALACHTQ
TRDLPDHIVLHPLPVFKLVGDLSVDTGVWFRDVGTRIESWIHTRKEFDPSAEETRMENELANQIFELDRCIECGCCVAAC
GTARMREDFIGATSINRIARFYMDPRDERSEDDYYDLIGNDAGVFGCMGLLACEDVCPKKIPLQDQLGIMRRMLALNSVK
GILPASVVKKLQNHKGCCHEKH

Sequences:

>Translated_262_residues
MSRKLHIEVFRYNPATPDTKPYMQSFFIDEFDSMTLFIALNIIRDQHDPSLQFDFCCRAGICGSCGMVINGRPALACHTQ
TRDLPDHIVLHPLPVFKLVGDLSVDTGVWFRDVGTRIESWIHTRKEFDPSAEETRMENELANQIFELDRCIECGCCVAAC
GTARMREDFIGATSINRIARFYMDPRDERSEDDYYDLIGNDAGVFGCMGLLACEDVCPKKIPLQDQLGIMRRMLALNSVK
GILPASVVKKLQNHKGCCHEKH
>Mature_261_residues
SRKLHIEVFRYNPATPDTKPYMQSFFIDEFDSMTLFIALNIIRDQHDPSLQFDFCCRAGICGSCGMVINGRPALACHTQT
RDLPDHIVLHPLPVFKLVGDLSVDTGVWFRDVGTRIESWIHTRKEFDPSAEETRMENELANQIFELDRCIECGCCVAACG
TARMREDFIGATSINRIARFYMDPRDERSEDDYYDLIGNDAGVFGCMGLLACEDVCPKKIPLQDQLGIMRRMLALNSVKG
ILPASVVKKLQNHKGCCHEKH

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=230, Percent_Identity=26.5217391304348, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1790596, Length=220, Percent_Identity=33.6363636363636, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786943, Length=237, Percent_Identity=32.9113924050633, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17533915, Length=237, Percent_Identity=28.6919831223629, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322987, Length=233, Percent_Identity=28.3261802575107, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=27.4678111587983, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24643156, Length=239, Percent_Identity=27.6150627615063, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29700; Mature: 29568

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00197 2FE2S_FER_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
9.5 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
9.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKLHIEVFRYNPATPDTKPYMQSFFIDEFDSMTLFIALNIIRDQHDPSLQFDFCCRAG
CCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHCCCCCCCEEHHHHCCC
ICGSCGMVINGRPALACHTQTRDLPDHIVLHPLPVFKLVGDLSVDTGVWFRDVGTRIESW
CCCCCCEEECCCCCEEECCCCCCCCCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
IHTRKEFDPSAEETRMENELANQIFELDRCIECGCCVAACGTARMREDFIGATSINRIAR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHH
FYMDPRDERSEDDYYDLIGNDAGVFGCMGLLACEDVCPKKIPLQDQLGIMRRMLALNSVK
HHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
GILPASVVKKLQNHKGCCHEKH
CCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRKLHIEVFRYNPATPDTKPYMQSFFIDEFDSMTLFIALNIIRDQHDPSLQFDFCCRAG
CCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHCCCCCCCEEHHHHCCC
ICGSCGMVINGRPALACHTQTRDLPDHIVLHPLPVFKLVGDLSVDTGVWFRDVGTRIESW
CCCCCCEEECCCCCEEECCCCCCCCCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
IHTRKEFDPSAEETRMENELANQIFELDRCIECGCCVAACGTARMREDFIGATSINRIAR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHH
FYMDPRDERSEDDYYDLIGNDAGVFGCMGLLACEDVCPKKIPLQDQLGIMRRMLALNSVK
HHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
GILPASVVKKLQNHKGCCHEKH
CCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]