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The map label for this gene is pyrH

Identifier: 78356176

GI number: 78356176

Start: 1158645

End: 1159361

Strand: Reverse

Name: pyrH

Synonym: Dde_1129

Alternate gene names: 78356176

Gene position: 1159361-1158645 (Counterclockwise)

Preceding gene: 78356177

Following gene: 78356175

Centisome position: 31.08

GC content: 56.07

Gene sequence:

>717_bases
ATGAGCGAACTGAAATACAAGCGCGCGCTGATCAAACTGAGCGGCGAGGCTCTTGCCGGCGACAAGAAGTTCGGTATTGA
CCCTGAAACGGTTTCGAATATATGTCGGGAAATCGCCGAGGTACTGGAAATGGGCCTTCAGGTCTCTCTGGTTATCGGCG
GCGGCAACATTTTCCGCGGGCTTTCCTCATCCGCCAAGGGCATGGACAGGTCTTCGGCAGACTACATGGGTATGCTGGCC
ACCGTGCTGAACGCAGTGGCCGTGCAGGATGCGCTGGAAAAACTGGGACACGCCACCCGGGTGCTTTCGGCCATAACCAT
GCAGGAAGTCTGCGAGCCCTACATCCGCCGCCGCGCCGAGCGTCATCTGGAAAAAGGCCGCGTGGTGATCTGCGCTGCCG
GTACCGGCAATCCGTATTTCACCACCGACACAGCCGCTGCGCTGCGCGGTATGGAACTGAAATGCGATGTCATCATAAAA
GCGACCAAAGTTGACGGCGTTTACGACAAAGACCCCATGCAGCATGACGATGCAGTCATGTACCGTCAGCTCAGCTACAT
TGAGGTGCTGCAGAAAAACCTGCGCGTCATGGACTCCACAGCCATCAGTCTGTGCATGGAAAACAACGTGCCCATCATCG
TCTGCAACATGTACAAAGGCGGCATAAAACGTGCTGTCATGGGCGAAGACGTGGGAACCATAGTGCAAGGAGGCTAA

Upstream 100 bases:

>100_bases
AAGGCGACTGGGGAGCGCCGTACGATCATTCATGAACACCGCAGAAAACAGCGGTCCGCCCCGGACCGGCCAAGCATAAC
ACTATTGAGGAAAGACAACG

Downstream 100 bases:

>100_bases
CTCACATGGATACAATTCTGCTCGAAACCGAAGAACGGATGGAAAAGGCAGTCGCCGCTCTTGACCGCGAATTCGGACGC
CTGCGCACCGGACGGGCCTC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSELKYKRALIKLSGEALAGDKKFGIDPETVSNICREIAEVLEMGLQVSLVIGGGNIFRGLSSSAKGMDRSSADYMGMLA
TVLNAVAVQDALEKLGHATRVLSAITMQEVCEPYIRRRAERHLEKGRVVICAAGTGNPYFTTDTAAALRGMELKCDVIIK
ATKVDGVYDKDPMQHDDAVMYRQLSYIEVLQKNLRVMDSTAISLCMENNVPIIVCNMYKGGIKRAVMGEDVGTIVQGG

Sequences:

>Translated_238_residues
MSELKYKRALIKLSGEALAGDKKFGIDPETVSNICREIAEVLEMGLQVSLVIGGGNIFRGLSSSAKGMDRSSADYMGMLA
TVLNAVAVQDALEKLGHATRVLSAITMQEVCEPYIRRRAERHLEKGRVVICAAGTGNPYFTTDTAAALRGMELKCDVIIK
ATKVDGVYDKDPMQHDDAVMYRQLSYIEVLQKNLRVMDSTAISLCMENNVPIIVCNMYKGGIKRAVMGEDVGTIVQGG
>Mature_237_residues
SELKYKRALIKLSGEALAGDKKFGIDPETVSNICREIAEVLEMGLQVSLVIGGGNIFRGLSSSAKGMDRSSADYMGMLAT
VLNAVAVQDALEKLGHATRVLSAITMQEVCEPYIRRRAERHLEKGRVVICAAGTGNPYFTTDTAAALRGMELKCDVIIKA
TKVDGVYDKDPMQHDDAVMYRQLSYIEVLQKNLRVMDSTAISLCMENNVPIIVCNMYKGGIKRAVMGEDVGTIVQGG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=51.5151515151515, Blast_Score=239, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_DESDG (Q313G6)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387625.1
- HSSP:   P65938
- ProteinModelPortal:   Q313G6
- SMR:   Q313G6
- STRING:   Q313G6
- GeneID:   3755153
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1129
- NMPDR:   fig|207559.3.peg.1304
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   DDES207559:DDE_1129-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25885; Mature: 25753

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKYKRALIKLSGEALAGDKKFGIDPETVSNICREIAEVLEMGLQVSLVIGGGNIFRG
CCCHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHC
LSSSAKGMDRSSADYMGMLATVLNAVAVQDALEKLGHATRVLSAITMQEVCEPYIRRRAE
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVICAAGTGNPYFTTDTAAALRGMELKCDVIIKATKVDGVYDKDPMQHDDAVM
HHHHCCCEEEEEECCCCCCEECCHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHH
YRQLSYIEVLQKNLRVMDSTAISLCMENNVPIIVCNMYKGGIKRAVMGEDVGTIVQGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCHHCCCC
>Mature Secondary Structure 
SELKYKRALIKLSGEALAGDKKFGIDPETVSNICREIAEVLEMGLQVSLVIGGGNIFRG
CCHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHC
LSSSAKGMDRSSADYMGMLATVLNAVAVQDALEKLGHATRVLSAITMQEVCEPYIRRRAE
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVICAAGTGNPYFTTDTAAALRGMELKCDVIIKATKVDGVYDKDPMQHDDAVM
HHHHCCCEEEEEECCCCCCEECCHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHH
YRQLSYIEVLQKNLRVMDSTAISLCMENNVPIIVCNMYKGGIKRAVMGEDVGTIVQGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA