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The map label for this gene is frdA [H]

Identifier: 78356304

GI number: 78356304

Start: 1271026

End: 1272921

Strand: Reverse

Name: frdA [H]

Synonym: Dde_1257

Alternate gene names: 78356304

Gene position: 1272921-1271026 (Counterclockwise)

Preceding gene: 78356305

Following gene: 78356303

Centisome position: 34.12

GC content: 60.02

Gene sequence:

>1896_bases
ATGCAAGTTATCTATACCGACGTCCTGTGCATAGGCGCCGGCCTTGCCGGTGAGCGGGTCGCCGTTGAAGCGGCCATGGC
AGGATTCGATGTGGTCTGTCTTTCCATCGTTCCCCCCAGACGTTCGCACTCTTCCGCCGCTCAGGGCGGCATGCAGGCCG
CTCTCGGCAATGCCATAATGGGTGACGGTGACTCCACCGATGTGCACTTTGCCGATACGGTCAAAGGCTCCGACTGGGGG
TGTGATCAGGAAGTGGCCCGGCTTTTTGCCGACACAGCCCCCATCGTCATGCGCGAAATGGCTCACTGGGGCGTGCCGTG
GAACCGCGTTGTGGCCGGCATGCATACTTATTACAAAGGCGGCAAACCCTTTGACGCCGAAGAAAAAAAAGAAAAACACG
GTCTCATCCATGCCCGCGCCTTCGGCGGCACCGCCAAATGGCGTACCTGCTACACATCCGACGGCACAGGACACTCCGTG
CTGTACACGCTGGACAACATCTGCCTGCAATACGGCGTAAACATTCATGACAGAGTACAGGCCGAAGCCATCATCCACGA
CGGTCAGACCTGCATGGGCTGCATTGCCCGCAGTCTGCGCACCGGCGAGCTGATAGCCTACTTCGCCTCTGCCACACTTA
TTGCCACCGGCGGTTACGGCCGTATCTACCGCGCTACAACCAACGCCGTCATCTGCGACGGCGGCGGACAGATAGCAGCG
CTGGACACCGGCATTGTTCCCATGGGCAATATGGAAGCCGTGCAGTTTCACCCCACGGGCACCGTGCCCACCGACATTCT
GGTGACCGAAGGCTGCCGCGGTGACGGCGGCACCCTGCTGGACGTCAATGAATACCGGTTCATGCCCGATTACGAACCGG
AAAAAGCCGAGCTGGCCTCGCGCGACGTGGTTTCGCGCCGCATGACCGAACACATGCGCAAGGGGCTGGGGGTCAAAAGC
CCCTACGGCGACCATCTGTGGCTCGACATCCGCCATCTGGGCGAAAAACACATCACCACCAACCTGCGCGAAGTGTACGA
CATCTGCACCAACTTCCTCGGTGTGAACCCCATCCATCAGCTTATTCCCGTGCGGCCCACCCAGCACTATTCCATGGGCG
GCGTGCGTACAGACAAAGACGGTGCGGCCTACGGGCTTACGGGTCTGTTTGCCGCAGGCGAAGCCGCCTGCTGGGACATG
CACGGCTTCAACCGGCTGGGCGGCAACTCGCTGGCAGAAACAGTTGTGGCCGGACGTCACATAGGCAAAAAAATCGTCGA
ATTCCTGCAGGGGCATTCCACCAGCTTCTCCACCGGCGCCATGCGCGATGCCGCAAACAAAATGAACCAGCGCATCAGCG
ACATCGCCGCCGGACGCAAGGGTAAAGAAAGCGCCGTAACCCTGCGCAACGAACTGCAGGACATCATGATGGAAGGAGTG
GGTATTTTCCGCAACGCCAAAGACCTGCAGACCGCCGTGGATAAACTGACAGCACTGCATGAGCGTTCCATGAAAATAGG
GCTGCAGTCCAACAGCGCCGGTTTTACGCCTGAAATGTCGCTGGCGCTGCGTGTGCCCGGCATGATCAAGCTGGCACTGT
GCACCGCCTACGGCGCGCTGATGCGCACCGAAAGCCGCGGTGCCCACACCCGCGAAGACTTCCCCGAACGCAACGACCGT
GACTGGCTGAACCGCACCCTTGCCTACTGGAAAGAAGGTGCCGCACTGCCCACGCTCGAATACGAGGAAGCCTCACCCTA
CTTTGAAATGCCTCCCGGCGAACGCGGCTACGGCGGCGGCAAGATAATCTATGCCGACATTCCCGAAGAAAAGCTGCGCA
AACCCGGTGCCGCACCCACCGCCAAGTCTGAAACAACGTCCAAGAAAAAGGCCTAG

Upstream 100 bases:

>100_bases
GCCATGATGATCGGCTTCATTGCGGTGGGGCTGCTTACTCTTGTCCGCTTCATGTTCCTTGACCTCATTTAATTATTTCA
GCCAGAGCAAGAGGTGTTCA

Downstream 100 bases:

>100_bases
GAGGGAGAGTTCATGAGTCGCAAACTTCATATAGAGGTGTTCCGGTACAATCCCGCCACCCCCGATACCAAACCTTACAT
GCAGTCGTTCTTCATCGACG

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MQVIYTDVLCIGAGLAGERVAVEAAMAGFDVVCLSIVPPRRSHSSAAQGGMQAALGNAIMGDGDSTDVHFADTVKGSDWG
CDQEVARLFADTAPIVMREMAHWGVPWNRVVAGMHTYYKGGKPFDAEEKKEKHGLIHARAFGGTAKWRTCYTSDGTGHSV
LYTLDNICLQYGVNIHDRVQAEAIIHDGQTCMGCIARSLRTGELIAYFASATLIATGGYGRIYRATTNAVICDGGGQIAA
LDTGIVPMGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELASRDVVSRRMTEHMRKGLGVKS
PYGDHLWLDIRHLGEKHITTNLREVYDICTNFLGVNPIHQLIPVRPTQHYSMGGVRTDKDGAAYGLTGLFAAGEAACWDM
HGFNRLGGNSLAETVVAGRHIGKKIVEFLQGHSTSFSTGAMRDAANKMNQRISDIAAGRKGKESAVTLRNELQDIMMEGV
GIFRNAKDLQTAVDKLTALHERSMKIGLQSNSAGFTPEMSLALRVPGMIKLALCTAYGALMRTESRGAHTREDFPERNDR
DWLNRTLAYWKEGAALPTLEYEEASPYFEMPPGERGYGGGKIIYADIPEEKLRKPGAAPTAKSETTSKKKA

Sequences:

>Translated_631_residues
MQVIYTDVLCIGAGLAGERVAVEAAMAGFDVVCLSIVPPRRSHSSAAQGGMQAALGNAIMGDGDSTDVHFADTVKGSDWG
CDQEVARLFADTAPIVMREMAHWGVPWNRVVAGMHTYYKGGKPFDAEEKKEKHGLIHARAFGGTAKWRTCYTSDGTGHSV
LYTLDNICLQYGVNIHDRVQAEAIIHDGQTCMGCIARSLRTGELIAYFASATLIATGGYGRIYRATTNAVICDGGGQIAA
LDTGIVPMGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELASRDVVSRRMTEHMRKGLGVKS
PYGDHLWLDIRHLGEKHITTNLREVYDICTNFLGVNPIHQLIPVRPTQHYSMGGVRTDKDGAAYGLTGLFAAGEAACWDM
HGFNRLGGNSLAETVVAGRHIGKKIVEFLQGHSTSFSTGAMRDAANKMNQRISDIAAGRKGKESAVTLRNELQDIMMEGV
GIFRNAKDLQTAVDKLTALHERSMKIGLQSNSAGFTPEMSLALRVPGMIKLALCTAYGALMRTESRGAHTREDFPERNDR
DWLNRTLAYWKEGAALPTLEYEEASPYFEMPPGERGYGGGKIIYADIPEEKLRKPGAAPTAKSETTSKKKA
>Mature_631_residues
MQVIYTDVLCIGAGLAGERVAVEAAMAGFDVVCLSIVPPRRSHSSAAQGGMQAALGNAIMGDGDSTDVHFADTVKGSDWG
CDQEVARLFADTAPIVMREMAHWGVPWNRVVAGMHTYYKGGKPFDAEEKKEKHGLIHARAFGGTAKWRTCYTSDGTGHSV
LYTLDNICLQYGVNIHDRVQAEAIIHDGQTCMGCIARSLRTGELIAYFASATLIATGGYGRIYRATTNAVICDGGGQIAA
LDTGIVPMGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELASRDVVSRRMTEHMRKGLGVKS
PYGDHLWLDIRHLGEKHITTNLREVYDICTNFLGVNPIHQLIPVRPTQHYSMGGVRTDKDGAAYGLTGLFAAGEAACWDM
HGFNRLGGNSLAETVVAGRHIGKKIVEFLQGHSTSFSTGAMRDAANKMNQRISDIAAGRKGKESAVTLRNELQDIMMEGV
GIFRNAKDLQTAVDKLTALHERSMKIGLQSNSAGFTPEMSLALRVPGMIKLALCTAYGALMRTESRGAHTREDFPERNDR
DWLNRTLAYWKEGAALPTLEYEEASPYFEMPPGERGYGGGKIIYADIPEEKLRKPGAAPTAKSETTSKKKA

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=591, Percent_Identity=34.3485617597293, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=36.8782161234991, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1786942, Length=584, Percent_Identity=37.6712328767123, Blast_Score=322, Evalue=5e-89,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=29.3072824156306, Blast_Score=175, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17505833, Length=558, Percent_Identity=35.84229390681, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17550100, Length=554, Percent_Identity=35.1985559566787, Blast_Score=288, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6322701, Length=604, Percent_Identity=34.7682119205298, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6322416, Length=605, Percent_Identity=35.0413223140496, Blast_Score=313, Evalue=5e-86,
Organism=Drosophila melanogaster, GI17137288, Length=557, Percent_Identity=35.9066427289048, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24655642, Length=557, Percent_Identity=35.9066427289048, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24655647, Length=557, Percent_Identity=35.9066427289048, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24663005, Length=548, Percent_Identity=33.2116788321168, Blast_Score=259, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 68574; Mature: 68574

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVIYTDVLCIGAGLAGERVAVEAAMAGFDVVCLSIVPPRRSHSSAAQGGMQAALGNAIM
CEEEEEEHHHHCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHCCHHHHHCCCEE
GDGDSTDVHFADTVKGSDWGCDQEVARLFADTAPIVMREMAHWGVPWNRVVAGMHTYYKG
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
GKPFDAEEKKEKHGLIHARAFGGTAKWRTCYTSDGTGHSVLYTLDNICLQYGVNIHDRVQ
CCCCCCHHHHHHCCEEEEEECCCCCCCEEEECCCCCCCEEHHHHHHHHHHHCCCHHHHHH
AEAIIHDGQTCMGCIARSLRTGELIAYFASATLIATGGYGRIYRATTNAVICDGGGQIAA
HHHHHCCCHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCEEEEEECCEEEECCCCEEEE
LDTGIVPMGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELAS
EECCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCEEEECCEECCCCCCCHHHHHHH
RDVVSRRMTEHMRKGLGVKSPYGDHLWLDIRHLGEKHITTNLREVYDICTNFLGVNPIHQ
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LIPVRPTQHYSMGGVRTDKDGAAYGLTGLFAAGEAACWDMHGFNRLGGNSLAETVVAGRH
HCCCCCCCCCCCCCEEECCCCCCCCHHHHHHCCCCCEEECCCCHHCCCHHHHHHHHHHHH
IGKKIVEFLQGHSTSFSTGAMRDAANKMNQRISDIAAGRKGKESAVTLRNELQDIMMEGV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GIFRNAKDLQTAVDKLTALHERSMKIGLQSNSAGFTPEMSLALRVPGMIKLALCTAYGAL
HHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
MRTESRGAHTREDFPERNDRDWLNRTLAYWKEGAALPTLEYEEASPYFEMPPGERGYGGG
HHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCEECCCCCCCCCCC
KIIYADIPEEKLRKPGAAPTAKSETTSKKKA
EEEEECCCHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQVIYTDVLCIGAGLAGERVAVEAAMAGFDVVCLSIVPPRRSHSSAAQGGMQAALGNAIM
CEEEEEEHHHHCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHCCHHHHHCCCEE
GDGDSTDVHFADTVKGSDWGCDQEVARLFADTAPIVMREMAHWGVPWNRVVAGMHTYYKG
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
GKPFDAEEKKEKHGLIHARAFGGTAKWRTCYTSDGTGHSVLYTLDNICLQYGVNIHDRVQ
CCCCCCHHHHHHCCEEEEEECCCCCCCEEEECCCCCCCEEHHHHHHHHHHHCCCHHHHHH
AEAIIHDGQTCMGCIARSLRTGELIAYFASATLIATGGYGRIYRATTNAVICDGGGQIAA
HHHHHCCCHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCEEEEEECCEEEECCCCEEEE
LDTGIVPMGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELAS
EECCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCEEEECCEECCCCCCCHHHHHHH
RDVVSRRMTEHMRKGLGVKSPYGDHLWLDIRHLGEKHITTNLREVYDICTNFLGVNPIHQ
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LIPVRPTQHYSMGGVRTDKDGAAYGLTGLFAAGEAACWDMHGFNRLGGNSLAETVVAGRH
HCCCCCCCCCCCCCEEECCCCCCCCHHHHHHCCCCCEEECCCCHHCCCHHHHHHHHHHHH
IGKKIVEFLQGHSTSFSTGAMRDAANKMNQRISDIAAGRKGKESAVTLRNELQDIMMEGV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GIFRNAKDLQTAVDKLTALHERSMKIGLQSNSAGFTPEMSLALRVPGMIKLALCTAYGAL
HHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
MRTESRGAHTREDFPERNDRDWLNRTLAYWKEGAALPTLEYEEASPYFEMPPGERGYGGG
HHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCEECCCCCCCCCCC
KIIYADIPEEKLRKPGAAPTAKSETTSKKKA
EEEEECCCHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]