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The map label for this gene is shc [H]

Identifier: 78224016

GI number: 78224016

Start: 3191839

End: 3193878

Strand: Direct

Name: shc [H]

Synonym: Gmet_2820

Alternate gene names: 78224016

Gene position: 3191839-3193878 (Clockwise)

Preceding gene: 78224013

Following gene: 78224017

Centisome position: 79.85

GC content: 62.7

Gene sequence:

>2040_bases
ATGAAGATTTCCAAGCATCCCATTTCACACGCACTCACCTCCTTCAACGAAACAGCGAAAGAGACAAAAGAGGAGCCGCA
GAAGAAACGGGGGGGCAAGGTCCACCACCTCCCCGCCTCCATCTGGAAAAAGCGGGACGTGGAAACCACGAGCCCCCTCG
ACCAGGCCATCAAACGGAGCCAGGAGTTCTTTTTGCGGGAGCAACTCCCCGCCGGGTACTGGTGGGCGGAGCTGGAGTCC
AACGTCACCATCACCGCCGAGTACGTCATCCTCTTCCACTTCATGGGGCTGGTGAACCGGGACAAAGATCGGAAGATGGC
TACCTATCTCCTCTCCAAGCAGACCGAGGAGGGGTGCTGGTGCATCTGGCACGGAGGGCCGGGCGACCTCTCCACCACCA
TCGAAGCATACTTCGCCCTGAAGCTGGCCGGCTACCCCGCCGACCATCCGGCCATGCAGAAGGCCCGCACGTTCATTCTC
GGGAAAGGGGGCATCCTCAAGGCACGGGTCTTCACCAAGATCTTCCTGGCCCTCTTCGGCGAATTCTCCTGGCTGGGGGT
CCCCTCCATGCCCATCGAGATGATGCTCCTTCCCAACGGCTTCACCTTCAACCTCTATGAGTTCTCCAGCTGGTCCCGGG
CGACCATTATTCCGCTCTCCATCGTCATGGCCGAGCGGCCGGTGCGCAAGCTCCCCCCCTGGGCGAGGGTGCAGGAACTC
TACGTGCGGCCGCCGCGCCCCATGGACTACACCTTCACCAAGGAAGACGGGATCCTTACCTGGAAGAACATCTTCATCGG
CATCGACCATATCCTCAAGGTCTATGAGGCGAGCCCCATCCGCCCCGGCATGAAGAAGGCCATGGCCATTGCCGAACAGT
GGGTGCTGGACCACCAGGAGCCCACCGGCGACTGGGGCGGCATCCAGCCGGCCATGCTCAACTCGGTTCTGGCCCTCCAT
TGCCTCGGCTACGCTAACGACCACCCGGCCGTTGCCAAGGGGCTTCAGGCCCTGGCCAACTTCTGCATCGAGAGCGACGA
CGAGATCGTCCTCCAATCCTGCATCTCGCCGGTATGGGACACGGCCCTGGCCCTCATGGCCATGGTCGACTCCGAAGTTC
CCACCGATCACCCGGCCCTGGTGAAAGCCGCCCAGTGGCTCCTGGACCGGGAAGTCCGCAAGGTTGGCGACTGGAAAATC
AAGGCCCCCAACCTGGAGCCGGGGGGATGGGCCTTCGAGTTCCAGAACGACTGGTACCCGGACGTGGACGACTCGGGGAT
CGTCATGATGGCCATCAAGGATGTGAAGGTGAAGGACTCGAAGGCCAAGGCGGAGGCGATCCAGCGCGGCATTGCCTGGT
GCATCGGCATGCAGAGCAAGAACGGCGGCTGGGGAGCCTTCGACAAGGACAACACCAAGCATATCCTCAACAAGATTCCC
TTCGCCGACCTGGAGGCCCTCATCGACCCCCCCACGGCGGATCTTACCGGCCGGATGCTGGAGTTGATGGGAACCTTCGG
CTACCCCAAGGACCACCCGGCCGCGGTGCGGGCGCTCCAGTTCGTCAAGGAGAACCAGGAACCGGACGGCCCCTGGTGGG
GACGCTGGGGGGTCAACTACATCTACGGCACCTGGTCGGTGCTCTGCGGCCTCAAGGCCTATGGCGAAGACATGGGACAG
CCTTACGTCCGCAAGGCCGTTGAATGGCTCGCCGCCCACCAGAACCCCGACGGCGGCTGGGGTGAGTGCTGCGAATCCTA
CTGCGATCAGAAGCTGGCCGGCACCGGCCCAAGCACCGCCTCCCAGACGGGATGGGCACTCCTCTCCATGCTCGCCGCAG
GCGACGTGGACCACCCGGCCGTGGCCCGGGGGATCCGGTACCTGATCGAGACCCAGCAACCCGATGGGACCTGGGACGAG
GACCAGTTCACCGGAACCGGCTTCCCAAAATACTTCATGATCAAGTATCATATCTACCGGAACTGCTTTCCGCTCATGGC
CATGGGACGCTACCGGGCGCTGAAGGGCCACAAGGGATAA

Upstream 100 bases:

>100_bases
GTTTTTTTTGTTAATTCTGTGCTAGAAGTACATGCTTATTTTTTCTCACTCATCCCGGCATCGGGAGAGAGTGTTCTGAG
AATCAAGGAGCAGCATTTCG

Downstream 100 bases:

>100_bases
CCAGCCAGTCGCAGAAACGGGCACCTGCGTAGGGGCGGTTCAAGAACCGCCCCTACATCAGTTTTGATAGAAGGAACCAT
GAAGGTTTTCGTTACCGGCG

Product: Terpene synthase:squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MKISKHPISHALTSFNETAKETKEEPQKKRGGKVHHLPASIWKKRDVETTSPLDQAIKRSQEFFLREQLPAGYWWAELES
NVTITAEYVILFHFMGLVNRDKDRKMATYLLSKQTEEGCWCIWHGGPGDLSTTIEAYFALKLAGYPADHPAMQKARTFIL
GKGGILKARVFTKIFLALFGEFSWLGVPSMPIEMMLLPNGFTFNLYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
YVRPPRPMDYTFTKEDGILTWKNIFIGIDHILKVYEASPIRPGMKKAMAIAEQWVLDHQEPTGDWGGIQPAMLNSVLALH
CLGYANDHPAVAKGLQALANFCIESDDEIVLQSCISPVWDTALALMAMVDSEVPTDHPALVKAAQWLLDREVRKVGDWKI
KAPNLEPGGWAFEFQNDWYPDVDDSGIVMMAIKDVKVKDSKAKAEAIQRGIAWCIGMQSKNGGWGAFDKDNTKHILNKIP
FADLEALIDPPTADLTGRMLELMGTFGYPKDHPAAVRALQFVKENQEPDGPWWGRWGVNYIYGTWSVLCGLKAYGEDMGQ
PYVRKAVEWLAAHQNPDGGWGECCESYCDQKLAGTGPSTASQTGWALLSMLAAGDVDHPAVARGIRYLIETQQPDGTWDE
DQFTGTGFPKYFMIKYHIYRNCFPLMAMGRYRALKGHKG

Sequences:

>Translated_679_residues
MKISKHPISHALTSFNETAKETKEEPQKKRGGKVHHLPASIWKKRDVETTSPLDQAIKRSQEFFLREQLPAGYWWAELES
NVTITAEYVILFHFMGLVNRDKDRKMATYLLSKQTEEGCWCIWHGGPGDLSTTIEAYFALKLAGYPADHPAMQKARTFIL
GKGGILKARVFTKIFLALFGEFSWLGVPSMPIEMMLLPNGFTFNLYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
YVRPPRPMDYTFTKEDGILTWKNIFIGIDHILKVYEASPIRPGMKKAMAIAEQWVLDHQEPTGDWGGIQPAMLNSVLALH
CLGYANDHPAVAKGLQALANFCIESDDEIVLQSCISPVWDTALALMAMVDSEVPTDHPALVKAAQWLLDREVRKVGDWKI
KAPNLEPGGWAFEFQNDWYPDVDDSGIVMMAIKDVKVKDSKAKAEAIQRGIAWCIGMQSKNGGWGAFDKDNTKHILNKIP
FADLEALIDPPTADLTGRMLELMGTFGYPKDHPAAVRALQFVKENQEPDGPWWGRWGVNYIYGTWSVLCGLKAYGEDMGQ
PYVRKAVEWLAAHQNPDGGWGECCESYCDQKLAGTGPSTASQTGWALLSMLAAGDVDHPAVARGIRYLIETQQPDGTWDE
DQFTGTGFPKYFMIKYHIYRNCFPLMAMGRYRALKGHKG
>Mature_679_residues
MKISKHPISHALTSFNETAKETKEEPQKKRGGKVHHLPASIWKKRDVETTSPLDQAIKRSQEFFLREQLPAGYWWAELES
NVTITAEYVILFHFMGLVNRDKDRKMATYLLSKQTEEGCWCIWHGGPGDLSTTIEAYFALKLAGYPADHPAMQKARTFIL
GKGGILKARVFTKIFLALFGEFSWLGVPSMPIEMMLLPNGFTFNLYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
YVRPPRPMDYTFTKEDGILTWKNIFIGIDHILKVYEASPIRPGMKKAMAIAEQWVLDHQEPTGDWGGIQPAMLNSVLALH
CLGYANDHPAVAKGLQALANFCIESDDEIVLQSCISPVWDTALALMAMVDSEVPTDHPALVKAAQWLLDREVRKVGDWKI
KAPNLEPGGWAFEFQNDWYPDVDDSGIVMMAIKDVKVKDSKAKAEAIQRGIAWCIGMQSKNGGWGAFDKDNTKHILNKIP
FADLEALIDPPTADLTGRMLELMGTFGYPKDHPAAVRALQFVKENQEPDGPWWGRWGVNYIYGTWSVLCGLKAYGEDMGQ
PYVRKAVEWLAAHQNPDGGWGECCESYCDQKLAGTGPSTASQTGWALLSMLAAGDVDHPAVARGIRYLIETQQPDGTWDE
DQFTGTGFPKYFMIKYHIYRNCFPLMAMGRYRALKGHKG

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=656, Percent_Identity=24.6951219512195, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI47933395, Length=656, Percent_Identity=24.6951219512195, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI47933397, Length=656, Percent_Identity=24.6951219512195, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI224177556, Length=581, Percent_Identity=25.6454388984509, Blast_Score=162, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6321863, Length=669, Percent_Identity=23.4678624813154, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 76371; Mature: 76371

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISKHPISHALTSFNETAKETKEEPQKKRGGKVHHLPASIWKKRDVETTSPLDQAIKRS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCCCCCCHHHHHHHHH
QEFFLREQLPAGYWWAELESNVTITAEYVILFHFMGLVNRDKDRKMATYLLSKQTEEGCW
HHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCE
CIWHGGPGDLSTTIEAYFALKLAGYPADHPAMQKARTFILGKGGILKARVFTKIFLALFG
EEECCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHC
EFSWLGVPSMPIEMMLLPNGFTFNLYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
CCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEHHHHHHHCCCHHHCCCHHHHHHH
YVRPPRPMDYTFTKEDGILTWKNIFIGIDHILKVYEASPIRPGMKKAMAIAEQWVLDHQE
HCCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
PTGDWGGIQPAMLNSVLALHCLGYANDHPAVAKGLQALANFCIESDDEIVLQSCISPVWD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TALALMAMVDSEVPTDHPALVKAAQWLLDREVRKVGDWKIKAPNLEPGGWAFEFQNDWYP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCC
DVDDSGIVMMAIKDVKVKDSKAKAEAIQRGIAWCIGMQSKNGGWGAFDKDNTKHILNKIP
CCCCCCEEEEEEECCEECCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHCC
FADLEALIDPPTADLTGRMLELMGTFGYPKDHPAAVRALQFVKENQEPDGPWWGRWGVNY
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
IYGTWSVLCGLKAYGEDMGQPYVRKAVEWLAAHQNPDGGWGECCESYCDQKLAGTGPSTA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHCCCCCCCC
SQTGWALLSMLAAGDVDHPAVARGIRYLIETQQPDGTWDEDQFTGTGFPKYFMIKYHIYR
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHH
NCFPLMAMGRYRALKGHKG
HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKISKHPISHALTSFNETAKETKEEPQKKRGGKVHHLPASIWKKRDVETTSPLDQAIKRS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCCCCCCHHHHHHHHH
QEFFLREQLPAGYWWAELESNVTITAEYVILFHFMGLVNRDKDRKMATYLLSKQTEEGCW
HHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCE
CIWHGGPGDLSTTIEAYFALKLAGYPADHPAMQKARTFILGKGGILKARVFTKIFLALFG
EEECCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHC
EFSWLGVPSMPIEMMLLPNGFTFNLYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
CCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEHHHHHHHCCCHHHCCCHHHHHHH
YVRPPRPMDYTFTKEDGILTWKNIFIGIDHILKVYEASPIRPGMKKAMAIAEQWVLDHQE
HCCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
PTGDWGGIQPAMLNSVLALHCLGYANDHPAVAKGLQALANFCIESDDEIVLQSCISPVWD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TALALMAMVDSEVPTDHPALVKAAQWLLDREVRKVGDWKIKAPNLEPGGWAFEFQNDWYP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCC
DVDDSGIVMMAIKDVKVKDSKAKAEAIQRGIAWCIGMQSKNGGWGAFDKDNTKHILNKIP
CCCCCCEEEEEEECCEECCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHCC
FADLEALIDPPTADLTGRMLELMGTFGYPKDHPAAVRALQFVKENQEPDGPWWGRWGVNY
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
IYGTWSVLCGLKAYGEDMGQPYVRKAVEWLAAHQNPDGGWGECCESYCDQKLAGTGPSTA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHCCCCCCCC
SQTGWALLSMLAAGDVDHPAVARGIRYLIETQQPDGTWDEDQFTGTGFPKYFMIKYHIYR
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHH
NCFPLMAMGRYRALKGHKG
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]